JP2014138849A - 薬剤容器 - Google Patents

薬剤容器 Download PDF

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JP2014138849A
JP2014138849A JP2014000391A JP2014000391A JP2014138849A JP 2014138849 A JP2014138849 A JP 2014138849A JP 2014000391 A JP2014000391 A JP 2014000391A JP 2014000391 A JP2014000391 A JP 2014000391A JP 2014138849 A JP2014138849 A JP 2014138849A
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container
medicament
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Raymond Bacon
ベーコン，レイモンド
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Clinical Designs Ltd
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C49/00—Blow-moulding, i.e. blowing a preform or parison to a desired shape within a mould; Apparatus therefor
    • B29C49/20—Blow-moulding, i.e. blowing a preform or parison to a desired shape within a mould; Apparatus therefor of articles having inserts or reinforcements ; Handling of inserts or reinforcements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
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    • B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
    • B29C45/16—Making multilayered or multicoloured articles
    • B29C45/1635—Making multilayered or multicoloured articles using displaceable mould parts, e.g. retractable partition between adjacent mould cavities
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D1/00—Containers having bodies formed in one piece, e.g. by casting metallic material, by moulding plastics, by blowing vitreous material, by throwing ceramic material, by moulding pulped fibrous material, by deep-drawing operations performed on sheet material
    • B65D1/02—Bottles or similar containers with necks or like restricted apertures, designed for pouring contents
    • B65D1/0207—Bottles or similar containers with necks or like restricted apertures, designed for pouring contents characterised by material, e.g. composition, physical features
    • B65D1/0215—Bottles or similar containers with necks or like restricted apertures, designed for pouring contents characterised by material, e.g. composition, physical features multilayered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
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    • B29C2049/2017—Blow-moulding, i.e. blowing a preform or parison to a desired shape within a mould; Apparatus therefor of articles having inserts or reinforcements ; Handling of inserts or reinforcements outside the article
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    • B29C49/00—Blow-moulding, i.e. blowing a preform or parison to a desired shape within a mould; Apparatus therefor
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    • B29C2049/2021—Inserts characterised by the material or type
    • B29C2049/2047—Tubular inserts, e.g. tubes
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    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
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    • B29C49/00—Blow-moulding, i.e. blowing a preform or parison to a desired shape within a mould; Apparatus therefor
    • B29C49/20—Blow-moulding, i.e. blowing a preform or parison to a desired shape within a mould; Apparatus therefor of articles having inserts or reinforcements ; Handling of inserts or reinforcements
    • B29C2049/2021—Inserts characterised by the material or type
    • B29C2049/2065—Inserts characterised by the material or type for reinforcing specific areas of the final blow moulded article
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
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    • B29C2049/2414—Linings or labels, e.g. specific geometry, multi-layered or material
    • B29C2049/2422—Cylindrical or sleeve shaped linings or labels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C2949/00—Indexing scheme relating to blow-moulding
    • B29C2949/07—Preforms or parisons characterised by their configuration
    • B29C2949/0715—Preforms or parisons characterised by their configuration the preform having one end closed
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
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    • B29C2949/00—Indexing scheme relating to blow-moulding
    • B29C2949/30—Preforms or parisons made of several components
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C2949/00—Indexing scheme relating to blow-moulding
    • B29C2949/30—Preforms or parisons made of several components
    • B29C2949/3012—Preforms or parisons made of several components at flange portion
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C2949/00—Indexing scheme relating to blow-moulding
    • B29C2949/30—Preforms or parisons made of several components
    • B29C2949/3016—Preforms or parisons made of several components at body portion
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C2949/00—Indexing scheme relating to blow-moulding
    • B29C2949/30—Preforms or parisons made of several components
    • B29C2949/302—Preforms or parisons made of several components at bottom portion
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C2949/00—Indexing scheme relating to blow-moulding
    • B29C2949/30—Preforms or parisons made of several components
    • B29C2949/3024—Preforms or parisons made of several components characterised by the number of components or by the manufacturing technique
    • B29C2949/3026—Preforms or parisons made of several components characterised by the number of components or by the manufacturing technique having two or more components
    • B29C2949/3028—Preforms or parisons made of several components characterised by the number of components or by the manufacturing technique having two or more components having three or more components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C2949/00—Indexing scheme relating to blow-moulding
    • B29C2949/30—Preforms or parisons made of several components
    • B29C2949/3032—Preforms or parisons made of several components having components being injected
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C49/00—Blow-moulding, i.e. blowing a preform or parison to a desired shape within a mould; Apparatus therefor
    • B29C49/02—Combined blow-moulding and manufacture of the preform or the parison
    • B29C49/06—Injection blow-moulding
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C49/00—Blow-moulding, i.e. blowing a preform or parison to a desired shape within a mould; Apparatus therefor
    • B29C49/08—Biaxial stretching during blow-moulding
    • B29C49/10—Biaxial stretching during blow-moulding using mechanical means for prestretching
    • B29C49/12—Stretching rods
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C49/00—Blow-moulding, i.e. blowing a preform or parison to a desired shape within a mould; Apparatus therefor
    • B29C49/24—Lining or labelling
    • B29C49/251—Lining or labelling explicit lining
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2023/00—Use of polyalkenes or derivatives thereof as moulding material
    • B29K2023/10—Polymers of propylene
    • B29K2023/12—PP, i.e. polypropylene
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2027/00—Use of polyvinylhalogenides or derivatives thereof as moulding material
    • B29K2027/12—Use of polyvinylhalogenides or derivatives thereof as moulding material containing fluorine
    • B29K2027/18—PTFE, i.e. polytetrafluorethene, e.g. ePTFE, i.e. expanded polytetrafluorethene
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2077/00—Use of PA, i.e. polyamides, e.g. polyesteramides or derivatives thereof, as moulding material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2105/00—Condition, form or state of moulded material or of the material to be shaped
    • B29K2105/25—Solid
    • B29K2105/253—Preform
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D83/00—Containers or packages with special means for dispensing contents
    • B65D83/14—Containers or packages with special means for dispensing contents for delivery of liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant for a product delivered by a propellant
    • B65D83/44—Valves specially adapted therefor; Regulating devices
    • B65D83/52—Valves specially adapted therefor; Regulating devices for metering
    • B65D83/54—Metering valves ; Metering valve assemblies
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/13—Hollow or container type article [e.g., tube, vase, etc.]
    • Y10T428/1352—Polymer or resin containing [i.e., natural or synthetic]

