JP2014500249A5 - - Google Patents
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- JP2014500249A5 JP2014500249A5 JP2013537803A JP2013537803A JP2014500249A5 JP 2014500249 A5 JP2014500249 A5 JP 2014500249A5 JP 2013537803 A JP2013537803 A JP 2013537803A JP 2013537803 A JP2013537803 A JP 2013537803A JP 2014500249 A5 JP2014500249 A5 JP 2014500249A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- alopecia
- composition according
- subject
- inhibitor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000008194 pharmaceutical composition Substances 0.000 claims 22
- 201000004384 Alopecia Diseases 0.000 claims 13
- 231100000360 alopecia Toxicity 0.000 claims 12
- 238000000034 method Methods 0.000 claims 6
- 108090000623 proteins and genes Proteins 0.000 claims 5
- 108020004459 Small interfering RNA Proteins 0.000 claims 4
- 230000003779 hair growth Effects 0.000 claims 4
- 239000003112 inhibitor Substances 0.000 claims 4
- 101150009057 JAK2 gene Proteins 0.000 claims 2
- 230000000284 resting effect Effects 0.000 claims 2
- 150000003384 small molecules Chemical class 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 101100366892 Anopheles gambiae Stat gene Proteins 0.000 claims 1
- 108020005544 Antisense RNA Proteins 0.000 claims 1
- 101100366894 Drosophila melanogaster Stat92E gene Proteins 0.000 claims 1
- WMBWREPUVVBILR-UHFFFAOYSA-N GCG Natural products C=1C(O)=C(O)C(O)=CC=1C1OC2=CC(O)=CC(O)=C2CC1OC(=O)C1=CC(O)=C(O)C(O)=C1 WMBWREPUVVBILR-UHFFFAOYSA-N 0.000 claims 1
- 229940116839 Janus kinase 1 inhibitor Drugs 0.000 claims 1
- 229940121730 Janus kinase 2 inhibitor Drugs 0.000 claims 1
- 239000002144 L01XE18 - Ruxolitinib Substances 0.000 claims 1
- UIARLYUEJFELEN-LROUJFHJSA-N LSM-1231 Chemical compound C12=C3N4C5=CC=CC=C5C3=C3C(=O)NCC3=C2C2=CC=CC=C2N1[C@]1(C)[C@](CO)(O)C[C@H]4O1 UIARLYUEJFELEN-LROUJFHJSA-N 0.000 claims 1
- JOOXLOJCABQBSG-UHFFFAOYSA-N N-tert-butyl-3-[[5-methyl-2-[4-[2-(1-pyrrolidinyl)ethoxy]anilino]-4-pyrimidinyl]amino]benzenesulfonamide Chemical compound N1=C(NC=2C=C(C=CC=2)S(=O)(=O)NC(C)(C)C)C(C)=CN=C1NC(C=C1)=CC=C1OCCN1CCCC1 JOOXLOJCABQBSG-UHFFFAOYSA-N 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 108010044012 STAT1 Transcription Factor Proteins 0.000 claims 1
- 102000006381 STAT1 Transcription Factor Human genes 0.000 claims 1
- 102000004265 STAT2 Transcription Factor Human genes 0.000 claims 1
- 108010081691 STAT2 Transcription Factor Proteins 0.000 claims 1
- 208000002474 Tinea Diseases 0.000 claims 1
- 241000130764 Tinea Species 0.000 claims 1
- 208000004631 alopecia areata Diseases 0.000 claims 1
- 201000002996 androgenic alopecia Diseases 0.000 claims 1
- 229950000971 baricitinib Drugs 0.000 claims 1
- XUZMWHLSFXCVMG-UHFFFAOYSA-N baricitinib Chemical compound C1N(S(=O)(=O)CC)CC1(CC#N)N1N=CC(C=2C=3C=CNC=3N=CN=2)=C1 XUZMWHLSFXCVMG-UHFFFAOYSA-N 0.000 claims 1
- JCINBYQJBYJGDM-UHFFFAOYSA-N bms-911543 Chemical compound CCN1C(C(=O)N(C2CC2)C2CC2)=CC(C=2N(C)C=NC=22)=C1N=C2NC=1C=C(C)N(C)N=1 JCINBYQJBYJGDM-UHFFFAOYSA-N 0.000 claims 1
- 239000003184 complementary RNA Substances 0.000 claims 1
- 208000034557 congenital alopecia Diseases 0.000 claims 1
- 229960000390 fludarabine Drugs 0.000 claims 1
- GIUYCYHIANZCFB-FJFJXFQQSA-N fludarabine phosphate Chemical group C1=NC=2C(N)=NC(F)=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O GIUYCYHIANZCFB-FJFJXFQQSA-N 0.000 claims 1
