JP2014500028A5 - - Google Patents
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- Publication number
- JP2014500028A5 JP2014500028A5 JP2013545098A JP2013545098A JP2014500028A5 JP 2014500028 A5 JP2014500028 A5 JP 2014500028A5 JP 2013545098 A JP2013545098 A JP 2013545098A JP 2013545098 A JP2013545098 A JP 2013545098A JP 2014500028 A5 JP2014500028 A5 JP 2014500028A5
- Authority
- JP
- Japan
- Prior art keywords
- oligonucleotide
- nucleic acid
- egfr
- seq
- sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108091034117 Oligonucleotide Proteins 0.000 claims 23
- 108020004707 nucleic acids Proteins 0.000 claims 17
- 102000039446 nucleic acids Human genes 0.000 claims 17
- 150000007523 nucleic acids Chemical class 0.000 claims 17
- 102000001301 EGF receptor Human genes 0.000 claims 9
- 108060006698 EGF receptor Proteins 0.000 claims 9
- 238000000034 method Methods 0.000 claims 7
- 230000035772 mutation Effects 0.000 claims 6
- 125000003277 amino group Chemical group 0.000 claims 5
- 230000003321 amplification Effects 0.000 claims 5
- 238000003199 nucleic acid amplification method Methods 0.000 claims 5
- 239000002773 nucleotide Substances 0.000 claims 5
- 125000003729 nucleotide group Chemical group 0.000 claims 5
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
- 101000851181 Homo sapiens Epidermal growth factor receptor Proteins 0.000 claims 3
- 229940121647 egfr inhibitor Drugs 0.000 claims 3
- 238000009396 hybridization Methods 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 239000011541 reaction mixture Substances 0.000 claims 2
- 239000005411 L01XE02 - Gefitinib Substances 0.000 claims 1
- 239000005551 L01XE03 - Erlotinib Substances 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 229960005395 cetuximab Drugs 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 229960001433 erlotinib Drugs 0.000 claims 1
- AAKJLRGGTJKAMG-UHFFFAOYSA-N erlotinib Chemical compound C=12C=C(OCCOC)C(OCCOC)=CC2=NC=NC=1NC1=CC=CC(C#C)=C1 AAKJLRGGTJKAMG-UHFFFAOYSA-N 0.000 claims 1
- 229960002584 gefitinib Drugs 0.000 claims 1
- XGALLCVXEZPNRQ-UHFFFAOYSA-N gefitinib Chemical compound C=12C=C(OCCCN3CCOCC3)C(OC)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 XGALLCVXEZPNRQ-UHFFFAOYSA-N 0.000 claims 1
- 229960001972 panitumumab Drugs 0.000 claims 1
- 238000003753 real-time PCR Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201061426436P | 2010-12-22 | 2010-12-22 | |
| US61/426,436 | 2010-12-22 | ||
| PCT/EP2011/006399 WO2012084173A2 (en) | 2010-12-22 | 2011-12-17 | Methods and compositions for detecting mutation in the human epidermal growth factor receptor gene |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014500028A JP2014500028A (ja) | 2014-01-09 |
| JP2014500028A5 true JP2014500028A5 (enExample) | 2015-02-05 |
Family
ID=45478263
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013545098A Pending JP2014500028A (ja) | 2010-12-22 | 2011-12-17 | ヒト上皮成長因子受容体遺伝子内の突然変異を検出するための方法及び組成物 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20120164641A1 (enExample) |
| EP (1) | EP2655659A2 (enExample) |
| JP (1) | JP2014500028A (enExample) |
| KR (1) | KR20130094342A (enExample) |
| CN (1) | CN103282515A (enExample) |
| AU (1) | AU2011348483A1 (enExample) |
| CA (1) | CA2822254A1 (enExample) |
| WO (1) | WO2012084173A2 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6050820B2 (ja) | 2011-09-23 | 2016-12-21 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 改良された対立遺伝子特異的ｐｃｒのためのｇ−クランプの使用 |
| US9382581B2 (en) | 2012-12-13 | 2016-07-05 | Roche Molecular Systems, Inc. | Primers with modified phosphate and base in allele-specific PCR |
