JP2014516518A5 - - Google Patents
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- JP2014516518A5 JP2014516518A5 JP2014508476A JP2014508476A JP2014516518A5 JP 2014516518 A5 JP2014516518 A5 JP 2014516518A5 JP 2014508476 A JP2014508476 A JP 2014508476A JP 2014508476 A JP2014508476 A JP 2014508476A JP 2014516518 A5 JP2014516518 A5 JP 2014516518A5
- Authority
- JP
- Japan
- Prior art keywords
- human
- sequence
- mouse
- immunoglobulin
- rearranged
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108090000623 proteins and genes Proteins 0.000 claims description 38
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 claims description 24
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 claims description 24
- 210000004602 germ cell Anatomy 0.000 claims description 20
- 210000003719 b-lymphocyte Anatomy 0.000 claims description 19
- 108060003951 Immunoglobulin Proteins 0.000 claims description 18
- 102000018358 immunoglobulin Human genes 0.000 claims description 18
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims description 16
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims description 16
- 238000000034 method Methods 0.000 claims 9
- 230000000392 somatic effect Effects 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 28
- 241000699670 Mus sp. Species 0.000 description 6
- 102000006395 Globulins Human genes 0.000 description 1
- 108010044091 Globulins Proteins 0.000 description 1
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 description 1
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 description 1
- 102100029567 Immunoglobulin kappa light chain Human genes 0.000 description 1
- 101710189008 Immunoglobulin kappa light chain Proteins 0.000 description 1
- 101000840255 Mus musculus Immunoglobulin kappa constant Proteins 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/093,156 | 2011-04-25 | ||
| US13/093,156 US20120021409A1 (en) | 2010-02-08 | 2011-04-25 | Common Light Chain Mouse |
| PCT/US2012/034737 WO2012148873A2 (en) | 2011-04-25 | 2012-04-24 | Non-human animals expressing antibodies having a common light chain |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016138445A Division JP6522557B2 (ja) | 2011-04-25 | 2016-07-13 | 共通の軽鎖を有する抗体を発現する非ヒト動物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014516518A JP2014516518A (ja) | 2014-07-17 |
| JP2014516518A5 true JP2014516518A5 (OSRAM) | 2016-04-07 |
| JP6393613B2 JP6393613B2 (ja) | 2018-09-19 |
Family
ID=46000410
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014508476A Active JP6393613B2 (ja) | 2011-04-25 | 2012-04-24 | 共通の軽鎖を有する抗体を発現する非ヒト動物 |
| JP2016138445A Active JP6522557B2 (ja) | 2011-04-25 | 2016-07-13 | 共通の軽鎖を有する抗体を発現する非ヒト動物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016138445A Active JP6522557B2 (ja) | 2011-04-25 | 2016-07-13 | 共通の軽鎖を有する抗体を発現する非ヒト動物 |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US20120021409A1 (OSRAM) |
| EP (2) | EP2989893B1 (OSRAM) |
| JP (2) | JP6393613B2 (OSRAM) |
| KR (1) | KR101995753B1 (OSRAM) |
| CN (2) | CN103596424B (OSRAM) |
| AU (3) | AU2012249953B2 (OSRAM) |
| BR (1) | BR112013027420A2 (OSRAM) |
| CA (1) | CA2846806A1 (OSRAM) |
| CY (2) | CY1117606T1 (OSRAM) |
| DK (2) | DK2989893T3 (OSRAM) |
| ES (2) | ES2573828T5 (OSRAM) |
| HR (2) | HRP20160484T4 (OSRAM) |
| HU (2) | HUE027949T2 (OSRAM) |
| IL (1) | IL228929A0 (OSRAM) |
