JP2016065086A5 - - Google Patents
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- Publication number
- JP2016065086A5 JP2016065086A5 JP2015226794A JP2015226794A JP2016065086A5 JP 2016065086 A5 JP2016065086 A5 JP 2016065086A5 JP 2015226794 A JP2015226794 A JP 2015226794A JP 2015226794 A JP2015226794 A JP 2015226794A JP 2016065086 A5 JP2016065086 A5 JP 2016065086A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- apixaban
- composition according
- equal
- less
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 31
- QNZCBYKSOIHPEH-UHFFFAOYSA-N Apixaban Chemical compound C1=CC(OC)=CC=C1N1C(C(=O)N(CC2)C=3C=CC(=CC=3)N3C(CCCC3)=O)=C2C(C(N)=O)=N1 QNZCBYKSOIHPEH-UHFFFAOYSA-N 0.000 claims 27
- 229960003886 apixaban Drugs 0.000 claims 27
- 239000012738 dissolution medium Substances 0.000 claims 11
- 239000002775 capsule Substances 0.000 claims 8
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims 5
- 239000002245 particle Substances 0.000 claims 5
- 239000002994 raw material Substances 0.000 claims 5
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims 5
- 239000003085 diluting agent Substances 0.000 claims 4
- 229910000162 sodium phosphate Inorganic materials 0.000 claims 4
- 239000001488 sodium phosphate Substances 0.000 claims 4
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims 4
- 238000002441 X-ray diffraction Methods 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- 239000004094 surface-active agent Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 1
- 238000007908 dry granulation Methods 0.000 claims 1
- 239000002609 medium Substances 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30805610P | 2010-02-25 | 2010-02-25 | |
| US61/308,056 | 2010-02-25 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012555127A Division JP5846647B2 (ja) | 2010-02-25 | 2011-02-24 | アピキサバン製剤 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016209347A Division JP6192078B2 (ja) | 2010-02-25 | 2016-10-26 | アピキサバン製剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016065086A JP2016065086A (ja) | 2016-04-28 |
| JP2016065086A5 true JP2016065086A5 (enExample) | 2016-08-25 |
| JP6033945B2 JP6033945B2 (ja) | 2016-11-30 |
Family
ID=43901603
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012555127A Active JP5846647B2 (ja) | 2010-02-25 | 2011-02-24 | アピキサバン製剤 |
| JP2015226794A Active JP6033945B2 (ja) | 2010-02-25 | 2015-11-19 | アピキサバン製剤 |
| JP2016209347A Active JP6192078B2 (ja) | 2010-02-25 | 2016-10-26 | アピキサバン製剤 |
| JP2017149644A Active JP6577980B2 (ja) | 2010-02-25 | 2017-08-02 | アピキサバン製剤 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012555127A Active JP5846647B2 (ja) | 2010-02-25 | 2011-02-24 | アピキサバン製剤 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016209347A Active JP6192078B2 (ja) | 2010-02-25 | 2016-10-26 | アピキサバン製剤 |
| JP2017149644A Active JP6577980B2 (ja) | 2010-02-25 | 2017-08-02 | アピキサバン製剤 |
Country Status (31)
| Country | Link |
|---|---|
| US (5) | US9326945B2 (enExample) |
| EP (7) | EP3017811B1 (enExample) |
