JP6027011B2 - 疎水性部分によって修飾されたペプチドを含むリポソームベースの構築物 - Google Patents
疎水性部分によって修飾されたペプチドを含むリポソームベースの構築物 Download PDFInfo
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- JP6027011B2 JP6027011B2 JP2013535421A JP2013535421A JP6027011B2 JP 6027011 B2 JP6027011 B2 JP 6027011B2 JP 2013535421 A JP2013535421 A JP 2013535421A JP 2013535421 A JP2013535421 A JP 2013535421A JP 6027011 B2 JP6027011 B2 JP 6027011B2
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- A—HUMAN NECESSITIES
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- A61K9/1277—Preparation processes; Proliposomes
- A61K9/1278—Post-loading, e.g. by ion or pH gradient
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10188832.9 | 2010-10-26 | ||
| EP10188832 | 2010-10-26 | ||
| PCT/EP2011/068797 WO2012055933A1 (en) | 2010-10-26 | 2011-10-26 | Liposome-based construct comprising a peptide modified through hydrophobic moieties |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014503475A JP2014503475A (ja) | 2014-02-13 |
| JP2014503475A5 JP2014503475A5 (enExample) | 2014-10-16 |
| JP6027011B2 true JP6027011B2 (ja) | 2016-11-16 |
Family
ID=44872345
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013535421A Active JP6027011B2 (ja) | 2010-10-26 | 2011-10-26 | 疎水性部分によって修飾されたペプチドを含むリポソームベースの構築物 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US9687447B2 (enExample) |
| EP (1) | EP2632434B1 (enExample) |
| JP (1) | JP6027011B2 (enExample) |
| KR (1) | KR101854943B1 (enExample) |
| CN (1) | CN103189050B (enExample) |
| AR (1) | AR083561A1 (enExample) |
| AU (1) | AU2011322553B2 (enExample) |
| CA (1) | CA2813833C (enExample) |
| TW (1) | TW201223561A (enExample) |
| WO (1) | WO2012055933A1 (enExample) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140314837A1 (en) * | 2011-09-23 | 2014-10-23 | Ac Immune S. A. | Vaccine Therapy |
| WO2015013673A1 (en) | 2013-07-25 | 2015-01-29 | Aurasense Therapeutics, Llc | Spherical nucleic acid-based constructs as immunostimulatory agents for prophylactic and therapeutic use |
| CN103601796B (zh) * | 2013-11-11 | 2016-09-21 | 杭州璞题生物科技有限公司 | 亨廷顿蛋白的棕榈化修饰方法 |
| MX389323B (es) | 2013-12-03 | 2025-03-20 | Univ Northwestern | Particulas liposomales, metodos para elaborarlas y sus usos. |
| WO2015163424A1 (ja) | 2014-04-23 | 2015-10-29 | 株式会社ニチレイバイオサイエンス | 標的マーカー検出用組合せ物 |
| US10434064B2 (en) | 2014-06-04 | 2019-10-08 | Exicure, Inc. | Multivalent delivery of immune modulators by liposomal spherical nucleic acids for prophylactic or therapeutic applications |
| EP3183007B1 (en) | 2014-08-19 | 2020-06-17 | Northwestern University | Protein/oligonucleotide core-shell nanoparticle therapeutics |
| JP6741673B2 (ja) | 2014-10-06 | 2020-08-19 | イグジキュア, インコーポレーテッドExicure, Inc. | 抗tnf化合物 |
| WO2017136467A1 (en) * | 2016-02-01 | 2017-08-10 | Exicure, Inc. | Surface functionaliztion of liposomes and liposomal spherical nucleic acids (snas) |
| KR102617833B1 (ko) | 2016-05-06 | 2023-12-27 | 엑시큐어 오퍼레이팅 컴퍼니 | 인터류킨 17 수용체 mRNA의 특이적 녹다운을 위한 안티센스 올리고뉴클레오티드 (ASO)를 제시하는 리포좀성 구형 핵산 (SNA) 구축물 |
| WO2018039629A2 (en) | 2016-08-25 | 2018-03-01 | Northwestern University | Micellar spherical nucleic acids from thermoresponsive, traceless templates |
| US11696954B2 (en) | 2017-04-28 | 2023-07-11 | Exicure Operating Company | Synthesis of spherical nucleic acids using lipophilic moieties |
| KR20200028997A (ko) | 2017-07-13 | 2020-03-17 | 노오쓰웨스턴 유니버시티 | 올리고뉴클레오타이드-작용화된 금속-유기 프레임워크 나노입자를 제조하는 일반적이고 직접적인 방법 |
| KR102710762B1 (ko) | 2017-10-25 | 2024-09-25 | 얀센 파마슈티칼즈, 인코포레이티드 | 인산화 타우 펩티드의 조성물 및 이의 용도 |
| WO2019134981A1 (en) | 2018-01-05 | 2019-07-11 | Ac Immune Sa | Misfolded tdp-43 binding molecules |
| US10828351B2 (en) * | 2018-04-10 | 2020-11-10 | Ac Immune Sa | Anti-abeta therapeutic vaccines |
| CN112165956A (zh) * | 2018-04-10 | 2021-01-01 | Ac免疫有限公司 | 抗Aβ治疗性疫苗 |
| CN112512508A (zh) * | 2018-07-24 | 2021-03-16 | 台湾微脂体股份有限公司 | 含有治疗失智症的治疗剂的缓释药物组合物及其用途 |
| CA3118692A1 (en) | 2018-11-06 | 2020-05-14 | Alsatech, Inc. | Cell-based gene therapy for neurodegenerative diseases |
