JP2013532974A5 - - Google Patents
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- JP2013532974A5 JP2013532974A5 JP2013516714A JP2013516714A JP2013532974A5 JP 2013532974 A5 JP2013532974 A5 JP 2013532974A5 JP 2013516714 A JP2013516714 A JP 2013516714A JP 2013516714 A JP2013516714 A JP 2013516714A JP 2013532974 A5 JP2013532974 A5 JP 2013532974A5
- Authority
- JP
- Japan
- Prior art keywords
- mouse
- human
- light chain
- gene
- endogenous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108090000623 proteins and genes Proteins 0.000 claims description 33
- 108060003951 Immunoglobulin Proteins 0.000 claims description 17
- 102000018358 immunoglobulin Human genes 0.000 claims description 17
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 9
- 239000000427 antigen Substances 0.000 claims description 9
- 108091007433 antigens Proteins 0.000 claims description 9
- 102000036639 antigens Human genes 0.000 claims description 9
- 210000004027 cell Anatomy 0.000 claims description 9
- 150000007523 nucleic acids Chemical group 0.000 claims description 9
- 210000003719 b-lymphocyte Anatomy 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 108700028369 Alleles Proteins 0.000 claims 15
- 108091008053 gene clusters Proteins 0.000 claims 4
- 238000012217 deletion Methods 0.000 claims 2
- 230000037430 deletion Effects 0.000 claims 2
- 210000004408 hybridoma Anatomy 0.000 claims 2
- 101100060131 Mus musculus Cdk5rap2 gene Proteins 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 210000001161 mammalian embryo Anatomy 0.000 claims 1
- 108700026220 vif Genes Proteins 0.000 claims 1
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 description 19
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 description 19
- 239000012634 fragment Substances 0.000 description 6
- 102000025171 antigen binding proteins Human genes 0.000 description 3
- 108091000831 antigen binding proteins Proteins 0.000 description 3
- 101001008255 Homo sapiens Immunoglobulin kappa variable 1D-8 Proteins 0.000 description 1
- 101001047628 Homo sapiens Immunoglobulin kappa variable 2-29 Proteins 0.000 description 1
- 101001008321 Homo sapiens Immunoglobulin kappa variable 2D-26 Proteins 0.000 description 1
- 101001047619 Homo sapiens Immunoglobulin kappa variable 3-20 Proteins 0.000 description 1
- 101001008263 Homo sapiens Immunoglobulin kappa variable 3D-15 Proteins 0.000 description 1
- 241001529936 Murinae Species 0.000 description 1
- 210000004602 germ cell Anatomy 0.000 description 1
- 229940099472 immunoglobulin a Drugs 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35731410P | 2010-06-22 | 2010-06-22 | |
| US35731710P | 2010-06-22 | 2010-06-22 | |
| US61/357,317 | 2010-06-22 | ||
| US61/357,314 | 2010-06-22 | ||
| PCT/US2011/041366 WO2011163311A1 (en) | 2010-06-22 | 2011-06-22 | Mice expressing alight chain with human lambda variable and mouse constant regions |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015205321A Division JP6243384B2 (ja) | 2010-06-22 | 2015-10-19 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013532974A JP2013532974A (ja) | 2013-08-22 |
