JP2014513727A5 - - Google Patents
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- Publication number
- JP2014513727A5 JP2014513727A5 JP2014511460A JP2014511460A JP2014513727A5 JP 2014513727 A5 JP2014513727 A5 JP 2014513727A5 JP 2014511460 A JP2014511460 A JP 2014511460A JP 2014511460 A JP2014511460 A JP 2014511460A JP 2014513727 A5 JP2014513727 A5 JP 2014513727A5
- Authority
- JP
- Japan
- Prior art keywords
- bis
- methylene
- phenylene
- tetraazacyclotetradecane
- pyridine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 50
- 150000001875 compounds Chemical class 0.000 claims 24
- 150000003839 salts Chemical class 0.000 claims 7
- -1 polymethylene Polymers 0.000 claims 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 4
- 102100031650 C-X-C chemokine receptor type 4 Human genes 0.000 claims 4
- 101000922348 Homo sapiens C-X-C chemokine receptor type 4 Proteins 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 4
- 150000004696 coordination complex Chemical class 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 230000035772 mutation Effects 0.000 claims 4
- 206010025327 Lymphopenia Diseases 0.000 claims 3
- 208000010115 WHIM syndrome Diseases 0.000 claims 3
- 231100001023 lymphopenia Toxicity 0.000 claims 3
- 208000004235 neutropenia Diseases 0.000 claims 3
- 230000002265 prevention Effects 0.000 claims 3
- 208000008190 Agammaglobulinemia Diseases 0.000 claims 2
- 208000035143 Bacterial infection Diseases 0.000 claims 2
- 241000282412 Homo Species 0.000 claims 2
- 206010020983 Hypogammaglobulinaemia Diseases 0.000 claims 2
- KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical compound C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 claims 2
- 208000036142 Viral infection Diseases 0.000 claims 2
- 230000005856 abnormality Effects 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 125000002947 alkylene group Chemical group 0.000 claims 2
- 208000022362 bacterial infectious disease Diseases 0.000 claims 2
- 239000002576 chemokine receptor CXCR4 antagonist Substances 0.000 claims 2
- 229940121384 cxc chemokine receptor type 4 (cxcr4) antagonist Drugs 0.000 claims 2
- 125000004122 cyclic group Chemical group 0.000 claims 2
- 206010013023 diphtheria Diseases 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 230000036737 immune function Effects 0.000 claims 2
- 210000000265 leukocyte Anatomy 0.000 claims 2
- 201000002364 leukopenia Diseases 0.000 claims 2
- 231100001022 leukopenia Toxicity 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 230000009385 viral infection Effects 0.000 claims 2
- MDAXKAUIABOHTD-UHFFFAOYSA-N 1,4,8,11-tetraazacyclotetradecane Chemical compound C1CNCCNCCCNCCNC1 MDAXKAUIABOHTD-UHFFFAOYSA-N 0.000 claims 1
- IMWNCVDLSHMHEL-UHFFFAOYSA-N 1-[1-(1,4,8,11-tetrazacyclotetradec-1-yl)butan-2-yl]-1,4,8,11-tetrazacyclotetradecane Chemical compound C1CCNCCNCCCNCCN1C(CC)CN1CCCNCCNCCCNCC1 IMWNCVDLSHMHEL-UHFFFAOYSA-N 0.000 claims 1
- QPFUQMRWZANCBG-UHFFFAOYSA-N 1-[1-(1,4,8,11-tetrazacyclotetradec-1-yl)hexan-2-yl]-1,4,8,11-tetrazacyclotetradecane Chemical compound C1CCNCCNCCCNCCN1C(CCCC)CN1CCCNCCNCCCNCC1 QPFUQMRWZANCBG-UHFFFAOYSA-N 0.000 claims 1
- VEEDYUPGPMCQTN-UHFFFAOYSA-N 1-[1-(1,4,8,11-tetrazacyclotetradec-1-yl)pentan-2-yl]-1,4,8,11-tetrazacyclotetradecane Chemical compound C1CCNCCNCCCNCCN1C(CCC)CN1CCCNCCNCCCNCC1 VEEDYUPGPMCQTN-UHFFFAOYSA-N 0.000 claims 1
- YUEOTDBNBGFZSZ-UHFFFAOYSA-N 1-[1-(1,4,8,11-tetrazacyclotetradec-1-yl)propan-2-yl]-1,4,8,11-tetrazacyclotetradecane Chemical compound C1CCNCCNCCCNCCN1C(C)CN1CCCNCCNCCCNCC1 YUEOTDBNBGFZSZ-UHFFFAOYSA-N 0.000 claims 1
- GVPVISVGQUQSSG-UHFFFAOYSA-N 1-[2-(1,4,8,11-tetrazacyclotetradec-1-yl)ethyl]-1,4,8,11-tetrazacyclotetradecane Chemical compound C1CCNCCNCCCNCCN1CCN1CCCNCCNCCCNCC1 GVPVISVGQUQSSG-UHFFFAOYSA-N 0.000 claims 1
- PMGQWFFOFZQXSJ-UHFFFAOYSA-N 1-[4-(1,7-diazacyclotetradec-4-ylmethyl)phenyl]-n-(pyridin-2-ylmethyl)methanamine Chemical compound C=1C=C(CC2CCNCCCCCCCNCC2)C=CC=1CNCC1=CC=CC=N1 PMGQWFFOFZQXSJ-UHFFFAOYSA-N 0.000 claims 1
- GKJYLJLZQLRHLX-UHFFFAOYSA-N 1-[4-[(11,11-difluoro-1,4,7-triazacyclotetradec-4-yl)methyl]phenyl]-n-(pyridin-2-ylmethyl)methanamine Chemical compound C1CNCCCC(F)(F)CCCNCCN1CC(C=C1)=CC=C1CNCC1=CC=CC=N1 GKJYLJLZQLRHLX-UHFFFAOYSA-N 0.000 claims 1
- KCIMFODBVYVAJW-UHFFFAOYSA-N 1-[4-[(11-fluoro-1,4,7-triazacyclotetradec-4-yl)methyl]phenyl]-n-(pyridin-2-ylmethyl)methanamine Chemical compound C1CNCCCC(F)CCCNCCN1CC(C=C1)=CC=C1CNCC1=CC=CC=N1 KCIMFODBVYVAJW-UHFFFAOYSA-N 0.000 claims 1
- SEFLKOOVNJZTFY-UHFFFAOYSA-N 1-[[2,3,5,6-tetrafluoro-4-(1,4,8,11-tetrazacyclotetradec-1-ylmethyl)phenyl]methyl]-1,4,8,11-tetrazacyclotetradecane Chemical compound FC=1C(F)=C(CN2CCNCCCNCCNCCC2)C(F)=C(F)C=1CN1CCCNCCNCCCNCC1 SEFLKOOVNJZTFY-UHFFFAOYSA-N 0.000 claims 1
- NYQPBUORMFOXKK-UHFFFAOYSA-N 1-[[2,5-dichloro-4-(1,4,8,11-tetrazacyclotetradec-1-ylmethyl)phenyl]methyl]-1,4,8,11-tetrazacyclotetradecane Chemical compound ClC=1C=C(CN2CCNCCCNCCNCCC2)C(Cl)=CC=1CN1CCCNCCNCCCNCC1 NYQPBUORMFOXKK-UHFFFAOYSA-N 0.000 claims 1
- GBUVEYKYEYRGEU-UHFFFAOYSA-N 1-[[2,5-dimethyl-4-(1,4,8,11-tetrazacyclotetradec-1-ylmethyl)phenyl]methyl]-1,4,8,11-tetrazacyclotetradecane Chemical compound CC=1C=C(CN2CCNCCCNCCNCCC2)C(C)=CC=1CN1CCCNCCNCCCNCC1 GBUVEYKYEYRGEU-UHFFFAOYSA-N 0.000 claims 1
- CGBPRRHXVCXIKY-UHFFFAOYSA-N 1-[[2-bromo-4-(1,4,8,11-tetrazacyclotetradec-1-ylmethyl)phenyl]methyl]-1,4,8,11-tetrazacyclotetradecane Chemical compound C=1C=C(CN2CCNCCCNCCNCCC2)C(Br)=CC=1CN1CCCNCCNCCCNCC1 CGBPRRHXVCXIKY-UHFFFAOYSA-N 0.000 claims 1
- PXTXSIAYIFRMDE-UHFFFAOYSA-N 1-[[3-(1,4,7,10-tetrazacyclotetradec-1-ylmethyl)phenyl]methyl]-1,4,7,10-tetrazacyclotetradecane Chemical compound C=1C=CC(CN2CCNCCNCCNCCCC2)=CC=1CN1CCCCNCCNCCNCC1 PXTXSIAYIFRMDE-UHFFFAOYSA-N 0.000 claims 1