| JP (4) | JP5846647B2 (enExample) |
| KR (4) | KR20170126016A (enExample) |
| CN (3) | CN102770126A (enExample) |
| AU (1) | AU2011220775B2 (enExample) |
| BR (1) | BR112012021337A8 (enExample) |
| CA (1) | CA2791171C (enExample) |
| CO (1) | CO6640207A2 (enExample) |
| CY (5) | CY1117434T1 (enExample) |
| DK (5) | DK3251660T3 (enExample) |
| ES (5) | ES2714363T3 (enExample) |
| HK (2) | HK1243947B (enExample) |
| HR (5) | HRP20160179T1 (enExample) |
| HU (4) | HUE047139T2 (enExample) |
| IL (3) | IL309564A (enExample) |
| IN (1) | IN2012DN06587A (enExample) |
| LT (4) | LT3251660T (enExample) |
| MX (3) | MX353145B (enExample) |
| NZ (1) | NZ601738A (enExample) |
| PE (3) | PE20210468A1 (enExample) |
| PL (5) | PL2538925T3 (enExample) |
| PT (5) | PT3017811T (enExample) |
| RS (5) | RS59593B1 (enExample) |
| RU (1) | RU2685724C2 (enExample) |
| SG (2) | SG182750A1 (enExample) |
| SI (5) | SI2538925T1 (enExample) |
| SM (5) | SMT201900212T1 (enExample) |
| TR (1) | TR201903195T4 (enExample) |
| WO (1) | WO2011106478A2 (enExample) |
| ZA (1) | ZA201205807B (enExample) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL309564A (en) * | 2010-02-25 | 2024-02-01 | Pfizer | Preparations containing apixaban |
| WO2013164839A2 (en) * | 2012-03-06 | 2013-11-07 | Cadila Healthcare Limited | Amorphous form of apixaban, process of preparation and compositions thereof |
| EP2854759B1 (en) * | 2012-05-24 | 2019-12-18 | ratiopharm GmbH | Dosage forms comprising apixaban and matrix former |
| RU2660358C2 (ru) * | 2012-09-26 | 2018-07-05 | Бристол-Майерс Сквибб Холдингс Айеленд | Жидкие лекарственные композиции апиксабана |
| CN102908324A (zh) * | 2012-10-31 | 2013-02-06 | 南京正科制药有限公司 | 一种阿哌沙班片 |
| EP2752414A1 (en) | 2013-01-04 | 2014-07-09 | Sandoz AG | Crystalline form of apixaban |
| CZ2013305A3 (cs) | 2013-04-23 | 2014-11-05 | Zentiva, K.S. | Nové krystalické formy APIXABANU a způsob jejich přípravy |
| WO2014203275A2 (en) * | 2013-06-18 | 2014-12-24 | Cadila Healthcare Limited | An improved process for the preparation of apixaban and intermediates thereof |
| EP2907507A1 (en) | 2014-02-17 | 2015-08-19 | Sandoz Ag | Pharmaceutical composition comprising apixaban |
| CN103830199A (zh) * | 2014-03-24 | 2014-06-04 | 重庆东得医药科技有限公司 | 含阿哌沙班的药用制剂及其制备方法 |
| SG10201900648SA (en) | 2014-07-25 | 2019-02-27 | Novartis Ag | Tablet formulation of 2-fluoro-n-methyl-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide |
| CN104316637B (zh) * | 2014-10-30 | 2016-08-17 | 江苏宝众宝达药业有限公司 | 高效液相色谱法测定阿哌沙班清洗残留量 |
| US9603846B2 (en) | 2014-11-25 | 2017-03-28 | Cadila Healthcare Limited | Process for the preparation of apixaban |
| AU2016259897A1 (en) * | 2015-05-08 | 2017-08-17 | Wockhardt Limited | Stable pharmaceutical compositions comprising antibacterial agent |
| WO2017088841A1 (en) | 2015-11-26 | 2017-06-01 | Zentiva, K.S. | Preparation of a drug form containing amorphous apixaban |
| CN106913528A (zh) * | 2015-12-25 | 2017-07-04 | 中美华世通生物医药科技（武汉）有限公司 | 阿哌沙班微丸及其制备方法 |