| LT (1) | LT2989893T (OSRAM) |
| MX (1) | MX353609B (OSRAM) |
| PL (2) | PL2701499T5 (OSRAM) |
| PT (1) | PT2989893T (OSRAM) |
| RS (2) | RS59331B1 (OSRAM) |
| RU (2) | RU2017108634A (OSRAM) |
| SG (1) | SG194466A1 (OSRAM) |
| SI (2) | SI2989893T1 (OSRAM) |
| SM (2) | SMT201900514T1 (OSRAM) |
| WO (1) | WO2012148873A2 (OSRAM) |
Families Citing this family (94)
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| USRE47770E1 (en) | 2002-07-18 | 2019-12-17 | Merus N.V. | Recombinant production of mixtures of antibodies |
| US20100069614A1 (en) | 2008-06-27 | 2010-03-18 | Merus B.V. | Antibody producing non-human mammals |
| EP2395017A3 (en) | 2003-05-30 | 2012-12-19 | Merus B.V. | Design and use of paired variable regions of specific binding molecules |
| EP2006381B1 (en) | 2006-03-31 | 2016-02-03 | Chugai Seiyaku Kabushiki Kaisha | Method for controlling blood pharmacokinetics of antibodies |
| CA2700701C (en) | 2007-09-26 | 2020-12-29 | Chugai Seiyaku Kabushiki Kaisha | Method of modifying isoelectric point of antibody via amino acid substitution in cdr |
| US9676845B2 (en) | 2009-06-16 | 2017-06-13 | Hoffmann-La Roche, Inc. | Bispecific antigen binding proteins |
| PT2564695E (pt) | 2009-07-08 | 2015-06-03 | Kymab Ltd | Modelos animais e moléculas terapêuticas |
| US9445581B2 (en) | 2012-03-28 | 2016-09-20 | Kymab Limited | Animal models and therapeutic molecules |
| US9796788B2 (en) | 2010-02-08 | 2017-10-24 | Regeneron Pharmaceuticals, Inc. | Mice expressing a limited immunoglobulin light chain repertoire |
| DK2505654T4 (da) | 2010-02-08 | 2020-07-27 | Regeneron Pharma | Mus med fælles letkæde |
| US20130045492A1 (en) | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
| CA3250882A1 (en) | 2010-08-02 | 2025-11-29 | Regeneron Pharamaceuticals, Inc. | Mice that Make Binding Proteins Comprising VL Domains |
| MX349057B (es) | 2010-11-30 | 2017-07-07 | Chugai Pharmaceutical Co Ltd | Agente terapeutico que induce citotoxicidad. |
| SI2738258T2 (sl) | 2011-02-25 | 2023-05-31 | Regeneron Pharmaceuticals, Inc. | Miši ADAM6 |
| BR112013019975A2 (pt) | 2011-02-28 | 2017-08-01 | Hoffmann La Roche | proteínas de ligação de antígeno, composição farmacêutica, uso de uma proteína de ligação de antígeno, método para o tratamento de um paciente e método para a preparação de uma proteína de ligação de antígeno, ácido nucleico, vetor e célula hospedeira" |
| CA2824824A1 (en) | 2011-02-28 | 2012-09-07 | F. Hoffmann-La Roche Ag | Monovalent antigen binding proteins |
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| WO2013041844A2 (en) | 2011-09-19 | 2013-03-28 | Kymab Limited | Antibodies, variable domains & chains tailored for human use |
| CA2791109C (en) | 2011-09-26 | 2021-02-16 | Merus B.V. | Generation of binding molecules |
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| MY172946A (en) | 2011-10-17 | 2019-12-16 | Regeneron Pharma | Restricted immunoglobulin heavy chain mice |
| US9253965B2 (en) | 2012-03-28 | 2016-02-09 | Kymab Limited | Animal models and therapeutic molecules |
| KR102081657B1 (ko) | 2011-12-20 | 2020-02-26 | 리제너론 파마슈티칼스 인코포레이티드 | 인간화 경쇄 마우스 |
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| CN104302170B (zh) | 2012-03-16 | 2016-09-28 | 瑞泽恩制药公司 | 生产具有ph依赖性结合特性的抗原结合蛋白的小鼠 |
| NZ730271A (en) | 2012-03-16 | 2022-09-30 | Regeneron Pharma | Non-human animals expressing ph-sensitive immunoglobulin sequences |
