JP2014139220A5 - - Google Patents
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- Publication number
- JP2014139220A5 JP2014139220A5 JP2014061763A JP2014061763A JP2014139220A5 JP 2014139220 A5 JP2014139220 A5 JP 2014139220A5 JP 2014061763 A JP2014061763 A JP 2014061763A JP 2014061763 A JP2014061763 A JP 2014061763A JP 2014139220 A5 JP2014139220 A5 JP 2014139220A5
- Authority
- JP
- Japan
- Prior art keywords
- patient
- drug
- administered
- parathyroid hormone
- risk
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 claims description 23
- 229940079593 drug Drugs 0.000 claims description 16
- 206010041569 spinal fracture Diseases 0.000 claims description 9
- 102000003982 Parathyroid hormone Human genes 0.000 claims description 7
- 108090000445 Parathyroid hormone Proteins 0.000 claims description 7
- 239000000199 parathyroid hormone Substances 0.000 claims description 7
- 229960001319 parathyroid hormone Drugs 0.000 claims description 7
- 101001135770 Homo sapiens Parathyroid hormone Proteins 0.000 claims description 6
- 101001135995 Homo sapiens Probable peptidyl-tRNA hydrolase Proteins 0.000 claims description 6
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 6
- 102000058004 human PTH Human genes 0.000 claims description 6
- 208000001132 Osteoporosis Diseases 0.000 claims description 4
- 238000010254 subcutaneous injection Methods 0.000 claims description 4
- 239000007929 subcutaneous injection Substances 0.000 claims description 4
- 239000004480 active ingredient Substances 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 238000000034 method Methods 0.000 description 7
- 210000000988 bone and bone Anatomy 0.000 description 6
- 206010017076 Fracture Diseases 0.000 description 3
- 208000011327 Increased bone mineral density Diseases 0.000 description 1
- 230000001054 cortical effect Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9715198P | 1998-08-19 | 1998-08-19 | |
| US60/097,151 | 1998-08-19 | ||
| US9974698P | 1998-09-10 | 1998-09-10 | |
| US60/099,746 | 1998-09-10 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010244314A Division JP2011021035A (ja) | 1998-08-19 | 2010-10-29 | 骨の靭性、及び、剛性を増し、骨折を減少させる方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014204577A Division JP2015028065A (ja) | 1998-08-19 | 2014-10-03 | 骨の靭性、及び、剛性を増し、骨折を減少させる方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014139220A JP2014139220A (ja) | 2014-07-31 |
| JP2014139220A5 true JP2014139220A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 2014-09-25 |
| JP6177718B2 JP6177718B2 (ja) | 2017-08-09 |
Family
ID=26792729
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000565916A Pending JP2002523375A (ja) | 1998-08-19 | 1999-08-19 | 骨の靭性、及び、剛性を増し、骨折を減少させる方法 |
| JP2010244314A Withdrawn JP2011021035A (ja) | 1998-08-19 | 2010-10-29 | 骨の靭性、及び、剛性を増し、骨折を減少させる方法 |
| JP2014061763A Expired - Lifetime JP6177718B2 (ja) | 1998-08-19 | 2014-03-25 | 骨の靭性、及び、剛性を増し、骨折を減少させる方法 |
| JP2014204577A Withdrawn JP2015028065A (ja) | 1998-08-19 | 2014-10-03 | 骨の靭性、及び、剛性を増し、骨折を減少させる方法 |
| JP2017124301A Withdrawn JP2017190332A (ja) | 1998-08-19 | 2017-06-26 | 骨の靭性、及び、剛性を増し、骨折を減少させる方法 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000565916A Pending JP2002523375A (ja) | 1998-08-19 | 1999-08-19 | 骨の靭性、及び、剛性を増し、骨折を減少させる方法 |