- TWROELGOZKDRSL-UHFFFAOYSA-N 1-[[3-(1,4,8,11-tetrazacyclotetradec-1-ylmethyl)phenyl]methyl]-1,4,8,11-tetrazacyclotetradecane Chemical compound C=1C=CC(CN2CCNCCCNCCNCCC2)=CC=1CN1CCCNCCNCCCNCC1 TWROELGOZKDRSL-UHFFFAOYSA-N 0.000 claims 1
- UPPOFVSOKBVXDP-UHFFFAOYSA-N 1-[[3-(1,5,9-triazacyclododec-1-ylmethyl)phenyl]methyl]-1,5,9-triazacyclododecane Chemical compound C=1C=CC(CN2CCCNCCCNCCC2)=CC=1CN1CCCNCCCNCCC1 UPPOFVSOKBVXDP-UHFFFAOYSA-N 0.000 claims 1
- PEVCHIZAJILPKB-UHFFFAOYSA-N 1-[[3-nitro-5-(1,4,8,11-tetrazacyclotetradec-1-ylmethyl)phenyl]methyl]-1,4,8,11-tetrazacyclotetradecane Chemical compound C=1C(CN2CCNCCCNCCNCCC2)=CC([N+](=O)[O-])=CC=1CN1CCCNCCNCCCNCC1 PEVCHIZAJILPKB-UHFFFAOYSA-N 0.000 claims 1
- BNXRQMCWXHZHTF-UHFFFAOYSA-N 1-[[4-(1,4,7,10-tetrazacyclotetradec-1-ylmethyl)phenyl]methyl]-1,4,7,10-tetrazacyclotetradecane Chemical compound C=1C=C(CN2CCNCCNCCNCCCC2)C=CC=1CN1CCCCNCCNCCNCC1 BNXRQMCWXHZHTF-UHFFFAOYSA-N 0.000 claims 1
- BKJDPXSXCZMISN-UHFFFAOYSA-N 1-[[6-(1,4,8,11-tetrazacyclotetradec-1-ylmethyl)pyridin-2-yl]methyl]-1,4,8,11-tetrazacyclotetradecane Chemical compound C=1C=CC(CN2CCNCCCNCCNCCC2)=NC=1CN1CCCNCCNCCCNCC1 BKJDPXSXCZMISN-UHFFFAOYSA-N 0.000 claims 1
- YRMKTQNDPSHONR-UHFFFAOYSA-N 1-phenyl-n-[[4-(1,4,8,11-tetrazacyclotetradec-1-ylmethyl)phenyl]methyl]methanamine Chemical compound C=1C=CC=CC=1CNCC(C=C1)=CC=C1CN1CCCNCCNCCCNCC1 YRMKTQNDPSHONR-UHFFFAOYSA-N 0.000 claims 1
- IAGWLDWQRRSAIK-UHFFFAOYSA-N 11-[[4-(1,4,7,11-tetrazacyclotetradec-11-ylmethyl)phenyl]methyl]-1,4,7,11-tetrazacyclotetradecane Chemical compound C=1C=C(CN2CCCNCCNCCNCCC2)C=CC=1CN1CCCNCCNCCNCCC1 IAGWLDWQRRSAIK-UHFFFAOYSA-N 0.000 claims 1
- WOXFMYVTSLAQMO-UHFFFAOYSA-N 2-Pyridinemethanamine Chemical compound NCC1=CC=CC=N1 WOXFMYVTSLAQMO-UHFFFAOYSA-N 0.000 claims 1
- UQJUPEBNPXJTGH-UHFFFAOYSA-N 2-[[[4-(1,4,8,11-tetrazacyclotetradec-1-ylmethyl)phenyl]methylamino]methyl]aniline Chemical compound NC1=CC=CC=C1CNCC(C=C1)=CC=C1CN1CCNCCCNCCNCCC1 UQJUPEBNPXJTGH-UHFFFAOYSA-N 0.000 claims 1
- WRXILBMKDNKDQT-UHFFFAOYSA-N 4-[[[4-(1,4,8,11-tetrazacyclotetradec-1-ylmethyl)phenyl]methylamino]methyl]aniline Chemical compound C1=CC(N)=CC=C1CNCC(C=C1)=CC=C1CN1CCNCCCNCCNCCC1 WRXILBMKDNKDQT-UHFFFAOYSA-N 0.000 claims 1
- 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 claims 1
- 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical group Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
- LSDPWZHWYPCBBB-UHFFFAOYSA-N Methanethiol Chemical compound SC LSDPWZHWYPCBBB-UHFFFAOYSA-N 0.000 claims 1
- PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Natural products C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 claims 1
- DGEZNRSVGBDHLK-UHFFFAOYSA-N [1,10]phenanthroline Chemical compound C1=CN=C2C3=NC=CC=C3C=CC2=C1 DGEZNRSVGBDHLK-UHFFFAOYSA-N 0.000 claims 1