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| CA2870821C (en) | 2012-04-20 | 2022-06-14 | Merus B.V. | Methods and means for the production of ig-like molecules |
| HUE055617T2 (hu) * | 2012-06-12 | 2021-12-28 | Regeneron Pharma | Korlátozott immunglobulin nehézlánc lókuszokkal rendelkezõ, humanizált, nem humán élõlények |
| US20150203591A1 (en) | 2012-08-02 | 2015-07-23 | Regeneron Pharmaceuticals, Inc. | Mutivalent antigen-binding proteins |
| ES2678221T3 (es) | 2013-02-20 | 2018-08-09 | Regeneron Pharmaceuticals, Inc. | Animales no humanos con secuencias de cadena pesada de inmunoglobulina modificadas |
| LT3501272T (lt) * | 2013-03-13 | 2023-03-27 | Regeneron Pharmaceuticals, Inc. | Pelės, vykdančios imunoglobulino lengvosios grandinės riboto rinkinio raišką |
| EP2970437A1 (en) * | 2013-03-13 | 2016-01-20 | Regeneron Pharmaceuticals, Inc. | Common light chain mouse |
| US9788534B2 (en) | 2013-03-18 | 2017-10-17 | Kymab Limited | Animal models and therapeutic molecules |
| KR102049990B1 (ko) | 2013-03-28 | 2019-12-03 | 삼성전자주식회사 | c-Met 항체 및 VEGF 결합 단편이 연결된 융합 단백질 |
| US9783618B2 (en) | 2013-05-01 | 2017-10-10 | Kymab Limited | Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics |
| US11707056B2 (en) | 2013-05-02 | 2023-07-25 | Kymab Limited | Animals, repertoires and methods |
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| PL3151921T3 (pl) | 2014-06-06 | 2020-02-28 | Bristol-Myers Squibb Company | Przeciwciała przeciwko receptorowi indukowanego glukokortykoidami czynnika martwicy nowotworu (gitr) i ich zastosowania |
| MA40764A (fr) * | 2014-09-26 | 2017-08-01 | Chugai Pharmaceutical Co Ltd | Agent thérapeutique induisant une cytotoxicité |
| CN106999566B (zh) | 2014-10-03 | 2022-01-28 | 麻省理工学院 | 结合埃博拉病毒糖蛋白的抗体及其用途 |
| LT3221363T (lt) | 2014-11-21 | 2020-08-10 | Bristol-Myers Squibb Company | Antikūnai prieš cd73 ir jų panaudojimas |
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| SG10202006538TA (en) | 2014-12-23 | 2020-08-28 | Bristol Myers Squibb Co | Antibodies to tigit |
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| AU2006322445B2 (en) * | 2005-12-05 | 2011-05-12 | Symphogen A/S | Anti-orthopoxvirus recombinant polyclonal antibody |
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| ITMI20071522A1 (it) * | 2007-07-27 | 2009-01-28 | Areta Internat S R L | Vaccino idiotipico |
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| DK2356270T3 (da) * | 2008-11-07 | 2016-12-12 | Fabrus Llc | Kombinatoriske antistofbiblioteker og anvendelser deraf |
| AU2010252939B2 (en) * | 2009-05-29 | 2014-06-26 | Morphosys Ag | A collection and methods for its use |
| SI2975051T1 (sl) * | 2009-06-26 | 2021-08-31 | Regeneron Pharmaceuticals, Inc. | Zlahka izolirana bispecifična protitelesa z nativnim imunoglobulinskim formatom |
| DK2505654T4 (da) * | 2010-02-08 | 2020-07-27 | Regeneron Pharma | Mus med fælles letkæde |
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2011
- 2011-04-25 US US13/093,156 patent/US20120021409A1/en not_active Abandoned
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- 2012-04-24 RS RS20160309A patent/RS54831B2/sr unknown
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- 2012-04-24 DK DK12717033.0T patent/DK2701499T4/da active
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