JP2014167027A5 - - Google Patents
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- Publication number
- JP2014167027A5 JP2014167027A5 JP2014121362A JP2014121362A JP2014167027A5 JP 2014167027 A5 JP2014167027 A5 JP 2014167027A5 JP 2014121362 A JP2014121362 A JP 2014121362A JP 2014121362 A JP2014121362 A JP 2014121362A JP 2014167027 A5 JP2014167027 A5 JP 2014167027A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- pharmaceutically acceptable
- acceptable salt
- responsive state
- infection
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 21
- 150000003839 salts Chemical class 0.000 claims 7
- 239000004098 Tetracycline Substances 0.000 claims 6
- 229960002180 tetracycline Drugs 0.000 claims 6
- 229930101283 tetracycline Natural products 0.000 claims 6
- 235000019364 tetracycline Nutrition 0.000 claims 6
- -1 tetracycline compound Chemical class 0.000 claims 5
- 150000003522 tetracyclines Chemical class 0.000 claims 5
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 4
- 201000004792 malaria Diseases 0.000 claims 4
- 208000030852 Parasitic disease Diseases 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 125000000842 isoxazolyl group Chemical group 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 125000001715 oxadiazolyl group Chemical group 0.000 claims 3
- 125000002971 oxazolyl group Chemical group 0.000 claims 3
- 125000003226 pyrazolyl group Chemical group 0.000 claims 3
- 125000000335 thiazolyl group Chemical group 0.000 claims 3
- 208000002874 Acne Vulgaris Diseases 0.000 claims 2
- 208000035143 Bacterial infection Diseases 0.000 claims 2
- 208000036142 Viral infection Diseases 0.000 claims 2
- 206010000496 acne Diseases 0.000 claims 2
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 2
- 208000022362 bacterial infectious disease Diseases 0.000 claims 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 2
- 230000004054 inflammatory process Effects 0.000 claims 2
- 201000006417 multiple sclerosis Diseases 0.000 claims 2
- 230000009385 viral infection Effects 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 241001024304 Mino Species 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 1
- 125000004442 acylamino group Chemical group 0.000 claims 1
- 125000005089 alkenylaminocarbonyl group Chemical group 0.000 claims 1
- 125000005090 alkenylcarbonyl group Chemical group 0.000 claims 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 1
- 125000005194 alkoxycarbonyloxy group Chemical group 0.000 claims 1
- 125000004457 alkyl amino carbonyl group Chemical group 0.000 claims 1
- 125000003282 alkyl amino group Chemical group 0.000 claims 1
- 125000004947 alkyl aryl amino group Chemical group 0.000 claims 1
- 125000002877 alkyl aryl group Chemical group 0.000 claims 1
- 125000003806 alkyl carbonyl amino group Chemical group 0.000 claims 1
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 claims 1
- 125000004644 alkyl sulfinyl group Chemical group 0.000 claims 1
- 125000004691 alkyl thio carbonyl group Chemical group 0.000 claims 1
- 125000004414 alkyl thio group Chemical group 0.000 claims 1
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims 1
- 125000005125 aryl alkyl amino carbonyl group Chemical group 0.000 claims 1