| JP2010244314A Withdrawn JP2011021035A (ja) | 1998-08-19 | 2010-10-29 | 骨の靭性、及び、剛性を増し、骨折を減少させる方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014204577A Withdrawn JP2015028065A (ja) | 1998-08-19 | 2014-10-03 | 骨の靭性、及び、剛性を増し、骨折を減少させる方法 |
| JP2017124301A Withdrawn JP2017190332A (ja) | 1998-08-19 | 2017-06-26 | 骨の靭性、及び、剛性を増し、骨折を減少させる方法 |
Country Status (32)
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6770623B1 (en) * | 1997-12-09 | 2004-08-03 | Eli Lilly And Company | Stabilized teriparatide solutions |
| AR033639A1 (es) * | 1998-08-19 | 2004-01-07 | Lilly Co Eli | Uso de hormonas paratiroideas para preparar medicamentos para reducir el riesgo de fracturas oseas vertebrales o no vertebrales en seres humanos con riesgo de padecer o que padecen osteoporosis |
| US20040033950A1 (en) * | 2000-09-26 | 2004-02-19 | Hock Janet M. | Method of increasing bone toughness and stiffness and reducing fractures |
| EP1222465A1 (en) * | 1999-09-20 | 2002-07-17 | Eli Lilly And Company | Method for monitoring treatment with a parathyroid hormone |
| US7247609B2 (en) | 2001-12-18 | 2007-07-24 | Universitat Zurich | Growth factor modified protein matrices for tissue engineering |
| AU2003207512B2 (en) * | 2002-01-10 | 2008-06-12 | Osteotrophin Llc | Treatment of bone disorders with skeletal anabolic drugs |
| US8088734B2 (en) | 2003-01-21 | 2012-01-03 | Unigene Laboratories Inc. | Oral delivery of peptides |
| RU2006108557A (ru) * | 2003-09-19 | 2007-09-27 | Пфайзер Продактс Инк. (Us) | Фармацевтические композиции, включающие в себя сочетания производных 2-алкилиден-19-нор-витамина d и паратиреоидного гормона, и способы (лечения) |
| US20060127320A1 (en) * | 2004-05-10 | 2006-06-15 | Nastech Pharmaceutical Company Inc. | Method of delivering parathyroid hormone to a human |
| EP1750756A2 (en) * | 2004-05-10 | 2007-02-14 | Nastech Pharmaceutical Company Inc. | Compositions and methods for enhanced mucosal delivery of parathyroid hormone |
| US20060189533A1 (en) * | 2004-05-10 | 2006-08-24 | Nastech Pharmaceutical Company Inc. | Stable pharmaceutical dosage forms of teriparatide |
| US20060052305A1 (en) * | 2004-05-10 | 2006-03-09 | Nastech Pharmaceutical Company Inc. | Method of treating osteoporosis using intranasal parathyroid hormone |
| ES2568259T3 (es) | 2004-05-13 | 2016-04-28 | Alza Corporation | Aparato y método para la administración transdérmica de agentes de hormona paratiroidea |
| WO2006124062A1 (en) * | 2005-05-11 | 2006-11-23 | Unigene Laboratories, Inc. | Method for fostering bone formation and preservation |
| US7648965B2 (en) | 2004-05-14 | 2010-01-19 | Unigene Laboratories Inc. | Method for fostering bone formation and preservation |
| US20060069021A1 (en) * | 2004-08-13 | 2006-03-30 | Nastech Pharmaceutical Company Inc. | Compositions and methods for intranasal administration of inactive analogs of PTH or inactivated preparations of PTH or PTH analogs |
| US8575101B2 (en) | 2005-01-06 | 2013-11-05 | Kuros Biosurgery Ag | Supplemented matrices for the repair of bone fractures |