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  • Medicines Containing Plant Substances (AREA)
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Abstract

【課題】定量放出弁を有する薬剤源は、従来、アルミニウム製容器を備えているため、使用者は、薬剤の残量を見ることができない。残りの投与回数を判断できるように、弁の操作回数を計数する高価な計数器が備えられつつある。視覚的に判断を与える代替手段を提供する。
【解決手段】容器２と圧着栓３とを有する薬剤源１。容器は、透明または半透明の高分子材からなり、アルミニウム製の穴の明いた外側スリーブを有して、圧力保持のための機械的強度を与える。高分子材は、３つの層からなる。内側の層は、薬剤およびその高圧ガスが反応または結合しない不活性層をなすように、ＰＴＦＥ材からなる。中間の層は、分子がＰＴＦＥ層を通過できる可能性のある高圧ガスを収容するための耐高圧ガス層をなすように、ナイロン材からなる。外側の層は、容器の耐水性および機械的完全性の両方を与えるために、ポリプロピレンからなる。
【選択図】図１

Description

本発明は、薬剤用の容器に関し、より具体的には、非限定的に、加圧された薬剤源での使用のための容器に関する。
定量放出弁を有する薬剤源は、従来、薬剤のアルミニウム製容器を備えている。そのため、使用者は、薬剤の残量を見ることができない。
残りの投与回数を使用者が判断できるように、弁の操作回数を計数する高価な計数器が備えられつつある。
本発明の目的は、すなわち視覚的に、上記判断を与える代替手段を提供することである。
[請求項１]
薬剤源における薬剤用の容器であって、
前記薬剤源の栓のための縁部を備えた口を有し、
前記容器が、高分子材料からなる複数の層を含み、前記複数の層が、
撥物質性の内側の層と、
気密性および液体不透過性の外側の層と
を少なくとも備え、前記２つの層が透明または少なくとも半透明の材料からなる容器。
[請求項２]
薬剤源における薬剤用の容器であって、
前記薬剤源の栓のための縁部を備えた口を有し、
前記容器が、高分子材料からなる複数の層を含み、前記複数の層が、
撥物質性の内側の層と、
気密性の第２の層と、
液体不透過性の第３の層と
を少なくとも備え、前記３つの層が透明または少なくとも半透明の材料からなる容器。
[請求項３]
前記気密性の層が、前記液体不透性の層の内側にある請求項２に記載の容器。
[請求項４]
前記気密性の層が、前記液体不透性の層の外側にある請求項２に記載の容器。
[請求項５]
溶接栓を含む、請求項１から４のいずれか一項に記載の容器。
[請求項６]
圧着栓を含む、請求項１から４のいずれか一項に記載の容器。
[請求項７]
前記内側の層が、ポリテトラフルオロエチレンからなる請求項１から６のいずれか一項に記載の容器。
[請求項８]
前記気密性の層が、ナイロン材からなる請求項１から７のいずれか一項に記載の容器。
[請求項９]
前記第３の層がある場合は、前記第３の層がポリプロピレン材からなる請求項１から８のいずれか一項に記載の容器。
[請求項１０]
補強層を含む請求項１から９のいずれか一項に記載の容器。
[請求項１１]
前記補強層が、穴の明いた金属層である請求項１０に記載の容器。
[請求項１２]
前記補強層が、繊維補強材を含む請求項１０に記載の容器。
[請求項１３]
前記補強層が、成形後の付加によって前記容器に組み込まれる請求項１２に記載の容器。
[請求項１４]
前記補強層が、成形の際に前記容器に組み込まれる請求項１２に記載の容器。
[請求項１５]
前記補強層が、前記容器内の前記薬剤の高さの目視判定のために、穴の明いたもの、糸目の粗い織物からなるもの、または螺旋状に巻回されたものである、請求項１０から１４のいずれか一項に記載の容器。
[請求項１６]
層状のプリフォームを射出成形するステップと、
