KR20160039682A - 생물학적 샘플에서 개선된 성능을 가지는 timp2에 대한 검정 - Google Patents

생물학적 샘플에서 개선된 성능을 가지는 timp2에 대한 검정 Download PDF

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Publication number
KR20160039682A
KR20160039682A KR1020167005705A KR20167005705A KR20160039682A KR 20160039682 A KR20160039682 A KR 20160039682A KR 1020167005705 A KR1020167005705 A KR 1020167005705A KR 20167005705 A KR20167005705 A KR 20167005705A KR 20160039682 A KR20160039682 A KR 20160039682A
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KR
South Korea
Prior art keywords
antibody
human
monoclonal antibody
seq
isolated monoclonal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
KR1020167005705A
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English (en)
Korean (ko)
Inventor
라비 에이. 비제인드런
스리뱃자 벤카태주배래오
Original Assignee
아스튜트 메디컬 인코포레이티드
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Publication of KR20160039682A publication Critical patent/KR20160039682A/ko
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/38—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against protease inhibitors of peptide structure
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/558—Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/81—Protease inhibitors
    • G01N2333/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • G01N2333/8146—Metalloprotease (E.C. 3.4.24) inhibitors, e.g. tissue inhibitor of metallo proteinase, TIMP
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/34—Genitourinary disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
KR1020167005705A 2013-08-07 2014-08-07 생물학적 샘플에서 개선된 성능을 가지는 timp2에 대한 검정 Withdrawn KR20160039682A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361863073P 2013-08-07 2013-08-07
US61/863,073 2013-08-07
PCT/US2014/050195 WO2015021308A1 (en) 2013-08-07 2014-08-07 Assays for timp2 having improved performance in biological samples

Publications (1)

Publication Number Publication Date
KR20160039682A true KR20160039682A (ko) 2016-04-11

Family

ID=52461941

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020167005705A Withdrawn KR20160039682A (ko) 2013-08-07 2014-08-07 생물학적 샘플에서 개선된 성능을 가지는 timp2에 대한 검정

Country Status (12)

Country Link
US (2) US9879091B2 (enExample)
EP (2) EP3030582A4 (enExample)
JP (1) JP2016528236A (enExample)
KR (1) KR20160039682A (enExample)
CN (1) CN105531291A (enExample)
AU (1) AU2014305883A1 (enExample)
BR (1) BR112016002685A2 (enExample)
CA (1) CA2920521A1 (enExample)
EA (1) EA201690185A1 (enExample)
HK (1) HK1222180A1 (enExample)
MX (1) MX2016001573A (enExample)
WO (1) WO2015021308A1 (enExample)

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EP3540440B1 (en) 2011-12-08 2022-09-28 Astute Medical, Inc. Methods and uses for evaluating renal injury and renal status
JP6681195B2 (ja) 2013-01-17 2020-04-15 アスチュート メディカル，インコーポレイテッド 腎損傷および腎不全の診断および予後診断のための方法ならびに組成物
CN110007084B (zh) 2013-12-03 2022-11-18 阿斯图特医药公司 用于肾损伤和肾衰竭的诊断和预后的方法和组合物
WO2016164854A1 (en) 2015-04-09 2016-10-13 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
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EP3532101B1 (en) * 2016-10-28 2021-12-08 Astute Medical, Inc. Use of antibodies to timp-2 for the improvement of renal function
CN110431422A (zh) 2017-02-06 2019-11-08 机敏医药股份有限公司 用于肾损伤和肾衰竭的诊断和预后的方法和组合物
WO2018187453A1 (en) * 2017-04-05 2018-10-11 Astute Medical, Inc. Assays for timp2 having improved performance in biological samples
US11435364B2 (en) 2018-05-24 2022-09-06 Renibus Therapeutics, Inc. Methods of treating patients at risk for renal injury and renal failure

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Also Published As

Publication number Publication date
US9879091B2 (en) 2018-01-30
WO2015021308A1 (en) 2015-02-12
EP3617234A1 (en) 2020-03-04
BR112016002685A2 (pt) 2018-01-30
CN105531291A (zh) 2016-04-27
US10457744B2 (en) 2019-10-29
HK1222180A1 (zh) 2017-06-23
EP3030582A1 (en) 2016-06-15
EP3030582A4 (en) 2017-05-17
EA201690185A1 (ru) 2016-07-29
CA2920521A1 (en) 2015-02-12
MX2016001573A (es) 2016-09-07
US20160297893A1 (en) 2016-10-13
US20180162953A1 (en) 2018-06-14
JP2016528236A (ja) 2016-09-15
AU2014305883A1 (en) 2016-02-25

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Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20160302

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid