JP2014500249A5 - - Google Patents
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- JP2014500249A5 JP2014500249A5 JP2013537803A JP2013537803A JP2014500249A5 JP 2014500249 A5 JP2014500249 A5 JP 2014500249A5 JP 2013537803 A JP2013537803 A JP 2013537803A JP 2013537803 A JP2013537803 A JP 2013537803A JP 2014500249 A5 JP2014500249 A5 JP 2014500249A5
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- pharmaceutical composition
- alopecia
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- 239000008194 pharmaceutical composition Substances 0.000 claims 22
- 201000004384 alopecia Diseases 0.000 claims 12
- 231100000360 alopecia Toxicity 0.000 claims 12
- 239000003112 inhibitor Substances 0.000 claims 5
- 230000002401 inhibitory effect Effects 0.000 claims 5
- 101700034277 JAK1 Proteins 0.000 claims 4
- 108020004459 Small Interfering RNA Proteins 0.000 claims 4
- 230000003698 anagen phase Effects 0.000 claims 4
- 230000003779 hair growth Effects 0.000 claims 4
- 239000002924 silencing RNA Substances 0.000 claims 4
- 101700016050 JAK2 Proteins 0.000 claims 3
- 101700043907 STAT1 Proteins 0.000 claims 3
- WMBWREPUVVBILR-WIYYLYMNSA-N (-)-Epigallocatechin-3-o-gallate Chemical compound O([C@@H]1CC2=C(O)C=C(C=C2O[C@@H]1C=1C=C(O)C(O)=C(O)C=1)O)C(=O)C1=CC(O)=C(O)C(O)=C1 WMBWREPUVVBILR-WIYYLYMNSA-N 0.000 claims 2
- IWBJJCOKGLUQIZ-HQKKAZOISA-N Hyperforin Chemical compound OC1=C(CC=C(C)C)C(=O)[C@@]2(CC=C(C)C)C[C@H](CC=C(C)C)[C@](CCC=C(C)C)(C)[C@]1(C(=O)C(C)C)C2=O IWBJJCOKGLUQIZ-HQKKAZOISA-N 0.000 claims 2
- 101700054244 STAT2 Proteins 0.000 claims 2
- 230000000284 resting Effects 0.000 claims 2
- 150000003384 small molecules Chemical class 0.000 claims 2
- 208000004631 Alopecia Areata Diseases 0.000 claims 1
- 206010068168 Androgenetic alopecia Diseases 0.000 claims 1
- 108020005544 Antisense RNA Proteins 0.000 claims 1
- JCINBYQJBYJGDM-UHFFFAOYSA-N BMS-911543 Chemical compound CCN1C(C(=O)N(C2CC2)C2CC2)=CC(C=2N(C)C=NC=22)=C1N=C2NC=1C=C(C)N(C)N=1 JCINBYQJBYJGDM-UHFFFAOYSA-N 0.000 claims 1
- ZVHNDZWQTBEVRY-UHFFFAOYSA-N CYT387 Chemical compound C1=CC(C(NCC#N)=O)=CC=C1C1=CC=NC(NC=2C=CC(=CC=2)N2CCOCC2)=N1 ZVHNDZWQTBEVRY-UHFFFAOYSA-N 0.000 claims 1
- 208000001824 Congenital alopecia X-linked Diseases 0.000 claims 1
- 239000002144 L01XE18 - Ruxolitinib Substances 0.000 claims 1
- UIARLYUEJFELEN-LROUJFHJSA-N Lestaurtinib Chemical compound C12=C3N4C5=CC=CC=C5C3=C3C(=O)NCC3=C2C2=CC=CC=C2N1[C@]1(C)[C@](CO)(O)C[C@H]4O1 UIARLYUEJFELEN-LROUJFHJSA-N 0.000 claims 1
- 229920001850 Nucleic acid sequence Polymers 0.000 claims 1
- 102000006381 STAT1 Transcription Factor Human genes 0.000 claims 1
- 108010044012 STAT1 Transcription Factor Proteins 0.000 claims 1
- 102000004265 STAT2 Transcription Factor Human genes 0.000 claims 1
- 108010081691 STAT2 Transcription Factor Proteins 0.000 claims 1
- 101710019175 STATH Proteins 0.000 claims 1
- 208000002474 Tinea Diseases 0.000 claims 1
- 241000130764 Tinea Species 0.000 claims 1
- 201000002996 androgenic alopecia Diseases 0.000 claims 1
- 102000004965 antibodies Human genes 0.000 claims 1
- 108090001123 antibodies Proteins 0.000 claims 1
