JP2014513727A5 - - Google Patents
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- Publication number
- JP2014513727A5 JP2014513727A5 JP2014511460A JP2014511460A JP2014513727A5 JP 2014513727 A5 JP2014513727 A5 JP 2014513727A5 JP 2014511460 A JP2014511460 A JP 2014511460A JP 2014511460 A JP2014511460 A JP 2014511460A JP 2014513727 A5 JP2014513727 A5 JP 2014513727A5
- Authority
- JP
- Japan
- Prior art keywords
- bis
- methylene
- phenylene
- tetraazacyclotetradecane
- pyridine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 50
- 150000001875 compounds Chemical class 0.000 claims 24
- 150000003839 salts Chemical class 0.000 claims 7
- -1 polymethylene Polymers 0.000 claims 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 4
- 102100031650 C-X-C chemokine receptor type 4 Human genes 0.000 claims 4
- 101000922348 Homo sapiens C-X-C chemokine receptor type 4 Proteins 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 4
- 150000004696 coordination complex Chemical class 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 230000035772 mutation Effects 0.000 claims 4
- 206010025327 Lymphopenia Diseases 0.000 claims 3
- 208000010115 WHIM syndrome Diseases 0.000 claims 3
- 231100001023 lymphopenia Toxicity 0.000 claims 3
- 208000004235 neutropenia Diseases 0.000 claims 3
- 230000002265 prevention Effects 0.000 claims 3
- 208000008190 Agammaglobulinemia Diseases 0.000 claims 2
- 208000035143 Bacterial infection Diseases 0.000 claims 2
- 241000282412 Homo Species 0.000 claims 2
- 206010020983 Hypogammaglobulinaemia Diseases 0.000 claims 2
- KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical compound C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 claims 2
- 208000036142 Viral infection Diseases 0.000 claims 2
- 230000005856 abnormality Effects 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 125000002947 alkylene group Chemical group 0.000 claims 2
- 208000022362 bacterial infectious disease Diseases 0.000 claims 2
- 239000002576 chemokine receptor CXCR4 antagonist Substances 0.000 claims 2
- 229940121384 cxc chemokine receptor type 4 (cxcr4) antagonist Drugs 0.000 claims 2
- 125000004122 cyclic group Chemical group 0.000 claims 2
- 206010013023 diphtheria Diseases 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 230000036737 immune function Effects 0.000 claims 2
- 210000000265 leukocyte Anatomy 0.000 claims 2
- 201000002364 leukopenia Diseases 0.000 claims 2
- 231100001022 leukopenia Toxicity 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 230000009385 viral infection Effects 0.000 claims 2
- MDAXKAUIABOHTD-UHFFFAOYSA-N 1,4,8,11-tetraazacyclotetradecane Chemical compound C1CNCCNCCCNCCNC1 MDAXKAUIABOHTD-UHFFFAOYSA-N 0.000 claims 1
- IMWNCVDLSHMHEL-UHFFFAOYSA-N 1-[1-(1,4,8,11-tetrazacyclotetradec-1-yl)butan-2-yl]-1,4,8,11-tetrazacyclotetradecane Chemical compound C1CCNCCNCCCNCCN1C(CC)CN1CCCNCCNCCCNCC1 IMWNCVDLSHMHEL-UHFFFAOYSA-N 0.000 claims 1