| JP2013532974A5 true JP2013532974A5 (OSRAM) | 2014-07-17 |
| JP5988969B2 JP5988969B2 (ja) | 2016-09-07 |
Family
ID=44509861
Family Applications (16)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013516716A Active JP6009441B2 (ja) | 2010-06-22 | 2011-06-22 | ハイブリッド軽鎖マウス |
| JP2013516714A Active JP5988969B2 (ja) | 2010-06-22 | 2011-06-22 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2015205439A Active JP6073441B2 (ja) | 2010-06-22 | 2015-10-19 | ハイブリッド軽鎖マウス |
| JP2015205321A Active JP6243384B2 (ja) | 2010-06-22 | 2015-10-19 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2016204854A Withdrawn JP2017006152A (ja) | 2010-06-22 | 2016-10-19 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2016208582A Active JP6341972B2 (ja) | 2010-06-22 | 2016-10-25 | ハイブリッド軽鎖マウス |
| JP2017222512A Active JP6545773B2 (ja) | 2010-06-22 | 2017-11-20 | ハイブリッド軽鎖マウス |
| JP2018188846A Pending JP2018201527A (ja) | 2010-06-22 | 2018-10-04 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2018188847A Pending JP2018201528A (ja) | 2010-06-22 | 2018-10-04 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2018228851A Active JP6963542B2 (ja) | 2010-06-22 | 2018-12-06 | ハイブリッド軽鎖マウス |
| JP2020015538A Withdrawn JP2020062061A (ja) | 2010-06-22 | 2020-01-31 | ハイブリッド軽鎖マウス |
| JP2020098480A Active JP7236409B2 (ja) | 2010-06-22 | 2020-06-05 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2021009451A Withdrawn JP2021061863A (ja) | 2010-06-22 | 2021-01-25 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2022034415A Withdrawn JP2022066449A (ja) | 2010-06-22 | 2022-03-07 | ハイブリッド軽鎖マウス |
| JP2023127047A Pending JP2023133554A (ja) | 2010-06-22 | 2023-08-03 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2024214653A Pending JP2025027148A (ja) | 2010-06-22 | 2024-12-09 | ハイブリッド軽鎖マウス |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013516716A Active JP6009441B2 (ja) | 2010-06-22 | 2011-06-22 | ハイブリッド軽鎖マウス |
Family Applications After (14)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015205439A Active JP6073441B2 (ja) | 2010-06-22 | 2015-10-19 | ハイブリッド軽鎖マウス |
| JP2015205321A Active JP6243384B2 (ja) | 2010-06-22 | 2015-10-19 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2016204854A Withdrawn JP2017006152A (ja) | 2010-06-22 | 2016-10-19 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2016208582A Active JP6341972B2 (ja) | 2010-06-22 | 2016-10-25 | ハイブリッド軽鎖マウス |
| JP2017222512A Active JP6545773B2 (ja) | 2010-06-22 | 2017-11-20 | ハイブリッド軽鎖マウス |
| JP2018188846A Pending JP2018201527A (ja) | 2010-06-22 | 2018-10-04 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2018188847A Pending JP2018201528A (ja) | 2010-06-22 | 2018-10-04 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2018228851A Active JP6963542B2 (ja) | 2010-06-22 | 2018-12-06 | ハイブリッド軽鎖マウス |
| JP2020015538A Withdrawn JP2020062061A (ja) | 2010-06-22 | 2020-01-31 | ハイブリッド軽鎖マウス |