- IWBJJCOKGLUQIZ-HQKKAZOISA-N hyperforin Chemical compound OC1=C(CC=C(C)C)C(=O)[C@@]2(CC=C(C)C)C[C@H](CC=C(C)C)[C@](CCC=C(C)C)(C)[C@]1(C(=O)C(C)C)C2=O IWBJJCOKGLUQIZ-HQKKAZOISA-N 0.000 claims 1
- QOVWXXKVLJOKNW-UHFFFAOYSA-N hyperforin Natural products CC(C)C(=O)C12CC(CC=C(C)C)(CC(CC=C(C)C)C1CCC=C(C)C)C(=C(CC=C(C)C)C2=O)O QOVWXXKVLJOKNW-UHFFFAOYSA-N 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- ZVHNDZWQTBEVRY-UHFFFAOYSA-N momelotinib Chemical compound C1=CC(C(NCC#N)=O)=CC=C1C1=CC=NC(NC=2C=CC(=CC=2)N2CCOCC2)=N1 ZVHNDZWQTBEVRY-UHFFFAOYSA-N 0.000 claims 1
- 229950008814 momelotinib Drugs 0.000 claims 1
- 150000007523 nucleic acids Chemical group 0.000 claims 1
- HWXVIOGONBBTBY-ONEGZZNKSA-N pacritinib Chemical compound C=1C=C(C=2)NC(N=3)=NC=CC=3C(C=3)=CC=CC=3COC\C=C\COCC=2C=1OCCN1CCCC1 HWXVIOGONBBTBY-ONEGZZNKSA-N 0.000 claims 1
- 229950011410 pacritinib Drugs 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 229960000215 ruxolitinib Drugs 0.000 claims 1
- HFNKQEVNSGCOJV-OAHLLOKOSA-N ruxolitinib Chemical group C1([C@@H](CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)CCCC1 HFNKQEVNSGCOJV-OAHLLOKOSA-N 0.000 claims 1
- 230000009885 systemic effect Effects 0.000 claims 1
- TUCIOBMMDDOEMM-RIYZIHGNSA-N tyrphostin B42 Chemical group C1=C(O)C(O)=CC=C1\C=C(/C#N)C(=O)NCC1=CC=CC=C1 TUCIOBMMDDOEMM-RIYZIHGNSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40950910P | 2010-11-02 | 2010-11-02 | |
| US61/409,509 | 2010-11-02 | ||
| PCT/US2011/059029 WO2012061537A2 (en) | 2010-11-02 | 2011-11-02 | Methods for treating hair loss disorders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016114395A Division JP6259012B2 (ja) | 2010-11-02 | 2016-06-08 | 脱毛症の治療方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014500249A JP2014500249A (ja) | 2014-01-09 |
| JP2014500249A5 true JP2014500249A5 (OSRAM) | 2014-12-18 |
| JP5948337B2 JP5948337B2 (ja) | 2016-07-06 |
Family
ID=46025096
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013537803A Active JP5948337B2 (ja) | 2010-11-02 | 2011-11-02 | 脱毛症の治療方法 |
| JP2016114395A Active JP6259012B2 (ja) | 2010-11-02 | 2016-06-08 | 脱毛症の治療方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016114395A Active JP6259012B2 (ja) | 2010-11-02 | 2016-06-08 | 脱毛症の治療方法 |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP2635299B1 (OSRAM) |
| JP (2) | JP5948337B2 (OSRAM) |
| KR (2) | KR101913293B1 (OSRAM) |
| CN (1) | CN103370076A (OSRAM) |
| DK (1) | DK2635299T3 (OSRAM) |
| ES (1) | ES2746554T3 (OSRAM) |
| HR (1) | HRP20191548T1 (OSRAM) |
| HU (1) | HUE045869T2 (OSRAM) |
| PL (1) | PL2635299T3 (OSRAM) |
| PT (1) | PT2635299T (OSRAM) |
| SI (1) | SI2635299T1 (OSRAM) |
| WO (1) | WO2012061537A2 (OSRAM) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2635299B1 (en) * | 2010-11-02 | 2019-07-31 | The Trustees of Columbia University in the City of New York | Methods for treating hair loss disorders |
| HUE040127T2 (hu) * | 2012-03-29 | 2019-02-28 | Univ Columbia | Eljárások hajhullási rendellenességek kezelésére |
| WO2014013014A1 (en) * | 2012-07-18 | 2014-01-23 | Fundació Privada Centre De Regulació Genòmica (Crg) | Jak inhibitors for activation of epidermal stem cell populations |
| GB2536650A (en) | 2015-03-24 | 2016-09-28 | Augmedics Ltd | Method and system for combining video-based and optic-based augmented reality in a near eye display |