| WO2006073711A2 (en) | 2005-01-06 | 2006-07-13 | Kuros Biosurgery Ag | Use of a matrix comprising a contrast agent in soft tissues |
| US20070173447A1 (en) * | 2005-10-25 | 2007-07-26 | Nastech Pharmaceutical Company Inc. | Method for treating osteoporosis by intranasal delivery of teriparatide with an anti-resorptive agent |
| CN101355959B (zh) * | 2005-11-10 | 2013-02-27 | 密歇根理工大学管理委员会 | 黑熊甲状旁腺素和使用黑熊甲状旁腺素的方法 |
| US20080051332A1 (en) * | 2005-11-18 | 2008-02-28 | Nastech Pharmaceutical Company Inc. | Method of modulating hematopoietic stem cells and treating hematologic diseases using intranasal parathyroid hormone |
| US20080119408A1 (en) * | 2006-07-07 | 2008-05-22 | Nastech Pharmaceutical Company Inc. | Pth formulations for intranasal delivery |
| EP1961765A1 (en) * | 2006-12-08 | 2008-08-27 | Zealand Pharma A/S | Truncated PTH peptides with a cyclic conformation |
| WO2008125655A1 (en) | 2007-04-13 | 2008-10-23 | Kuros Biosurgery Ag | Polymeric tissue sealant |
| US20110137243A1 (en) * | 2007-09-06 | 2011-06-09 | Abbott Cardiovascular Systems Inc. | Coating On A Balloon Device |
| WO2009072119A2 (en) * | 2007-12-04 | 2009-06-11 | Ben-Gurion University Of The Negev Research And Development Authority | Amphiphilic peptide matrices for treatment of osteoporosis |
| EP2227263A2 (en) | 2007-12-28 | 2010-09-15 | Kuros Biosurgery AG | Pdgf fusion proteins incorporated into fibrin foams |
| ES2843649T3 (es) | 2009-09-09 | 2021-07-20 | Asahi Kasei Pharma Corp | Agente terapéutico/profiláctico que contiene PTH para la osteoporosis, caracterizado porque la PTH se administra una vez por semana en una dosis unitaria de 200 unidades |
| US8987201B2 (en) | 2009-12-07 | 2015-03-24 | Michigan Technological University | Black bear parathyroid hormone and methods of using black bear parathyroid hormone |
| US9295663B2 (en) | 2010-07-14 | 2016-03-29 | Abbott Cardiovascular Systems Inc. | Drug coated balloon with in-situ formed drug containing microspheres |
| WO2012111852A1 (ja) * | 2011-02-17 | 2012-08-23 | 帝人ファーマ株式会社 | 椎体骨折治療剤及びその評価方法 |
| WO2012123028A1 (en) | 2011-03-16 | 2012-09-20 | Kuros Biosurgery Ag | Pharmaceutical formulation for use in spinal fusion |
| ES2761635T3 (es) | 2011-06-07 | 2020-05-20 | Asahi Kasei Pharma Corp | Preparación liofilizada que contiene PTH de alta pureza y método para producirla |
| US9700485B2 (en) | 2013-04-24 | 2017-07-11 | Corning Incorporated | Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients |
| WO2017136195A1 (en) | 2016-02-01 | 2017-08-10 | Eli Lilly And Company | Parathyroid hormone – anti-rankl antibody fusion compounds |
| US20190381341A1 (en) * | 2017-02-01 | 2019-12-19 | The Johns Hopkins University | Parathyroid hormone and regeneration of degenerative discs disease |
| CN110996988A (zh) * | 2017-09-22 | 2020-04-10 | 旭化成制药株式会社 | 稳定性优异的含有特立帕肽的液态药物组合物 |
| CN111447943A (zh) | 2018-10-29 | 2020-07-24 | 旭化成制药株式会社 | 以按每周2次的频率给予特立帕肽或其盐为特征的骨质疏松症的预防或治疗方法 |
| JP7684951B2 (ja) | 2019-08-09 | 2025-05-28 | フラッグシップ・パイオニアリング・イノベーションズ・ブイアイ，エルエルシー | 副甲状腺ホルモン受容体（ｐｔｈｒ１）の調節剤 |
| GB2590692A (en) * | 2019-12-24 | 2021-07-07 | Corthotec Ltd | Composition for improved bone fracture healing |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4086196A (en) | 1975-03-28 | 1978-04-25 | Armour Pharmaceutical Company | Parathyroid hormone |