前記プリフォームを最終形状にブロー成形するステップと
を含む、請求項１または２に記載の容器を成形する方法。
[請求項１７]
補強層が、前記プリフォームをブロー成形する前記ステップの前に、前記ブロー成形型に含められる請求項１６に記載の方法。
本発明の第１の態様に従って、薬剤源における薬剤用の容器が提供され、この容器は、
薬剤源の栓のための縁部を備えた口を有し、
上記容器が、高分子材料からなる複数の層を含み、これらの層が、
撥物質性の内側の層と、
気密性および液体不透過性の外側の層と
を少なくとも備え、これら２つの層が透明または少なくとも半透明の材料からなる。
本発明の第２の態様に従って、薬剤源における薬剤用の容器が提供され、この容器は、
薬剤供給源の栓のための縁部を備えた口を有し、
上記容器が、高分子材料からなる複数の層を含み、これらの層が
撥物質性の内側の層と、
気密性の第２の層と、
液体不透過性の第３の層と
を少なくとも備え、これら３つの層が透明または少なくとも半透明の材料からなる。
気密性の層は、液体不透性の層の内側にあっても、または外側にあってもよい。
他の形態の栓、特に溶接栓が考えられるが、通常の栓は圧着栓であることが望ましい。
内側の層は、容器の内側の表面が、薬剤、または容器の材料による薬剤の吸着によって濡れるのを防止するために設けられる。好適には、ポリテトラフルオロエチレンが内側の層に使用可能である。
容器が加圧された薬剤源において用いられる場合（これは普通のことだが）、圧力の下で薬剤が容器を通って浸透しないように、また、高圧ガスを容器内に保持するように、第２の気密層が設けられる。好適には、ナイロンが第２層に使用可能である。
第３の層は、通常は水である、薬剤の液体担体を保持するように設けられる。好適には、ポリプロピレンが第３の層に使用可能である。第３の層のさらなる目的は、特に薬剤が水分の存在で劣化する可能性がある場合、容器がなくても水分の浸入を止めることである。
補強層が設けられてもよい。補強層は、穴の明いた金属層または繊維補強材であってよい。補強層は、容器の成形の後に加えられてもよく、または成形の際に容器の中に組み込まれてもよい。
補強層は、容器内の薬剤の高さが判定可能であるように、通常、穴の明いたもの、糸目の粗い織物、または場合によっては螺旋状に巻回されたものである。
本発明の第３の態様に従って、第１の態様の容器を作製する方法が提供され、本方法は、
層状のプリフォームを射出成形するステップと、
そのプリフォームを最終形状にブロー成形するステップと
を含む。
プリフォームを適切な形状にブロー成形する前に、補強層がブロー成形型に含められてもよい。
本発明の理解を助けるために、ここで、例によって、また添付の図面を参照して、本発明の特定の実施形態が説明される。
図を参照して、図１の薬剤源１は、本発明の容器２と、圧着栓３とを有する。この栓は、定量式放出弁（図１ではその吐出口４のみが見えている）を容器に対して封止的に保持する。
図２に示すように、容器は、頸部５と、圧着部の位置にある突出した縁部６とを有する。容器は、成形された高分子材７からなり、圧力保持のための機械的強度を与える、アルミニウム製のスリーブである外側の穴明きスリーブ８を有する。頸部は、圧力保持を可能にする比較的厚い壁厚の高分子材を有し、高分子材の端部９は、これも圧力保持のために内向きの半球形である。
高分子材は、３つの層または薄板からなる。最も内側の層はポリテトラフロオロエチエン（ＰＴＦＥ）材からなる。これは、薬剤およびその高圧ガスが、その層といかようにも反応または結合しないように、不活性層として設けられる。中間の高分子層は、ナイロン材からなる。これは、分子がＰＴＦＥ層を通過できる可能性のある高圧ガスを収容するために、耐高圧ガス層１２として設けられる。外側の高分子層１４は、ポリプロピレン（ＰＰ）からなる。この層は、容器の耐水性および機械的完全性の両方を与えるために、他の２つの層より厚い。３つの層は互いに密着し、またＰＰ層がアルミニウム材と密着している。
