JP2014500028A - ヒト上皮成長因子受容体遺伝子内の突然変異を検出するための方法及び組成物 - Google Patents

ヒト上皮成長因子受容体遺伝子内の突然変異を検出するための方法及び組成物 Download PDF

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JP2014500028A
JP2014500028A JP2013545098A JP2013545098A JP2014500028A JP 2014500028 A JP2014500028 A JP 2014500028A JP 2013545098 A JP2013545098 A JP 2013545098A JP 2013545098 A JP2013545098 A JP 2013545098A JP 2014500028 A JP2014500028 A JP 2014500028A
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oligonucleotide
seq
pair
nucleic acid
kit
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JP2014500028A5 (enExample
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バウアー キース
シェーンブルナー ナンシー
ツァン アリソン
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F Hoffmann La Roche AG
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6851—Quantitative amplification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
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  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
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  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2013545098A 2010-12-22 2011-12-17 ヒト上皮成長因子受容体遺伝子内の突然変異を検出するための方法及び組成物 Pending JP2014500028A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201061426436P 2010-12-22 2010-12-22
US61/426,436 2010-12-22
PCT/EP2011/006399 WO2012084173A2 (en) 2010-12-22 2011-12-17 Methods and compositions for detecting mutation in the human epidermal growth factor receptor gene

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JP2014500028A true JP2014500028A (ja) 2014-01-09
JP2014500028A5 JP2014500028A5 (enExample) 2015-02-05

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JP2013545098A Pending JP2014500028A (ja) 2010-12-22 2011-12-17 ヒト上皮成長因子受容体遺伝子内の突然変異を検出するための方法及び組成物

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US (1) US20120164641A1 (enExample)
EP (1) EP2655659A2 (enExample)
JP (1) JP2014500028A (enExample)
KR (1) KR20130094342A (enExample)
CN (1) CN103282515A (enExample)
AU (1) AU2011348483A1 (enExample)
CA (1) CA2822254A1 (enExample)
WO (1) WO2012084173A2 (enExample)

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EP2758546B1 (en) 2011-09-23 2017-11-22 Roche Diagnostics GmbH Use of g-clamp for improved allele-specific pcr
US9382581B2 (en) 2012-12-13 2016-07-05 Roche Molecular Systems, Inc. Primers with modified phosphate and base in allele-specific PCR
US9279146B2 (en) 2012-12-21 2016-03-08 Roche Molecular Systems, Inc. Compounds and methods for the enrichment of mutated nucleic acid from a mixture
US9873908B2 (en) 2013-11-27 2018-01-23 Roche Molecular Systems, Inc. Methods for the enrichment of mutated nucleic acid from a mixture
CN104087674B (zh) * 2014-07-15 2016-02-10 江苏同科医药科技有限公司 一种人表皮生长因子受体突变基因检测试剂盒
CN106795567B (zh) * 2014-10-09 2021-07-30 豪夫迈·罗氏有限公司 在表皮生长因子受体激酶结构域中的突变
CZ308881B6 (cs) 2014-12-09 2021-08-04 Univerzita Palackého v Olomouci 6-aryl-9-glykosylpuriny a jejich použití
CN105177156B (zh) * 2015-10-12 2018-04-10 苏州华益美生物科技有限公司 人egfr基因突变检测试剂盒及其应用
CN108676848B (zh) * 2018-05-31 2022-04-22 上海科医联创医学检验所有限公司 用于检测融合基因的混合基因、标准质粒、试剂盒及其制备方法
CN111607593A (zh) * 2019-02-26 2020-09-01 成都华青精准医疗科技有限公司 一种用于检测egfr基因突变的核苷酸序列组及其应用
CN113355423B (zh) * 2021-07-07 2022-06-07 安徽科技学院 Egfr基因l858r突变检测的引物探针、试剂盒及其应用
CN117106865B (zh) * 2023-08-23 2024-05-10 北京医院 基于双扩增放大和双lna探针特异识别dna突变的高灵敏检测方法

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AU2520799A (en) * 1998-02-05 1999-08-23 Bavarian Nordic Research Institute A/S Quantification by inhibition of amplification
US6235480B1 (en) * 1998-03-13 2001-05-22 Promega Corporation Detection of nucleic acid hybrids
JP2004508019A (ja) * 2000-07-28 2004-03-18 コンピュジェン　インコーポレイテッド トランスクリプトームの中に場所を占めるｒｎａ転写物及びスプライス変異体を検出するためのオリゴヌクレオチドライブラリー
EP2439285B1 (en) 2004-03-31 2019-05-08 The General Hospital Corporation Method to determine responsiveness of cancer to epidermal growth factor receptor targeting treatments
EP2592155B2 (en) 2004-06-04 2019-09-11 Genentech, Inc. EGFR mutations
KR20070106029A (ko) * 2005-02-24 2007-10-31 암젠 인코포레이티드 상피세포 성장 인자 수용체 돌연변이
GB2424886A (en) * 2005-04-04 2006-10-11 Dxs Ltd Polynucleotide primers against epidermal growth factor receptor and method of detecting gene mutations
CN1710102A (zh) * 2005-06-20 2005-12-21 上海市肺科医院 一种肿瘤相关基因突变的pcr检测方法及试剂系统
US20070072211A1 (en) * 2005-06-30 2007-03-29 Roche Molecular Systems, Inc. Asymmetric PCR coupled with post-PCR characterization for the identification of nucleic acids
CN101041850A (zh) * 2006-03-20 2007-09-26 吕成伟 一种人类表皮生长因子受体（egfr）基因外显子20的t790m突变快速检测方法和试剂盒
US8598333B2 (en) * 2006-05-26 2013-12-03 Alnylam Pharmaceuticals, Inc. SiRNA silencing of genes expressed in cancer
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JPN6015047436; Ｊｏｕｒｎａｌ　ｏｆ　Ｃｌｉｎｉｃａｌ　Ｏｎｃｏｌｏｇｙ，　２００５，　Ｖｏｌ．２３，　ｐｐ．２４９３-２５０１ *
JPN6015047437; Ｏｎｃｏｇｅｎｅ，　２００９，　Ｖｏｌ．２８，　ｐｐ．Ｓ１４-Ｓ２３ *
JPN6015047438; Ｎｕｃｌｅｉｃ　Ａｃｉｄｓ　Ｒｅｓ．，　１９８９，　Ｖｏｌ．１７，　ｐｐ．２５０３-２５１６ *
JPN6015047439; Ｅｕｒｏｐｅａｎ　Ｊｏｕｒｎａｌ　ｏｆ　Ｃａｎｃｅｒ，　２００９，　Ｖｏｌ．４５，　ｐｐ．１５１８-１５２６ *

Also Published As

Publication number Publication date
AU2011348483A1 (en) 2013-06-13
WO2012084173A2 (en) 2012-06-28
CN103282515A (zh) 2013-09-04
CA2822254A1 (en) 2012-06-28
KR20130094342A (ko) 2013-08-23
WO2012084173A3 (en) 2012-10-26
EP2655659A2 (en) 2013-10-30
US20120164641A1 (en) 2012-06-28

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