| IL78342A (en) * | 1985-04-04 | 1991-06-10 | Gen Hospital Corp | Pharmaceutical composition for treatment of osteoporosis in humans comprising a parathyroid hormone or a fragment thereof |
| DE3935738A1 (de) | 1989-10-27 | 1991-05-08 | Forssmann Wolf Georg | Arzneimittel, enthaltend das humane parathormon-fragment (1-37) als aktiven wirkstoff |
| US5208041A (en) | 1991-05-23 | 1993-05-04 | Allelix Biopharmaceuticals Inc. | Essentially pure human parathyroid hormone |
| CA2126299C (en) | 1994-06-20 | 2000-12-12 | Gordon E. Willick | Parathyroid hormone analogues for the treatment of osteoporosis |
| JPH0873376A (ja) | 1994-09-07 | 1996-03-19 | Asahi Chem Ind Co Ltd | 骨粗鬆症治療薬 |
| US5747456A (en) * | 1994-12-19 | 1998-05-05 | Beth Israel Deaconess Medical Center | Continuous low-dose administration of parathyroid hormone or its agonist |
| EP0800405A4 (en) * | 1994-12-19 | 1998-11-11 | Beth Israel Hospital | CONTINUOUS LOW-DOSE ADMINISTRATION OF PARATHYROIDHORMONE OR THEIR AGONIST |
| HU218940B (hu) * | 1994-12-22 | 2001-01-29 | Astra Aktiebolag | Paratiroid hormont (PHT) tartalmazó, inhalációs célra szolgáló gyógyszerkészítmény, eljárás előállítására, alkalmazása inhalációs készülék töltésére és ezt tartalmazó inhalációs készülék |
| JPH08310965A (ja) * | 1995-05-16 | 1996-11-26 | Chugai Pharmaceut Co Ltd | 骨癒合促進剤 |
| IL134719A0 (en) * | 1997-09-09 | 2001-04-30 | Hoffmann La Roche | FRACTURE HEALING USING PTHrP ANALOGS |
| MY120063A (en) | 1997-12-09 | 2005-08-30 | Lilly Co Eli | Stabilized teriparatide solutions |
| AR033639A1 (es) | 1998-08-19 | 2004-01-07 | Lilly Co Eli | Uso de hormonas paratiroideas para preparar medicamentos para reducir el riesgo de fracturas oseas vertebrales o no vertebrales en seres humanos con riesgo de padecer o que padecen osteoporosis |
| US20040033950A1 (en) * | 2000-09-26 | 2004-02-19 | Hock Janet M. | Method of increasing bone toughness and stiffness and reducing fractures |
| US6907597B1 (en) | 2000-10-13 | 2005-06-14 | Ati International Srl | Method and apparatus for constructing an executable program in memory |
| US6967759B2 (en) | 2001-12-31 | 2005-11-22 | Texas Instruments Incorporated | Pulse width modulation sequence generation |
| JP5796714B2 (ja) | 2012-01-13 | 2015-10-21 | 株式会社リコー | 定着装置及び画像形成装置 |
| EP2949301B1 (en) | 2014-05-27 | 2018-04-18 | The Procter and Gamble Company | Absorbent core with curved and straight absorbent material areas |
-
1999
- 1999-08-18 AR ARP990104133A patent/AR033639A1/es unknown
- 1999-08-18 DZ DZ990173A patent/DZ2873A1/xx active
- 1999-08-19 DK DK06027055.0T patent/DK1769804T3/da active
- 1999-08-19 DE DE69904918T patent/DE69904918T2/de not_active Expired - Lifetime
- 1999-08-19 CN CNB998083534A patent/CN1205997C/zh not_active Expired - Lifetime
- 1999-08-19 DE DE15152726.4T patent/DE15152726T1/de active Pending
- 1999-08-19 MY MYPI99003553A patent/MY129227A/en unknown
- 1999-08-19 PT PT99942350T patent/PT1059933E/pt unknown
- 1999-08-19 EA EA200001015A patent/EA003362B1/ru not_active IP Right Cessation
- 1999-08-19 PT PT101804474T patent/PT2266598T/pt unknown