図３および４を参照して、容器２は、図３に示すプリフォームからブロー成形品として成形され、そのプリフォームは、図４に示す成形型で射出成形される。プリフォームは、容器をより短くずんぐりさせた形状であり、プリフォームの層が、
内側ＰＴＦＥ層２１
中間ナイロン層２２
外側ＰＰ層２４
と称される以外は、別に説明されない。
成形型２５の作動部品のみが示され、その作動部品は、雄部２６と雌部２７とを有する。雄部は、雄芯部２６２に取り付けられた空気抜きタペット弁２６１を除いて、動作部を有さない従来式のもので、雄芯部２６２は、支持板２６３と一体になっている。一方、雌部は、ＰＴＦＥ用の２７２１、ナイロン用の２７２２、およびＰＰ用の２７２３の３つのゲートを有する中央ゲート２７１を含む、複数の動作部を有する。ゲート部は、層２２および２４に対応する厚みだけ可動する、すなわち、ＰＴＦＥ層の射出および成形のために、中央部が雄芯部２６２に向かって前進され、ＰＴＦＥの厚み分だけ雄芯部から離間される。次に、ナイロン層の射出のために、ナイロン部の厚み分だけ中央部が後退され、ＰＰ層の射出のために、ＰＰ層の厚み分だけ中央部がさらに後退される。中央部および成形型全般の構成における機械的および油圧的な詳細は、当業者の能力のうちにあると考えられるため、さらなる詳細は説明されない。
雄芯部２６２および雌ゲート部２７１と同軸であるのは、３つのスリーブ２７３、２７４、２７５であり、すべて個々に、かつ選択的に、雄支持板２６３から離れるように後退されることができる。ＰＴＦＥ層２１の成形のためには、第１のスリーブが図４に示す前進位置にある。ＰＴＦＥ層２１は、雄芯部と、雌ゲート部と、スリーブ２７３との間に形成された空洞部の中で成形される。ナイロン層の成形のためには、スリーブ２７３がゲート部２７１とともに、第１後退位置まで後退される。こうして、ＰＴＦＥ層２１と、スリーブ２７４と、ゲート部との間に、成形用の空洞部ができ、ナイロン層がこの中へ射出される（図５を参照）。
ＰＴＦＥ層およびナイロン層の両方は、環状の円筒形であり、一方の端部が開放し、他方が閉鎖している。ＰＰ層は、肩部すなわち縁部６を有する以外は、同様である。ＰＰ層を形成するには、スリーブ２７４が後退されるだけではなく、外側スリーブ２７５も部分的に後退される。こうして、型の空洞部が、肩部を備えて完成するＰＰ層の成形に適する形状に形成される（図６を参照）。この肩部の円周部は、雌型部の固定部２７７に対して形成される。
その結果生じる型が射出成形型から排出され、図７に示すブロー成形型３０１に移される。ブロー成形型は、プリフォームの挿入の前に補強スリーブ８が設けられること以外は、概ね従来式の型である。プリフォームは、その肩部６を型の特徴部分３０２によって把持され、使用時の全長まで棒３０３によって延伸される。棒の孔３０４を介してプリフォーム内にガスが射出され、プリフォームはその全径まで膨らまされて、そこでＰＰ層がアルミニウム製のスリーブに密着する。
本発明は、上述の実施形態の詳細に対して制限を受けるように意図されていない。たとえば、ＰＴＦＥ、ナイロン、およびＰＰのそれぞれと同様の特性を有する他の高分子材が使用されてもよい。また、繊維補強材などの他の補強材が使用可能である。さらに、補強材は全く必要ない可能性も考えられる。また、本発明の容器を製作するために、プリフォームおよびブロー成形以外の他の工程が用いられてもよい。
さらに、本発明は、定量式の薬剤源と同様に、本発明の容器を用いた定量式でない加圧された薬剤源に同等に適用可能である。
薬剤源が本発明の容器を含む、定量式の薬剤源の側面図である。 図１の薬剤源の容器の同様の側面断面図である。 図２の容器のためのプリフォームの同様の図である。 容器の内側層の射出用に構成された射出成形型の縦断面図である。 第２層の射出用に構成された成形型の同様の図である。 第３層の射出用に構成された成形型の第３の図である。 ブロー成形用の空洞内で適切な大きさに膨らまされた、射出成形プリフォームの同様の図である。