- 125000005099 aryl alkyl carbonyl group Chemical group 0.000 claims 1
- 125000004658 aryl carbonyl amino group Chemical group 0.000 claims 1
- 125000005129 aryl carbonyl group Chemical group 0.000 claims 1
- 125000005199 aryl carbonyloxy group Chemical group 0.000 claims 1
- 125000005161 aryl oxy carbonyl group Chemical group 0.000 claims 1
- 125000005110 aryl thio group Chemical group 0.000 claims 1
- 125000001951 carbamoylamino group Chemical group C(N)(=O)N* 0.000 claims 1
- KWEDUNSJJZVRKR-UHFFFAOYSA-N carbononitridic azide Chemical compound [N-]=[N+]=NC#N KWEDUNSJJZVRKR-UHFFFAOYSA-N 0.000 claims 1
- 150000007942 carboxylates Chemical class 0.000 claims 1
- 125000004663 dialkyl amino group Chemical group 0.000 claims 1
- 125000004986 diarylamino group Chemical group 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 150000002431 hydrogen Chemical group 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 claims 1
- 244000045947 parasite Species 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- ACVYVLVWPXVTIT-UHFFFAOYSA-M phosphinate Chemical compound [O-][PH2]=O ACVYVLVWPXVTIT-UHFFFAOYSA-M 0.000 claims 1
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 claims 1
- 125000005420 sulfonamido group Chemical group S(=O)(=O)(N*)* 0.000 claims 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
- CZLDFBRICDJOMM-IGSRQBSMSA-N CN(C)c(cc1-c2ncc[o]2)c(C[C@@H](C[C@@H](CC(O)=C(C(N)=O)C2=O)[C@@]22O)C(C3=O)=C2O)c3c1O Chemical compound CN(C)c(cc1-c2ncc[o]2)c(C[C@@H](C[C@@H](CC(O)=C(C(N)=O)C2=O)[C@@]22O)C(C3=O)=C2O)c3c1O CZLDFBRICDJOMM-IGSRQBSMSA-N 0.000 description 1
- 0 CN(C)c(cc1[*+])c(CC(CC(CC(O)=C(C(N)=O)C2=O)[C@@]22O)C(C3=O)=C2O)c3c1O Chemical compound CN(C)c(cc1[*+])c(CC(CC(CC(O)=C(C(N)=O)C2=O)[C@@]22O)C(C3=O)=C2O)c3c1O 0.000 description 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87631306P | 2006-12-21 | 2006-12-21 | |
| US60/876,313 | 2006-12-21 | ||
| US94300307P | 2007-06-08 | 2007-06-08 | |
| US60/943,003 | 2007-06-08 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009542938A Division JP5583411B2 (ja) | 2006-12-21 | 2007-12-21 | 細菌感染、ウイルス感染、および寄生虫感染の治療のためのテトラサイクリン誘導体 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015160343A Division JP2015205939A (ja) | 2006-12-21 | 2015-08-17 | 細菌感染、ウイルス感染、および寄生虫感染の治療のためのテトラサイクリン誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014167027A JP2014167027A (ja) | 2014-09-11 |
| JP2014167027A5 true JP2014167027A5 (enExample) | 2014-11-13 |
| JP6061897B2 JP6061897B2 (ja) | 2017-01-18 |
Family
ID=39495878
Family Applications (8)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009542938A Active JP5583411B2 (ja) | 2006-12-21 | 2007-12-21 | 細菌感染、ウイルス感染、および寄生虫感染の治療のためのテトラサイクリン誘導体 |
| JP2010283844A Pending JP2011093914A (ja) | 2006-12-21 | 2010-12-20 | 細菌感染、ウイルス感染、および寄生虫感染の治療のためのテトラサイクリン誘導体 |
| JP2014121362A Expired - Fee Related JP6061897B2 (ja) | 2006-12-21 | 2014-06-12 | 細菌感染、ウイルス感染、および寄生虫感染の治療のためのテトラサイクリン誘導体 |
| JP2015160343A Withdrawn JP2015205939A (ja) | 2006-12-21 | 2015-08-17 | 細菌感染、ウイルス感染、および寄生虫感染の治療のためのテトラサイクリン誘導体 |
| JP2017238683A Ceased JP2018039846A (ja) | 2006-12-21 | 2017-12-13 | 細菌感染、ウイルス感染、および寄生虫感染の治療のためのテトラサイクリン誘導体 |
| JP2019038753A Withdrawn JP2019081802A (ja) | 2006-12-21 | 2019-03-04 | 細菌感染、ウイルス感染、および寄生虫感染の治療のためのテトラサイクリン誘導体 |
