CA2920521A1 - Assays for timp2 having improved performance in biological samples - Google Patents

Assays for timp2 having improved performance in biological samples Download PDF

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Publication number
CA2920521A1
CA2920521A1 CA2920521A CA2920521A CA2920521A1 CA 2920521 A1 CA2920521 A1 CA 2920521A1 CA 2920521 A CA2920521 A CA 2920521A CA 2920521 A CA2920521 A CA 2920521A CA 2920521 A1 CA2920521 A1 CA 2920521A1
Authority
CA
Canada
Prior art keywords
antibody
monoclonal antibody
seq
isolated monoclonal
human
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2920521A
Other languages
English (en)
French (fr)
Inventor
Ravi A. Vijayendran
Srivatsa Venkatasubbarao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astute Medical Inc
Original Assignee
Astute Medical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astute Medical Inc filed Critical Astute Medical Inc
Publication of CA2920521A1 publication Critical patent/CA2920521A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/38Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against protease inhibitors of peptide structure
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/577Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies; monoclonal antibodies per se are classified with their corresponding antigens
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/81Protease inhibitors
    • G01N2333/8107Endopeptidase (E.C. 3.4.21-99) inhibitors
    • G01N2333/8146Metalloprotease (E.C. 3.4.24) inhibitors, e.g. tissue inhibitor of metallo proteinase, TIMP

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CA2920521A 2013-08-07 2014-08-07 Assays for timp2 having improved performance in biological samples Abandoned CA2920521A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361863073P 2013-08-07 2013-08-07
US61/863,073 2013-08-07
PCT/US2014/050195 WO2015021308A1 (en) 2013-08-07 2014-08-07 Assays for timp2 having improved performance in biological samples

Publications (1)

Publication Number Publication Date
CA2920521A1 true CA2920521A1 (en) 2015-02-12

Family

ID=52461941

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2920521A Abandoned CA2920521A1 (en) 2013-08-07 2014-08-07 Assays for timp2 having improved performance in biological samples

Country Status (12)

Country Link
US (2) US9879091B2 (enExample)
EP (2) EP3030582A4 (enExample)
JP (1) JP2016528236A (enExample)
KR (1) KR20160039682A (enExample)
CN (1) CN105531291A (enExample)
AU (1) AU2014305883A1 (enExample)
BR (1) BR112016002685A2 (enExample)
CA (1) CA2920521A1 (enExample)
EA (1) EA201690185A1 (enExample)
HK (1) HK1222180A1 (enExample)
MX (1) MX2016001573A (enExample)
WO (1) WO2015021308A1 (enExample)

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CN106370857A (zh) 2008-10-21 2017-02-01 阿斯图特医药公司 用于诊断和预后肾损伤和肾衰竭的方法和组合物
NZ600828A (en) 2009-12-20 2014-09-26 Astute Medical Inc Methods and compositions for diagnosis and prognosis of renal injury and renal failure
AU2011269775B2 (en) 2010-06-23 2015-01-15 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
ES2734494T3 (es) 2011-12-08 2019-12-10 Astute Medical Inc Métodos y usos para el diagnóstico de una lesión renal y de una insuficiencia renal
JP6681195B2 (ja) 2013-01-17 2020-04-15 アスチュート メディカル,インコーポレイテッド 腎損傷および腎不全の診断および予後診断のための方法ならびに組成物
US10300108B2 (en) 2013-12-03 2019-05-28 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
WO2016164854A1 (en) 2015-04-09 2016-10-13 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
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CA3026502A1 (en) 2016-06-06 2017-12-14 Astute Medical, Inc. Management of acute kidney injury using insulin-like growth factor-binding protein 7 and tissue inhibitor of metalloproteinase 2
WO2018006049A1 (en) * 2016-06-30 2018-01-04 The Research Foundation For The State University Of New York Compositions and methods for modifying activity of extracellular mmp-2
ES2908239T3 (es) * 2016-10-28 2022-04-28 Astute Medical Inc Uso de anticuerpos contra timp-2 para la mejora de la función renal
EP3577458A4 (en) 2017-02-06 2021-04-07 Astute Medical, Inc. METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PREDICTION OF RENAL LESION AND RENAL INSUFFICIENCY
CN110709103B (zh) * 2017-04-05 2024-02-02 机敏医药股份有限公司 用于生物学样品中具有改善的性能的timp2的测定法
CA3101470A1 (en) 2018-05-24 2019-11-28 Renibus Therapeutics, Inc. Methods of treating patients at risk for renal injury and renal failure

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Also Published As

Publication number Publication date
MX2016001573A (es) 2016-09-07
WO2015021308A1 (en) 2015-02-12
BR112016002685A2 (pt) 2018-01-30
CN105531291A (zh) 2016-04-27
AU2014305883A1 (en) 2016-02-25
EA201690185A1 (ru) 2016-07-29
EP3030582A4 (en) 2017-05-17
EP3617234A1 (en) 2020-03-04
EP3030582A1 (en) 2016-06-15
HK1222180A1 (zh) 2017-06-23
US9879091B2 (en) 2018-01-30
JP2016528236A (ja) 2016-09-15
US10457744B2 (en) 2019-10-29
US20180162953A1 (en) 2018-06-14
US20160297893A1 (en) 2016-10-13
KR20160039682A (ko) 2016-04-11

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Effective date: 20200831