- 229920002847 antisense RNA Polymers 0.000 claims 1
- 239000003184 complementary RNA Substances 0.000 claims 1
- 229960000390 fludarabine Drugs 0.000 claims 1
- GIUYCYHIANZCFB-FJFJXFQQSA-N fludarabine phosphate Chemical group C1=NC=2C(N)=NC(F)=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O GIUYCYHIANZCFB-FJFJXFQQSA-N 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 150000007523 nucleic acids Chemical group 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- HFNKQEVNSGCOJV-OAHLLOKOSA-N ruxolitinib Chemical group C1([C@@H](CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)CCCC1 HFNKQEVNSGCOJV-OAHLLOKOSA-N 0.000 claims 1
- 229960000215 ruxolitinib Drugs 0.000 claims 1
Claims (14)
- 脱毛症の治療を必要とする哺乳動物被験体における脱毛症を治療する方法において使用するための、Jak1および/またはJak2阻害剤を含む医薬組成物であって、該方法が、該医薬組成物を該被験体に投与することを含む、前記医薬組成物。
- 脱毛症の治療を必要とする哺乳動物被験体における脱毛症を治療する方法において使用するための、Stat1および/またはStat2阻害剤を含む医薬組成物であって、該方法が、該医薬組成物を該被験体に投与することを含む、前記医薬組成物。
- 被験体における毛髪増殖を誘導する方法において使用するための、有効量のJak/Stat阻害剤を含む医薬組成物であって、該方法が、(a) 該医薬組成物を被験体に投与し、それによって被験体における毛髪増殖を制御することを含む、前記医薬組成物。
- 阻害剤が配列番号１、３、５または７を含むタンパク質に特異的に結合する抗体を含む、請求項１、２または３に記載の医薬組成物。
- 被験体が脱毛症に罹患している、請求項３に記載の医薬組成物。
- 脱毛症がアンドロゲン性脱毛症、休止期脱毛、円形脱毛症、休止期脱毛、頭部白癬、完全脱毛症、貧毛症、遺伝性先天性貧毛症、または全身性脱毛症を含む、請求項１、２または５に記載の医薬組成物。
- 前記方法において、投与された医薬組成物が、該医薬組成物を用いる治療の前の脱毛症に罹患した被験体の毛髪増殖と比較して、該被験体において毛髪増殖を誘導したかどうかを決定するステップ(b)をさらに含む、請求項１、２または３に記載の医薬組成物。
- 阻害剤が、Jak1、Jak2、Stat1もしくはStat2タンパク質をコードする遺伝子の発現を特異的に阻害するアンチセンスRNA；Jak1、Jak2、Stat1もしくはStat2をコードする遺伝子を特異的に標的化するsiRNA；または小分子である、請求項１、２または３に記載の医薬組成物。
- 阻害剤がINCB018424である、請求項１、２または３に記載の医薬組成物。
- 小分子がAG490、CYT387、SB1518、LY3009104、TG101348、BMS-911543、またはCEP-701である、請求項８に記載の医薬組成物。
- 小分子がフルダラビン、エピガロカテキン-3-ガレート(EGCG)、またはハイパーフォリンである、請求項８に記載の医薬組成物。
- siRNAが配列番号２、４、６または８を含むヒト核酸配列に対するものである、請求項８に記載の医薬組成物。
- Jak1遺伝子に対するsiRNAが表１１に列挙された配列のいずれか1つである、請求項８に記載の医薬組成物。
- Stat1遺伝子に対するsiRNAが表１２に列挙された配列のいずれか1つである、請求項８に記載の医薬組成物。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40950910P | 2010-11-02 | 2010-11-02 | |
| US61/409,509 | 2010-11-02 | ||
| PCT/US2011/059029 WO2012061537A2 (en) | 2010-11-02 | 2011-11-02 | Methods for treating hair loss disorders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016114395A Division JP6259012B2 (ja) | 2010-11-02 | 2016-06-08 | 脱毛症の治療方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014500249A JP2014500249A (ja) | 2014-01-09 |
| JP2014500249A5 true JP2014500249A5 (ja) | 2014-12-18 |
| JP5948337B2 JP5948337B2 (ja) | 2016-07-06 |
Family
ID=46025096
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013537803A Active JP5948337B2 (ja) | 2010-11-02 | 2011-11-02 | 脱毛症の治療方法 |
| JP2016114395A Active JP6259012B2 (ja) | 2010-11-02 | 2016-06-08 | 脱毛症の治療方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016114395A Active JP6259012B2 (ja) | 2010-11-02 | 2016-06-08 | 脱毛症の治療方法 |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP2635299B1 (ja) |
| JP (2) | JP5948337B2 (ja) |
| KR (2) | KR101913293B1 (ja) |
| CN (1) | CN103370076A (ja) |
| DK (1) | DK2635299T3 (ja) |
| ES (1) | ES2746554T3 (ja) |
| HR (1) | HRP20191548T1 (ja) |
| HU (1) | HUE045869T2 (ja) |
| PL (1) | PL2635299T3 (ja) |
| PT (1) | PT2635299T (ja) |
| SI (1) | SI2635299T1 (ja) |
