JP2016528236A5 - - Google Patents
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- Publication number
- JP2016528236A5 JP2016528236A5 JP2016533450A JP2016533450A JP2016528236A5 JP 2016528236 A5 JP2016528236 A5 JP 2016528236A5 JP 2016533450 A JP2016533450 A JP 2016533450A JP 2016533450 A JP2016533450 A JP 2016533450A JP 2016528236 A5 JP2016528236 A5 JP 2016528236A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- antibody
- monoclonal antibody
- human
- timp2
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 101000645296 Homo sapiens Metalloproteinase inhibitor 2 Proteins 0.000 claims 12
- 102000053875 human TIMP2 Human genes 0.000 claims 9
- 238000000034 method Methods 0.000 claims 8
- 239000012472 biological sample Substances 0.000 claims 6
- 238000003018 immunoassay Methods 0.000 claims 6
- 241000282414 Homo sapiens Species 0.000 claims 5
- 241000283973 Oryctolagus cuniculus Species 0.000 claims 4
- 229920001184 polypeptide Polymers 0.000 claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims 4
- 102100026262 Metalloproteinase inhibitor 2 Human genes 0.000 claims 3
- 239000013610 patient sample Substances 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 235000002198 Annona diversifolia Nutrition 0.000 claims 2
- 241000282836 Camelus dromedarius Species 0.000 claims 2
- 241000283707 Capra Species 0.000 claims 2
- 241000283074 Equus asinus Species 0.000 claims 2
- 241000287828 Gallus gallus Species 0.000 claims 2
- 241000282842 Lama glama Species 0.000 claims 2
- 241000699666 Mus <mouse, genus> Species 0.000 claims 2
- 241001494479 Pecora Species 0.000 claims 2
- 238000003556 assay Methods 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 238000007689 inspection Methods 0.000 claims 2
- 239000011541 reaction mixture Substances 0.000 claims 2
- 238000011088 calibration curve Methods 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 239000007790 solid phase Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361863073P | 2013-08-07 | 2013-08-07 | |
| US61/863,073 | 2013-08-07 | ||
| PCT/US2014/050195 WO2015021308A1 (en) | 2013-08-07 | 2014-08-07 | Assays for timp2 having improved performance in biological samples |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016528236A JP2016528236A (ja) | 2016-09-15 |
| JP2016528236A5 true JP2016528236A5 (enExample) | 2017-08-10 |
Family
ID=52461941
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016533450A Pending JP2016528236A (ja) | 2013-08-07 | 2014-08-07 | 生物学的試料において改善された性能を有するｔｉｍｐ２のためのアッセイ |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US9879091B2 (enExample) |
| EP (2) | EP3617234A1 (enExample) |
| JP (1) | JP2016528236A (enExample) |
| KR (1) | KR20160039682A (enExample) |
| CN (1) | CN105531291A (enExample) |
| AU (1) | AU2014305883A1 (enExample) |
| BR (1) | BR112016002685A2 (enExample) |
| CA (1) | CA2920521A1 (enExample) |
| EA (1) | EA201690185A1 (enExample) |
| HK (1) | HK1222180A1 (enExample) |
| MX (1) | MX2016001573A (enExample) |
| WO (1) | WO2015021308A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ628843A (en) | 2008-10-21 | 2016-02-26 | Astute Medical Inc | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| JP5763098B2 (ja) | 2009-12-20 | 2015-08-12 | アスチュート メディカル，インコーポレイテッド | 腎損傷および腎不全の診断および予後診断のための方法ならびに組成物 |
| WO2011162821A1 (en) | 2010-06-23 | 2011-12-29 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| WO2013086359A1 (en) | 2011-12-08 | 2013-06-13 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| CA3158996C (en) | 2013-01-17 | 2024-06-04 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| CN105917229B (zh) | 2013-12-03 | 2019-04-26 | 阿斯图特医药公司 | 用于肾损伤和肾衰竭的诊断和预后的方法和组合物 |