| US10537524B2 (en) * | 2016-01-12 | 2020-01-21 | North & South Brother Pharmacy Investment Company Limited | Apixaban solid composition and preparation method thereof |
| EP3195860A1 (de) * | 2016-01-22 | 2017-07-26 | STADA Arzneimittel AG | Verfahren zur herstellung eines apixaban-granulates |
| WO2017163170A1 (en) * | 2016-03-21 | 2017-09-28 | Sun Pharmaceutical Industries Limited | Pharmaceutical composition comprising apixaban |
| WO2017182908A1 (en) * | 2016-04-18 | 2017-10-26 | Emcure Pharmaceuticals Limited | Pharmaceutical compositions of apixaban |
| EP3243505A1 (en) | 2016-05-13 | 2017-11-15 | Zaklady Farmaceutyczne Polpharma SA | A pharmaceutical composition comprising amorphous apixaban |
| CN106822006B (zh) * | 2016-06-08 | 2020-08-28 | 北京普德康利医药科技发展有限公司 | 一种阿哌沙班片及其制备方法 |
| WO2017221209A1 (en) | 2016-06-23 | 2017-12-28 | Lupin Limited | Pharmaceutical formulations of apixaban |
| WO2018054357A1 (zh) * | 2016-09-24 | 2018-03-29 | 山东亨利医药科技有限责任公司 | 含盐皮质激素受体拮抗剂的药物组合物及其用途 |
| CN106420651B (zh) * | 2016-09-28 | 2019-03-08 | 乐普药业股份有限公司 | 一种阿哌沙班片的制备方法 |
| EP3582777A4 (en) | 2017-02-17 | 2020-12-23 | Unichem Laboratories Ltd | PHARMACEUTICAL COMPOSITION OF APIXABAN |
| JP7044115B2 (ja) | 2017-11-27 | 2022-03-30 | 三菱ケミカル株式会社 | ゴム含有グラフト重合体組成物を含む熱可塑性樹脂の樹脂改質用組成物、ゴム含有グラフト重合体含有樹脂組成物およびその成形体 |
| KR20190075566A (ko) | 2017-12-21 | 2019-07-01 | 전자부품연구원 | 다중 센서를 활용한 용변 습관 모니터링 시스템 및 방법 |
| TR201722523A2 (tr) | 2017-12-28 | 2019-07-22 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Api̇ksaban i̇çeren kati oral farmasöti̇k kompozi̇syonlar |
| CN108236604A (zh) * | 2018-02-07 | 2018-07-03 | 中国药科大学 | 阿哌沙班柔性脂质体 |
| MX2020010673A (es) | 2018-04-16 | 2020-10-28 | Bristol Myers Squibb Co | Formulaciones de apixaban. |
| KR20190130411A (ko) | 2018-05-14 | 2019-11-22 | 신일제약주식회사 | 아픽사반 약제학적 제제 및 그의 제조방법 |
| WO2020034989A1 (zh) | 2018-08-14 | 2020-02-20 | 江苏恒瑞医药股份有限公司 | 一种可注射的药物组合物及其制备方法 |
| EP3666773A1 (en) | 2018-12-11 | 2020-06-17 | KRKA, D.D., Novo Mesto | Process for preparing apixaban |
| EP3669866A1 (en) | 2018-12-19 | 2020-06-24 | KRKA, d.d., Novo mesto | Pharmaceutical composition comprising apixaban |
| CN111377915B (zh) * | 2018-12-30 | 2023-10-24 | 鲁南制药集团股份有限公司 | 一种吡唑并-吡啶酮化合物晶型d |
| CN109464415B (zh) * | 2019-01-09 | 2021-08-17 | 常州恒邦药业有限公司 | 阿哌沙班药物组合物及其制备方法 |
| KR20220101103A (ko) | 2019-11-13 | 2022-07-19 | 유니슨 파마슈티컬스 피브이티. 엘티디. | 아픽사반의 구강 붕해성 약학적 조성물 |
| CN111214442B (zh) * | 2020-02-13 | 2021-12-10 | 山东百诺医药股份有限公司 | 一种阿哌沙班共微粉化物 |
| CN111494326A (zh) * | 2020-04-11 | 2020-08-07 | 南京正大天晴制药有限公司 | 一种阿哌沙班片及其制备方法 |
| EP4251155A4 (en) | 2020-11-27 | 2024-07-31 | Santa Farma Ilac Sanayii A.S. | IMPROVED WET GRANULATION PROCESSES FOR APIXABAN WITH FORMULATIONS |
| EP4251271A4 (en) | 2020-11-27 | 2024-07-31 | Santa Farma Ilac Sanayii A.S. | Direct compression method for non-micronised apixaban formulations |
| TR202100250A2 (tr) | 2021-01-08 | 2022-07-21 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Api̇ksaban i̇çeren fi̇lm kapli tablet |
| WO2022150030A2 (en) | 2021-01-08 | 2022-07-14 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | A film coated tablet of apixaban |
