JP2014517311A5 - - Google Patents
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- Publication number
- JP2014517311A5 JP2014517311A5 JP2014514560A JP2014514560A JP2014517311A5 JP 2014517311 A5 JP2014517311 A5 JP 2014517311A5 JP 2014514560 A JP2014514560 A JP 2014514560A JP 2014514560 A JP2014514560 A JP 2014514560A JP 2014517311 A5 JP2014517311 A5 JP 2014517311A5
- Authority
- JP
- Japan
- Prior art keywords
- zone
- antibody
- conjugate
- pad
- sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000004211 Platelet factor 4 Human genes 0.000 claims 17
- 108090000778 Platelet factor 4 Proteins 0.000 claims 17
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 11
- 229960002897 heparin Drugs 0.000 claims 11
- 229920000669 heparin Polymers 0.000 claims 11
- 239000000523 sample Substances 0.000 claims 10
- 239000012530 fluid Substances 0.000 claims 8
- 229920000447 polyanionic polymer Polymers 0.000 claims 7
- 238000001514 detection method Methods 0.000 claims 6
- 239000012528 membrane Substances 0.000 claims 6
- 239000007850 fluorescent dye Substances 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- 150000001412 amines Chemical class 0.000 claims 4
- 239000007787 solid Substances 0.000 claims 4
- 229920002554 vinyl polymer Polymers 0.000 claims 4
- 101000582950 Homo sapiens Platelet factor 4 Proteins 0.000 claims 3
- 102000052196 human PF4 Human genes 0.000 claims 3
- 230000003100 immobilizing effect Effects 0.000 claims 3
- 238000011144 upstream manufacturing Methods 0.000 claims 3
- 239000012099 Alexa Fluor family Substances 0.000 claims 2
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 239000000975 dye Substances 0.000 claims 2
- 239000000985 reactive dye Substances 0.000 claims 2
- 239000012723 sample buffer Substances 0.000 claims 2
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 claims 1
- 229920000172 poly(styrenesulfonic acid) Polymers 0.000 claims 1
- 229940005642 polystyrene sulfonic acid Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161495171P | 2011-06-09 | 2011-06-09 | |
| US61/495,171 | 2011-06-09 | ||
| PCT/US2012/040938 WO2012170435A2 (en) | 2011-06-09 | 2012-06-05 | Diagnostic devices, methods and systems for detecting platelet factor 4 (pf4)/heparin antibodies |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014517311A JP2014517311A (ja) | 2014-07-17 |
| JP2014517311A5 true JP2014517311A5 (enExample) | 2015-07-23 |
| JP6075799B2 JP6075799B2 (ja) | 2017-02-08 |
Family
ID=46317508
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014514560A Active JP6075799B2 (ja) | 2011-06-09 | 2012-06-05 | 血小板第４因子（ｐｆ４）／ヘパリン抗体を検出する診断デバイス、方法及びシステム |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9599623B2 (enExample) |
| EP (1) | EP2718724B1 (enExample) |
| JP (1) | JP6075799B2 (enExample) |
| AU (1) | AU2012268393B2 (enExample) |
| CA (1) | CA2838708C (enExample) |
| WO (1) | WO2012170435A2 (enExample) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI498166B (zh) * | 2013-07-02 | 2015-09-01 | Univ Nat Taiwan | 以表面電漿共振定量分析之自動操作檢測程序的多孔性薄膜微流體裝置 |
| EP3063544B1 (en) * | 2013-10-29 | 2021-05-26 | Versiti Blood Research Institute Foundation, Inc. | Method of detecting platelet activating antibodies that cause heparin-induced thrombocytopenia/thrombosis |
| US10877031B2 (en) | 2013-12-06 | 2020-12-29 | Ortho-Clinical Diagnostics, Inc. | Assay device having a wash port |
| GB2523135A (en) * | 2014-02-13 | 2015-08-19 | Molecular Vision Ltd | Assay device |
