JP2014504259A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2014504259A5 JP2014504259A5 JP2013533916A JP2013533916A JP2014504259A5 JP 2014504259 A5 JP2014504259 A5 JP 2014504259A5 JP 2013533916 A JP2013533916 A JP 2013533916A JP 2013533916 A JP2013533916 A JP 2013533916A JP 2014504259 A5 JP2014504259 A5 JP 2014504259A5
- Authority
- JP
- Japan
- Prior art keywords
- oil
- pharmaceutical formulation
- group
- pharmaceutically acceptable
- formulation according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- -1 polyoxyethylene Polymers 0.000 claims 4
- 239000000825 pharmaceutical preparation Substances 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 239000011780 sodium chloride Substances 0.000 claims 3
- 229940095259 Butylated Hydroxytoluene Drugs 0.000 claims 2
- 239000004322 Butylated hydroxytoluene Substances 0.000 claims 2
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 claims 2
- GEHJYWRUCIMESM-UHFFFAOYSA-L Sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 150000007513 acids Chemical class 0.000 claims 2
- 235000010354 butylated hydroxytoluene Nutrition 0.000 claims 2
- 235000014113 dietary fatty acids Nutrition 0.000 claims 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N edta Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims 2
- 239000003995 emulsifying agent Substances 0.000 claims 2
- 239000000194 fatty acid Substances 0.000 claims 2
- 150000002632 lipids Chemical class 0.000 claims 2
- 244000005700 microbiome Species 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- DNIAPMSPPWPWGF-UHFFFAOYSA-N propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 2
- BVDRUCCQKHGCRX-UHFFFAOYSA-N 2,3-dihydroxypropyl formate Chemical compound OCC(O)COC=O BVDRUCCQKHGCRX-UHFFFAOYSA-N 0.000 claims 1
- 239000004380 Cholic acid Substances 0.000 claims 1
- BHQCQFFYRZLCQQ-OELDTZBJSA-N Cholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 BHQCQFFYRZLCQQ-OELDTZBJSA-N 0.000 claims 1
- KPBZROQVTHLCDU-GOSISDBHSA-N Clevidipine Chemical compound CCCC(=O)OCOC(=O)C1=C(C)NC(C)=C(C(=O)OC)[C@H]1C1=CC=CC(Cl)=C1Cl KPBZROQVTHLCDU-GOSISDBHSA-N 0.000 claims 1
- 229960001305 Cysteine Hydrochloride Drugs 0.000 claims 1
- IELOKBJPULMYRW-NJQVLOCASA-N D-α-Tocopheryl Acid Succinate Chemical compound OC(=O)CCC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C IELOKBJPULMYRW-NJQVLOCASA-N 0.000 claims 1
- KXGVEGMKQFWNSR-LLQZFEROSA-N Deoxycholic acid Chemical compound C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 KXGVEGMKQFWNSR-LLQZFEROSA-N 0.000 claims 1
- 229940068998 EGG YOLK PHOSPHOLIPIDS Drugs 0.000 claims 1
- 235000010469 Glycine max Nutrition 0.000 claims 1
- QAQJMLQRFWZOBN-LAUBAEHRSA-N L-ascorbyl-6-palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-LAUBAEHRSA-N 0.000 claims 1
- 239000011786 L-ascorbyl-6-palmitate Substances 0.000 claims 1
- 235000019483 Peanut oil Nutrition 0.000 claims 1
- 229940067631 Phospholipids Drugs 0.000 claims 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 1