| AU2016259023A1 (en) * | 2015-05-07 | 2017-11-30 | The Trustees Of Columbia University In The City Of New York | Methods and compositions for promoting hair growth |
| CA2995750A1 (en) * | 2015-08-14 | 2017-02-23 | The Trustees Of Columbia University In The City Of New York | Biomarkers for treatment of alopecia areata |
| DE102015119880B4 (de) * | 2015-11-17 | 2018-05-24 | Technische Universität Berlin | Verfahren zur Herstellung von Haarfollikeln und de novo Papillen sowie deren Verwendung für in vitro Tests und in vivo Implantate |
| AR107195A1 (es) * | 2015-12-28 | 2018-03-28 | Natura Cosmeticos Sa | Composición lípida vegetal para promover el crecimiento del cabello, método para promover el crecimiento del cabello y uso de dichos lípidos vegetales |
| KR20250070139A (ko) | 2016-05-04 | 2025-05-20 | 썬 파마슈티칼 인더스트리즈 인코포레이티드 | 중수소화된 jak 저해제를 이용한 탈모 장애의 치료 |
| KR101657082B1 (ko) * | 2016-08-08 | 2016-09-13 | 에스씨엠생명과학 주식회사 | CXCL1(chemokine (C-X-C motif) ligand 1) 단백질을 유효성분으로 포함하는 탈모 예방 또는 치료용 약학적 조성물 |
| US10512670B2 (en) | 2016-08-08 | 2019-12-24 | Scm Lifescience Co., Ltd. | Pharmaceutical composition for preventing or treating hair loss comprising chemokine (C-X-C motif) ligand 1 (CXCL1) protein or CXCL1 protein and minoxidil as active ingredient |
| TW201920150A (zh) | 2017-08-01 | 2019-06-01 | 美商施萬生物製藥研發 Ip有限責任公司 | 作為jak激酶抑制劑之吡唑并及三唑并雙環化合物 |
| JP6979582B6 (ja) * | 2017-09-22 | 2022-01-17 | 学校法人東海大学 | 変異型蛋白質、及び該変異型蛋白質を発現し円形脱毛を発症する遺伝子改変マウス |
| US12458411B2 (en) | 2017-12-07 | 2025-11-04 | Augmedics Ltd. | Spinous process clamp |
| EP3787543A4 (en) | 2018-05-02 | 2022-01-19 | Augmedics Ltd. | REGISTRATION OF A FIDUCIAL MARKER FOR AN AUGMENTED REALITY SYSTEM |
| AU2019276713A1 (en) | 2018-05-30 | 2021-01-21 | Direct Biologics Llc | A growth factor and extracellular vesicle frozen or powdered additive comprising a mesenchymal stem cell (MSC) preparation and methods of use |
| JP2021532066A (ja) * | 2018-06-04 | 2021-11-25 | ケミストリーアールエックス.Chemistryrx. | 発毛を刺激するための局所的組成物 |
| US11766296B2 (en) | 2018-11-26 | 2023-09-26 | Augmedics Ltd. | Tracking system for image-guided surgery |
| BR112021012661A2 (pt) * | 2018-12-26 | 2021-09-08 | Direct Biologics Llc | Métodos e composições para o tratamento de doenças de pele e cabelo |
| WO2020154350A1 (en) | 2019-01-23 | 2020-07-30 | Theravance Biopharma R&D Ip, Llc | Imidazo[1,5-a]pyridine, 1,2,4-triazolo[4,3-a]pyridine and imidazo[1,5-a]pyrazine as jak inhibitors |
| AU2020214832A1 (en) * | 2019-01-30 | 2021-08-19 | Direct Biologics Llc | Methods and compositions for developing target specific exosome and growth factor products |
| WO2021011935A1 (en) | 2019-07-18 | 2021-01-21 | Direct Biologics, Llc | Preparations comprising mesenchymal stem cells and cannabinoids and methods of their use |
| US11980506B2 (en) | 2019-07-29 | 2024-05-14 | Augmedics Ltd. | Fiducial marker |
| US12178666B2 (en) | 2019-07-29 | 2024-12-31 | Augmedics Ltd. | Fiducial marker |
| JP2021042161A (ja) * | 2019-09-11 | 2021-03-18 | 国立大学法人東海国立大学機構 | 脱毛剤、脱毛モデル動物及び白髪モデル動物 |
| CN114901659A (zh) | 2019-11-26 | 2022-08-12 | 施万生物制药研发Ip有限责任公司 | 作为jak抑制剂的稠合嘧啶吡啶酮化合物 |
| US11382712B2 (en) | 2019-12-22 | 2022-07-12 | Augmedics Ltd. | Mirroring in image guided surgery |
| US11389252B2 (en) | 2020-06-15 | 2022-07-19 | Augmedics Ltd. | Rotating marker for image guided surgery |