| KR20210125048A (ko) | 2019-02-08 | 2021-10-15 | 에이씨 이뮨 에스.에이. | 인산화 타우 펩티드 백신의 안전한 투여 방법 |
| WO2020212593A1 (en) | 2019-04-18 | 2020-10-22 | Ac Immune Sa | Novel molecules for therapy and diagnosis |
| CN114173812A (zh) | 2019-04-24 | 2022-03-11 | 杨森制药公司 | Tau疫苗的异源给予 |
| CN113853214A (zh) | 2019-05-21 | 2021-12-28 | Ac免疫有限公司 | 抗Aβ疫苗治疗 |
| CA3137882A1 (en) | 2019-05-23 | 2020-11-26 | Tamara SEREDENINA | Anti-tdp-43 binding molecules and uses thereof |
| WO2021048324A1 (en) | 2019-09-10 | 2021-03-18 | Ac Immune Sa | Novel molecules for diagnosis |
| US12319711B2 (en) | 2019-09-20 | 2025-06-03 | Northwestern University | Spherical nucleic acids with tailored and active protein coronae |
| US12378560B2 (en) | 2019-10-29 | 2025-08-05 | Northwestern University | Sequence multiplicity within spherical nucleic acids |
| JP2023504699A (ja) | 2019-12-04 | 2023-02-06 | エイシー イミューン ソシエテ アノニム | 治療および診断のための新規な分子 |
| US11913964B2 (en) * | 2020-02-27 | 2024-02-27 | Adeptrix Corp. | Multiplexed bead-based analytical assays |
| WO2022003443A1 (ko) * | 2020-06-30 | 2022-01-06 | 아이진 주식회사 | 양이온성 리포좀을 포함하는 사포닌의 용혈 억제용 조성물 |
| JP2023537761A (ja) | 2020-08-14 | 2023-09-05 | エイシー イミューン ソシエテ アノニム | ヒト化抗tdp-43結合分子およびその使用 |
| WO2022079297A1 (en) | 2020-10-16 | 2022-04-21 | Ac Immune Sa | Antibodies binding to alpha-synuclein for therapy and diagnosis |
| CR20240378A (es) | 2022-02-16 | 2024-10-03 | Ac Immune Sa | Moléculas de unión anti -tdp-43 humanizadas y usos de las mismas |
| WO2023194565A1 (en) | 2022-04-08 | 2023-10-12 | Ac Immune Sa | Anti-tdp-43 binding molecules |
| WO2024156908A1 (en) | 2023-01-26 | 2024-08-02 | Ac Immune Sa | Liposomal construct |
| EP4654990A1 (en) | 2023-01-26 | 2025-12-03 | AC Immune SA | Anti-abeta vaccine therapy |
| CN120917043A (zh) | 2023-03-08 | 2025-11-07 | Ac免疫有限公司 | 抗tdp-43结合分子及其用途 |
| WO2025196262A1 (en) | 2024-03-22 | 2025-09-25 | Ac Immune Sa | Immunoassay involving antibodies binding vaccine adjuvants |
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| EP0203676B1 (en) * | 1985-04-19 | 1992-01-29 | The Wistar Institute Of Anatomy And Biology | Vaccine for generating an immunogenic t cell response protective against a virus |
| US5004697A (en) | 1987-08-17 | 1991-04-02 | Univ. Of Ca | Cationized antibodies for delivery through the blood-brain barrier |
| US5620689A (en) | 1989-10-20 | 1997-04-15 | Sequus Pharmaceuuticals, Inc. | Liposomes for treatment of B-cell and T-cell disorders |
| US5112596A (en) | 1990-04-23 | 1992-05-12 | Alkermes, Inc. | Method for increasing blood-brain barrier permeability by administering a bradykinin agonist of blood-brain barrier permeability |
| US5268164A (en) | 1990-04-23 | 1993-12-07 | Alkermes, Inc. | Increasing blood-brain barrier permeability with permeabilizer peptides |
| US5434050A (en) | 1991-08-13 | 1995-07-18 | Regents Of The University Of Minnesota | Labelled β-amyloid peptide and methods of screening for Alzheimer's disease |
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- 2011-10-26 JP JP2013535421A patent/JP6027011B2/ja active Active
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- 2011-10-26 CA CA2813833A patent/CA2813833C/en active Active
- 2011-10-26 CN CN201180051932.3A patent/CN103189050B/zh active Active
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Also Published As
| Publication number | Publication date |
|---|---|
| CA2813833C (en) | 2020-09-22 |
| TW201223561A (en) | 2012-06-16 |
| CN103189050A (zh) | 2013-07-03 |
| AU2011322553B2 (en) | 2015-07-02 |
| AR083561A1 (es) | 2013-03-06 |
| EP2632434A1 (en) | 2013-09-04 |
| WO2012055933A1 (en) | 2012-05-03 |
| KR101854943B1 (ko) | 2018-05-04 |
| CN103189050B (zh) | 2017-09-29 |
| US20130224287A1 (en) | 2013-08-29 |
| KR20140009206A (ko) | 2014-01-22 |
| CA2813833A1 (en) | 2012-05-03 |
| EP2632434B1 (en) | 2025-08-20 |
| JP2014503475A (ja) | 2014-02-13 |
| US9687447B2 (en) | 2017-06-27 |
| AU2011322553A1 (en) | 2013-04-18 |
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