- 229920001214 Polysorbate 60 Polymers 0.000 claims 1
- 229940068965 Polysorbates Drugs 0.000 claims 1
- 229940075579 Propyl Gallate Drugs 0.000 claims 1
- 229960005055 SODIUM ASCORBATE Drugs 0.000 claims 1
- WBHQBSYUUJJSRZ-UHFFFAOYSA-M Sodium bisulfate Chemical compound [Na+].OS([O-])(=O)=O WBHQBSYUUJJSRZ-UHFFFAOYSA-M 0.000 claims 1
- 235000019486 Sunflower oil Nutrition 0.000 claims 1
- 229960001295 Tocopherol Drugs 0.000 claims 1
- URAYPUMNDPQOKB-UHFFFAOYSA-N Triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 claims 1
- 229960002622 Triacetin Drugs 0.000 claims 1
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K Trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 claims 1
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Vitamin C Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 1
- QIJRTFXNRTXDIP-JIZZDEOASA-N [(1R)-1-carboxy-2-sulfanylethyl]azanium;chloride;hydrate Chemical compound O.Cl.SC[C@H](N)C(O)=O QIJRTFXNRTXDIP-JIZZDEOASA-N 0.000 claims 1
- 239000004599 antimicrobial Substances 0.000 claims 1
- 230000003078 antioxidant Effects 0.000 claims 1
- 239000003963 antioxidant agent Substances 0.000 claims 1
- 235000006708 antioxidants Nutrition 0.000 claims 1
- 229960005070 ascorbic acid Drugs 0.000 claims 1
- 235000010385 ascorbyl palmitate Nutrition 0.000 claims 1
- 235000019282 butylated hydroxyanisole Nutrition 0.000 claims 1
- 239000004359 castor oil Substances 0.000 claims 1
- 235000019438 castor oil Nutrition 0.000 claims 1
- 229960002471 cholic acid Drugs 0.000 claims 1
- 235000019416 cholic acid Nutrition 0.000 claims 1
- 229960003597 clevidipine Drugs 0.000 claims 1
- 239000007957 coemulsifier Substances 0.000 claims 1
- 235000005687 corn oil Nutrition 0.000 claims 1
- 239000002285 corn oil Substances 0.000 claims 1
- 235000012343 cottonseed oil Nutrition 0.000 claims 1
- 239000002385 cottonseed oil Substances 0.000 claims 1
- 230000003111 delayed Effects 0.000 claims 1
- 229960003964 deoxycholic acid Drugs 0.000 claims 1
- 239000008344 egg yolk phospholipid Substances 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 1
- 235000011187 glycerol Nutrition 0.000 claims 1
- 239000001087 glyceryl triacetate Substances 0.000 claims 1
- 235000013773 glyceryl triacetate Nutrition 0.000 claims 1
- 239000008350 hydrogenated phosphatidyl choline Substances 0.000 claims 1
- 238000007654 immersion Methods 0.000 claims 1
- 239000002609 media Substances 0.000 claims 1
- 230000000813 microbial Effects 0.000 claims 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid group Chemical group C(CCCCCCC\C=C/CCCCCCCC)(=O)O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims 1
- 239000004006 olive oil Substances 0.000 claims 1
- 235000008390 olive oil Nutrition 0.000 claims 1
- 239000000312 peanut oil Substances 0.000 claims 1
- 150000008105 phosphatidylcholines Chemical class 0.000 claims 1
- 150000003904 phospholipids Chemical class 0.000 claims 1
- 229920001983 poloxamer Polymers 0.000 claims 1