- AMNPXXIGUOKIPP-UHFFFAOYSA-N [4-(carbamothioylamino)phenyl]thiourea Chemical compound NC(=S)NC1=CC=C(NC(N)=S)C=C1 AMNPXXIGUOKIPP-UHFFFAOYSA-N 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 230000002452 interceptive effect Effects 0.000 claims 1
- 125000000468 ketone group Chemical group 0.000 claims 1
- 125000005647 linker group Chemical group 0.000 claims 1
- CWJJHESJXJQCJA-UHFFFAOYSA-N n-(pyridin-2-ylmethyl)-1-[4-(1,4,8,11-tetrazacyclotetradec-1-ylmethyl)phenyl]methanamine Chemical compound C=1C=C(CN2CCNCCCNCCNCCC2)C=CC=1CNCC1=CC=CC=N1 CWJJHESJXJQCJA-UHFFFAOYSA-N 0.000 claims 1
- TWTLJZJKDUYSON-UHFFFAOYSA-N n-(pyridin-3-ylmethyl)-1-[4-(1,4,8,11-tetrazacyclotetradec-1-ylmethyl)phenyl]methanamine Chemical compound C=1C=C(CN2CCNCCCNCCNCCC2)C=CC=1CNCC1=CC=CN=C1 TWTLJZJKDUYSON-UHFFFAOYSA-N 0.000 claims 1
- RTHCDPLDSUOFCC-UHFFFAOYSA-N n-(pyridin-4-ylmethyl)-1-[4-(1,4,8,11-tetrazacyclotetradec-1-ylmethyl)phenyl]methanamine Chemical compound C=1C=NC=CC=1CNCC(C=C1)=CC=C1CN1CCCNCCNCCCNCC1 RTHCDPLDSUOFCC-UHFFFAOYSA-N 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 125000001037 p-tolyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 claims 1
- YIQPUIGJQJDJOS-UHFFFAOYSA-N plerixafor Chemical compound C=1C=C(CN2CCNCCCNCCNCCC2)C=CC=1CN1CCCNCCNCCCNCC1 YIQPUIGJQJDJOS-UHFFFAOYSA-N 0.000 claims 1
- 229920000768 polyamine Polymers 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 125000004434 sulfur atom Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161486632P | 2011-05-16 | 2011-05-16 | |
| US61/486,632 | 2011-05-16 | ||
| PCT/US2012/037970 WO2012158707A1 (en) | 2011-05-16 | 2012-05-15 | Use of cxcr4 antagonists |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017017227A Division JP2017105809A (ja) | 2011-05-16 | 2017-02-02 | Ｃｘｃｒ４拮抗薬の使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014513727A JP2014513727A (ja) | 2014-06-05 |
| JP2014513727A5 true JP2014513727A5 (enExample) | 2015-07-02 |
Family
ID=81755014
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014511460A Withdrawn JP2014513727A (ja) | 2011-05-16 | 2012-05-15 | Ｃｘｃｒ４拮抗薬の使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20150030561A1 (enExample) |
| EP (1) | EP2709991B1 (enExample) |
| JP (1) | JP2014513727A (enExample) |
| KR (3) | KR20140045411A (enExample) |
| CN (1) | CN103596935A (enExample) |
| BR (1) | BR112013029482A2 (enExample) |
| ES (1) | ES2831049T3 (enExample) |
| MX (1) | MX365242B (enExample) |
| PL (1) | PL2709991T3 (enExample) |
| RU (1) | RU2638802C2 (enExample) |
| WO (1) | WO2012158707A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL3058959T3 (pl) | 2005-05-02 | 2019-07-31 | Genzyme Corporation | Terapia genowa dla zaburzeń neurometabolicznych |
| US9419667B2 (en) | 2013-04-16 | 2016-08-16 | Skyworks Solutions, Inc. | Apparatus and methods related to conformal coating implemented with surface mount devices |
| US9375406B2 (en) * | 2014-09-30 | 2016-06-28 | Taigen Biotechnology Co., Ltd. | Substituted pyrimidines for mobilizing cells expressing a type 4 CXC chemokine receptor |