| JP2021010842A Withdrawn JP2021063137A (ja) | 2006-12-21 | 2021-01-27 | 細菌感染、ウイルス感染、および寄生虫感染の治療のためのテトラサイクリン誘導体 |
| JP2023199075A Pending JP2024009235A (ja) | 2006-12-21 | 2023-11-24 | 細菌感染、ウイルス感染、および寄生虫感染の治療のためのテトラサイクリン誘導体 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009542938A Active JP5583411B2 (ja) | 2006-12-21 | 2007-12-21 | 細菌感染、ウイルス感染、および寄生虫感染の治療のためのテトラサイクリン誘導体 |
| JP2010283844A Pending JP2011093914A (ja) | 2006-12-21 | 2010-12-20 | 細菌感染、ウイルス感染、および寄生虫感染の治療のためのテトラサイクリン誘導体 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015160343A Withdrawn JP2015205939A (ja) | 2006-12-21 | 2015-08-17 | 細菌感染、ウイルス感染、および寄生虫感染の治療のためのテトラサイクリン誘導体 |
| JP2017238683A Ceased JP2018039846A (ja) | 2006-12-21 | 2017-12-13 | 細菌感染、ウイルス感染、および寄生虫感染の治療のためのテトラサイクリン誘導体 |
| JP2019038753A Withdrawn JP2019081802A (ja) | 2006-12-21 | 2019-03-04 | 細菌感染、ウイルス感染、および寄生虫感染の治療のためのテトラサイクリン誘導体 |
| JP2021010842A Withdrawn JP2021063137A (ja) | 2006-12-21 | 2021-01-27 | 細菌感染、ウイルス感染、および寄生虫感染の治療のためのテトラサイクリン誘導体 |
| JP2023199075A Pending JP2024009235A (ja) | 2006-12-21 | 2023-11-24 | 細菌感染、ウイルス感染、および寄生虫感染の治療のためのテトラサイクリン誘導体 |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US8318706B2 (enExample) |
| EP (6) | EP3045449A1 (enExample) |
| JP (8) | JP5583411B2 (enExample) |
| KR (1) | KR101538175B1 (enExample) |
| AU (1) | AU2007338747B2 (enExample) |
| BR (1) | BRPI0720569B8 (enExample) |
| CA (3) | CA2925939C (enExample) |
| DK (1) | DK2109602T3 (enExample) |
| ES (2) | ES2548261T3 (enExample) |
| IL (4) | IL302749A (enExample) |
| MX (1) | MX2009006846A (enExample) |
| PL (1) | PL2109602T3 (enExample) |
| PT (1) | PT2109602E (enExample) |
| SI (1) | SI2109602T1 (enExample) |
| WO (1) | WO2008079339A2 (enExample) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8088820B2 (en) | 2001-04-24 | 2012-01-03 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for the treatment of malaria |
| CA2585418A1 (en) | 2004-10-25 | 2006-05-04 | Paratek Pharmaceuticals, Inc. | 4-aminotetracyclines and methods of use thereof |
| AU2006210406C1 (en) | 2005-02-04 | 2013-03-07 | Paratek Pharmaceuticals, Inc. | 11a, 12-derivatives of tetracycline compounds |
| WO2008045507A2 (en) | 2006-10-11 | 2008-04-17 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for treatment of bacillus anthracis infections |
| CA2673486C (en) | 2006-12-21 | 2015-09-08 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for treatment of inflammatory skin disorders |
| EP3045449A1 (en) * | 2006-12-21 | 2016-07-20 | Paratek Pharmaceuticals, Inc. | Tetracycline derivatives for the treatment of bacterial, viral and parasitic infections |
| EA201070048A1 (ru) * | 2007-07-06 | 2010-10-29 | Паратек Фармасьютикалс, Инк. | Способы синтеза замещённых соединений тетрациклина (варианты) |
| BRPI0908951A2 (pt) | 2008-03-05 | 2017-01-17 | Paratek Pharm Innc | compostos de minociclina e método de uso dos mesmos |
| EP2276342A4 (en) * | 2008-04-14 | 2012-02-22 | Paratek Pharm Innc | SUBSTITUTED TETRACYCLIN COMPOUNDS |
| WO2010033939A1 (en) * | 2008-09-19 | 2010-03-25 | Paratek Pharmaceuticals, Inc. | Tetracycline compounds for the treatment of rheumatoid arthritis and related methods of treatment |