- QPFUQMRWZANCBG-UHFFFAOYSA-N 1-[1-(1,4,8,11-tetrazacyclotetradec-1-yl)hexan-2-yl]-1,4,8,11-tetrazacyclotetradecane Chemical compound C1CCNCCNCCCNCCN1C(CCCC)CN1CCCNCCNCCCNCC1 QPFUQMRWZANCBG-UHFFFAOYSA-N 0.000 claims 1
- VEEDYUPGPMCQTN-UHFFFAOYSA-N 1-[1-(1,4,8,11-tetrazacyclotetradec-1-yl)pentan-2-yl]-1,4,8,11-tetrazacyclotetradecane Chemical compound C1CCNCCNCCCNCCN1C(CCC)CN1CCCNCCNCCCNCC1 VEEDYUPGPMCQTN-UHFFFAOYSA-N 0.000 claims 1
- YUEOTDBNBGFZSZ-UHFFFAOYSA-N 1-[1-(1,4,8,11-tetrazacyclotetradec-1-yl)propan-2-yl]-1,4,8,11-tetrazacyclotetradecane Chemical compound C1CCNCCNCCCNCCN1C(C)CN1CCCNCCNCCCNCC1 YUEOTDBNBGFZSZ-UHFFFAOYSA-N 0.000 claims 1
- GVPVISVGQUQSSG-UHFFFAOYSA-N 1-[2-(1,4,8,11-tetrazacyclotetradec-1-yl)ethyl]-1,4,8,11-tetrazacyclotetradecane Chemical compound C1CCNCCNCCCNCCN1CCN1CCCNCCNCCCNCC1 GVPVISVGQUQSSG-UHFFFAOYSA-N 0.000 claims 1
- PMGQWFFOFZQXSJ-UHFFFAOYSA-N 1-[4-(1,7-diazacyclotetradec-4-ylmethyl)phenyl]-n-(pyridin-2-ylmethyl)methanamine Chemical compound C=1C=C(CC2CCNCCCCCCCNCC2)C=CC=1CNCC1=CC=CC=N1 PMGQWFFOFZQXSJ-UHFFFAOYSA-N 0.000 claims 1
- GKJYLJLZQLRHLX-UHFFFAOYSA-N 1-[4-[(11,11-difluoro-1,4,7-triazacyclotetradec-4-yl)methyl]phenyl]-n-(pyridin-2-ylmethyl)methanamine Chemical compound C1CNCCCC(F)(F)CCCNCCN1CC(C=C1)=CC=C1CNCC1=CC=CC=N1 GKJYLJLZQLRHLX-UHFFFAOYSA-N 0.000 claims 1
- KCIMFODBVYVAJW-UHFFFAOYSA-N 1-[4-[(11-fluoro-1,4,7-triazacyclotetradec-4-yl)methyl]phenyl]-n-(pyridin-2-ylmethyl)methanamine Chemical compound C1CNCCCC(F)CCCNCCN1CC(C=C1)=CC=C1CNCC1=CC=CC=N1 KCIMFODBVYVAJW-UHFFFAOYSA-N 0.000 claims 1
- SEFLKOOVNJZTFY-UHFFFAOYSA-N 1-[[2,3,5,6-tetrafluoro-4-(1,4,8,11-tetrazacyclotetradec-1-ylmethyl)phenyl]methyl]-1,4,8,11-tetrazacyclotetradecane Chemical compound FC=1C(F)=C(CN2CCNCCCNCCNCCC2)C(F)=C(F)C=1CN1CCCNCCNCCCNCC1 SEFLKOOVNJZTFY-UHFFFAOYSA-N 0.000 claims 1
- NYQPBUORMFOXKK-UHFFFAOYSA-N 1-[[2,5-dichloro-4-(1,4,8,11-tetrazacyclotetradec-1-ylmethyl)phenyl]methyl]-1,4,8,11-tetrazacyclotetradecane Chemical compound ClC=1C=C(CN2CCNCCCNCCNCCC2)C(Cl)=CC=1CN1CCCNCCNCCCNCC1 NYQPBUORMFOXKK-UHFFFAOYSA-N 0.000 claims 1
- GBUVEYKYEYRGEU-UHFFFAOYSA-N 1-[[2,5-dimethyl-4-(1,4,8,11-tetrazacyclotetradec-1-ylmethyl)phenyl]methyl]-1,4,8,11-tetrazacyclotetradecane Chemical compound CC=1C=C(CN2CCNCCCNCCNCCC2)C(C)=CC=1CN1CCCNCCNCCCNCC1 GBUVEYKYEYRGEU-UHFFFAOYSA-N 0.000 claims 1
- CGBPRRHXVCXIKY-UHFFFAOYSA-N 1-[[2-bromo-4-(1,4,8,11-tetrazacyclotetradec-1-ylmethyl)phenyl]methyl]-1,4,8,11-tetrazacyclotetradecane Chemical compound C=1C=C(CN2CCNCCCNCCNCCC2)C(Br)=CC=1CN1CCCNCCNCCCNCC1 CGBPRRHXVCXIKY-UHFFFAOYSA-N 0.000 claims 1
- PXTXSIAYIFRMDE-UHFFFAOYSA-N 1-[[3-(1,4,7,10-tetrazacyclotetradec-1-ylmethyl)phenyl]methyl]-1,4,7,10-tetrazacyclotetradecane Chemical compound C=1C=CC(CN2CCNCCNCCNCCCC2)=CC=1CN1CCCCNCCNCCNCC1 PXTXSIAYIFRMDE-UHFFFAOYSA-N 0.000 claims 1
- TWROELGOZKDRSL-UHFFFAOYSA-N 1-[[3-(1,4,8,11-tetrazacyclotetradec-1-ylmethyl)phenyl]methyl]-1,4,8,11-tetrazacyclotetradecane Chemical compound C=1C=CC(CN2CCNCCCNCCNCCC2)=CC=1CN1CCCNCCNCCCNCC1 TWROELGOZKDRSL-UHFFFAOYSA-N 0.000 claims 1
