ES2831049T3 - Uso de antagonistas de cxcr4 para tratar síndrome de WHIM, mielocatexis, neutropenia y linfocitopenia - Google Patents
Uso de antagonistas de cxcr4 para tratar síndrome de WHIM, mielocatexis, neutropenia y linfocitopenia Download PDFInfo
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- ES2831049T3 ES2831049T3 ES12786739T ES12786739T ES2831049T3 ES 2831049 T3 ES2831049 T3 ES 2831049T3 ES 12786739 T ES12786739 T ES 12786739T ES 12786739 T ES12786739 T ES 12786739T ES 2831049 T3 ES2831049 T3 ES 2831049T3
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- methylene
- bis
- compound
- cxcr4
- phenylenebis
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Classifications
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
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- A—HUMAN NECESSITIES
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- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
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| US201161486632P | 2011-05-16 | 2011-05-16 | |
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| AU2006243776A1 (en) | 2005-05-02 | 2006-11-09 | Genzyme Corporation | Gene therapy for neurometabolic disorders |
| US9788466B2 (en) | 2013-04-16 | 2017-10-10 | Skyworks Solutions, Inc. | Apparatus and methods related to ground paths implemented with surface mount devices |
| US9375406B2 (en) * | 2014-09-30 | 2016-06-28 | Taigen Biotechnology Co., Ltd. | Substituted pyrimidines for mobilizing cells expressing a type 4 CXC chemokine receptor |
| EP3389634B1 (en) | 2015-12-14 | 2021-10-06 | X4 Pharmaceuticals, Inc. | Methods for treating cancer |
| WO2017106332A1 (en) | 2015-12-14 | 2017-06-22 | X4 Pharmaceuticals, Inc. | Methods for treating cancer |
| JP7055380B2 (ja) | 2015-12-22 | 2022-04-18 | エックス４ ファーマシューティカルズ， インコーポレイテッド | 免疫不全疾患を処置するための方法 |
| GB201604213D0 (en) * | 2016-03-11 | 2016-04-27 | Proximagen Ltd | Drug combination and its use in therapy |
| EP3440112A4 (en) | 2016-04-08 | 2019-10-09 | X4 Pharmaceuticals, Inc. | METHOD FOR THE TREATMENT OF CANCER |
| CA3027495A1 (en) | 2016-06-21 | 2017-12-28 | X4 Pharmaceuticals, Inc. | Cxcr4 inhibitors and uses thereof |
| ES2870920T3 (es) | 2016-06-21 | 2021-10-28 | X4 Pharmaceuticals Inc | Inhibidores de CXCR4 y usos de los mismos |
| CN109641838A (zh) * | 2016-06-21 | 2019-04-16 | X4 制药有限公司 | Cxcr4抑制剂及其用途 |
| AU2017322511B2 (en) * | 2016-09-08 | 2021-08-26 | Centro de Investigaciones Energeticas, Medioambientales Y Tecnologicas, O.A., M.P. | Gene therapy for patients with Fanconi anemia |
| CN109988153B (zh) * | 2017-12-29 | 2021-11-19 | 深圳夏浠湾医药科技有限公司 | 一种川芎嗪衍生物及其制备方法和应用 |
| US10548889B1 (en) | 2018-08-31 | 2020-02-04 | X4 Pharmaceuticals, Inc. | Compositions of CXCR4 inhibitors and methods of preparation and use |
| JP2023517956A (ja) | 2020-03-10 | 2023-04-27 | エックス４ ファーマシューティカルズ， インコーポレイテッド | 好中球減少症を処置する方法 |
| US20250276030A1 (en) * | 2020-10-20 | 2025-09-04 | Eom Pharmaceuticals Inc. | Eom613 for treatment of covid-19 |
| CN113662937B (zh) * | 2021-10-09 | 2022-08-23 | 江苏省人民医院（南京医科大学第一附属医院） | Plerixafor在上调EFTUD2表达和抑制HBV药物中的用途 |
| CN116675708A (zh) * | 2023-04-23 | 2023-09-01 | 华南师范大学 | 一类氧化响应的大环化合物、大环配合物及其应用 |
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| CN101500595A (zh) | 2006-08-07 | 2009-08-05 | 健赞股份有限公司 | 组合治疗 |
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Also Published As
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| WO2012158707A1 (en) | 2012-11-22 |
| CN103596935A (zh) | 2014-02-19 |
| EP2709991B1 (en) | 2020-09-02 |
| MX2013013308A (es) | 2014-02-27 |
| PL2709991T3 (pl) | 2021-04-06 |
| KR20210094672A (ko) | 2021-07-29 |
| US20210161859A1 (en) | 2021-06-03 |
| KR20140045411A (ko) | 2014-04-16 |
| RU2638802C2 (ru) | 2017-12-15 |
| EP2709991A1 (en) | 2014-03-26 |
| BR112013029482A2 (pt) | 2016-08-09 |
| JP2014513727A (ja) | 2014-06-05 |
| EP2709991A4 (en) | 2014-10-01 |
| KR20200016407A (ko) | 2020-02-14 |
| RU2013155601A (ru) | 2015-06-27 |
| MX365242B (es) | 2019-05-28 |
| US20150030561A1 (en) | 2015-01-29 |
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