| JP2022112698A (ja) * | 2021-01-22 | 2022-08-03 | 東和薬品株式会社 | アピキサバン含有医薬組成物 |
| GB202102575D0 (en) | 2021-02-23 | 2021-04-07 | Teva Pharmaceutical Industries Ltd | Fixed-dose pharmaceutical compositions |
| AU2022288053B2 (en) * | 2021-06-08 | 2025-08-07 | Taho Pharmaceuticals Ltd. | Apixaban film product and uses thereof |
| AU2022374714B2 (en) | 2021-10-27 | 2024-05-23 | Pharma-Data Research And Development Single Member S.A. | Apixaban suspension and preparation method |
| JP7834007B2 (ja) * | 2022-10-12 | 2026-03-23 | 日本ジェネリック株式会社 | アピキサバンを含有する錠剤 |
| JP2024064876A (ja) * | 2022-10-28 | 2024-05-14 | ニプロ株式会社 | 医薬組成物 |
| KR102760108B1 (ko) | 2024-04-09 | 2025-01-24 | 에바바이오 주식회사 | 수용해도와 투과도를 향상시켜 생체이용률이 개선된 무정형 아픽사반 고체분산체 제제 및 그의 서방성 정제 |
| JP7854233B2 (ja) * | 2024-10-10 | 2026-05-01 | 富士化学工業株式会社 | アピキサバン含有組成物、アピキサバン含有固形製剤、及びアピキサバン含有固形製剤の製造方法 |
| EP4759304A1 (en) | 2024-12-10 | 2026-06-17 | Laboratoires S.M.B. | Pellet compositions comprising apixaban and methods for the production thereof |
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| US20070025991A1 (en) * | 2003-03-19 | 2007-02-01 | Charalabos Pothoulakis | Use of antagonists of ghrelin or ghrelin receptor to treat intestinal inflammation |
| US20050059719A1 (en) * | 2003-09-16 | 2005-03-17 | Badawy Sherif Ibrahim Farag | Solid dosage formulation containing a Factor Xa inhibitor and method |
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| US7396932B2 (en) | 2004-09-28 | 2008-07-08 | Bristol-Myers Squibb Company | Process for preparing 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones |
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| US20070191306A1 (en) * | 2005-08-17 | 2007-08-16 | Bristol-Myers Squibb Company | FACTOR Xa INHIBITOR FORMULATION AND METHOD |
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| US20070259913A1 (en) | 2006-05-04 | 2007-11-08 | David Deitchman | Prophylaxis of thromboembolic events in cancer patients |
| US20090285887A1 (en) * | 2006-09-12 | 2009-11-19 | Omar Abdelfattah Abu-Baker | Pharmaceutical Composition Comprising A Plurality of Mini-Tablets Comprising A Factor XA Inhibitor |
| FI20080351A0 (fi) | 2008-05-09 | 2008-05-09 | Atacama Labs Oy | Prosessi matalan lääkepitoisuuden tabletin valmistamiseksi |
| KR101509829B1 (ko) * | 2007-05-02 | 2015-04-06 | 포톨라 파마슈티컬스, 인코포레이티드 | 혈소판 ａｄｐ 수용체 억제제로 작용하는 화합물을 이용한 병용요법 |
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| SMT202000093T1 (it) * | 2009-06-16 | 2020-03-13 | Pfizer | Forme di dosaggio di apixaban |
| IL309564A (en) * | 2010-02-25 | 2024-02-01 | Pfizer | Preparations containing apixaban |
| AU2011225810B2 (en) * | 2010-03-10 | 2014-11-06 | Lupin Limited | Rifaximin ready-to-use suspension |
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2011
- 2011-02-24 IL IL309564A patent/IL309564A/en unknown
- 2011-02-24 EP EP15190823.3A patent/EP3017811B1/en not_active Revoked
- 2011-02-24 RU RU2012140690A patent/RU2685724C2/ru active