- UPPOFVSOKBVXDP-UHFFFAOYSA-N 1-[[3-(1,5,9-triazacyclododec-1-ylmethyl)phenyl]methyl]-1,5,9-triazacyclododecane Chemical compound C=1C=CC(CN2CCCNCCCNCCC2)=CC=1CN1CCCNCCCNCCC1 UPPOFVSOKBVXDP-UHFFFAOYSA-N 0.000 claims 1
- PEVCHIZAJILPKB-UHFFFAOYSA-N 1-[[3-nitro-5-(1,4,8,11-tetrazacyclotetradec-1-ylmethyl)phenyl]methyl]-1,4,8,11-tetrazacyclotetradecane Chemical compound C=1C(CN2CCNCCCNCCNCCC2)=CC([N+](=O)[O-])=CC=1CN1CCCNCCNCCCNCC1 PEVCHIZAJILPKB-UHFFFAOYSA-N 0.000 claims 1
- BNXRQMCWXHZHTF-UHFFFAOYSA-N 1-[[4-(1,4,7,10-tetrazacyclotetradec-1-ylmethyl)phenyl]methyl]-1,4,7,10-tetrazacyclotetradecane Chemical compound C=1C=C(CN2CCNCCNCCNCCCC2)C=CC=1CN1CCCCNCCNCCNCC1 BNXRQMCWXHZHTF-UHFFFAOYSA-N 0.000 claims 1
- BKJDPXSXCZMISN-UHFFFAOYSA-N 1-[[6-(1,4,8,11-tetrazacyclotetradec-1-ylmethyl)pyridin-2-yl]methyl]-1,4,8,11-tetrazacyclotetradecane Chemical compound C=1C=CC(CN2CCNCCCNCCNCCC2)=NC=1CN1CCCNCCNCCCNCC1 BKJDPXSXCZMISN-UHFFFAOYSA-N 0.000 claims 1
- YRMKTQNDPSHONR-UHFFFAOYSA-N 1-phenyl-n-[[4-(1,4,8,11-tetrazacyclotetradec-1-ylmethyl)phenyl]methyl]methanamine Chemical compound C=1C=CC=CC=1CNCC(C=C1)=CC=C1CN1CCCNCCNCCCNCC1 YRMKTQNDPSHONR-UHFFFAOYSA-N 0.000 claims 1
- IAGWLDWQRRSAIK-UHFFFAOYSA-N 11-[[4-(1,4,7,11-tetrazacyclotetradec-11-ylmethyl)phenyl]methyl]-1,4,7,11-tetrazacyclotetradecane Chemical compound C=1C=C(CN2CCCNCCNCCNCCC2)C=CC=1CN1CCCNCCNCCNCCC1 IAGWLDWQRRSAIK-UHFFFAOYSA-N 0.000 claims 1
- WOXFMYVTSLAQMO-UHFFFAOYSA-N 2-Pyridinemethanamine Chemical compound NCC1=CC=CC=N1 WOXFMYVTSLAQMO-UHFFFAOYSA-N 0.000 claims 1
- UQJUPEBNPXJTGH-UHFFFAOYSA-N 2-[[[4-(1,4,8,11-tetrazacyclotetradec-1-ylmethyl)phenyl]methylamino]methyl]aniline Chemical compound NC1=CC=CC=C1CNCC(C=C1)=CC=C1CN1CCNCCCNCCNCCC1 UQJUPEBNPXJTGH-UHFFFAOYSA-N 0.000 claims 1
- WRXILBMKDNKDQT-UHFFFAOYSA-N 4-[[[4-(1,4,8,11-tetrazacyclotetradec-1-ylmethyl)phenyl]methylamino]methyl]aniline Chemical compound C1=CC(N)=CC=C1CNCC(C=C1)=CC=C1CN1CCNCCCNCCNCCC1 WRXILBMKDNKDQT-UHFFFAOYSA-N 0.000 claims 1
- 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 claims 1
- 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical group Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
- LSDPWZHWYPCBBB-UHFFFAOYSA-N Methanethiol Chemical compound SC LSDPWZHWYPCBBB-UHFFFAOYSA-N 0.000 claims 1
- PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Natural products C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 claims 1
- DGEZNRSVGBDHLK-UHFFFAOYSA-N [1,10]phenanthroline Chemical compound C1=CN=C2C3=NC=CC=C3C=CC2=C1 DGEZNRSVGBDHLK-UHFFFAOYSA-N 0.000 claims 1
- AMNPXXIGUOKIPP-UHFFFAOYSA-N [4-(carbamothioylamino)phenyl]thiourea Chemical compound NC(=S)NC1=CC=C(NC(N)=S)C=C1 AMNPXXIGUOKIPP-UHFFFAOYSA-N 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 230000002452 interceptive effect Effects 0.000 claims 1
- 125000000468 ketone group Chemical group 0.000 claims 1
- 125000005647 linker group Chemical group 0.000 claims 1