| WO2016164854A1 (en) | 2015-04-09 | 2016-10-13 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| WO2017117490A1 (en) * | 2015-12-30 | 2017-07-06 | Bio-Rad Laboratories, Inc. | Droplet assay system with automatic calibration |
| AU2017277305A1 (en) | 2016-06-06 | 2018-12-20 | Astute Medical, Inc. | Management of acute kidney injury using insulin-like growth factor-binding protein 7 and tissue inhibitor of metalloproteinase 2 |
| WO2018006049A1 (en) * | 2016-06-30 | 2018-01-04 | The Research Foundation For The State University Of New York | Compositions and methods for modifying activity of extracellular mmp-2 |
| US20190263926A1 (en) * | 2016-10-28 | 2019-08-29 | Astute Medical, Inc. | Use of Antibodies to TIMP-2 for the Improvement of Renal Function |
| US11346846B2 (en) | 2017-02-06 | 2022-05-31 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| CN110709103B (zh) * | 2017-04-05 | 2024-02-02 | 机敏医药股份有限公司 | 用于生物学样品中具有改善的性能的timp2的测定法 |
| CN112384807A (zh) | 2018-05-24 | 2021-02-19 | 雷尼布斯治疗公司 | 治疗有风险患有肾损伤和肾衰竭的患者的方法 |
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|---|---|---|---|---|
| US459004A (en) | 1891-09-08 | Box for steaming cops | ||
| DE3029579C2 (de) | 1980-08-05 | 1985-12-12 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren und Mittel zur Abtrennung von Plasma oder Serum aus Vollblut |
| US5807715A (en) | 1984-08-27 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
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| JP4312259B2 (ja) | 1995-04-27 | 2009-08-12 | アムジェン フレモント インク． | 免疫したゼノマウス（ＸｅｎｏＭｏｕｓｅ）に由来するヒト抗体 |
| EP0823941A4 (en) | 1995-04-28 | 2001-09-19 | Abgenix Inc | HUMAN ANTIBODIES DERIVED FROM IMMUNIZED XENO MOUSES |
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| NZ628843A (en) | 2008-10-21 | 2016-02-26 | Astute Medical Inc | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| US8900881B2 (en) * | 2008-12-30 | 2014-12-02 | Jin Po Lee | Quantitative analyte assay device and method |
| JP5763098B2 (ja) | 2009-12-20 | 2015-08-12 | アスチュート メディカル，インコーポレイテッド | 腎損傷および腎不全の診断および予後診断のための方法ならびに組成物 |
| CA2794721A1 (en) * | 2010-03-31 | 2011-10-13 | Sekisui Medical Co., Ltd. | Assay utilizing immunochromatography, immunochromatographic test strip, and assay reagent kit for immunochromatography |
-
2014
- 2014-08-07 WO PCT/US2014/050195 patent/WO2015021308A1/en not_active Ceased
- 2014-08-07 CA CA2920521A patent/CA2920521A1/en not_active Abandoned
- 2014-08-07 EP EP19183111.4A patent/EP3617234A1/en not_active Withdrawn
- 2014-08-07 CN CN201480048192.1A patent/CN105531291A/zh active Pending
- 2014-08-07 US US14/910,661 patent/US9879091B2/en active Active
- 2014-08-07 AU AU2014305883A patent/AU2014305883A1/en not_active Abandoned
- 2014-08-07 HK HK16110255.1A patent/HK1222180A1/zh unknown
- 2014-08-07 JP JP2016533450A patent/JP2016528236A/ja active Pending
- 2014-08-07 KR KR1020167005705A patent/KR20160039682A/ko not_active Withdrawn
- 2014-08-07 BR BR112016002685A patent/BR112016002685A2/pt not_active Application Discontinuation
- 2014-08-07 EP EP14834090.4A patent/EP3030582A4/en not_active Withdrawn
- 2014-08-07 EA EA201690185A patent/EA201690185A1/ru unknown
- 2014-08-07 MX MX2016001573A patent/MX2016001573A/es unknown
-
2018
- 2018-01-29 US US15/882,936 patent/US10457744B2/en active Active
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