| JP2020098480A Active JP7236409B2 (ja) | 2010-06-22 | 2020-06-05 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2021009451A Withdrawn JP2021061863A (ja) | 2010-06-22 | 2021-01-25 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2022034415A Withdrawn JP2022066449A (ja) | 2010-06-22 | 2022-03-07 | ハイブリッド軽鎖マウス |
| JP2023127047A Pending JP2023133554A (ja) | 2010-06-22 | 2023-08-03 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2024214653A Pending JP2025027148A (ja) | 2010-06-22 | 2024-12-09 | ハイブリッド軽鎖マウス |
Country Status (30)
| Country | Link |
|---|---|
| US (22) | US9035128B2 (OSRAM) |
| EP (7) | EP2568049B1 (OSRAM) |
| JP (16) | JP6009441B2 (OSRAM) |
| KR (16) | KR101970944B1 (OSRAM) |
| CN (4) | CN103068994B (OSRAM) |
| AU (1) | AU2011271046B2 (OSRAM) |
| BR (3) | BR112012033248A2 (OSRAM) |
| CA (2) | CA2804311C (OSRAM) |
| CY (5) | CY1117537T1 (OSRAM) |
| DK (5) | DK2905338T3 (OSRAM) |
| ES (5) | ES2576928T3 (OSRAM) |
| HR (5) | HRP20160497T1 (OSRAM) |
| HU (5) | HUE044001T2 (OSRAM) |
| IL (12) | IL300712B2 (OSRAM) |
| LT (4) | LT3034608T (OSRAM) |
| ME (5) | ME02444B (OSRAM) |
| MX (6) | MX347322B (OSRAM) |
| MY (6) | MY195217A (OSRAM) |
| NO (1) | NO2905338T3 (OSRAM) |
| NZ (6) | NZ627119A (OSRAM) |
| PL (5) | PL2568049T3 (OSRAM) |
| PT (5) | PT2480676E (OSRAM) |
| RS (5) | RS54891B1 (OSRAM) |
| RU (3) | RU2590594C2 (OSRAM) |
| SG (4) | SG186391A1 (OSRAM) |
| SI (5) | SI3034608T1 (OSRAM) |
| SM (5) | SMT201700506T1 (OSRAM) |
| TR (1) | TR201905992T4 (OSRAM) |
| WO (2) | WO2011163314A1 (OSRAM) |
| ZA (5) | ZA201300063B (OSRAM) |
Families Citing this family (93)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US20050144655A1 (en) | 2000-10-31 | 2005-06-30 | Economides Aris N. | Methods of modifying eukaryotic cells |
| WO2010039900A2 (en) | 2008-09-30 | 2010-04-08 | Aliva Biopharmaceuticals, Inc. | Non-human mammals for the production of chimeric antibodies |
| KR101711222B1 (ko) | 2008-12-18 | 2017-02-28 | 에라스무스 유니버시티 메디컬 센터 로테르담 | 인간화 항체들을 발현하는 비-인간 유전자이식 동물들 및 그의 이용 |
| US9445581B2 (en) * | 2012-03-28 | 2016-09-20 | Kymab Limited | Animal models and therapeutic molecules |
| ES2948572T3 (es) | 2009-07-08 | 2023-09-14 | Kymab Ltd | Modelos de roedores y moléculas terapéuticas |
| US20130045492A1 (en) | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
| US9796788B2 (en) | 2010-02-08 | 2017-10-24 | Regeneron Pharmaceuticals, Inc. | Mice expressing a limited immunoglobulin light chain repertoire |
| ES2547142T5 (es) | 2010-02-08 | 2021-12-09 | Regeneron Pharma | Cadena ligera común de ratón |
| KR20210010942A (ko) | 2010-03-31 | 2021-01-28 | 아블렉시스, 엘엘씨 | 키메라 항체의 제조를 위한 비-인간 동물의 유전적 조작 |
| MY195217A (en) * | 2010-06-22 | 2023-01-11 | Regeneron Pharma | MICE Expressing An Immunoglobulin Hybrid Light Chain |
| US10662256B2 (en) | 2010-07-26 | 2020-05-26 | Trianni, Inc. | Transgenic mammals and methods of use thereof |
| EP2597945B1 (en) | 2010-07-26 | 2020-07-22 | Trianni, Inc. | Transgenic animals and methods of use |