| US20150044707A1 (en) * | 2014-02-18 | 2015-02-12 | Melinda Sanders | At-Home Blood Pregnancy Test Kit |
| CN104076014A (zh) * | 2014-06-30 | 2014-10-01 | 安徽师范大学 | 一种荧光传感器，其制备方法，用途以及检测Heparin分子的方法 |
| GB2528657B (en) * | 2014-07-24 | 2019-03-13 | Intelligent Fingerprinting Ltd | Sample analysing device |
| US11536707B2 (en) * | 2014-09-23 | 2022-12-27 | Tearlab Research, Inc. | Systems and methods for integration of microfluidic tear collection and lateral flow analysis of analytes of interest |
| US10324089B2 (en) | 2014-12-11 | 2019-06-18 | Critical Care Diagnostics, Inc. | Test apparatus and methods for ST2 cardiac biomarker |
| EP3230738B1 (en) * | 2014-12-11 | 2019-11-20 | Critical Care Diagnostics, Inc. | Test apparatus for st2 cardiac biomarker |
| GB2535998A (en) * | 2015-02-27 | 2016-09-07 | Intelligent Fingerprinting Ltd | A device for receiving and analysing a sample |
| KR101635956B1 (ko) * | 2015-03-16 | 2016-07-06 | (주)큐브바이오 | 천공 부재를 구비하는 진단 키트 |
| CN108369228B (zh) | 2015-12-18 | 2020-11-17 | 富士胶片株式会社 | 免疫层析试剂盒 |
| AU2017212742A1 (en) * | 2016-01-27 | 2018-07-26 | Undercover Colors, Inc. | Wearable apparatus for detecting a target substance in a liquid |
| US10073092B2 (en) * | 2016-02-19 | 2018-09-11 | Andrew Wang | Apparatus for assay strip(s) with specimen loading to multiple zones and related methods |
| WO2017151642A1 (en) * | 2016-02-29 | 2017-09-08 | Flora Bioscience, Inc. | Detection apparatus |
| JP7066212B2 (ja) * | 2017-01-06 | 2022-05-13 | ディーエヌティー サイエンティフィック リサーチ，エルエルシー | 駆動流技術による迅速診断試験装置 |
| US10458974B2 (en) * | 2017-06-09 | 2019-10-29 | Optimum Imaging Diagnostics LLC | Universal testing system for quantitative analysis |
| EP3413051B1 (de) * | 2017-06-09 | 2020-07-29 | Siemens Healthcare Diagnostics Products GmbH | Aktivierungstest zur diagnose einer heparin-induzierten thrombozytopenie |
| ES2862434T3 (es) * | 2017-08-02 | 2021-10-07 | Siemens Healthcare Diagnostics Products Gmbh | Prueba de unión para el diagnóstico de trombocitopenia inducida por heparina |
| CN107727851A (zh) * | 2017-11-15 | 2018-02-23 | 北京舜雷科技有限公司 | 一种免疫凝集和胶体金层析试纸条相结合的用于检测hit抗体的系统 |
| WO2019202395A1 (en) * | 2018-04-20 | 2019-10-24 | Biokit Research & Developments, S.L.U. | Heparin-induced thrombocytopenia assay |
| USD959015S1 (en) * | 2020-06-05 | 2022-07-26 | Zhejiang Orient Gene Biotech Co., LTD | COVID immunoassay test device |
| USD954982S1 (en) * | 2020-06-30 | 2022-06-14 | Hangzhou Biotest Biotech Co., Ltd. | COVID immunoassay test device |
| USD954983S1 (en) * | 2020-09-04 | 2022-06-14 | Hangzhou Biotest Biotech Co., Ltd. | COVID immunoassay test device |
| CN112842334A (zh) * | 2021-02-08 | 2021-05-28 | 德莫德（苏州）机械科技有限公司 | 一种翻转式加样及按压式加液的一体化胶体金卡盒 |
| USD977673S1 (en) * | 2021-03-26 | 2023-02-07 | Zhejiang Orient Gene Biotech Co., LTD | Test card |
| USD1069617S1 (en) * | 2021-03-29 | 2025-04-08 | Owen Mumford Limited | Testing device |
| KR102281805B1 (ko) * | 2021-04-22 | 2021-07-26 | 주식회사 제트바이오텍 | 형광염료를 이용한 건식 타입 형광 정량분석 체외 진단키트 및 그 제조방법 |
| USD1025392S1 (en) * | 2022-01-25 | 2024-04-30 | Acon Biotech (Hangzhou) Co.Ltd. | Test device |
| USD990704S1 (en) * | 2022-07-14 | 2023-06-27 | Andon Health Co., Ltd. | Test strip for medical or laboratory purposes |
| USD1054585S1 (en) * | 2023-01-14 | 2024-12-17 | Zhejiang Orient Gene Biotech Co., LTD | Test card |
| JP1747082S (ja) * | 2023-01-16 | 2023-06-22 | 検査器具 | |
| USD1053379S1 (en) * | 2023-01-19 | 2024-12-03 | Zhejiang Orient Gene Biotech Co., LTD | United test card |
| USD1101961S1 (en) * | 2023-04-28 | 2025-11-11 | Charles River Laboratories International, Inc. | Cartridge |
