JP2014517698A5 - - Google Patents
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- Publication number
- JP2014517698A5 JP2014517698A5 JP2014512858A JP2014512858A JP2014517698A5 JP 2014517698 A5 JP2014517698 A5 JP 2014517698A5 JP 2014512858 A JP2014512858 A JP 2014512858A JP 2014512858 A JP2014512858 A JP 2014512858A JP 2014517698 A5 JP2014517698 A5 JP 2014517698A5
- Authority
- JP
- Japan
- Prior art keywords
- ngf
- complex
- pichia
- subunit
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 14
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 8
- 241000235648 Pichia Species 0.000 claims 7
- 108090000623 proteins and genes Proteins 0.000 claims 5
- 210000003527 eukaryotic cell Anatomy 0.000 claims 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 3
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 2
- 230000002159 abnormal effect Effects 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 241000235058 Komagataella pastoris Species 0.000 claims 1
- YTGJWQPHMWSCST-UHFFFAOYSA-N Tiopronin Chemical compound CC(S)C(=O)NCC(O)=O YTGJWQPHMWSCST-UHFFFAOYSA-N 0.000 claims 1
- 108010058907 Tiopronin Proteins 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 238000012136 culture method Methods 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
- 235000018417 cysteine Nutrition 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000028327 secretion Effects 0.000 claims 1
- 229940028870 thiola Drugs 0.000 claims 1
- 210000005253 yeast cell Anatomy 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161488660P | 2011-05-20 | 2011-05-20 | |
| US61/488,660 | 2011-05-20 | ||
| US201161496873P | 2011-06-14 | 2011-06-14 | |
| US201161496860P | 2011-06-14 | 2011-06-14 | |
| US61/496,873 | 2011-06-14 | ||
| US61/496,860 | 2011-06-14 | ||
| US201161525307P | 2011-08-19 | 2011-08-19 | |
| US61/525,307 | 2011-08-19 | ||
| PCT/US2012/036953 WO2012161956A2 (en) | 2011-05-20 | 2012-05-08 | High-purity production of multi-subunit proteins such as antibodies in transformed microbes such as pichia pastoris |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017119537A Division JP6491696B2 (ja) | 2011-05-20 | 2017-06-19 | 形質転換されたピキア・パストリス（Ｐｉｃｈｉａ ｐａｓｔｏｒｉｓ）などの微生物における抗体などのマルチサブユニットタンパク質の高純度生産 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014517698A JP2014517698A (ja) | 2014-07-24 |
| JP2014517698A5 true JP2014517698A5 (https=) | 2015-06-25 |
| JP6193220B2 JP6193220B2 (ja) | 2017-09-06 |
Family
ID=47217961
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014512858A Active JP6193220B2 (ja) | 2011-05-20 | 2012-05-08 | 形質転換されたピキア・パストリス（Ｐｉｃｈｉａｐａｓｔｏｒｉｓ）などの微生物における抗体などのマルチサブユニットタンパク質の高純度生産 |
| JP2017119537A Active JP6491696B2 (ja) | 2011-05-20 | 2017-06-19 | 形質転換されたピキア・パストリス（Ｐｉｃｈｉａ ｐａｓｔｏｒｉｓ）などの微生物における抗体などのマルチサブユニットタンパク質の高純度生産 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017119537A Active JP6491696B2 (ja) | 2011-05-20 | 2017-06-19 | 形質転換されたピキア・パストリス（Ｐｉｃｈｉａ ｐａｓｔｏｒｉｓ）などの微生物における抗体などのマルチサブユニットタンパク質の高純度生産 |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP2710114B1 (https=) |
| JP (2) | JP6193220B2 (https=) |
| KR (1) | KR101981662B1 (https=) |
| CN (2) | CN103827290A (https=) |
| CA (1) | CA2837000C (https=) |
| CY (1) | CY1124796T1 (https=) |
| DK (1) | DK2710114T3 (https=) |
| EA (1) | EA028913B9 (https=) |
| ES (1) | ES2899381T3 (https=) |
| HR (1) | HRP20211873T1 (https=) |
| HU (1) | HUE060418T2 (https=) |
| IL (1) | IL229430B (https=) |
| LT (1) | LT2710114T (https=) |
| MX (2) | MX368546B (https=) |
| PL (1) | PL2710114T3 (https=) |
| PT (1) | PT2710114T (https=) |
| RS (1) | RS62628B1 (https=) |
| SG (1) | SG194937A1 (https=) |
| SI (1) | SI2710114T1 (https=) |
| SM (1) | SMT202100677T1 (https=) |
| WO (1) | WO2012161956A2 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20161439A1 (es) * | 2014-03-21 | 2017-01-26 | Teva Pharmaceuticals Int Gmbh | Anticuerpos antagonistas dirigidos contra el peptido relacionado con el gen de calcitonina y metodos que usan los mismos |
| TWI734775B (zh) | 2016-04-26 | 2021-08-01 | 美商美國泰福生技股份有限公司 | 細胞培養基 |
| WO2018055574A1 (en) | 2016-09-23 | 2018-03-29 | Teva Pharmaceuticals International Gmbh | Treating refractory migraine |
| GB201803832D0 (en) * | 2018-03-09 | 2018-04-25 | Syndermix Ag | Methods and compositions for lectin production |