- 1999-08-19 HU HUP1200430 patent/HU1200430D0/hu not_active Application Discontinuation
- 1999-08-19 AT AT99942350T patent/ATE231000T1/de not_active IP Right Cessation
- 1999-08-19 AU AU55750/99A patent/AU746277B2/en not_active Expired
- 1999-08-19 ES ES06027055T patent/ES2393200T3/es not_active Expired - Lifetime
- 1999-08-19 CO CO99052525A patent/CO5130020A1/es unknown
- 1999-08-19 ES ES15152726.4T patent/ES2549551T3/es not_active Expired - Lifetime
- 1999-08-19 EP EP15152726.4A patent/EP2907522B1/en not_active Revoked
- 1999-08-19 TR TR2000/03455T patent/TR200003455T2/xx unknown
- 1999-08-19 PL PL343595A patent/PL201688B1/pl not_active IP Right Cessation
- 1999-08-19 UA UA2000095457A patent/UA72205C2/uk unknown
- 1999-08-19 NZ NZ507056A patent/NZ507056A/en not_active IP Right Cessation
- 1999-08-19 ID IDW20010612A patent/ID29039A/id unknown
- 1999-08-19 WO PCT/US1999/018961 patent/WO2000010596A1/en active IP Right Grant
- 1999-08-19 PT PT15152726T patent/PT2907522T/pt unknown
- 1999-08-19 DK DK15152726.4T patent/DK2907522T3/en active
- 1999-08-19 US US09/647,278 patent/US6977077B1/en not_active Expired - Lifetime
- 1999-08-19 CA CA002325371A patent/CA2325371C/en not_active Expired - Lifetime
- 1999-08-19 PE PE1999000839A patent/PE20001089A1/es not_active Application Discontinuation
- 1999-08-19 JP JP2000565916A patent/JP2002523375A/ja active Pending
- 1999-08-19 ES ES99942350T patent/ES2190244T3/es not_active Expired - Lifetime
- 1999-08-19 HR HR20000755A patent/HRP20000755A2/hr not_active Application Discontinuation
- 1999-08-19 CZ CZ20004134A patent/CZ301017B6/cs not_active IP Right Cessation
- 1999-08-19 EP EP99942350A patent/EP1059933B1/en not_active Revoked
- 1999-08-19 HU HU0101594A patent/HU230697B1/hu unknown
- 1999-08-19 DK DK99942350T patent/DK1059933T3/da active
- 1999-08-19 IL IL13882999A patent/IL138829A0/xx unknown
- 1999-08-19 DK DK10180447.4T patent/DK2266598T3/en active
- 1999-08-19 ES ES10180447.4T patent/ES2621653T3/es not_active Expired - Lifetime
- 1999-08-19 BR BR9909445-2A patent/BR9909445A/pt not_active Application Discontinuation
- 1999-08-19 PT PT06027055T patent/PT1769804E/pt unknown
- 1999-08-19 KR KR10-2001-7002092A patent/KR100454207B1/ko not_active Expired - Lifetime
- 1999-08-19 EP EP10180447.4A patent/EP2266598B1/en not_active Expired - Lifetime
- 1999-10-26 TW TW088114185A patent/TW576747B/zh not_active IP Right Cessation
-
2000
- 2000-10-03 IL IL138829A patent/IL138829A/en unknown
- 2000-11-24 NO NO20005947A patent/NO323984B1/no not_active IP Right Cessation
-
2005
- 2005-04-05 US US11/098,894 patent/US7163684B2/en not_active Expired - Lifetime
-
2007
- 2007-06-11 NO NO20072983A patent/NO20072983L/no not_active Application Discontinuation
-
2010
- 2010-10-29 JP JP2010244314A patent/JP2011021035A/ja not_active Withdrawn
-
2012
- 2012-11-14 CY CY20121101096T patent/CY1113343T1/el unknown
-
2014
- 2014-03-25 JP JP2014061763A patent/JP6177718B2/ja not_active Expired - Lifetime
- 2014-10-03 JP JP2014204577A patent/JP2015028065A/ja not_active Withdrawn
-
2017
- 2017-06-26 JP JP2017124301A patent/JP2017190332A/ja not_active Withdrawn
- 2017-10-13 CY CY20171101077T patent/CY1119552T1/el unknown
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