- 229920001987 poloxamine Polymers 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 229920000136 polysorbate Polymers 0.000 claims 1
- ZTHYODDOHIVTJV-UHFFFAOYSA-N propyl 3,4,5-trihydroxybenzoate Chemical compound CCCOC(=O)C1=CC(O)=C(O)C(O)=C1 ZTHYODDOHIVTJV-UHFFFAOYSA-N 0.000 claims 1
- 235000010388 propyl gallate Nutrition 0.000 claims 1
- 239000000473 propyl gallate Substances 0.000 claims 1
- 239000008349 purified phosphatidyl choline Substances 0.000 claims 1
- 239000003813 safflower oil Substances 0.000 claims 1
- 239000008159 sesame oil Substances 0.000 claims 1
- 235000011803 sesame oil Nutrition 0.000 claims 1
- 235000010378 sodium ascorbate Nutrition 0.000 claims 1
- PPASLZSBLFJQEF-RKJRWTFHSA-M sodium ascorbate Substances [Na+].OC[C@@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RKJRWTFHSA-M 0.000 claims 1
- 229910000342 sodium bisulfate Inorganic materials 0.000 claims 1
- DWAQJAXMDSEUJJ-UHFFFAOYSA-M sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 claims 1
- 239000001509 sodium citrate Substances 0.000 claims 1
- 229960001790 sodium citrate Drugs 0.000 claims 1
- 229940079827 sodium hydrogen sulfite Drugs 0.000 claims 1
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 claims 1
- 235000010265 sodium sulphite Nutrition 0.000 claims 1
- 239000003549 soybean oil Substances 0.000 claims 1
- 235000012424 soybean oil Nutrition 0.000 claims 1
- 239000002600 sunflower oil Substances 0.000 claims 1
- 230000001629 suppression Effects 0.000 claims 1
- 239000008348 synthetic phosphatidyl choline Substances 0.000 claims 1
- 235000010384 tocopherol Nutrition 0.000 claims 1
- 239000011732 tocopherol Substances 0.000 claims 1
- 229950000300 tocopherol succinate Drugs 0.000 claims 1
- 229930003799 tocopherols Natural products 0.000 claims 1
- 150000003626 triacylglycerols Chemical class 0.000 claims 1
- 239000011778 trisodium citrate Substances 0.000 claims 1
- 235000019263 trisodium citrate Nutrition 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims 1
Claims (8)
- （a）有効量のクレビジピンまたは製薬上許容され得るその塩もしくはエステル、
（b）0.001から1.5％w/vで存在する抗菌剤EDTA、
（c）脂質、
（d）乳化剤、
（e）浸透圧調整剤、および
（f）水
を含み、微生物の増殖を阻害する、医薬製剤。 - EDTAが0.001から0.025％w/vで存在する、請求項１に記載の医薬製剤。
- 脂質が、ダイズ油、ベニバナ種子油、オリーブ油、綿実油、ヒマワリ油、ゴマ油、ラッカセイ油、トウモロコシ油、中鎖脂肪酸トリグリセリド、トリアセチン、プロピレングリコールジエステル、モノグリセリド、およびそれらの２つ以上の混合物から成る群より選択される、請求項１または２に記載の医薬製剤。
- 乳化剤が、卵黄リン脂質類、ダイズリン脂質類、合成ホスファチジルコリン類、精製ホスファチジルコリン類、および水素化ホスファチジルコリン、ならびにそれらの２つ以上の混合物から成る群より選択される、請求項１〜３のいずれか１項に記載の医薬製剤。
- アスコルビン酸ナトリウム、クエン酸ナトリウム、塩酸システイン、硫酸水素ナトリウム、メタ亜硫酸水素ナトリウム、亜硫酸ナトリウム、パルミチン酸アスコルビル、ブチル化ヒドロキシアニソール（BHA）、ブチル化ヒドロキシトルエン（BHT）、没食子酸プロピル、トコフェロール、およびそれらの製薬上許容され得る塩から成る群より選択される抗酸化剤をさらに含む、請求項１〜４のいずれか１項に記載の医薬製剤。
- 医薬製剤が6.0から8.8のpHを有する、請求項１〜５のいずれか１項に記載の医薬製剤。
- グリセリン、ポロクサマー類、ポリオキシエチレンヒマシ油誘導体、ポロクサミン類、ステアリン酸ポリオキシエチレン類、ポリオキシエチレンソルビタン脂肪酸エステル、ソルビタン脂肪酸エステル、ポリソルベート類、コハク酸トコフェロールＰＥＧ、コール酸、デオキシコール酸、オレイン酸、および製薬上許容され得るそれらの塩から成る群より選択される共乳化剤をさらに含む、請求項１〜６のいずれか１項に記載の医薬製剤。
- 微生物の増殖は、24時間にわたって生存微生物コロニーが10倍（1 log）未満に遅延または抑制される、請求項１〜７のいずれか１項に記載の医薬製剤。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39229410P | 2010-10-12 | 2010-10-12 | |