| US9279146B2 (en) | 2012-12-21 | 2016-03-08 | Roche Molecular Systems, Inc. | Compounds and methods for the enrichment of mutated nucleic acid from a mixture |
| US9873908B2 (en) | 2013-11-27 | 2018-01-23 | Roche Molecular Systems, Inc. | Methods for the enrichment of mutated nucleic acid from a mixture |
| CN104087674B (zh) * | 2014-07-15 | 2016-02-10 | 江苏同科医药科技有限公司 | 一种人表皮生长因子受体突变基因检测试剂盒 |
| CA2961437C (en) * | 2014-10-09 | 2019-01-15 | F. Hoffmann-La Roche Ag | Mutations in the epidermal growth factor receptor kinase domain |
| CZ308881B6 (cs) | 2014-12-09 | 2021-08-04 | Univerzita Palackého v Olomouci | 6-aryl-9-glykosylpuriny a jejich použití |
| CN105177156B (zh) * | 2015-10-12 | 2018-04-10 | 苏州华益美生物科技有限公司 | 人egfr基因突变检测试剂盒及其应用 |
| CN108676848B (zh) * | 2018-05-31 | 2022-04-22 | 上海科医联创医学检验所有限公司 | 用于检测融合基因的混合基因、标准质粒、试剂盒及其制备方法 |
| CN111607593A (zh) * | 2019-02-26 | 2020-09-01 | 成都华青精准医疗科技有限公司 | 一种用于检测egfr基因突变的核苷酸序列组及其应用 |
| CN113355423B (zh) * | 2021-07-07 | 2022-06-07 | 安徽科技学院 | Egfr基因l858r突变检测的引物探针、试剂盒及其应用 |
| CN117106865B (zh) * | 2023-08-23 | 2024-05-10 | 北京医院 | 基于双扩增放大和双lna探针特异识别dna突变的高灵敏检测方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5981725A (en) * | 1989-09-08 | 1999-11-09 | The Johns Hopkins Univiersity | Structural alterations of the EGF receptor gene in human tumors |
| US5981176A (en) | 1992-06-17 | 1999-11-09 | City Of Hope | Method of detecting and discriminating between nucleic acid sequences |
| DE69827060T2 (de) * | 1997-03-20 | 2005-03-24 | F. Hoffmann-La Roche Ag | Modifizierte Primer |
| EP1055001A1 (en) * | 1998-02-05 | 2000-11-29 | Bavarian Nordic Research Institute A/S | Quantification by inhibition of amplification |
| US6235480B1 (en) * | 1998-03-13 | 2001-05-22 | Promega Corporation | Detection of nucleic acid hybrids |
| EP1305450A2 (en) * | 2000-07-28 | 2003-05-02 | Compugen Inc. | Oligonucleotide library for detecting rna transcripts and splice variants that populate a transcriptome |
| CN107988363A (zh) | 2004-03-31 | 2018-05-04 | 综合医院公司 | 测定癌症对表皮生长因子受体靶向性治疗反应性的方法 |
| JP2008504809A (ja) | 2004-06-04 | 2008-02-21 | ジェネンテック・インコーポレーテッド | Ｅｇｆｒ突然変異 |
| JP2008535477A (ja) * | 2005-02-24 | 2008-09-04 | アムジエン・インコーポレーテツド | 上皮成長因子受容体変異 |
| GB2424886A (en) * | 2005-04-04 | 2006-10-11 | Dxs Ltd | Polynucleotide primers against epidermal growth factor receptor and method of detecting gene mutations |
| CN1710102A (zh) * | 2005-06-20 | 2005-12-21 | 上海市肺科医院 | 一种肿瘤相关基因突变的pcr检测方法及试剂系统 |
| US7465561B2 (en) * | 2005-06-30 | 2008-12-16 | Roche Molecular Systems, Inc. | Probes and methods for hepatitis C virus typing using single probe analysis |
| CN101041850A (zh) * | 2006-03-20 | 2007-09-26 | 吕成伟 | 一种人类表皮生长因子受体（egfr）基因外显子20的t790m突变快速检测方法和试剂盒 |
| US8598333B2 (en) * | 2006-05-26 | 2013-12-03 | Alnylam Pharmaceuticals, Inc. | SiRNA silencing of genes expressed in cancer |
| JP5624044B2 (ja) | 2008-10-20 | 2014-11-12 | エフ．ホフマン−ラ ロシュアーゲーＦ．Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 改善されたアレル−特異的増幅 |
| US20100143901A1 (en) | 2008-12-09 | 2010-06-10 | Roche Molecular Systems, Inc. | Nuclease-Free Real-Time Detection of Nucleic Acids |
-
2011
- 2011-12-13 US US13/324,705 patent/US20120164641A1/en not_active Abandoned
- 2011-12-17 KR KR1020137015963A patent/KR20130094342A/ko not_active Ceased
- 2011-12-17 CA CA2822254A patent/CA2822254A1/en not_active Abandoned
- 2011-12-17 WO PCT/EP2011/006399 patent/WO2012084173A2/en not_active Ceased
- 2011-12-17 JP JP2013545098A patent/JP2014500028A/ja active Pending
- 2011-12-17 CN CN2011800611832A patent/CN103282515A/zh active Pending
- 2011-12-17 AU AU2011348483A patent/AU2011348483A1/en not_active Abandoned
- 2011-12-17 EP EP11808168.6A patent/EP2655659A2/en not_active Withdrawn
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