JP2014501250A5 - - Google Patents
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- JP2014501250A5 JP2014501250A5 JP2013544872A JP2013544872A JP2014501250A5 JP 2014501250 A5 JP2014501250 A5 JP 2014501250A5 JP 2013544872 A JP2013544872 A JP 2013544872A JP 2013544872 A JP2013544872 A JP 2013544872A JP 2014501250 A5 JP2014501250 A5 JP 2014501250A5
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- compound
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- aryl
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- Prior art date
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- BVSUIGWVDIZNCW-PZPSAWLHSA-N CC(C)(C1[C@](C)(CC2(C)C#N)c3nc(-c4cccnc4)ncc3CC1)C2=O Chemical compound CC(C)(C1[C@](C)(CC2(C)C#N)c3nc(-c4cccnc4)ncc3CC1)C2=O BVSUIGWVDIZNCW-PZPSAWLHSA-N 0.000 description 2
- HXPDCERWPYPLDF-MBSDFSHPSA-N CC(C)([C@H]1[C@](C)(C=C2C#N)c3nc(-c(cc4)ccc4OC)ncc3CC1)C2=O Chemical compound CC(C)([C@H]1[C@](C)(C=C2C#N)c3nc(-c(cc4)ccc4OC)ncc3CC1)C2=O HXPDCERWPYPLDF-MBSDFSHPSA-N 0.000 description 2
- AWNKVNUSWYTISD-KKSFZXQISA-N CC(C)([C@H]1[C@](C)(C=C2C#N)c3nc(-c4ccccn4)ncc3CC1)C2=O Chemical compound CC(C)([C@H]1[C@](C)(C=C2C#N)c3nc(-c4ccccn4)ncc3CC1)C2=O AWNKVNUSWYTISD-KKSFZXQISA-N 0.000 description 2
- VGKMSBIMGMCNCK-YHDJDMAPSA-N CCCC1C([C@](C)(CC(C)(C)C2=O)C=C2C#N)=NC(C)=NC1(C)OC Chemical compound CCCC1C([C@](C)(CC(C)(C)C2=O)C=C2C#N)=NC(C)=NC1(C)OC VGKMSBIMGMCNCK-YHDJDMAPSA-N 0.000 description 2
- JEPVKNXVHTYEGJ-OXOIEEGHSA-N CCOC(c1nc(OC)c(CC[C@@H]([C@H](C)C2O)[C@]3(C)C=C2C#N)c3n1)=O Chemical compound CCOC(c1nc(OC)c(CC[C@@H]([C@H](C)C2O)[C@]3(C)C=C2C#N)c3n1)=O JEPVKNXVHTYEGJ-OXOIEEGHSA-N 0.000 description 2
- NAIZMISNLZATQF-HQMMJMAESA-N CCOc1c(CC[C@@H]([C@H](C)C2=O)C3(C)C=C2C#N)c3nc(-c2ccccc2)n1 Chemical compound CCOc1c(CC[C@@H]([C@H](C)C2=O)C3(C)C=C2C#N)c3nc(-c2ccccc2)n1 NAIZMISNLZATQF-HQMMJMAESA-N 0.000 description 2
- UGFLIRGABUGULC-KLRAXDNASA-N CCOc1c(CC[C@@H]([C@H](C)C2=O)[C@]3(C)C=C2C#N)c3nc(OCC)n1 Chemical compound CCOc1c(CC[C@@H]([C@H](C)C2=O)[C@]3(C)C=C2C#N)c3nc(OCC)n1 UGFLIRGABUGULC-KLRAXDNASA-N 0.000 description 2
- GZYXTYURMDJKEM-DYALPIRYSA-N C[C@@H]([C@H]1[C@](C)(C=C2C#N)c3nc(-c(cccc4)c4OC)nc(OC)c3CC1)C2=O Chemical compound C[C@@H]([C@H]1[C@](C)(C=C2C#N)c3nc(-c(cccc4)c4OC)nc(OC)c3CC1)C2=O GZYXTYURMDJKEM-DYALPIRYSA-N 0.000 description 2
- XGEGUFBFJQYKOH-GTXQTCRKSA-N C[C@@H]([C@H]1[C@](C)(C=C2C#N)c3nc(-c4ccccc4)ncc3CC1)C2=O Chemical compound C[C@@H]([C@H]1[C@](C)(C=C2C#N)c3nc(-c4ccccc4)ncc3CC1)C2=O XGEGUFBFJQYKOH-GTXQTCRKSA-N 0.000 description 2
- KSQTVKKTLNTPHO-YHYSRRTLSA-N C[C@@H]([C@H]1[C@](C)(C=C2C#N)c3nc(C)nc(OC)c3CC1)C2=O Chemical compound C[C@@H]([C@H]1[C@](C)(C=C2C#N)c3nc(C)nc(OC)c3CC1)C2=O KSQTVKKTLNTPHO-YHYSRRTLSA-N 0.000 description 2
- UBSFPQASQDJAJC-OVSFNBESSA-N C[C@@H]([C@H]1[C@](C)(C=C2C#N)c3nc(OC)nc(OC)c3CC1)C2=O Chemical compound C[C@@H]([C@H]1[C@](C)(C=C2C#N)c3nc(OC)nc(OC)c3CC1)C2=O UBSFPQASQDJAJC-OVSFNBESSA-N 0.000 description 2