| US61/392,294 | 2010-10-12 | ||
| PCT/US2011/055617 WO2012051116A1 (en) | 2010-10-12 | 2011-10-10 | Clevidipine emulsion formulations containing antimicrobial agents |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014120354A Division JP6437743B2 (ja) | 2010-10-12 | 2014-06-11 | 抗菌剤を含むクレビジピン乳化製剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014504259A JP2014504259A (ja) | 2014-02-20 |
| JP2014504259A5 true JP2014504259A5 (ja) | 2014-04-10 |
| JP6040437B2 JP6040437B2 (ja) | 2016-12-07 |
Family
ID=45925617
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013533916A Active JP6040437B2 (ja) | 2010-10-12 | 2011-10-10 | 抗菌剤を含むクレビジピン乳化製剤 |
| JP2014120354A Active JP6437743B2 (ja) | 2010-10-12 | 2014-06-11 | 抗菌剤を含むクレビジピン乳化製剤 |
| JP2016123498A Active JP6326094B2 (ja) | 2010-10-12 | 2016-06-22 | 抗菌剤を含むクレビジピン乳化製剤 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014120354A Active JP6437743B2 (ja) | 2010-10-12 | 2014-06-11 | 抗菌剤を含むクレビジピン乳化製剤 |
| JP2016123498A Active JP6326094B2 (ja) | 2010-10-12 | 2016-06-22 | 抗菌剤を含むクレビジピン乳化製剤 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US10010537B2 (ja) |
| EP (1) | EP2627173B2 (ja) |
| JP (3) | JP6040437B2 (ja) |
| KR (2) | KR20130101080A (ja) |
| CN (1) | CN103237446B (ja) |
| AU (1) | AU2011313852B2 (ja) |
| BR (1) | BR112013008601B1 (ja) |
| CA (1) | CA2814495C (ja) |
| DK (1) | DK2627173T4 (ja) |
| EA (1) | EA022849B1 (ja) |
| ES (1) | ES2539861T5 (ja) |
| HK (1) | HK1187495A1 (ja) |
| HU (1) | HUE026295T2 (ja) |
| MX (2) | MX2013004151A (ja) |
| NZ (1) | NZ610465A (ja) |
| PL (1) | PL2627173T5 (ja) |
| PT (1) | PT2627173E (ja) |
| WO (1) | WO2012051116A1 (ja) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2320740T3 (pl) | 2008-08-01 | 2014-09-30 | The Medicines Co | Kompozycje farmaceutyczne klewidypiny oraz sposoby ich wytwarzania z niskim stężeniem zanieczyszczeń |
| US8658676B2 (en) | 2010-10-12 | 2014-02-25 | The Medicines Company | Clevidipine emulsion formulations containing antimicrobial agents |
| PT2627173E (pt) | 2010-10-12 | 2015-07-24 | Medicines Co | Formulações de clevidipina em emulsão contendo agentes antimicrobianos |
| CN103781479A (zh) * | 2011-04-01 | 2014-05-07 | 医药公司 | 用于减轻中风损害的短效二氢吡啶（氯维地平） |
| CA2889584C (en) * | 2012-10-26 | 2018-08-14 | The Medicines Company | Methods for controlling blood pressure and reducing dyspnea in heart failure |
| CN103169672A (zh) * | 2012-12-26 | 2013-06-26 | 辰欣药业股份有限公司 | 一种丁酸氯维地平冻干乳剂 |
| CN103110580B (zh) * | 2013-02-20 | 2014-09-17 | 北京德立福瑞医药科技有限公司 | 丁酸氯维地平注射剂 |
| CN103126986A (zh) * | 2013-03-19 | 2013-06-05 | 董慧芳 | 一种丁酸氯维地平静脉注射用乳剂及其制备方法 |
| TW201538181A (zh) * | 2014-03-19 | 2015-10-16 | Pures Biotech Co Ltd | 用於潤滑保濕消毒滅菌之半流體組成物及其使用方法 |
| CA2947486C (en) * | 2014-05-19 | 2023-09-26 | The Medicines Company | Clevidipine nanoparticles and pharmaceutical compositions thereof |
| CN105456189A (zh) * | 2014-09-12 | 2016-04-06 | 武汉大安制药有限公司 | 一种丁酸氯维地平乳剂注射剂及其制备方法 |
