JP2014503475A5 - - Google Patents
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- JP2014503475A5 JP2014503475A5 JP2013535421A JP2013535421A JP2014503475A5 JP 2014503475 A5 JP2014503475 A5 JP 2014503475A5 JP 2013535421 A JP2013535421 A JP 2013535421A JP 2013535421 A JP2013535421 A JP 2013535421A JP 2014503475 A5 JP2014503475 A5 JP 2014503475A5
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- JP
- Japan
- Prior art keywords
- peptide
- disease
- liposome
- terminus
- modified
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 66
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 52
- 201000010099 disease Diseases 0.000 claims description 41
- 239000002502 liposome Substances 0.000 claims description 40
- 208000035475 disorder Diseases 0.000 claims description 25
- 238000000034 method Methods 0.000 claims description 25
- 108090000623 proteins and genes Proteins 0.000 claims description 16
- 102000004169 proteins and genes Human genes 0.000 claims description 16
- 241000124008 Mammalia Species 0.000 claims description 15
- 230000000890 antigenic effect Effects 0.000 claims description 14
- 239000002671 adjuvant Substances 0.000 claims description 12
- 230000002209 hydrophobic effect Effects 0.000 claims description 12
- 239000000203 mixture Substances 0.000 claims description 10
- 206010020751 Hypersensitivity Diseases 0.000 claims description 8
- 206010061218 Inflammation Diseases 0.000 claims description 8
- 238000009825 accumulation Methods 0.000 claims description 8
- 230000002776 aggregation Effects 0.000 claims description 8
- 238000004220 aggregation Methods 0.000 claims description 8
- 230000007815 allergy Effects 0.000 claims description 8
- 125000000539 amino acid group Chemical group 0.000 claims description 8
- -1 diglycerides Chemical class 0.000 claims description 8
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims description 8
- 230000004054 inflammatory process Effects 0.000 claims description 8
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims description 8
- 208000035473 Communicable disease Diseases 0.000 claims description 7
- 238000001514 detection method Methods 0.000 claims description 7
- 238000011321 prophylaxis Methods 0.000 claims description 7
- 230000001225 therapeutic effect Effects 0.000 claims description 7
- 241000282412 Homo Species 0.000 claims description 5
- 238000003745 diagnosis Methods 0.000 claims description 5
- 238000009007 Diagnostic Kit Methods 0.000 claims description 4
- 229930186217 Glycolipid Natural products 0.000 claims description 4
- 239000000232 Lipid Bilayer Substances 0.000 claims description 4
- 235000021314 Palmitic acid Nutrition 0.000 claims description 4
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 4
- 229930195729 fatty acid Natural products 0.000 claims description 4
- 239000000194 fatty acid Substances 0.000 claims description 4
- 150000004665 fatty acids Chemical class 0.000 claims description 4
- 108091005601 modified peptides Proteins 0.000 claims description 4
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 claims description 4
- 150000003904 phospholipids Chemical class 0.000 claims description 4
- 150000003408 sphingolipids Chemical class 0.000 claims description 4
- 150000003431 steroids Chemical class 0.000 claims description 4
- 239000004094 surface-active agent Substances 0.000 claims description 4
- 150000003626 triacylglycerols Chemical class 0.000 claims description 4
- 230000003381 solubilizing effect Effects 0.000 claims description 3
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- 239000003937 drug carrier Substances 0.000 claims description 2