| US10793829B2 (en) | 2010-07-26 | 2020-10-06 | Trianni, Inc. | Transgenic mammals and methods of use thereof |
| IL315833A (en) * | 2010-08-02 | 2024-11-01 | Regeneron Pharma | Mice producing binding proteins containing VL regions |
| IL273982B2 (en) | 2011-08-05 | 2023-03-01 | Regeneron Pharma | Humanized mice possess a universal light chain |
| WO2013041845A2 (en) | 2011-09-19 | 2013-03-28 | Kymab Limited | Animals, repertoires & methods |
| EP2757875B2 (en) | 2011-09-19 | 2023-03-22 | Kymab Limited | Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics |
| WO2013045916A1 (en) | 2011-09-26 | 2013-04-04 | Kymab Limited | Chimaeric surrogate light chains (slc) comprising human vpreb |
| US9253965B2 (en) * | 2012-03-28 | 2016-02-09 | Kymab Limited | Animal models and therapeutic molecules |
| SG11201403326VA (en) * | 2011-12-20 | 2014-07-30 | Regeneron Pharma | Humanized light chain mice |
| RU2664473C2 (ru) | 2012-03-16 | 2018-08-17 | Регенерон Фармасьютикалз, Инк. | ОТЛИЧНЫЕ ОТ ЧЕЛОВЕКА ЖИВОТНЫЕ, ЭКСПРЕССИРУЮЩИЕ ЧУВСТВИТЕЛЬНЫЕ К pН ПОСЛЕДОВАТЕЛЬНОСТИ ИММУНОГЛОБУЛИНОВ |
| EP2825036B1 (en) | 2012-03-16 | 2018-05-02 | Regeneron Pharmaceuticals, Inc. | Histidine engineered light chain antibodies and genetically modified rodents for generating the same |
| US20140013456A1 (en) | 2012-03-16 | 2014-01-09 | Regeneron Pharmaceuticals, Inc. | Histidine Engineered Light Chain Antibodies and Genetically Modified Non-Human Animals for Generating the Same |
| AU2013204581B2 (en) | 2012-03-16 | 2015-06-25 | Regeneron Pharmaceuticals, Inc. | Non-human animals expressing pH-sensitive immunoglobulin sequences |
| US10251377B2 (en) | 2012-03-28 | 2019-04-09 | Kymab Limited | Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies |
| GB2502127A (en) | 2012-05-17 | 2013-11-20 | Kymab Ltd | Multivalent antibodies and in vivo methods for their production |
| WO2013144567A1 (en) | 2012-03-28 | 2013-10-03 | Kymab Limited | Transgenic non-human vertebrate for the expression of class - switched, fully human, antibodies |
| SMT201800435T1 (it) | 2013-02-20 | 2018-09-13 | Regeneron Pharma | Animali non umani con sequenze della catena pesante dell’immunoglobulina modificate riferimento incrociato a domande correlate |
| AU2014244020B2 (en) * | 2013-03-13 | 2020-06-04 | Regeneron Pharmaceuticals, Inc. | Mice expressing a limited immunoglobulin light chain repertoire |
| EP3841876A1 (en) | 2013-03-14 | 2021-06-30 | Erasmus University Medical Center Rotterdam | Transgenic mouse for antibody production |
| US9788534B2 (en) | 2013-03-18 | 2017-10-17 | Kymab Limited | Animal models and therapeutic molecules |
| US9783618B2 (en) | 2013-05-01 | 2017-10-10 | Kymab Limited | Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics |
| US9783593B2 (en) | 2013-05-02 | 2017-10-10 | Kymab Limited | Antibodies, variable domains and chains tailored for human use |
| US11707056B2 (en) | 2013-05-02 | 2023-07-25 | Kymab Limited | Animals, repertoires and methods |