| CN104523590B (zh) * | 2014-12-09 | 2017-09-15 | 山东威高药业股份有限公司 | 一种丁酸氯维地平脂肪乳注射液 |
| CN107661294B (zh) * | 2016-07-27 | 2020-04-14 | 武汉科福新药有限责任公司 | 抗高血压药物脂肪乳注射剂及其制备方法 |
| WO2019123221A1 (en) * | 2017-12-20 | 2019-06-27 | Aurobindo Pharma Limited | Pharmaceutical composition comprising clevidipine and process for preparation thereof |
| CN108324703B (zh) * | 2018-01-26 | 2020-07-28 | 中国医学科学院阜外医院 | 用于保护缺血心肌的注射剂及其制备方法 |
| CN109602704A (zh) * | 2019-01-23 | 2019-04-12 | 广东嘉博制药有限公司 | 丁酸氯维地平脂肪乳注射液及其制备工艺 |
| CN109776405A (zh) * | 2019-03-07 | 2019-05-21 | 重庆安格龙翔医药科技有限公司 | 一种丁酸氯维地平杂质的制备方法 |
| US11135208B2 (en) | 2019-08-12 | 2021-10-05 | American Regent, Inc. | 1,4-dihydropyridine compositions, methods of making and use |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4217842A1 (de) | 1992-05-29 | 1993-12-02 | Dietl Hans | Calciumantagonisten enthaltende pharmazeutische Zubereitung zur intravenösen und intrakoronaren Applikation sowie Verfahren zu ihrer Herstellung |
| JPH08506081A (ja) | 1993-02-12 | 1996-07-02 | ファーモス コーポレイション | サブミクロン・エマルジョンの調製のための乾燥組成物 |
| SE9303657D0 (sv) | 1993-11-05 | 1993-11-05 | Astra Ab | Short-acting dihydropyridines |
| SE9303744D0 (sv) | 1993-11-12 | 1993-11-12 | Astra Ab | Pharmaceutical emulsion |
| GB9405593D0 (en) * | 1994-03-22 | 1994-05-11 | Zeneca Ltd | Pharmaceutical compositions |
| IT1275532B (it) | 1995-07-14 | 1997-08-07 | Recordati Chem Pharm | Uso di derivati 1,4-diidropiridinici per la prevenzione e la terapia della degenerazione aterosclerotica della parete arteriosa |
| CN1227490A (zh) | 1996-08-07 | 1999-09-01 | 协和发酵工业株式会社 | 含有黄嘌呤衍生物的脂肪乳剂 |
| PT1052975E (pt) | 1998-02-10 | 2007-10-29 | Sicor Inc | Composição de propofol que contém sulfito |
| IT1301807B1 (it) * | 1998-06-25 | 2000-07-07 | Tiberio Bruzzese | Formulazioni farmaceutiche iniettabili di derivati della partricina. |
| CN1146423C (zh) | 1998-07-14 | 2004-04-21 | 阿尔康实验室公司 | 前列腺素产品 |
| SE9804002D0 (sv) | 1998-11-23 | 1998-11-23 | Astra Ab | New manufacturing process |
| GB0012597D0 (en) | 2000-05-25 | 2000-07-12 | Astrazeneca Ab | Formulation |
| US6858596B2 (en) | 2000-08-05 | 2005-02-22 | Smithkline Beecham Corporation | Formulation containing anti-inflammatory androstane derivative |
| CA2494297C (en) | 2002-07-29 | 2011-10-18 | Transform Pharmaceuticals, Inc. | Aqueous 2,6-diisopropylphenol pharmaceutical compositions |
| US20060094699A1 (en) | 2003-04-11 | 2006-05-04 | Kampen Gita Camilla T | Combination therapy using an 11beta-hydroxysteroid dehydrogenase type 1 inhibitor and a glucocorticoid receptor agonist to minimize the side effects associated with glucocorticoid receptor agonist therapy |
| US20040265238A1 (en) * | 2003-06-27 | 2004-12-30 | Imtiaz Chaudry | Inhalable formulations for treating pulmonary hypertension and methods of using same |
| US20050186230A1 (en) * | 2004-01-23 | 2005-08-25 | Sd Pharmaceuticals, Inc. | Elemene compositions containing liquid oil |