| US12239385B2 (en) | 2020-09-09 | 2025-03-04 | Augmedics Ltd. | Universal tool adapter |
| US11896445B2 (en) | 2021-07-07 | 2024-02-13 | Augmedics Ltd. | Iliac pin and adapter |
| US12150821B2 (en) | 2021-07-29 | 2024-11-26 | Augmedics Ltd. | Rotating marker and adapter for image-guided surgery |
| WO2023018904A1 (en) | 2021-08-11 | 2023-02-16 | Concert Pharmaceuticals, Inc. | Treatment of hair loss disorders with deuterated jak inhibitors |
| EP4387552A4 (en) | 2021-08-18 | 2025-04-30 | Augmedics Ltd. | AUGMENTED REALITY SURGICAL SYSTEM USING DEPTH SENSING |
| WO2023203521A1 (en) | 2022-04-21 | 2023-10-26 | Augmedics Ltd. | Systems and methods for medical image visualization |
| CN116064461A (zh) * | 2022-08-12 | 2023-05-05 | 扬州大学 | Jak1蛋白泛素化位点在制备干扰素耐受细胞中的应用 |
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| US12364699B2 (en) | 2023-10-10 | 2025-07-22 | Sun Pharmaceuticals Industries, Inc. | Method of treating hair loss disorders |
| CN119746094A (zh) * | 2024-12-31 | 2025-04-04 | 深圳大学 | 脱毛化合物、动物脱毛模型及其制备方法与应用 |
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| JP2008539731A (ja) | 2005-05-02 | 2008-11-20 | コールド スプリング ハーバー ラボラトリー | 癌の診断及び治療のための組成物及び方法 |
| EP2007877B1 (en) | 2006-02-28 | 2013-04-17 | The Trustees of Columbia University in the City of New York | Methods for compact aggregation of dermal cells |
| TWI423814B (zh) * | 2006-09-01 | 2014-01-21 | Genticel | 用於引發特異性細胞毒性ｔ淋巴細胞（ｃｔｌ）反應之組成物，包含一淋巴去除性化合物以及一含有抗原序列且以專業化抗原呈現細胞為標靶之分子 |
| RS53245B2 (sr) * | 2007-06-13 | 2022-10-31 | Incyte Holdings Corp | Soli inhibitora janus kinaze (r)-3-(4-(7h-pirolo(2,3-d) pirimidin-4-il)-1h-pirazol-1-il)-3-ciklopentilpropan-nitrila |
| CL2008001709A1 (es) * | 2007-06-13 | 2008-11-03 | Incyte Corp | Compuestos derivados de pirrolo [2,3-b]pirimidina, moduladores de quinasas jak; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer, psoriasis, artritis reumatoide, entre otras. |
| EP2274288A2 (en) * | 2008-04-24 | 2011-01-19 | Incyte Corporation | Macrocyclic compounds and their use as kinase inhibitors |
| JP2012517448A (ja) * | 2009-02-11 | 2012-08-02 | リアクション バイオロジー コープ． | 選択的キナーゼ阻害剤 |
| EP2635299B1 (en) * | 2010-11-02 | 2019-07-31 | The Trustees of Columbia University in the City of New York | Methods for treating hair loss disorders |
-
2011
- 2011-11-02 EP EP11838771.1A patent/EP2635299B1/en active Active
- 2011-11-02 HU HUE11838771A patent/HUE045869T2/hu unknown
- 2011-11-02 JP JP2013537803A patent/JP5948337B2/ja active Active
- 2011-11-02 ES ES11838771T patent/ES2746554T3/es active Active
- 2011-11-02 KR KR1020137014155A patent/KR101913293B1/ko active Active
- 2011-11-02 HR HRP20191548TT patent/HRP20191548T1/hr unknown
- 2011-11-02 PT PT118387711T patent/PT2635299T/pt unknown
- 2011-11-02 SI SI201131778T patent/SI2635299T1/sl unknown
- 2011-11-02 WO PCT/US2011/059029 patent/WO2012061537A2/en not_active Ceased
- 2011-11-02 DK DK11838771.1T patent/DK2635299T3/da active
- 2011-11-02 CN CN2011800637870A patent/CN103370076A/zh active Pending
- 2011-11-02 PL PL11838771T patent/PL2635299T3/pl unknown
- 2011-11-02 KR KR1020187030745A patent/KR102027394B1/ko active Active
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2016
- 2016-06-08 JP JP2016114395A patent/JP6259012B2/ja active Active
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