| RU2019121863A (ru) * | 2013-09-18 | 2019-08-29 | Регенерон Фармасьютикалз, Инк. | Антитела со встроенным в легкие цепи гистидином и генетически модифицированные отличные от человека животные для их получения |
| ES2993142T3 (en) | 2013-10-01 | 2024-12-23 | Kymab Ltd | Animal models and therapeutic molecules |
| EP3092007A4 (en) * | 2014-01-10 | 2017-06-07 | Allermabs Co. Ltd. | Transgenic animals capable of producing humanized ige at much higher levels than mouse ige |
| BR112016021572A2 (pt) | 2014-03-21 | 2017-10-03 | Regeneron Pharma | Métodos para preparar um animal não humano geneticamente modificado e para produzir proteínas de ligação, hibridoma, ácido nucleico, célula, e, proteína de ligação |
| ES2762640T3 (es) | 2014-03-21 | 2020-05-25 | Regeneron Pharma | Proteínas VL de unión a antígeno que exhiben diferentes características de unión |
| AU2015271709B2 (en) | 2014-06-06 | 2020-11-26 | Bristol-Myers Squibb Company | Antibodies against glucocorticoid-induced tumor necrosis factor receptor (GITR) and uses thereof |
| RU2017113134A (ru) | 2014-09-19 | 2018-10-19 | Регенерон Фармасьютикалз, Инк. | Химерные антигенные рецепторы |
| SG11201702606TA (en) | 2014-10-03 | 2017-04-27 | Massachusetts Inst Technology | Antibodies that bind ebola glycoprotein and uses thereof |
| TWI711630B (zh) | 2014-11-21 | 2020-12-01 | 美商必治妥美雅史谷比公司 | 抗ｃｄ７３抗體及其用途 |
| PT3233912T (pt) | 2014-12-19 | 2021-08-09 | Regenesance B V | Antocorpos que se ligam a c6 humano e utilizações destes |
| JP6180663B2 (ja) | 2014-12-23 | 2017-08-16 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | Ｔｉｇｉｔに対する抗体 |
| WO2016124709A1 (de) | 2015-02-05 | 2016-08-11 | Basf Se | Solarkraftwerk mit einem ersten wärmeträgerkreislauf und einem zweiten wärmeträgerkreislauf |
| EP3271403A1 (en) * | 2015-03-19 | 2018-01-24 | Regeneron Pharmaceuticals, Inc. | Non-human animals that select for light chain variable regions that bind antigen |
| MX2017015041A (es) | 2015-05-29 | 2018-02-26 | Squibb Bristol Myers Co | Anticuerpos contra el miembro 4 de la superfamilia del receptor del factor de necrosis tumoral (ox40) y sus usos. |
| MX2017016502A (es) | 2015-06-29 | 2018-03-12 | Univ Rockefeller | Anticuerpos contra cd40 con actividad agonista mejorada. |
| CN105274116B (zh) * | 2015-10-21 | 2020-09-29 | 重庆金迈博生物科技有限公司 | 一种制备人源化抗体的核酸分子及其应用 |
| JP6983776B2 (ja) | 2015-11-19 | 2021-12-17 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | グルココルチコイド誘発腫瘍壊死因子受容体（ｇｉｔｒ）に対する抗体およびその使用 |
| EP3384030A4 (en) | 2015-12-03 | 2019-07-03 | Trianni, Inc. | IMPROVED IMMUNOGLULINIVITY |
| WO2017136734A1 (en) | 2016-02-04 | 2017-08-10 | Trianni, Inc. | Enhanced production of immunoglobulins |
| EP4406550A3 (en) | 2016-03-04 | 2024-10-16 | The Rockefeller University | Antibodies to cd40 with enhanced agonist activity |
| CA3016187A1 (en) | 2016-03-04 | 2017-09-08 | Bristol-Myers Squibb Company | Combination therapy with anti-cd73 antibodies |
| US10968279B2 (en) | 2016-05-09 | 2021-04-06 | Bristol-Myers Squibb Company | TL1A antibodies and uses thereof |