- 2011-02-24 PL PL11707284T patent/PL2538925T3/pl unknown
- 2011-02-24 SI SI201130742T patent/SI2538925T1/sl unknown
- 2011-02-24 DK DK17175788T patent/DK3251660T3/da active
- 2011-02-24 MX MX2015007763A patent/MX353145B/es unknown
- 2011-02-24 SG SG2012055547A patent/SG182750A1/en unknown
- 2011-02-24 SM SM20190212T patent/SMT201900212T1/it unknown
- 2011-02-24 MX MX2017016605A patent/MX364938B/es unknown
- 2011-02-24 PT PT15190823T patent/PT3017811T/pt unknown
- 2011-02-24 US US13/579,796 patent/US9326945B2/en active Active
- 2011-02-24 IN IN6587DEN2012 patent/IN2012DN06587A/en unknown
- 2011-02-24 DK DK17175864.2T patent/DK3246021T3/da active
- 2011-02-24 CN CN201180011229XA patent/CN102770126A/zh active Pending
- 2011-02-24 RS RS20191493A patent/RS59593B1/sr unknown
- 2011-02-24 JP JP2012555127A patent/JP5846647B2/ja active Active
- 2011-02-24 MX MX2012009244A patent/MX2012009244A/es active IP Right Grant
- 2011-02-24 SI SI201131811T patent/SI3251660T1/sl unknown
- 2011-02-24 BR BR112012021337A patent/BR112012021337A8/pt not_active Application Discontinuation
- 2011-02-24 DK DK15190823.3T patent/DK3017811T3/en active
- 2011-02-24 PL PL17175788T patent/PL3251660T3/pl unknown
- 2011-02-24 PE PE2020000316A patent/PE20210468A1/es unknown
- 2011-02-24 SM SM20190650T patent/SMT201900650T1/it unknown
- 2011-02-24 KR KR1020177031997A patent/KR20170126016A/ko not_active Ceased
- 2011-02-24 SI SI201131813T patent/SI3257500T1/sl unknown
- 2011-02-24 EP EP17175864.2A patent/EP3246021B1/en not_active Revoked
- 2011-02-24 SG SG10201501349VA patent/SG10201501349VA/en unknown
- 2011-02-24 PL PL17175864T patent/PL3246021T3/pl unknown
- 2011-02-24 KR KR1020237035193A patent/KR20230149861A/ko not_active Ceased
- 2011-02-24 HU HUE17175788A patent/HUE047139T2/hu unknown
- 2011-02-24 CN CN201810769647.9A patent/CN109602716A/zh active Pending
- 2011-02-24 HR HRP20160179TT patent/HRP20160179T1/hr unknown
- 2011-02-24 PL PL17178613T patent/PL3257500T3/pl unknown
- 2011-02-24 RS RS20200017A patent/RS59810B1/sr unknown
- 2011-02-24 DK DK17178613T patent/DK3257500T3/da active
- 2011-02-24 TR TR2019/03195T patent/TR201903195T4/tr unknown
- 2011-02-24 PT PT171758642T patent/PT3246021T/pt unknown
- 2011-02-24 WO PCT/US2011/025994 patent/WO2011106478A2/en not_active Ceased
- 2011-02-24 KR KR1020217031947A patent/KR20210124532A/ko not_active Ceased
- 2011-02-24 SM SM20190649T patent/SMT201900649T1/it unknown
- 2011-02-24 EP EP17178613.0A patent/EP3257500B1/en not_active Revoked
- 2011-02-24 PE PE2015002402A patent/PE20160042A1/es unknown
- 2011-02-24 RS RS20190290A patent/RS58699B1/sr unknown
- 2011-02-24 EP EP11707284.3A patent/EP2538925B1/en not_active Revoked
- 2011-02-24 KR KR1020127022152A patent/KR101796300B1/ko not_active Ceased
- 2011-02-24 ES ES15190823T patent/ES2714363T3/es active Active
- 2011-02-24 RS RS20160088A patent/RS54559B1/sr unknown
- 2011-02-24 AU AU2011220775A patent/AU2011220775B2/en active Active
- 2011-02-24 SI SI201131665T patent/SI3017811T1/sl unknown
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