| WO (1) | WO2012061537A2 (ja) |
Families Citing this family (23)
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| WO2012061537A2 (en) * | 2010-11-02 | 2012-05-10 | The Trustees Of Columbia University In The City Of New York | Methods for treating hair loss disorders |
| PT2830662T (pt) * | 2012-03-29 | 2018-11-29 | Univ Columbia | Métodos para tratamento de distúrbios de perda de pelo |
| WO2014013014A1 (en) * | 2012-07-18 | 2014-01-23 | Fundació Privada Centre De Regulació Genòmica (Crg) | Jak inhibitors for activation of epidermal stem cell populations |
| GB2536650A (en) | 2015-03-24 | 2016-09-28 | Augmedics Ltd | Method and system for combining video-based and optic-based augmented reality in a near eye display |
| KR20180002838A (ko) * | 2015-05-07 | 2018-01-08 | 더 트러스티스 오브 콜롬비아 유니버시티 인 더 시티 오브 뉴욕 | 모발 생장을 촉진하기 위한 방법 및 조성물 |
| JP2018526362A (ja) * | 2015-08-14 | 2018-09-13 | ザ トラスティーズ オブ コロンビア ユニヴァーシティ イン ザ シティ オブ ニューヨーク | 円形脱毛症の処置のためのバイオマーカー |
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| JP6979582B6 (ja) | 2017-09-22 | 2022-01-17 | 学校法人東海大学 | 変異型蛋白質、及び該変異型蛋白質を発現し円形脱毛を発症する遺伝子改変マウス |
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| CL2008001709A1 (es) * | 2007-06-13 | 2008-11-03 | Incyte Corp | Compuestos derivados de pirrolo [2,3-b]pirimidina, moduladores de quinasas jak; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer, psoriasis, artritis reumatoide, entre otras. |
| LT3070090T (lt) * | 2007-06-13 | 2019-06-25 | Incyte Holdings Corporation | Janus kinazės inhibitoriaus (r)-3-(4-(7h-pirol[2,3-d]pirimidin-4-il)-1h-pirazol-1-il)-3-ciklopentilpropannitrilo druskų panaudojimas |
| EP2274288A2 (en) * | 2008-04-24 | 2011-01-19 | Incyte Corporation | Macrocyclic compounds and their use as kinase inhibitors |
| EP2396004A4 (en) * | 2009-02-11 | 2012-07-25 | Reaction Biology Corp | SELECTIVE KINASE HEMMER |
| WO2012061537A2 (en) * | 2010-11-02 | 2012-05-10 | The Trustees Of Columbia University In The City Of New York | Methods for treating hair loss disorders |
-
2011
- 2011-11-02 WO PCT/US2011/059029 patent/WO2012061537A2/en active Application Filing
- 2011-11-02 DK DK11838771.1T patent/DK2635299T3/da active
- 2011-11-02 KR KR1020137014155A patent/KR101913293B1/ko active IP Right Grant
- 2011-11-02 KR KR1020187030745A patent/KR102027394B1/ko active IP Right Grant
- 2011-11-02 PT PT118387711T patent/PT2635299T/pt unknown
- 2011-11-02 JP JP2013537803A patent/JP5948337B2/ja active Active
- 2011-11-02 ES ES11838771T patent/ES2746554T3/es active Active
- 2011-11-02 HU HUE11838771A patent/HUE045869T2/hu unknown
- 2011-11-02 PL PL11838771T patent/PL2635299T3/pl unknown
- 2011-11-02 CN CN2011800637870A patent/CN103370076A/zh active Pending
- 2011-11-02 SI SI201131778T patent/SI2635299T1/sl unknown
- 2011-11-02 EP EP11838771.1A patent/EP2635299B1/en active Active
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2016
- 2016-06-08 JP JP2016114395A patent/JP6259012B2/ja active Active
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2019
- 2019-08-28 HR HRP20191548TT patent/HRP20191548T1/hr unknown
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