- CWJJHESJXJQCJA-UHFFFAOYSA-N n-(pyridin-2-ylmethyl)-1-[4-(1,4,8,11-tetrazacyclotetradec-1-ylmethyl)phenyl]methanamine Chemical compound C=1C=C(CN2CCNCCCNCCNCCC2)C=CC=1CNCC1=CC=CC=N1 CWJJHESJXJQCJA-UHFFFAOYSA-N 0.000 claims 1
- TWTLJZJKDUYSON-UHFFFAOYSA-N n-(pyridin-3-ylmethyl)-1-[4-(1,4,8,11-tetrazacyclotetradec-1-ylmethyl)phenyl]methanamine Chemical compound C=1C=C(CN2CCNCCCNCCNCCC2)C=CC=1CNCC1=CC=CN=C1 TWTLJZJKDUYSON-UHFFFAOYSA-N 0.000 claims 1
- RTHCDPLDSUOFCC-UHFFFAOYSA-N n-(pyridin-4-ylmethyl)-1-[4-(1,4,8,11-tetrazacyclotetradec-1-ylmethyl)phenyl]methanamine Chemical compound C=1C=NC=CC=1CNCC(C=C1)=CC=C1CN1CCCNCCNCCCNCC1 RTHCDPLDSUOFCC-UHFFFAOYSA-N 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 125000001037 p-tolyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 claims 1
- YIQPUIGJQJDJOS-UHFFFAOYSA-N plerixafor Chemical compound C=1C=C(CN2CCNCCCNCCNCCC2)C=CC=1CN1CCCNCCNCCCNCC1 YIQPUIGJQJDJOS-UHFFFAOYSA-N 0.000 claims 1
- 229920000768 polyamine Polymers 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 125000004434 sulfur atom Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161486632P | 2011-05-16 | 2011-05-16 | |
| US61/486,632 | 2011-05-16 | ||
| PCT/US2012/037970 WO2012158707A1 (en) | 2011-05-16 | 2012-05-15 | Use of cxcr4 antagonists |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017017227A Division JP2017105809A (ja) | 2011-05-16 | 2017-02-02 | Ｃｘｃｒ４拮抗薬の使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014513727A JP2014513727A (ja) | 2014-06-05 |
| JP2014513727A5 true JP2014513727A5 (enExample) | 2015-07-02 |
Family
ID=81755014
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014511460A Withdrawn JP2014513727A (ja) | 2011-05-16 | 2012-05-15 | Ｃｘｃｒ４拮抗薬の使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20150030561A1 (enExample) |
| EP (1) | EP2709991B1 (enExample) |
| JP (1) | JP2014513727A (enExample) |
| KR (3) | KR20140045411A (enExample) |
| CN (1) | CN103596935A (enExample) |
| BR (1) | BR112013029482A2 (enExample) |
| ES (1) | ES2831049T3 (enExample) |
| MX (1) | MX365242B (enExample) |
| PL (1) | PL2709991T3 (enExample) |
| RU (1) | RU2638802C2 (enExample) |
| WO (1) | WO2012158707A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2006243776A1 (en) | 2005-05-02 | 2006-11-09 | Genzyme Corporation | Gene therapy for neurometabolic disorders |
| US9419667B2 (en) | 2013-04-16 | 2016-08-16 | Skyworks Solutions, Inc. | Apparatus and methods related to conformal coating implemented with surface mount devices |
| US9375406B2 (en) * | 2014-09-30 | 2016-06-28 | Taigen Biotechnology Co., Ltd. | Substituted pyrimidines for mobilizing cells expressing a type 4 CXC chemokine receptor |
| CN109069426B (zh) | 2015-12-14 | 2021-10-29 | X4 制药有限公司 | 治疗癌症的方法 |
| CN109069486A (zh) | 2015-12-14 | 2018-12-21 | X4 制药有限公司 | 治疗癌症的方法 |
| US10610527B2 (en) * | 2015-12-22 | 2020-04-07 | X4 Pharmaceuticals, Inc. | Methods for treating immunodeficiency disease |
| GB201604213D0 (en) * | 2016-03-11 | 2016-04-27 | Proximagen Ltd | Drug combination and its use in therapy |