| AU2005216298B2 (en) | 2004-02-26 | 2010-09-02 | Baylor Research Institute | Compositions and methods for the systemic treatment of arthritis |
| US20050271710A1 (en) | 2004-06-04 | 2005-12-08 | Argo Brian P | Antimicrobial tissue products with reduced skin irritation potential |
| US20050282895A1 (en) | 2004-06-21 | 2005-12-22 | Dosch Michael H | Antimicrobial compositions and methods of use thereof |
| KR20080064171A (ko) * | 2005-10-20 | 2008-07-08 | 나스텍 파마수티컬 컴퍼니 인코포레이티드 | 속효성 인슐린의 비강내 투여 |
| FR2900052B1 (fr) | 2006-04-19 | 2011-02-18 | Galderma Sa | Composition comprenant au moins une phase aqueuse et au moins une phase grasse comprenant de l'ivermectine |
| EP2054036B1 (en) | 2006-07-24 | 2019-12-18 | Singh-Broemer and Company, Inc. | Solid nanoparticle formulation of water insoluble pharmaceutical substances with reduced ostwald ripening |
| US20080206170A1 (en) | 2006-12-07 | 2008-08-28 | Belinda Tsao Nivaggioli | Creatine compositions for skin treatment |
| KR101607244B1 (ko) | 2007-06-11 | 2016-03-30 | 알. 로치 맥도날드 | 뇌혈관 연축의 예방을 위한 약물 전달 시스템 |
| EP2008651A1 (en) | 2007-06-26 | 2008-12-31 | Drug Delivery Solutions Limited | A bioerodible patch |
| WO2010014234A1 (en) * | 2008-08-01 | 2010-02-04 | The Medicines Company | Pharmaceutical compositions and methods for stabilizing the same |
| PL2320740T3 (pl) * | 2008-08-01 | 2014-09-30 | The Medicines Co | Kompozycje farmaceutyczne klewidypiny oraz sposoby ich wytwarzania z niskim stężeniem zanieczyszczeń |
| EP2330895A4 (en) | 2008-08-22 | 2013-07-31 | Milestone Pharmaceuticals Inc | SHORT-ACTING BENZOTHIAZEPINE CALCIUM CHANNEL BLOCKERS AND USES THEREOF |
| US20100130619A1 (en) | 2008-11-24 | 2010-05-27 | Joseph Schwarz | Pharmaceutical composition for parenteral administration of idebenone |
| CN101766668B (zh) | 2008-12-30 | 2011-11-23 | 上海中医药大学 | 牛蒡子提取物及其制备方法和用途 |
| CN101766568A (zh) | 2008-12-31 | 2010-07-07 | 北京利乐生制药科技有限公司 | 一种含有氯维地平的乳剂及其制备工艺和用途 |
| DE102009003980A1 (de) | 2009-01-07 | 2010-07-08 | B. Braun Melsungen Ag | Propofol in triheptanoinhaltiger Trägeremulsion |
| CN101791311A (zh) | 2009-12-31 | 2010-08-04 | 广州中大创新药物研究与开发中心有限公司 | 一种具有短效降压作用的药物组合物 |
| CN101780036B (zh) | 2010-03-30 | 2011-11-16 | 武汉武药科技有限公司 | 丁酸氯维地平脂微球注射液及其制备方法 |
| PT2627173E (pt) | 2010-10-12 | 2015-07-24 | Medicines Co | Formulações de clevidipina em emulsão contendo agentes antimicrobianos |
-
2011
- 2011-10-10 PT PT118332071T patent/PT2627173E/pt unknown
- 2011-10-10 MX MX2013004151A patent/MX2013004151A/es active IP Right Grant
- 2011-10-10 KR KR1020137012057A patent/KR20130101080A/ko active Application Filing
- 2011-10-10 HU HUE11833207A patent/HUE026295T2/en unknown
- 2011-10-10 DK DK11833207.1T patent/DK2627173T4/en active
- 2011-10-10 MX MX2014014773A patent/MX356537B/es unknown
- 2011-10-10 EA EA201390541A patent/EA022849B1/ru unknown
- 2011-10-10 WO PCT/US2011/055617 patent/WO2012051116A1/en active Application Filing
- 2011-10-10 NZ NZ610465A patent/NZ610465A/en unknown
- 2011-10-10 AU AU2011313852A patent/AU2011313852B2/en active Active