| MX2018014172A (es) | 2016-05-20 | 2019-08-22 | Regeneron Pharma | Métodos para romper la tolerancia inmunológica usando múltiples arn guías. |
| CN109640644B (zh) | 2016-06-03 | 2021-10-26 | 瑞泽恩制药公司 | 表达外源末端脱氧核苷酸转移酶的非人动物 |
| WO2017214089A1 (en) * | 2016-06-06 | 2017-12-14 | Regeneron Pharmaceuticals, Inc. | Non-human animals expressing antibodies with human lambda light chains |
| US20170371963A1 (en) * | 2016-06-27 | 2017-12-28 | Facebook, Inc. | Systems and methods for identifying matching content |
| EP4512829A3 (en) | 2016-07-14 | 2025-06-11 | Bristol-Myers Squibb Company | Antibodies against tim3 and uses thereof |
| WO2018044970A1 (en) | 2016-08-31 | 2018-03-08 | University Of Rochester | Human monoclonal antibodies to human endogenous retrovirus k envelope (herv-k) and uses thereof |
| CR20210094A (es) | 2016-10-13 | 2021-03-31 | Massachusetts Inst Technology | ANTICUERPOS QUE SE UNEN A LA PROTEÍNA DE ENVOLTURA DEL VIRUS ZIKA Y USOS DE LOS MISMOS (Divisional 2019-0193) |
| CN109906272A (zh) | 2016-10-31 | 2019-06-18 | 国立大学法人鸟取大学 | 产生人抗体的非人动物和使用该非人动物的人抗体制作方法 |
| CA3038720A1 (en) | 2016-11-04 | 2018-07-12 | Regeneron Pharmaceuticals, Inc. | Non-human animals having an engineered immunoglobulin lambda light chain locus |
| EP3583124A1 (en) | 2017-02-17 | 2019-12-25 | Bristol-Myers Squibb Company | Antibodies to alpha-synuclein and uses thereof |
| TWI788340B (zh) | 2017-04-07 | 2023-01-01 | 美商必治妥美雅史谷比公司 | 抗icos促效劑抗體及其用途 |
| SG11202003044SA (en) | 2017-12-05 | 2020-04-29 | Regeneron Pharma | Non-human animals having an engineered immunoglobulin lambda light chain and uses thereof |
| CN120192415A (zh) | 2018-01-12 | 2025-06-24 | 百时美施贵宝公司 | 抗tim3抗体及其用途 |
| PE20210665A1 (es) | 2018-03-23 | 2021-03-31 | Bristol Myers Squibb Co | Anticuerpos contra mica y/o micb y sus usos |
| US20210051929A1 (en) | 2018-03-24 | 2021-02-25 | Regeneron Pharmaceuticals, Inc. | Genetically modified non-human animals for generating therapeutic antibodies against peptide-mhc complexes, methods of making and uses thereof |
| CA3093850A1 (en) | 2018-03-26 | 2019-10-03 | Regeneron Pharmaceuticals, Inc. | Humanized rodents for testing therapeutic agents |
| US11337409B2 (en) | 2018-06-08 | 2022-05-24 | Crystal Bioscience Inc. | Transgenic animal for producing diversified antibodies that have the same light chain I |
| IL318469A (en) | 2018-06-14 | 2025-03-01 | Regeneron Pharma | Non-human animals capable of reorganizing transgenic DH-DH, and their uses |
| WO2020085011A1 (ja) | 2018-10-26 | 2020-04-30 | ビークルエナジージャパン株式会社 | 電池制御装置 |
| US11274150B2 (en) | 2018-11-16 | 2022-03-15 | Bristol-Myers Squibb Company | Anti-human natural killer cell inhibitory receptor group 2A protein (NKG2A) antibodies |
| WO2020154293A1 (en) | 2019-01-22 | 2020-07-30 | Bristol-Myers Squibb Company | Antibodies against il-7r alpha subunit and uses thereof |
| US11464217B2 (en) | 2019-02-22 | 2022-10-11 | Regeneron Pharmaceuticals, Inc. | Rodents having genetically modified sodium channels and methods of use thereof |
