EA201690185A1 - Анализ timp2, обладающий улучшенной эффективностью в биологическом образце - Google Patents

Анализ timp2, обладающий улучшенной эффективностью в биологическом образце

Info

Publication number
EA201690185A1
EA201690185A1 EA201690185A EA201690185A EA201690185A1 EA 201690185 A1 EA201690185 A1 EA 201690185A1 EA 201690185 A EA201690185 A EA 201690185A EA 201690185 A EA201690185 A EA 201690185A EA 201690185 A1 EA201690185 A1 EA 201690185A1
Authority
EA
Eurasian Patent Office
Prior art keywords
timp2
analysis
owning
biological sample
improved efficiency
Prior art date
Application number
EA201690185A
Other languages
English (en)
Inventor
Рави А. Виджаендран
Сриватса Венкатасуббарао
Original Assignee
Астьют Медикал, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Астьют Медикал, Инк. filed Critical Астьют Медикал, Инк.
Publication of EA201690185A1 publication Critical patent/EA201690185A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/38—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against protease inhibitors of peptide structure
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies; monoclonal antibodies per se are classified with their corresponding antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/81—Protease inhibitors
    • G01N2333/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • G01N2333/8146—Metalloprotease (E.C. 3.4.24) inhibitors, e.g. tissue inhibitor of metallo proteinase, TIMP

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

В настоящем изобретении предложены иммуноанализы TIMP2 с улучшенной клинической эффективностью, в частности, при применении для оценки поражений почек. В основе указанных иммуноанализов лежит выбор и применение антител и пар антител, демонстрирующих улучшенные аналитические рабочие характеристики при применении в комплексных клинических образцах, таких как биологические жидкости, и, в частности, при применении в формате экспресс-анализа, таком как устройства, основанные на анализе растекания образца.
EA201690185A 2013-08-07 2014-08-07 Анализ timp2, обладающий улучшенной эффективностью в биологическом образце EA201690185A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361863073P 2013-08-07 2013-08-07
PCT/US2014/050195 WO2015021308A1 (en) 2013-08-07 2014-08-07 Assays for timp2 having improved performance in biological samples

Publications (1)

Publication Number Publication Date
EA201690185A1 true EA201690185A1 (ru) 2016-07-29

Family

ID=52461941

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201690185A EA201690185A1 (ru) 2013-08-07 2014-08-07 Анализ timp2, обладающий улучшенной эффективностью в биологическом образце

Country Status (12)

Country Link
US (2) US9879091B2 (ru)
EP (2) EP3030582A4 (ru)
JP (1) JP2016528236A (ru)
KR (1) KR20160039682A (ru)
CN (1) CN105531291A (ru)
AU (1) AU2014305883A1 (ru)
BR (1) BR112016002685A2 (ru)
CA (1) CA2920521A1 (ru)
EA (1) EA201690185A1 (ru)
HK (1) HK1222180A1 (ru)
MX (1) MX2016001573A (ru)
WO (1) WO2015021308A1 (ru)

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Also Published As

Publication number Publication date
KR20160039682A (ko) 2016-04-11
MX2016001573A (es) 2016-09-07
JP2016528236A (ja) 2016-09-15
US20180162953A1 (en) 2018-06-14
AU2014305883A1 (en) 2016-02-25
CA2920521A1 (en) 2015-02-12
EP3030582A1 (en) 2016-06-15
WO2015021308A1 (en) 2015-02-12
BR112016002685A2 (pt) 2018-01-30
HK1222180A1 (zh) 2017-06-23
CN105531291A (zh) 2016-04-27
US20160297893A1 (en) 2016-10-13
US10457744B2 (en) 2019-10-29
US9879091B2 (en) 2018-01-30
EP3030582A4 (en) 2017-05-17
EP3617234A1 (en) 2020-03-04

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