| JP6958820B2 (ja) | 2015-12-14 | 2021-11-02 | エックス４ ファーマシューティカルズ， インコーポレイテッド | がんを処置する方法 |
| EP3389634B1 (en) | 2015-12-14 | 2021-10-06 | X4 Pharmaceuticals, Inc. | Methods for treating cancer |
| JP7055380B2 (ja) * | 2015-12-22 | 2022-04-18 | エックス４ ファーマシューティカルズ， インコーポレイテッド | 免疫不全疾患を処置するための方法 |
| GB201604213D0 (en) * | 2016-03-11 | 2016-04-27 | Proximagen Ltd | Drug combination and its use in therapy |
| WO2017177230A1 (en) | 2016-04-08 | 2017-10-12 | X4 Pharmaceuticals, Inc. | Methods for treating cancer |
| EP3808748A1 (en) | 2016-06-21 | 2021-04-21 | X4 Pharmaceuticals, Inc. | Substituted piperidines as cxcr4-inhibitors |
| CN109640988A (zh) | 2016-06-21 | 2019-04-16 | X4 制药有限公司 | Cxcr4抑制剂及其用途 |
| CA3027500A1 (en) | 2016-06-21 | 2017-12-28 | X4 Pharmaceuticals, Inc. | Cxcr4 inhibitors and uses thereof |
| MX2019002699A (es) * | 2016-09-08 | 2019-12-16 | Centro De Investig Energeticas Medioambientales Y Tecnologicas O A M P | Terapia genica para pacientes con anemia de fanconi. |
| CN109988153B (zh) * | 2017-12-29 | 2021-11-19 | 深圳夏浠湾医药科技有限公司 | 一种川芎嗪衍生物及其制备方法和应用 |
| US10548889B1 (en) | 2018-08-31 | 2020-02-04 | X4 Pharmaceuticals, Inc. | Compositions of CXCR4 inhibitors and methods of preparation and use |
| JP2023517956A (ja) | 2020-03-10 | 2023-04-27 | エックス４ ファーマシューティカルズ， インコーポレイテッド | 好中球減少症を処置する方法 |
| JP2023547261A (ja) * | 2020-10-20 | 2023-11-09 | イーオーエム ファーマシューティカルズ インコーポレイテッド | Ｃｏｖｉｄ－１９の処置のためのｅｏｍ６１３ |
| CN113662937B (zh) * | 2021-10-09 | 2022-08-23 | 江苏省人民医院（南京医科大学第一附属医院） | Plerixafor在上调EFTUD2表达和抑制HBV药物中的用途 |
| CN116675708A (zh) * | 2023-04-23 | 2023-09-01 | 华南师范大学 | 一类氧化响应的大环化合物、大环配合物及其应用 |
| WO2025122961A1 (en) * | 2023-12-08 | 2025-06-12 | X4 Pharmaceuticals, Inc. | Methods for treating neutropenia |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE640616A (enExample) | 1962-12-19 | |||
| US3492397A (en) | 1967-04-07 | 1970-01-27 | Warner Lambert Pharmaceutical | Sustained release dosage in the pellet form and process thereof |
| US4060598A (en) | 1967-06-28 | 1977-11-29 | Boehringer Mannheim G.M.B.H. | Tablets coated with aqueous resin dispersions |
| US3538214A (en) | 1969-04-22 | 1970-11-03 | Merck & Co Inc | Controlled release medicinal tablets |
| GB1524747A (en) | 1976-05-11 | 1978-09-13 | Ici Ltd | Polypeptide |
| US4173626A (en) | 1978-12-11 | 1979-11-06 | Merck & Co., Inc. | Sustained release indomethacin |
| EP0100172B1 (en) | 1982-07-23 | 1987-08-12 | Imperial Chemical Industries Plc | Amide derivatives |
| US6001826A (en) | 1989-12-21 | 1999-12-14 | Anormed, Inc. | Chemical compounds |
| US5021409A (en) | 1989-12-21 | 1991-06-04 | Johnson Matthey Plc | Antiviral cyclic polyamines |
| GB9105489D0 (en) | 1991-03-15 | 1991-05-01 | Johnson Matthey Plc | Improvements in chemical compounds |
| GB9126677D0 (en) | 1991-12-16 | 1992-02-12 | Johnson Matthey Plc | Improvements in chemical compounds |