| CN108913732B (zh) * | 2018-07-31 | 2022-02-08 | 华东理工大学 | 一种莫纳可林j异源生产的方法及应用 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4855231A (en) | 1984-10-30 | 1989-08-08 | Phillips Petroleum Company | Regulatory region for heterologous gene expression in yeast |
| US4818700A (en) | 1985-10-25 | 1989-04-04 | Phillips Petroleum Company | Pichia pastoris argininosuccinate lyase gene and uses thereof |
| US4812405A (en) | 1986-02-18 | 1989-03-14 | Phillips Petroleum Company | Double auxotrophic mutants of Pichia pastoris and methods for preparation |
| US4929555A (en) | 1987-10-19 | 1990-05-29 | Phillips Petroleum Company | Pichia transformation |
| WO1994021293A1 (en) | 1993-03-19 | 1994-09-29 | Duke University | Method of treatment of tumors with an antibody binding to tenascin |
| ES2251723T3 (es) | 1994-08-12 | 2006-05-01 | Immunomedics, Inc. | Inmunoconjugados y anticuerpos humanizados especificos para linfoma de celulas b y celulas de leucemia. |
| US5955349A (en) | 1996-08-26 | 1999-09-21 | Zymogenetics, Inc. | Compositions and methods for producing heterologous polypeptides in Pichia methanolica |
| US5736383A (en) | 1996-08-26 | 1998-04-07 | Zymogenetics, Inc. | Preparation of Pichia methanolica auxotrophic mutants |
| US6653104B2 (en) | 1996-10-17 | 2003-11-25 | Immunomedics, Inc. | Immunotoxins, comprising an internalizing antibody, directed against malignant and normal cells |
| US6730499B1 (en) | 1998-07-03 | 2004-05-04 | Research Corporation Technologies, Inc. | Promoter for the Pichia pastoris formaldehyde dehydrogenase gene FLD1 |
| US6258559B1 (en) | 1999-03-22 | 2001-07-10 | Zymogenetics, Inc. | Method for producing proteins in transformed Pichia |
| AU3910000A (en) * | 1999-03-22 | 2000-10-09 | Zymogenetics Inc. | Improved methods for producing proteins in transformed (pichia) |
| BR0116675A (pt) * | 2000-12-13 | 2003-11-04 | Unilever Nv | Método de produção de uma proteìna heteróloga por um fungo e proteìna heteróloga |
| PT1678314E (pt) | 2003-10-22 | 2012-11-27 | Keck Graduate Inst | Métodos de síntese de polipéptidos heteromultiméricos em levedura utilizando uma estratégia de conjugação haplóide |
| US8222386B2 (en) | 2006-10-10 | 2012-07-17 | Keck Graduate Institute | P. pastoris ADH promoter and use thereof to direct expression of proteins |
| HUE032563T2 (en) | 2007-05-21 | 2017-09-28 | Alderbio Holdings Llc | Antibodies to IL-6 and their use |
| KR20170036814A (ko) | 2007-05-21 | 2017-04-03 | 앨더바이오 홀딩스 엘엘씨 | 신규한 래빗 항체 인간화 방법 및 인간화된 래빗 항체 |
| JP6190723B2 (ja) * | 2010-12-01 | 2017-08-30 | アルダーバイオ ホールディングス エルエルシー | 抗ｎｇｆ組成物およびその使用 |
-
2012
- 2012-05-08 DK DK12789187.7T patent/DK2710114T3/da active
- 2012-05-08 SG SG2013084041A patent/SG194937A1/en unknown
- 2012-05-08 HU HUE12789187A patent/HUE060418T2/hu unknown
- 2012-05-08 WO PCT/US2012/036953 patent/WO2012161956A2/en not_active Ceased
- 2012-05-08 JP JP2014512858A patent/JP6193220B2/ja active Active
- 2012-05-08 CA CA2837000A patent/CA2837000C/en active Active
- 2012-05-08 SI SI201231967T patent/SI2710114T1/sl unknown
- 2012-05-08 CN CN201280035868.4A patent/CN103827290A/zh active Pending
- 2012-05-08 CN CN201910566412.4A patent/CN110408644A/zh active Pending
- 2012-05-08 LT LTEPPCT/US2012/036953T patent/LT2710114T/lt unknown
- 2012-05-08 EA EA201301294A patent/EA028913B9/ru not_active IP Right Cessation
- 2012-05-08 RS RS20211462A patent/RS62628B1/sr unknown
- 2012-05-08 MX MX2013013532A patent/MX368546B/es active IP Right Grant
- 2012-05-08 ES ES12789187T patent/ES2899381T3/es active Active
- 2012-05-08 EP EP12789187.7A patent/EP2710114B1/en active Active
- 2012-05-08 KR KR1020137033842A patent/KR101981662B1/ko active Active
- 2012-05-08 PT PT127891877T patent/PT2710114T/pt unknown
- 2012-05-08 PL PL12789187T patent/PL2710114T3/pl unknown
- 2012-05-08 SM SM20210677T patent/SMT202100677T1/it unknown
- 2012-05-08 HR HRP20211873TT patent/HRP20211873T1/hr unknown
-
2013
- 2013-11-14 IL IL229430A patent/IL229430B/en active IP Right Grant
- 2013-11-19 MX MX2019012022A patent/MX2019012022A/es unknown
-
2017
- 2017-06-19 JP JP2017119537A patent/JP6491696B2/ja active Active
-
2021
- 2021-12-02 CY CY20211101055T patent/CY1124796T1/el unknown
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