- WJOCCFDDZXJRGR-NRBRWOBXSA-N C[C@@]12c3nc(-c4ccncc4)ncc3CC[C@H]1C(C)(C)C1OC1C(C#N)=C2 Chemical compound C[C@@]12c3nc(-c4ccncc4)ncc3CC[C@H]1C(C)(C)C1OC1C(C#N)=C2 WJOCCFDDZXJRGR-NRBRWOBXSA-N 0.000 description 2
- 0 C[C@]([C@@](CCC1=C2c3nc(C)n[o]3)[C@](*)(CC3C#N)C1=N[N+]2[I-])C3=O Chemical compound C[C@]([C@@](CCC1=C2c3nc(C)n[o]3)[C@](*)(CC3C#N)C1=N[N+]2[I-])C3=O 0.000 description 2
- CPMUWNGCVAODOK-DGCLKSJQSA-N CC(C)([C@H](CC1)[C@@H](CCC=C2C#N)C(NN3C)=C1C3=O)C2=O Chemical compound CC(C)([C@H](CC1)[C@@H](CCC=C2C#N)C(NN3C)=C1C3=O)C2=O CPMUWNGCVAODOK-DGCLKSJQSA-N 0.000 description 1
- WDVOGUBCDZCVAD-BTYIYWSLSA-N CC(C)[n]1nc(-c2c(CC[C@@H](C(C)(C)C3=O)[C@]4(C)C=C3C#N)c4n[n]2C)nc1 Chemical compound CC(C)[n]1nc(-c2c(CC[C@@H](C(C)(C)C3=O)[C@]4(C)C=C3C#N)c4n[n]2C)nc1 WDVOGUBCDZCVAD-BTYIYWSLSA-N 0.000 description 1
- CTBROMATMYJRQN-QDRROVJBSA-N CCOC([n]1nc([C@](C)(C(CC2)[C@H](C)C3C)C=C3C#N)c2c1-c1ccccc1)=O Chemical compound CCOC([n]1nc([C@](C)(C(CC2)[C@H](C)C3C)C=C3C#N)c2c1-c1ccccc1)=O CTBROMATMYJRQN-QDRROVJBSA-N 0.000 description 1
- IPBMOJBHCRZDAL-CHHXXQPCSA-N C[C@@H](C1[C@](C)(C=C2C#N)c3n[n](C)c(C4=NC=CCC4)c3CC1)C2=O Chemical compound C[C@@H](C1[C@](C)(C=C2C#N)c3n[n](C)c(C4=NC=CCC4)c3CC1)C2=O IPBMOJBHCRZDAL-CHHXXQPCSA-N 0.000 description 1
- ZXGBKEALIWVHML-DBSYTXKESA-N C[C@@H]([C@H]1C(C)(C=C2C#N)c3n[n](C)c(-c4nnc(C)[o]4)c3CC1)C2=O Chemical compound C[C@@H]([C@H]1C(C)(C=C2C#N)c3n[n](C)c(-c4nnc(C)[o]4)c3CC1)C2=O ZXGBKEALIWVHML-DBSYTXKESA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201061424601P | 2010-12-17 | 2010-12-17 | |
| US61/424,601 | 2010-12-17 | ||
| PCT/US2011/065897 WO2012083306A2 (en) | 2010-12-17 | 2011-12-19 | Pyrazolyl and pyrimidinyl tricyclic enones as antioxidant inflammation modulators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014501250A JP2014501250A (ja) | 2014-01-20 |
| JP2014501250A5 true JP2014501250A5 (enExample) | 2015-01-29 |
| JP5857068B2 JP5857068B2 (ja) | 2016-02-10 |
Family
ID=45470714
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013544872A Active JP5857068B2 (ja) | 2010-12-17 | 2011-12-19 | 抗酸化炎症モジュレーターとしてのピラゾリルおよびピリミジニル三環式エノン |
Country Status (32)
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE043175T2 (hu) | 2008-01-11 | 2019-08-28 | Reata Pharmaceuticals Inc | Szintetikus triterpenoidok és alkalmazásuk betegség kezelésében |
| MX339476B (es) | 2008-04-18 | 2016-05-27 | Reata Pharmaceuticals Inc | Compuestos que incluyen un nucleo farmaceutico antiinflamatorio y sus metodos de uso. |
| ES2703274T3 (es) | 2008-04-18 | 2019-03-07 | Reata Pharmaceuticals Inc | Moduladores de la inflamación antioxidantes: derivados del ácido oleanólico con modificaciones amino y otras en C-17 |