| ES2627772T3 (es) | 2009-05-08 | 2017-07-31 | Tetraphase Pharmaceuticals, Inc. | Compuestos de tetraciclina |
| WO2011025982A2 (en) * | 2009-08-28 | 2011-03-03 | Tetraphase Pharmaceuticals, Inc. | Tetracycline compounds |
| US8754054B2 (en) | 2010-07-09 | 2014-06-17 | Albany Molecular Research, Inc. | Antibacterial compounds, methods of making them, and uses thereof |
| PT2707003T (pt) * | 2011-05-12 | 2019-08-05 | Paratek Pharm Innc | Sais cristalinos da amida do ácido (4s,4as,5ar,12as)-4-dimetilamino-3,10,12,12a-tetra-hidroxi-7-[(metoxi(metil)amino]-metil]-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octa-hidro-naftaceno-2-carboxílico e métodos de utilização dos mesmos |
| HUE036696T2 (hu) * | 2011-07-26 | 2018-07-30 | Kbp Biosciences Usa Inc | 9-aminometil-szubsztituált tetraciklin-vegyületek |
| WO2013072703A1 (en) * | 2011-11-18 | 2013-05-23 | Redx Pharma Limited | Antibacterial drug derivatives |
| CN103387512B (zh) * | 2012-05-08 | 2016-08-31 | 成都睿智化学研究有限公司 | 一种米诺环素的制备方法及其中间体 |
| JP2015517524A (ja) * | 2012-05-14 | 2015-06-22 | パラテック ファーマシューティカルズ インコーポレイテッド | （４Ｓ，４ａＳ，５ａＲ，１２ａＳ）−４−ジメチルアミノ−３，１０，１２，１２ａ−テトラヒドロキシ−７−［（メトキシ（メチル）アミノ）−メチル］−１，１１−ジオキソ−１，４，４ａ，５，５ａ，６，１１，１２ａ−オクタヒドロ−ナフタセン−２−カルボン酸アミドの使用方法 |
| JP6522498B2 (ja) * | 2012-05-30 | 2019-05-29 | パラテック ファーマシューティカルズ インコーポレイテッド | ７−二置換フェニルテトラサイクリン誘導体 |
| HK1210593A1 (en) * | 2012-07-13 | 2016-04-29 | Paratek Pharmaceuticals, Inc. | Tetracycline compounds for treating neurodegenerative disorders |
| AU2013308504B2 (en) | 2012-08-31 | 2016-11-10 | Tetraphase Pharmaceuticals, Inc. | Tetracycline compounds |
| JP2016089002A (ja) * | 2014-10-31 | 2016-05-23 | 出光興産株式会社 | ベンゾフラノチオフェン骨格を有するモノマー及びポリマー、及びそのポリマーを用いた有機薄膜太陽電池材料 |
| DE102015013086A1 (de) | 2015-10-01 | 2017-04-06 | Jutta Regina Giller | Attika für Gebäude |
| GB201615693D0 (en) | 2016-09-15 | 2016-11-02 | Combinatorx Infection Ltd | Combinations |
| KR102880712B1 (ko) | 2016-10-19 | 2025-11-03 | 테트라페이즈 파마슈티컬스, 인코포레이티드 | 에라바사이클린의 결정질 형태 |
| WO2018085216A1 (en) | 2016-11-01 | 2018-05-11 | Paratek Pharmaceuticals, Inc. | 9-aminomethyl minocycline compounds and use thereof in treating community-acquire bacterial pneumonia (cabp) |
| JP2020527607A (ja) | 2017-07-21 | 2020-09-10 | アルミラール・リミテッド・ライアビリティ・カンパニーＡｌｍｉｒａｌｌ， Ｌｌｃ | 非炎症性病変の処置 |
| KR102011721B1 (ko) * | 2017-11-28 | 2019-08-19 | 고려대학교 산학협력단 | 포도상구균의 생육을 억제하는 한천 유래 올리고당의 용도 |
| AU2019248350B2 (en) * | 2018-04-06 | 2023-07-27 | Almirall, Llc | Process for making sarecycline hydrochloride |
| CN109970590A (zh) * | 2018-12-20 | 2019-07-05 | 深圳市祥根生物科技有限公司 | 一种7-氨基米诺环素的制备方法 |
| CN109574868B (zh) * | 2018-12-28 | 2021-11-16 | 天津阿尔塔科技有限公司 | 一种四环素类及其差向异构体氘代内标物的制备方法 |
| WO2020263484A1 (en) * | 2019-06-28 | 2020-12-30 | Mayo Foundation For Medical Education And Research | Methods and materials for treating neuromyelitis optica spectrum diseases |
| WO2021231314A1 (en) * | 2020-05-11 | 2021-11-18 | Paratek Pharmaceuticals Inc. | Methods of treating covid-19 using tetracycline compounds |
| CN111574392A (zh) * | 2020-05-27 | 2020-08-25 | 浙江工业大学 | 一种6-去甲基-6-脱水四环素的制备方法 |
| WO2025175063A1 (en) * | 2024-02-14 | 2025-08-21 | Cyclone Therapeutics, Inc. | Tetracycline derivatives, and uses thereof |
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