JP2014169318A5 - - Google Patents
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- Publication number
- JP2014169318A5 JP2014169318A5 JP2014103666A JP2014103666A JP2014169318A5 JP 2014169318 A5 JP2014169318 A5 JP 2014169318A5 JP 2014103666 A JP2014103666 A JP 2014103666A JP 2014103666 A JP2014103666 A JP 2014103666A JP 2014169318 A5 JP2014169318 A5 JP 2014169318A5
- Authority
- JP
- Japan
- Prior art keywords
- inorganic material
- granulation
- disintegration
- manufacturing
- hpc
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000004519 manufacturing process Methods 0.000 claims description 12
- 239000007771 core particle Substances 0.000 claims description 10
- 229910010272 inorganic material Inorganic materials 0.000 claims description 10
- 239000011147 inorganic material Substances 0.000 claims description 10
- 239000002245 particle Substances 0.000 claims description 7
- 230000001737 promoting effect Effects 0.000 claims description 7
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 6
- 238000005469 granulation Methods 0.000 claims description 6
- 230000003179 granulation Effects 0.000 claims description 6
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 6
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 6
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 6
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 6
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 6
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 6
- 229940031703 low substituted hydroxypropyl cellulose Drugs 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 244000215068 Acacia senegal Species 0.000 claims description 3
- 229920002907 Guar gum Polymers 0.000 claims description 3
- 229920000084 Gum arabic Polymers 0.000 claims description 3
- 229920002472 Starch Polymers 0.000 claims description 3
- 239000000205 acacia gum Substances 0.000 claims description 3
- 235000010489 acacia gum Nutrition 0.000 claims description 3
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 3
- 229940084030 carboxymethylcellulose calcium Drugs 0.000 claims description 3
- 239000000665 guar gum Substances 0.000 claims description 3
- 235000010417 guar gum Nutrition 0.000 claims description 3
- 229960002154 guar gum Drugs 0.000 claims description 3
- 229920000609 methyl cellulose Polymers 0.000 claims description 3
- 239000001923 methylcellulose Substances 0.000 claims description 3
- 235000010981 methylcellulose Nutrition 0.000 claims description 3
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 3
- 239000008107 starch Substances 0.000 claims description 3
- 235000019698 starch Nutrition 0.000 claims description 3
- 229940032147 starch Drugs 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 2
- YKTSYUJCYHOUJP-UHFFFAOYSA-N [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] Chemical compound [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] YKTSYUJCYHOUJP-UHFFFAOYSA-N 0.000 claims description 2
- 239000004480 active ingredient Substances 0.000 claims description 2
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims description 2
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 claims description 2
- 239000000378 calcium silicate Substances 0.000 claims description 2
- 229910052918 calcium silicate Inorganic materials 0.000 claims description 2
- OYACROKNLOSFPA-UHFFFAOYSA-N calcium;dioxido(oxo)silane Chemical compound [Ca+2].[O-][Si]([O-])=O OYACROKNLOSFPA-UHFFFAOYSA-N 0.000 claims description 2
- 229920003123 carboxymethyl cellulose sodium Polymers 0.000 claims description 2
- 229940063834 carboxymethylcellulose sodium Drugs 0.000 claims description 2
- 229960000913 crospovidone Drugs 0.000 claims description 2
- 235000019700 dicalcium phosphate Nutrition 0.000 claims description 2
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 claims description 2
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 claims description 2
- 239000001095 magnesium carbonate Substances 0.000 claims description 2
- 229910000021 magnesium carbonate Inorganic materials 0.000 claims description 2
- VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical compound [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 claims description 2
- 239000000347 magnesium hydroxide Substances 0.000 claims description 2
- 229910001862 magnesium hydroxide Inorganic materials 0.000 claims description 2
- 239000000395 magnesium oxide Substances 0.000 claims description 2
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 claims description 2
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 claims description 2
- 229960002900 methylcellulose Drugs 0.000 claims description 2
- 239000012046 mixed solvent Substances 0.000 claims description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 2
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 claims description 2
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 claims description 2