| CA221817S (en) * | 2023-05-24 | 2024-09-25 | Zhejiang Orient Gene Biotech Co Ltd | Test card |
| CA221818S (en) * | 2023-05-24 | 2024-10-22 | Zhejiang Orient Gene Biotech Co Ltd | Test card |
| USD1086484S1 (en) * | 2023-06-26 | 2025-07-29 | Hangzhou Biotest Biotech Co., Ltd | Liquid sample test device |
| CN117471105B (zh) * | 2023-12-27 | 2024-03-26 | 北京芯迈微生物技术有限公司 | 双向双驱序贯式血小板hla抗体检测的微流控芯片及应用 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4981786A (en) * | 1987-09-04 | 1991-01-01 | Syntex (U.S.A.) Inc. | Multiple port assay device |
| US5466582A (en) | 1990-08-09 | 1995-11-14 | Serbio | Thrombocytopenia determination |
| US5972717A (en) | 1995-05-10 | 1999-10-26 | The Blood Center Research Foundation, Inc. | Method and kit for detecting heparin induced thrombocytopenia |
| US5972718A (en) * | 1996-02-28 | 1999-10-26 | The Blood Center Research Foundation | Method of detecting heparin-induced thrombocytopenia |
| DE19927783A1 (de) * | 1999-06-18 | 2000-12-21 | Roche Diagnostics Gmbh | Element zur Bestimmung eines Analyts in einer Flüssigkeit, entsprechendes Bestimmungsverfahren unter Verwendung des Elementes sowie Kit zur Bestimmugn eines Analyts |
| US6964854B1 (en) | 1999-07-13 | 2005-11-15 | Science & Technology Corporation | Compositions and methods useful for the diagnosis and treatment of heparin induced thrombocytopenia/thrombosis |
| US6713309B1 (en) * | 1999-07-30 | 2004-03-30 | Large Scale Proteomics Corporation | Microarrays and their manufacture |
| ATE343597T1 (de) | 1999-08-30 | 2006-11-15 | Wesagen Inc | Diagnostisches assay für typ-2-heparin induzierte thrombocytopenie |
| JP4931821B2 (ja) | 2004-10-04 | 2012-05-16 | アケルス バイオサイエンス インコーポレーテッド | ヘパリン／血小板第４因子抗体の検出法及びキット |
| US7629127B2 (en) * | 2005-01-21 | 2009-12-08 | Dexall Biomedical Labs, Inc. | Method for the visual detection of specific antibodies by the use of lateral flow assays |
| CA2608162C (en) * | 2005-05-23 | 2013-11-12 | Phadia Ab | Two step lateral flow assay methods and devices |
| FR2902884B1 (fr) | 2006-06-23 | 2008-12-26 | Hyphen Biomed Soc Par Actions | Procede pour la detection des anticorps heparine-dependants et le diagnostic des pathologies immunes ou auto-immnues potentialisees par l'heparine telle que la thrombopenie induite par l'heparine |
| JP4198182B1 (ja) * | 2007-12-28 | 2008-12-17 | 有限会社バイオデバイステクノロジー | イムノクロマト分析法及びイムノクロマト分析キット |
| EP2265948A4 (en) | 2008-02-29 | 2011-04-20 | Biomedomics Inc | FAST AND SENSITIVE METHOD FOR THE QUANTITATIVE DETERMINATION OF THE MIRROR OF IMMUNOGLOBULIN ANTIBODIES INDUCED BY HEPARIN-PF4 COMPLEX |
| CA2671142C (en) * | 2008-07-03 | 2016-12-06 | Amic Ab | Method for the analysis of circulating antibodies |
| WO2010024271A1 (ja) | 2008-08-27 | 2010-03-04 | 三菱化学メディエンス株式会社 | 修飾抗ヘパリン／pf4複合体抗体及びhit抗体標準品 |
| US10114012B2 (en) * | 2008-10-31 | 2018-10-30 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and assays for detecting and quantifying pure subpopulations of white blood cells in immune system disorders |
-
2012
- 2012-06-05 US US14/124,533 patent/US9599623B2/en active Active
- 2012-06-05 EP EP12727977.6A patent/EP2718724B1/en active Active
- 2012-06-05 AU AU2012268393A patent/AU2012268393B2/en active Active
- 2012-06-05 CA CA2838708A patent/CA2838708C/en active Active
- 2012-06-05 WO PCT/US2012/040938 patent/WO2012170435A2/en not_active Ceased
- 2012-06-05 JP JP2014514560A patent/JP6075799B2/ja active Active
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