| SG11202111258TA (en) * | 2019-06-05 | 2021-11-29 | Regeneron Pharma | Non-human animals having a limited lambda light chain repertoire expressed from the kappa locus and uses thereof |
| EP3993623B1 (en) * | 2019-07-01 | 2025-02-19 | Trianni, Inc. | Transgenic rodents and methods of use thereof |
| CN114901678A (zh) | 2019-12-02 | 2022-08-12 | 瑞泽恩制药公司 | 肽-mhc ii蛋白构建体及其用途 |
| US20230192867A1 (en) | 2020-05-15 | 2023-06-22 | Bristol-Myers Squibb Company | Antibodies to garp |
| KR20230024822A (ko) * | 2020-06-25 | 2023-02-21 | 주식회사 휴맵 | 이형접합성 형질전환 동물 |
| TW202229328A (zh) | 2020-09-11 | 2022-08-01 | 美商再生元醫藥公司 | 抗原特異性抗體之鑑定及產生 |
| JP2024500399A (ja) | 2020-12-16 | 2024-01-09 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ヒト化Ｆｃアルファ受容体を発現するマウス |
| IL303868A (en) | 2020-12-23 | 2023-08-01 | Regeneron Pharma | Nucleic acids encoding anchor-modified antibodies and uses thereof |
| CA3197426A1 (en) | 2020-12-23 | 2022-06-30 | Regeneron Pharmaceuticals, Inc. | Methods for obtaining antibodies that bind transmembrane proteins and cells that produce the same |
| WO2023199655A1 (ja) | 2022-04-13 | 2023-10-19 | 日本精工株式会社 | 軸受装置の状態の検出方法、検出装置、およびプログラム |
| USD999969S1 (en) * | 2022-04-29 | 2023-09-26 | Shenzhen Intellirocks Tech. Co., Ltd. | Lamp |
| WO2024163477A1 (en) | 2023-01-31 | 2024-08-08 | University Of Rochester | Immune checkpoint blockade therapy for treating staphylococcus aureus infections |
| CN121079326A (zh) | 2023-05-04 | 2025-12-05 | 诺瓦森塔股份有限公司 | 抗cd161抗体及其使用方法 |
| WO2025184208A1 (en) | 2024-02-27 | 2025-09-04 | Bristol-Myers Squibb Company | Anti-ceacam5 antibodies and uses thereof |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US6673986B1 (en) | 1990-01-12 | 2004-01-06 | Abgenix, Inc. | Generation of xenogeneic antibodies |
| US7041871B1 (en) * | 1995-10-10 | 2006-05-09 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5770429A (en) * | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| WO1992018619A1 (en) | 1991-04-10 | 1992-10-29 | The Scripps Research Institute | Heterodimeric receptor libraries using phagemids |
| CA2078539C (en) * | 1991-09-18 | 2005-08-02 | Kenya Shitara | Process for producing humanized chimera antibody |
| US6632976B1 (en) | 1995-08-29 | 2003-10-14 | Kirin Beer Kabushiki Kaisha | Chimeric mice that are produced by microcell mediated chromosome transfer and that retain a human antibody gene |
| EP1500329B1 (en) * | 1996-12-03 | 2012-03-21 | Amgen Fremont Inc. | Human antibodies that specifically bind human TNF alpha |
| US6774279B2 (en) | 1997-05-30 | 2004-08-10 | Carnegie Institution Of Washington | Use of FLP recombinase in mice |
| GB9823930D0 (en) * | 1998-11-03 | 1998-12-30 | Babraham Inst | Murine expression of human ig\ locus |
| CN101498731A (zh) * | 2000-05-18 | 2009-08-05 | 日本烟草产业株式会社 | 抗协同刺激信号转导分子ailim的人单克隆抗体及其药物用途 |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US6586251B2 (en) | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| ES2405944T3 (es) * | 2000-11-30 | 2013-06-04 | Medarex, Inc. | Ácidos nucleicos que codifican las secuencias de inmunoglobulina humana reorganizadas a partir de ratones transcromoscómicos transgénicos zadas |