- 239000000377 silicon dioxide Substances 0.000 claims description 2
- 235000012239 silicon dioxide Nutrition 0.000 claims description 2
- 239000002904 solvent Substances 0.000 claims description 2
- 238000003756 stirring Methods 0.000 claims description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2014103666A JP5910949B2 (ja) | 2010-12-27 | 2014-05-19 | 製剤用崩壊型核粒子 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010290831 | 2010-12-27 | ||
| JP2010290831 | 2010-12-27 | ||
| JP2014103666A JP5910949B2 (ja) | 2010-12-27 | 2014-05-19 | 製剤用崩壊型核粒子 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012550997A Division JP5578534B2 (ja) | 2010-12-27 | 2011-12-27 | 製剤用崩壊型核粒子 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014169318A JP2014169318A (ja) | 2014-09-18 |
| JP2014169318A5 true JP2014169318A5 (enExample) | 2015-02-19 |
| JP5910949B2 JP5910949B2 (ja) | 2016-04-27 |
Family
ID=46383131
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012550997A Expired - Fee Related JP5578534B2 (ja) | 2010-12-27 | 2011-12-27 | 製剤用崩壊型核粒子 |
| JP2014103666A Active JP5910949B2 (ja) | 2010-12-27 | 2014-05-19 | 製剤用崩壊型核粒子 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012550997A Expired - Fee Related JP5578534B2 (ja) | 2010-12-27 | 2011-12-27 | 製剤用崩壊型核粒子 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20140030346A1 (enExample) |
| EP (1) | EP2659882A4 (enExample) |
| JP (2) | JP5578534B2 (enExample) |
| CN (1) | CN103313703A (enExample) |
| WO (1) | WO2012091040A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6251946B2 (ja) * | 2012-10-14 | 2017-12-27 | 富田製薬株式会社 | 複合核粒子及びそれを含む医薬組成物 |
| JP6498607B2 (ja) * | 2012-12-21 | 2019-04-10 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | 有効成分の放出性が向上した医薬調製物における賦形剤としての炭酸水酸化マグネシウム |
| NZ759443A (en) * | 2017-05-10 | 2020-06-26 | Thankapan VADAKEKUTTU | Agricultural compositions |
| CA3107696A1 (en) | 2018-10-04 | 2020-04-09 | Chemische Fabrik Budenheim Kg | Spherical beads for use in producing pharmaceutically active pellets |
| EP3892262A1 (en) | 2020-04-06 | 2021-10-13 | Chemische Fabrik Budenheim KG | Beads comprising a buffer system |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8414221D0 (en) * | 1984-06-04 | 1984-07-11 | Sterwin Ag | Unit dosage form |
| JP2542122B2 (ja) | 1990-04-18 | 1996-10-09 | 旭化成工業株式会社 | 球状核、球形顆粒およびその製造方法 |
| JP2820829B2 (ja) * | 1991-03-07 | 1998-11-05 | 武田薬品工業株式会社 | 有核散剤およびその製造方法 |
| JP3219787B2 (ja) | 1991-05-28 | 2001-10-15 | フロイント産業株式会社 | 球形粒子の製造方法 |
| JP3349535B2 (ja) | 1993-01-12 | 2002-11-25 | フロイント産業株式会社 | 球形顆粒の製造方法 |
| DK0765157T3 (da) * | 1994-06-15 | 1999-10-25 | Dumex Ltd As | Pellets |
| JPH08217801A (ja) * | 1995-02-10 | 1996-08-27 | Kanegafuchi Chem Ind Co Ltd | 球形顆粒用水膨潤性球状核および球形顆粒並びにそれらの製造方法 |
| JPH09175999A (ja) | 1995-12-22 | 1997-07-08 | Freunt Ind Co Ltd | 球形顆粒およびその製造方法 |
| DE19637082A1 (de) * | 1996-09-12 | 1998-03-19 | Boehringer Mannheim Gmbh | Schnellzerfallende Pellets |
| TW486370B (en) * | 1996-12-25 | 2002-05-11 | Yamanouchi Pharma Co Ltd | Rapidly disintegrable pharmaceutical composition |
| JP3447042B2 (ja) | 1997-07-23 | 2003-09-16 | フロイント産業株式会社 | 単一物質球形粒の製造方法 |
| AU4778500A (en) * | 1999-05-20 | 2000-12-12 | Takeda Chemical Industries Ltd. | Composition containing ascorbic acid salt |
| KR100381834B1 (ko) * | 2000-05-20 | 2003-04-26 | 이상득 | 용출성이 개선된 프란루카스트 고체분산체 조성물 및 그제조 방법 |
| US20030096018A1 (en) * | 2000-12-15 | 2003-05-22 | Schloss Caroline Maxine | Multi-vitamin and hormone replacement supplement |
| US20050226923A1 (en) * | 2004-04-07 | 2005-10-13 | Gassert Chad M | Venlafaxine compositions in the form of microtablets |
| JP2006016329A (ja) * | 2004-06-30 | 2006-01-19 | Lion Corp | 粒状医薬品 |
| ES2526415T3 (es) * | 2005-03-17 | 2015-01-12 | Synthon B.V. | Comprimidos farmacéuticos de aripiprazol cristalino de tipo II |
| JP2007015982A (ja) * | 2005-07-07 | 2007-01-25 | Tendou Seiyaku Kk | 緩下剤 |
| JP4168157B1 (ja) * | 2007-03-12 | 2008-10-22 | 富田製薬株式会社 | 製剤用球形核粒子 |
| JPWO2009072334A1 (ja) * | 2007-12-03 | 2011-04-21 | 富田製薬株式会社 | 製剤用核粒子 |
| JPWO2009157214A1 (ja) * | 2008-06-27 | 2011-12-08 | 富士化学工業株式会社 | 球状非結晶ケイ酸アルミン酸マグネシウム |
| JP5359061B2 (ja) * | 2008-06-28 | 2013-12-04 | 富田製薬株式会社 | 製剤用核粒子 |
| CN101507718B (zh) * | 2009-03-03 | 2011-05-04 | 张登科 | 雷贝拉唑钠肠溶口崩片及其制备方法 |
| JP2011026307A (ja) * | 2009-06-28 | 2011-02-10 | Tomita Pharmaceutical Co Ltd | 製剤用核粒子 |
| JP2011157348A (ja) * | 2010-01-05 | 2011-08-18 | Fuji Chem Ind Co Ltd | 崩壊性高強度球状粒子組成物 |
-
2011
- 2011-12-27 CN CN2011800628320A patent/CN103313703A/zh active Pending
- 2011-12-27 JP JP2012550997A patent/JP5578534B2/ja not_active Expired - Fee Related
- 2011-12-27 EP EP11854059.0A patent/EP2659882A4/en not_active Withdrawn
- 2011-12-27 US US13/996,412 patent/US20140030346A1/en not_active Abandoned
- 2011-12-27 WO PCT/JP2011/080276 patent/WO2012091040A1/ja not_active Ceased
-
2014
- 2014-05-19 JP JP2014103666A patent/JP5910949B2/ja active Active
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