| PH12013501254A1 (en) | 2010-12-17 | 2016-07-29 | Novartis Ag | Crystalline forms of 5-chloro-n2-(2-isopropoxy-5-methyl-4-piperidin-4-yl-phenyl)-n4[2-(propane-2-sulfonyl)-phenyl]-pyrimidine-2,4-diamine |
| HRP20171859T1 (hr) | 2010-12-17 | 2018-01-26 | Reata Pharmaceuticals, Inc. | Pirazolil i pirimidinil triciklički enoni kao antioksidacijski modulatori upale |
| DK3444261T3 (da) | 2012-04-27 | 2021-03-08 | Reata Pharmaceuticals Inc | 2,2-difluorpropionamidderivat af bardoxolonmethyl, farmaceutiske sammensætninger og polymorfer deraf til anvendelse ved behandling af visse lidelser |
| US9556222B2 (en) | 2012-06-15 | 2017-01-31 | Reata Pharmaceuticals, Inc. | A-ring epoxidized triterpenoid-based anti-inflammation modulators and methods of use thereof |
| US9512094B2 (en) | 2012-09-10 | 2016-12-06 | Reata Pharmaceuticals, Inc. | C17-heteroaryl derivatives of oleanolic acid and methods of use thereof |
| US9278912B2 (en) | 2012-09-10 | 2016-03-08 | Reata Pharmaceuticals, Inc. | C13-hydroxy derivatives of oleanolic acid and methods of use thereof |
| PL2892912T3 (pl) | 2012-09-10 | 2019-10-31 | Reata Pharmaceuticals Inc | C17-alkanodiylowe i alkenodiylowe pochodne kwasu oleanolowego i sposoby ich zastosowania |
| TWI649330B (zh) | 2013-04-24 | 2019-02-01 | 艾伯維有限公司 | 甲基巴多索龍之２，２－二氟丙醯胺衍生物、其多晶形及其使用方法 |
| MX372772B (es) * | 2014-01-24 | 2020-06-29 | Reata Pharmaceuticals Inc | Enonas piridazolilo y pirimidinilo tricíclicas sustituidas con arilo y arilalquilo como moduladores de la inflamación antioxidantes. |
| US11059792B2 (en) | 2015-02-12 | 2021-07-13 | Reata Pharmaceuticals, Inc. | Imidazolyl tricyclic enones as antioxidant inflammation modulators |
| AU2017356955B2 (en) | 2016-11-08 | 2023-11-09 | Reata Pharmaceuticals Holdings, LLC | Methods of treating Alport syndrome using bardoxolone methyl or analogs thereof |
| TWI831738B (zh) * | 2016-12-16 | 2024-02-11 | 美商瑞塔醫藥有限責任公司 | 用於抑制ＲＯＲγ及其他用途的嘧啶三環烯酮衍生物 |
| US11286226B2 (en) | 2017-09-21 | 2022-03-29 | Northwestern University | Polycyclic carbogenic molecules and uses thereof as anti-cancer agents |
| WO2019104030A1 (en) * | 2017-11-21 | 2019-05-31 | Biogen Ma Inc. | Tetrahydronaphthalene derivatives useful as nrf2 activators |
| CN112654610B (zh) * | 2018-06-15 | 2024-12-24 | 里亚塔医药公司 | 用于抑制IL-17和RORγ的吡唑和咪唑化合物 |
| EP3810141A1 (en) | 2018-06-20 | 2021-04-28 | Reata Pharmaceuticals, Inc. | Cysteine-dependent inverse agonists of nuclear receptors ror-gamma/ror-gamma-t and methods of treating diseases or disorders therewith |
| CN114945561A (zh) | 2020-01-13 | 2022-08-26 | 阿普塔生物治疗公司 | 新吡唑衍生物 |
| US20250025465A1 (en) * | 2021-11-17 | 2025-01-23 | Northwestern University | Wt-idh1 inhibition using a covalent and brain-penetrant small molecular inhibitor for ferroptosis induction in high-grade glioma |
| CN121358860A (zh) * | 2023-06-16 | 2026-01-16 | 南京科捷基因技术有限公司 | 肿瘤特异性表达盒及其用途 |
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