| GB9400411D0 (en) | 1994-01-11 | 1994-03-09 | Johnson Matthey Plc | Improvements in chemical compounds |
| US5612478A (en) | 1995-03-30 | 1997-03-18 | Johnson Matthey Plc | Process for preparing 1,1'-[1,4-phenylenebis-(methylene)]-bis-1,4,8,11-tetraazacyclotetradecane |
| US5606053A (en) | 1995-05-02 | 1997-02-25 | Johnson Matthey Plc | Process for preparing 1,1'-[1,4-phenylenebis-(methylene)]-bis-1,4,8,11-tetraazacyclotetradecane |
| US6506770B1 (en) | 1996-06-06 | 2003-01-14 | Anormed, Inc. | Antiviral compounds |
| GB9511357D0 (en) | 1995-06-06 | 1995-08-02 | Johnson Matthey Plc | Improved antiviral compounds |
| WO1999047158A2 (en) | 1998-03-13 | 1999-09-23 | The University Of British Columbia | Therapeutic chemokine receptor antagonists |
| WO2000009152A1 (en) | 1998-08-14 | 2000-02-24 | The University Of British Columbia | Therapeutic chemokine receptor antagonists |
| DE1068357T1 (de) | 1998-03-30 | 2001-07-19 | Northwest Biotherapeutics, Inc. | Therapeutische und diagnostische anwendungen welche auf der rolle von cxcr-4 in der tumorgenese basieren |
| US6365583B1 (en) * | 1999-02-02 | 2002-04-02 | Anormed, Inc. | Methods to enhance white blood cell count |
| CN100335478C (zh) | 1999-12-17 | 2007-09-05 | 阿诺麦德股份有限公司 | 结合趋化因子受体的杂环化合物 |
| CA2335109A1 (en) | 2000-04-12 | 2001-10-12 | Chemokine Therapeutics Corporation | Cxcr4 agonist treatment of hematopoietic cells |
| US20070160574A1 (en) | 2000-04-12 | 2007-07-12 | Ahmed Merzouk | Design of CXC chemokine analogs for the treatment of human diseases |
| DE60103052T2 (de) | 2000-05-09 | 2005-03-03 | The University Of British Columbia, Vancouver | Verwendung von cxcr4 antagonisten zur behandlung von krebs und autoimmunkrankheiten |
| EP1290033B1 (en) | 2000-06-05 | 2012-10-31 | The Trustees of Columbia University in the City of New York | Identification and use of human bone marrow-derived endothelial progenitor cells to improve myocardial function after ischemic injury |
| EP1322626B1 (en) | 2000-09-29 | 2008-11-05 | Anormed Inc. | Process for preparation of n-1 protected n ring nitrogen containing cyclic polyamines and products thereof |
| US20040157818A1 (en) | 2001-05-24 | 2004-08-12 | Mikiro Yanaka | Cxcr4-antagonistic drugs composed of nitrogen-containing compound |
| EP2371361B1 (en) | 2001-07-31 | 2019-08-07 | Genzyme Corporation | Methods to mobilize progenitor/stem cells |
| US20030221931A1 (en) | 2002-02-28 | 2003-12-04 | Steve Marsh | Sliding device |
| US20030199464A1 (en) | 2002-04-23 | 2003-10-23 | Silviu Itescu | Regeneration of endogenous myocardial tissue by induction of neovascularization |
| EP1541585B1 (en) | 2002-08-27 | 2013-01-30 | Biokine Therapeutics Ltd. | Cxcr4 antagonist and use thereof |
| JP3949708B2 (ja) | 2003-04-02 | 2007-07-25 | タイゲン・バイオテクノロジー | ケモカイン受容体介在疾患を治療するためのポリアミン化合物 |