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- 229940046168 CpG oligodeoxynucleotide Drugs 0.000 description 11
- GZQKNULLWNGMCW-PWQABINMSA-N lipid A (E. coli) Chemical group O1[C@H](CO)[C@@H](OP(O)(O)=O)[C@H](OC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)[C@@H](NC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)[C@@H]1OC[C@@H]1[C@@H](O)[C@H](OC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](NC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](OP(O)(O)=O)O1 GZQKNULLWNGMCW-PWQABINMSA-N 0.000 description 6
- 206010028980 Neoplasm Diseases 0.000 description 5
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- 210000003169 central nervous system Anatomy 0.000 description 4
- LJUIOEFZFQRWJG-GHYFRYPYSA-N (2s)-6-amino-2-[[(2s)-6-amino-2-[[(2s)-6-amino-2-[[(2s)-6-amino-2-[[(2s)-2-[[(2r)-2-amino-3-[(2r)-2,3-di(hexadecanoyloxy)propyl]sulfanylpropanoyl]amino]-3-hydroxypropanoyl]amino]hexanoyl]amino]hexanoyl]amino]hexanoyl]amino]hexanoic acid Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCCCCCCCCCC)CSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(O)=O LJUIOEFZFQRWJG-GHYFRYPYSA-N 0.000 description 2
- OEDPHAKKZGDBEV-GFPBKZJXSA-N (2s)-6-amino-2-[[(2s)-6-amino-2-[[(2s)-6-amino-2-[[(2s)-6-amino-2-[[(2s)-2-[[(2r)-3-[2,3-di(hexadecanoyloxy)propylsulfanyl]-2-(hexadecanoylamino)propanoyl]amino]-3-hydroxypropanoyl]amino]hexanoyl]amino]hexanoyl]amino]hexanoyl]amino]hexanoic acid Chemical compound NCCCC[C@@H](C(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)CCCCCCCCCCCCCCC)CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC OEDPHAKKZGDBEV-GFPBKZJXSA-N 0.000 description 2
- 208000003174 Brain Neoplasms Diseases 0.000 description 2
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- IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 description 2
- 208000026935 allergic disease Diseases 0.000 description 2
- 229940037003 alum Drugs 0.000 description 2
- 210000004408 hybridoma Anatomy 0.000 description 2
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 2
- 229930182490 saponin Natural products 0.000 description 2
- 150000007949 saponins Chemical class 0.000 description 2
- DWRXFEITVBNRMK-UHFFFAOYSA-N Beta-D-1-Arabinofuranosylthymine Natural products O=C1NC(=O)C(C)=CN1C1C(O)C(O)C(CO)O1 DWRXFEITVBNRMK-UHFFFAOYSA-N 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- 241000222122 Candida albicans Species 0.000 description 1
- 206010007134 Candida infections Diseases 0.000 description 1
- 206010009944 Colon cancer Diseases 0.000 description 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 description 1
- 102000004457 Granulocyte-Macrophage Colony-Stimulating Factor Human genes 0.000 description 1
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 description 1
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 description 1
- 102000004218 Insulin-Like Growth Factor I Human genes 0.000 description 1
- 108010002350 Interleukin-2 Proteins 0.000 description 1
- 208000004554 Leishmaniasis Diseases 0.000 description 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
- 206010027406 Mesothelioma Diseases 0.000 description 1
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- 206010035226 Plasma cell myeloma Diseases 0.000 description 1
- 102000001253 Protein Kinase Human genes 0.000 description 1
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- 208000005718 Stomach Neoplasms Diseases 0.000 description 1
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- 241000893966 Trichophyton verrucosum Species 0.000 description 1
- 230000000692 anti-sense effect Effects 0.000 description 1
- IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 description 1
- 201000003984 candidiasis Diseases 0.000 description 1
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- 229940046166 oligodeoxynucleotide Drugs 0.000 description 1
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- 230000002062 proliferating effect Effects 0.000 description 1
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- 229940104230 thymidine Drugs 0.000 description 1
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10188832 | 2010-10-26 | ||
| EP10188832.9 | 2010-10-26 | ||
| PCT/EP2011/068797 WO2012055933A1 (en) | 2010-10-26 | 2011-10-26 | Liposome-based construct comprising a peptide modified through hydrophobic moieties |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014503475A JP2014503475A (ja) | 2014-02-13 |
| JP2014503475A5 true JP2014503475A5 (enExample) | 2014-10-16 |
| JP6027011B2 JP6027011B2 (ja) | 2016-11-16 |
Family
ID=44872345
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013535421A Active JP6027011B2 (ja) | 2010-10-26 | 2011-10-26 | 疎水性部分によって修飾されたペプチドを含むリポソームベースの構築物 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US9687447B2 (enExample) |
| EP (1) | EP2632434B1 (enExample) |
| JP (1) | JP6027011B2 (enExample) |
| KR (1) | KR101854943B1 (enExample) |
| CN (1) | CN103189050B (enExample) |
| AR (1) | AR083561A1 (enExample) |
| AU (1) | AU2011322553B2 (enExample) |
| CA (1) | CA2813833C (enExample) |
| TW (1) | TW201223561A (enExample) |
| WO (1) | WO2012055933A1 (enExample) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CA2811188C (en) * | 2011-09-23 | 2020-04-28 | Andrea Pfeifer | Vaccine therapy |
| CA2919268C (en) | 2013-07-25 | 2023-09-05 | Exicure, Inc. | Spherical nucleic acid-based constructs as immunostimulatory agents for prophylactic and therapeutic use |
| CN103601796B (zh) * | 2013-11-11 | 2016-09-21 | 杭州璞题生物科技有限公司 | 亨廷顿蛋白的棕榈化修饰方法 |
| WO2015126502A2 (en) | 2013-12-03 | 2015-08-27 | Northwestern University | Liposomal particles, methods of making same and uses thereof |
| EP3136096B1 (en) * | 2014-04-23 | 2021-12-01 | Nichirei Biosciences Inc. | Combination for target marker detection |
| AU2015269412B2 (en) * | 2014-06-04 | 2020-03-12 | Exicure Operating Company | Multivalent delivery of immune modulators by liposomal spherical nucleic acids for prophylactic or therapeutic applications |
| EP3183007B1 (en) | 2014-08-19 | 2020-06-17 | Northwestern University | Protein/oligonucleotide core-shell nanoparticle therapeutics |
| BR112017007012A2 (pt) | 2014-10-06 | 2018-03-06 | Exicure Inc | compostos anti-tnf |
| US20200297867A1 (en) * | 2016-02-01 | 2020-09-24 | Exicure, Inc. | Surface functionalization of liposomes and liposomal spherical nucleic acids (snas) |
| CA3023451A1 (en) | 2016-05-06 | 2017-11-09 | Exicure, Inc. | Liposomal spherical nucleic acid (sna) constructs presenting antisense oligonucleotides (aso) for specific knockdown of interleukin 17 receptor mrna |
| WO2018039629A2 (en) | 2016-08-25 | 2018-03-01 | Northwestern University | Micellar spherical nucleic acids from thermoresponsive, traceless templates |
| WO2018201090A1 (en) | 2017-04-28 | 2018-11-01 | Exicure, Inc. | Synthesis of spherical nucleic acids using lipophilic moieties |
| JP2020526558A (ja) | 2017-07-13 | 2020-08-31 | ノースウェスタン ユニバーシティ | オリゴヌクレオチド官能化金属有機構造体ナノ粒子を調製するための一般的かつ直接的な方法 |
| TW202333768A (zh) * | 2017-10-25 | 2023-09-01 | 美商健生醫藥公司 | Tau胜肽之組成物及其用途 |
| US11466077B2 (en) | 2018-01-05 | 2022-10-11 | Ac Immune Sa | Misfolded TDP-43 binding molecules |
| CN112165956A (zh) * | 2018-04-10 | 2021-01-01 | Ac免疫有限公司 | 抗Aβ治疗性疫苗 |