- 2011-10-10 BR BR112013008601-7A patent/BR112013008601B1/pt active IP Right Grant
- 2011-10-10 EP EP11833207.1A patent/EP2627173B2/en active Active
- 2011-10-10 PL PL11833207T patent/PL2627173T5/pl unknown
- 2011-10-10 CA CA2814495A patent/CA2814495C/en active Active
- 2011-10-10 KR KR1020167006219A patent/KR101786857B1/ko active IP Right Grant
- 2011-10-10 US US13/270,004 patent/US10010537B2/en active Active
- 2011-10-10 CN CN201180048865.XA patent/CN103237446B/zh not_active Ceased
- 2011-10-10 ES ES11833207.1T patent/ES2539861T5/es active Active
- 2011-10-10 JP JP2013533916A patent/JP6040437B2/ja active Active
-
2014
- 2014-01-22 HK HK14100653.2A patent/HK1187495A1/xx unknown
- 2014-06-11 JP JP2014120354A patent/JP6437743B2/ja active Active
-
2016
- 2016-06-22 JP JP2016123498A patent/JP6326094B2/ja active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2014504259A5 (ja) | ||
| US11207286B2 (en) | Self-emulsifying composition of w3 fatty acid | |
| ES2881885T3 (es) | Composiciones que comprenden una mezcla de aceites de ácidos grasos que comprende EPA y DHA en forma de ácido libre y un tensioactivo, y procedimientos y usos de las mismas | |
| NZ610465A (en) | Clevidipine emulsion formulations containing antimicrobial agents | |
| ES2817527T3 (es) | Composición autoemulsionante de ácidos grasos omega-3 | |
| US20210128510A1 (en) | Self-emulsifying composition of omega3 fatty acid | |
| JP2015520235A5 (ja) | ||
| JP2013508296A5 (ja) | ||
| CN105120842B (zh) | 包含脂质化合物、甘油三酯和表面活性剂的组合物以及使用它们的方法 | |
| JP2012519728A5 (ja) | ||
| KR20110058881A (ko) | 지방산 오일-함유 에멀션을 포함한 폴리사카라이드 캡슐 | |
| JP5864735B2 (ja) | 非経口オキアミ油の治療用途 | |
| RU2011148140A (ru) | Самомикроэмульгирующаяся оральная фармацевтическая композиция, содержащая гидрофильное лекарственное средство, и способ ее приготовления | |
| ES2889874T3 (es) | Tratamiento de neuropatía óptica y reducción del estrés oxidativo inducido por esteroides con sustancias polinsaturadas estabilizadas | |
| HRP20160446T1 (hr) | Farmaceutski pripravci koji sadrže derivat kamptotecina | |
| RU2015102597A (ru) | Липидные композиции рацекадотрила | |
| JP2015516418A5 (ja) | ||
| RU2007137182A (ru) | Микроэмульсии соединений, связывающихся с каннабиноидными рецепторами | |
| JP2011006380A (ja) | ω３脂肪酸の乳化組成物 | |
| MX2007007859A (es) | Composiciones comestibles las cuales comprenden un lipido primario, un co-lipido y un ingrediente fisiologicamente activo lipofilico y agua, y su preparacion. | |
| RS52735B (en) | APPLICATION OF A COMBINATION CONTAINING L-CARNITINE OR ALKANOIL L-CARNITINE, OIL-SOLUBLE OIL-BENZOQUINON AND OMEGA-3-POLYESATURATED FATTY ACID FOR PREPARATION OF NUTRITION OR MEDICINAL PRODUCTS | |
| JP2012533597A (ja) | 栄養剤として適用するためのクルミ抽出物 | |
| NZ598082A (en) | Pharmaceutical composition including a dha ester to be parenterally administered | |
| JP2006248928A (ja) | メナテトレノン含有医薬組成物 | |
| EP1974733A1 (en) | Use of a masked or coated copper salt for the treatment of macular degeneration |