| US7504422B2 (en) | 2003-04-02 | 2009-03-17 | Taigen Biotechnology Co. Ltd. | Polyamine compounds |
| WO2006020891A2 (en) | 2004-08-13 | 2006-02-23 | Anormed Inc. | Chemokine combinations to mobilize progenitor/stem cells |
| US7501526B2 (en) | 2005-01-20 | 2009-03-10 | Taigen Biotechnology | Synthesis of polyamine compounds |
| WO2006095542A1 (ja) | 2005-03-04 | 2006-09-14 | Kureha Corporation | アミン系化合物を含む医薬組成物 |
| WO2007022385A2 (en) * | 2005-08-18 | 2007-02-22 | Novartis Ag | Use of cxcr4 binding molecules for the treatment of whim syndrome |
| CN101365336B (zh) | 2005-08-19 | 2013-05-29 | 健赞股份有限公司 | 增强化疗的方法 |
| WO2007047882A2 (en) * | 2005-10-18 | 2007-04-26 | Caritas St. Elizabeth Medical Center Of Boston, Inc. | Combination of cxcr4 antagonist and morphogen to increase angiogenesis |
| JP2009527552A (ja) | 2006-02-24 | 2009-07-30 | ジェンザイム・コーポレーション | 血流の増加および組織再生の促進またはそのいずれかのための方法 |
| US8080659B2 (en) | 2006-07-11 | 2011-12-20 | Emory University | CXCR4 antagonists including diazine and triazine structures for the treatment of medical disorders |
| AR063470A1 (es) | 2006-08-02 | 2009-01-28 | Genzyme Corp | Terapia combinada |
| AR062271A1 (es) | 2006-08-07 | 2008-10-29 | Genzyme Corp | Uso de una cantidad efectiva de al menos un inhibidor de cxcr4, al menos un agonista de cxcr2 y g-csf para movilizar las celulas progenitoras y/o celulas madre |
| JP5140686B2 (ja) | 2007-02-28 | 2013-02-06 | ポリファー リミテッド | テンプレート固定ペプチド模倣薬 |
| KR101210774B1 (ko) | 2008-06-23 | 2012-12-10 | 리서치 인 모션 리미티드 | 디바이스 및 서버 능력을 전달하는 방법 |
| WO2010025416A1 (en) | 2008-08-29 | 2010-03-04 | Genzyme Corporation | Cxcr4 antagonists for kidney injury |
| EP2384115A4 (en) * | 2009-01-30 | 2012-11-07 | Genzyme Corp | METHODS AND COMPOSITIONS FOR TREATING HEMATOLOGICAL MALIGNANT TUMORS |
-
2012
- 2012-05-15 PL PL12786739T patent/PL2709991T3/pl unknown
- 2012-05-15 ES ES12786739T patent/ES2831049T3/es active Active
- 2012-05-15 WO PCT/US2012/037970 patent/WO2012158707A1/en not_active Ceased
- 2012-05-15 JP JP2014511460A patent/JP2014513727A/ja not_active Withdrawn
- 2012-05-15 RU RU2013155601A patent/RU2638802C2/ru active
- 2012-05-15 CN CN201280024014.6A patent/CN103596935A/zh active Pending
- 2012-05-15 KR KR1020137033309A patent/KR20140045411A/ko not_active Ceased
- 2012-05-15 MX MX2013013308A patent/MX365242B/es active IP Right Grant
- 2012-05-15 KR KR1020217023153A patent/KR20210094672A/ko not_active Ceased
- 2012-05-15 BR BR112013029482A patent/BR112013029482A2/pt not_active IP Right Cessation
- 2012-05-15 EP EP12786739.8A patent/EP2709991B1/en active Active
- 2012-05-15 US US14/118,144 patent/US20150030561A1/en not_active Abandoned
- 2012-05-15 KR KR1020207003632A patent/KR20200016407A/ko not_active Ceased
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2020
- 2020-07-13 US US16/927,856 patent/US20210161859A1/en not_active Abandoned
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