| GB0031284D0 (en) * | 2000-12-21 | 2001-01-31 | Ks Biomedix Ltd | High affinity antibodies |
| EP1970448A1 (en) * | 2001-05-11 | 2008-09-17 | Kirin Pharma Kabushiki Kaisha | Human artificial chromosome containting human antibody lambda light chain and non-human animal containting the human artificial chromosome capable of genetic transmission |
| GB0115256D0 (en) * | 2001-06-21 | 2001-08-15 | Babraham Inst | Mouse light chain locus |
| EP1461442B1 (en) | 2001-11-30 | 2017-09-06 | Amgen Fremont Inc. | Transgenic animals bearing human ig lambda light chain genes |
| US20030217171A1 (en) | 2002-05-17 | 2003-11-20 | Von Stuermer Wolfgang R. | Self-replicating and self-installing software apparatus |
| MXPA06000562A (es) * | 2003-07-15 | 2006-03-30 | Therapeutic Human Polyclonals | Loci de inmunoglobulina humanizada. |
| CN1605628A (zh) * | 2003-09-03 | 2005-04-13 | 中国疾病预防控制中心病毒病预防控制所 | Cho细胞生产的人源抗甲肝病毒基因工程抗体 |
| ME01803B (me) * | 2004-08-05 | 2010-12-31 | Genentech Inc | Humanizovani anti-cmet antagonisti |
| PL2767161T3 (pl) | 2004-10-19 | 2018-09-28 | Regeneron Pharmaceuticals, Inc. | Sposób wytwarzania zwierzęcia homozygotycznego pod względem modyfikacji genetycznej |
| JP4642862B2 (ja) * | 2004-12-29 | 2011-03-02 | ユーハン・コーポレイション | ヒト腫瘍壊死因子−アルファに特異的なヒト化抗体 |
| WO2007117410A2 (en) | 2006-03-31 | 2007-10-18 | Medarex, Inc. | Transgenic animals expressing chimeric antibodies for use in preparing human antibodies |
| CN101501073A (zh) * | 2006-08-22 | 2009-08-05 | G2英弗勒美欣私人有限公司 | 抗体制备方法 |
| CN101522716B (zh) | 2006-10-02 | 2013-03-20 | 瑞泽恩制药公司 | 抗人il-4受体的高亲和力人抗体 |
| US7864492B2 (en) | 2006-10-31 | 2011-01-04 | Siemens Industry, Inc. | Systems and methods for arc fault detection |
| DE102007045897A1 (de) | 2007-09-26 | 2009-04-09 | Carl Zeiss Microimaging Gmbh | Verfahren zur mikroskopischen dreidimensionalen Abbildung einer Probe |
| CA2721231C (en) * | 2008-04-14 | 2015-10-06 | Innovative Targeting Solutions Inc. | Sequence diversity generation in immunoglobulins |
| EP2669298A3 (en) | 2008-05-23 | 2014-02-26 | Ablexis, LLC | Single variable immunoglobulin domain comprising VL-DH-JL |
| WO2010039900A2 (en) * | 2008-09-30 | 2010-04-08 | Aliva Biopharmaceuticals, Inc. | Non-human mammals for the production of chimeric antibodies |
| KR101711222B1 (ko) * | 2008-12-18 | 2017-02-28 | 에라스무스 유니버시티 메디컬 센터 로테르담 | 인간화 항체들을 발현하는 비-인간 유전자이식 동물들 및 그의 이용 |
| ES2948572T3 (es) * | 2009-07-08 | 2023-09-14 | Kymab Ltd | Modelos de roedores y moléculas terapéuticas |
| ES2547142T5 (es) * | 2010-02-08 | 2021-12-09 | Regeneron Pharma | Cadena ligera común de ratón |
| CA2802591A1 (en) | 2010-06-17 | 2011-12-22 | Kymab Limited | Animal models and therapeutic molecules |
| MY195217A (en) * | 2010-06-22 | 2023-01-11 | Regeneron Pharma | MICE Expressing An Immunoglobulin Hybrid Light Chain |
-
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