| MA52180A (fr) * | 2018-04-10 | 2021-02-17 | Ac Immune Sa | Vaccins thérapeutiques anti-abêta |
| WO2020023445A1 (en) * | 2018-07-24 | 2020-01-30 | Taiwan Liposome Co., Ltd. | Sustained-release pharmaceutical compositions comprising a therapeutic agent for treating dementia and uses thereof |
| CA3118692A1 (en) | 2018-11-06 | 2020-05-14 | Alsatech, Inc. | Cell-based gene therapy for neurodegenerative diseases |
| SG11202108312PA (en) | 2019-02-08 | 2021-08-30 | Ac Immune Sa | Method of safe administration of phosphorylated tau peptide vaccine |
| US12702719B2 (en) | 2019-03-06 | 2026-08-11 | Northwestern University | Hairpin-like oligonucleotide-conjugated spherical nucleic acid |
| CA3133909A1 (en) | 2019-04-18 | 2020-10-22 | Elpida TSIKA | Novel molecules for therapy and diagnosis |
| MX2021012994A (es) * | 2019-04-24 | 2022-03-04 | Janssen Pharmaceuticals Inc | Administracion heterologa de vacunas tau. |
| CN113853214A (zh) | 2019-05-21 | 2021-12-28 | Ac免疫有限公司 | 抗Aβ疫苗治疗 |
| CN114008073B (zh) | 2019-05-23 | 2025-08-12 | Ac免疫有限公司 | 抗tdp-43结合分子及其用途 |
| AU2020347483A1 (en) * | 2019-09-10 | 2022-03-31 | Ac Immune Sa | Novel molecules for diagnosis |
| US12319711B2 (en) | 2019-09-20 | 2025-06-03 | Northwestern University | Spherical nucleic acids with tailored and active protein coronae |
| US12378560B2 (en) | 2019-10-29 | 2025-08-05 | Northwestern University | Sequence multiplicity within spherical nucleic acids |
| MX2022006676A (es) | 2019-12-04 | 2022-07-05 | Ac Immune Sa | Nuevas moleculas para terapia y diagnostico. |
| US11913964B2 (en) * | 2020-02-27 | 2024-02-27 | Adeptrix Corp. | Multiplexed bead-based analytical assays |
| CN115087435A (zh) * | 2020-06-30 | 2022-09-20 | 艾金株式会社 | 包含阳离子脂质体的用于抑制皂素溶血的组合物 |
| CN116615452A (zh) | 2020-08-14 | 2023-08-18 | Ac免疫有限公司 | 人源化抗tdp-43结合分子及其用途 |
| WO2022079297A1 (en) | 2020-10-16 | 2022-04-21 | Ac Immune Sa | Antibodies binding to alpha-synuclein for therapy and diagnosis |
| EP4304640A1 (en) | 2021-03-12 | 2024-01-17 | Northwestern University | Antiviral vaccines using spherical nucleic acids |
| AU2023221539A1 (en) | 2022-02-16 | 2024-08-22 | Ac Immune Sa | Humanized anti-tdp-43 binding molecules and uses thereof |
| IL316153A (en) | 2022-04-08 | 2024-12-01 | Ac Immune Sa | Anti-tdp-43 binding molecules |
| WO2024156912A1 (en) | 2023-01-26 | 2024-08-02 | Ac Immune Sa | Anti-abeta vaccine therapy |
| KR20250135293A (ko) | 2023-01-26 | 2025-09-12 | 에이씨 이뮨 에스에이 | 리포좀 구조체 |
| WO2024184494A1 (en) | 2023-03-08 | 2024-09-12 | Ac Immune Sa | Anti-tdp-43 binding molecules and uses thereof |
| WO2025196262A1 (en) | 2024-03-22 | 2025-09-25 | Ac Immune Sa | Immunoassay involving antibodies binding vaccine adjuvants |
| WO2026013218A1 (en) | 2024-07-10 | 2026-01-15 | Ac Immune Sa | Anti-tdp-43 vectors, binding molecules and uses thereof |
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-
2011
- 2011-10-26 EP EP11775949.8A patent/EP2632434B1/en active Active
- 2011-10-26 JP JP2013535421A patent/JP6027011B2/ja active Active
- 2011-10-26 US US13/881,502 patent/US9687447B2/en active Active
- 2011-10-26 WO PCT/EP2011/068797 patent/WO2012055933A1/en not_active Ceased
- 2011-10-26 TW TW100139025A patent/TW201223561A/zh unknown
- 2011-10-26 CN CN201180051932.3A patent/CN103189050B/zh active Active
- 2011-10-26 AR ARP110103959A patent/AR083561A1/es not_active Application Discontinuation
- 2011-10-26 CA CA2813833A patent/CA2813833C/en active Active
- 2011-10-26 AU AU2011322553A patent/AU2011322553B2/en active Active
- 2011-10-26 KR KR1020137013183A patent/KR101854943B1/ko active Active
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