| US11337969B2 (en) | 2016-04-08 | 2022-05-24 | X4 Pharmaceuticals, Inc. | Methods for treating cancer |
| JP6994767B2 (ja) | 2016-06-21 | 2022-01-14 | エックス４ ファーマシューティカルズ， インコーポレイテッド | Ｃｘｃｒ４阻害剤およびその使用 |
| US10988465B2 (en) | 2016-06-21 | 2021-04-27 | X4 Pharmaceuticals, Inc. | CXCR4 inhibitors and uses thereof |
| EP3808748B1 (en) | 2016-06-21 | 2026-05-20 | X4 Pharmaceuticals, Inc. | Substituted piperidines as cxcr4-inhibitors |
| IL320371A (en) * | 2016-09-08 | 2025-06-01 | Centro De Investig Energeticas Medioambientales Y Tecnologicas O A M P | Gene therapy for patients with fanconi anemia |
| CN109988153B (zh) * | 2017-12-29 | 2021-11-19 | 深圳夏浠湾医药科技有限公司 | 一种川芎嗪衍生物及其制备方法和应用 |
| US12539316B2 (en) | 2018-04-11 | 2026-02-03 | Spacecraft Seven, Llc | Compositions and methods for stem cell transplant |
| US10548889B1 (en) | 2018-08-31 | 2020-02-04 | X4 Pharmaceuticals, Inc. | Compositions of CXCR4 inhibitors and methods of preparation and use |
| CN115515585A (zh) | 2020-03-10 | 2022-12-23 | X4 制药有限公司 | 用于治疗中性粒细胞减少症的方法 |
| US20250276030A1 (en) * | 2020-10-20 | 2025-09-04 | Eom Pharmaceuticals Inc. | Eom613 for treatment of covid-19 |
| CN113662937B (zh) * | 2021-10-09 | 2022-08-23 | 江苏省人民医院（南京医科大学第一附属医院） | Plerixafor在上调EFTUD2表达和抑制HBV药物中的用途 |
| CN116675708B (zh) * | 2023-04-23 | 2026-06-23 | 华南师范大学 | 一类氧化响应的大环化合物、大环配合物及其应用 |
| WO2025122961A1 (en) * | 2023-12-08 | 2025-06-12 | X4 Pharmaceuticals, Inc. | Methods for treating neutropenia |
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| WO2006095542A1 (ja) | 2005-03-04 | 2006-09-14 | Kureha Corporation | アミン系化合物を含む医薬組成物 |
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| US20070043012A1 (en) | 2005-08-19 | 2007-02-22 | Bridger Gary J | Methods to enhance chemotherapy |
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| JP2012516353A (ja) * | 2009-01-30 | 2012-07-19 | ジェンザイム・コーポレーション | 血液系悪性腫瘍を治療するための方法及び組成物 |
-
2012
- 2012-05-15 RU RU2013155601A patent/RU2638802C2/ru active
- 2012-05-15 KR KR1020137033309A patent/KR20140045411A/ko not_active Ceased
- 2012-05-15 MX MX2013013308A patent/MX365242B/es active IP Right Grant
- 2012-05-15 KR KR1020207003632A patent/KR20200016407A/ko not_active Ceased
- 2012-05-15 BR BR112013029482A patent/BR112013029482A2/pt not_active IP Right Cessation
- 2012-05-15 US US14/118,144 patent/US20150030561A1/en not_active Abandoned
- 2012-05-15 PL PL12786739T patent/PL2709991T3/pl unknown
- 2012-05-15 CN CN201280024014.6A patent/CN103596935A/zh active Pending
- 2012-05-15 EP EP12786739.8A patent/EP2709991B1/en active Active
- 2012-05-15 KR KR1020217023153A patent/KR20210094672A/ko not_active Ceased
- 2012-05-15 JP JP2014511460A patent/JP2014513727A/ja not_active Withdrawn
- 2012-05-15 WO PCT/US2012/037970 patent/WO2012158707A1/en not_active Ceased
- 2012-05-15 ES ES12786739T patent/ES2831049T3/es active Active
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2020
- 2020-07-13 US US16/927,856 patent/US20210161859A1/en not_active Abandoned
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