Claims (1)

  1. 薬剤源における薬剤用の容器であって、
    前記薬剤源の栓のための縁部を備えた口を有し、
    前記容器が、高分子材料からなる複数の層を含み、前記複数の層が、
    撥物質性の内側の層と、
    気密性および液体不透過性の外側の層と
    を少なくとも備え、前記２つの層が透明または少なくとも半透明の材料からなる容器。
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Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0425518D0 (en) 2004-11-19 2004-12-22 Clinical Designs Ltd Substance source
EP1922204A2 (en) * 2005-07-22 2008-05-21 Leafgreen Limited Moulding apparatus and method
DE102006002632A1 (de) * 2006-01-19 2007-07-26 Khs Ag Verfahren zum Herstellen von Flaschen oder dergleichen Behältern aus Kunststoff durch Blasen sowie nach diesem Verfahren hergestellte Flaschen oder dergleichen Behälter
GB0904040D0 (en) 2009-03-10 2009-04-22 Euro Celtique Sa Counter
GB0904059D0 (en) 2009-03-10 2009-04-22 Euro Celtique Sa Counter
CN102247287B (zh) * 2010-05-20 2013-05-15 石家庄四药有限公司 一种聚丙烯塑瓶大输液制瓶及灭菌方法
GB201118842D0 (en) 2011-11-01 2011-12-14 Euro Celtique Sa Dispenser cap arrangement
GB201118845D0 (en) 2011-11-01 2011-12-14 Euro Celtique Sa Dispenser
CN111634519B (zh) 2014-12-08 2022-02-18 大日本印刷株式会社 复合容器和塑料制部件

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5613337A (en) * 1979-07-05 1981-02-09 Toppan Printing Co Ltd Multilayer hollow container
JPH0531154A (ja) * 1991-07-29 1993-02-09 Kyoraku Co Ltd 薬液用プラスチツク容器
JPH05293159A (ja) * 1991-07-22 1993-11-09 Daikyo Seiko:Kk 衛生品用容器
JPH0857017A (ja) * 1994-08-25 1996-03-05 Terumo Corp 医薬液用遮光性プラスチック容器

Family Cites Families (267)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB161969A (en) 1921-04-18 1922-07-18 Johannes Bretschneider Inhaler
US776816A (en) * 1904-06-09 1904-12-06 William Tevendale Jr Gas-cock.
US2002835A (en) 1934-05-11 1935-05-28 William H Rose Siphon device
US2716013A (en) 1948-11-24 1955-08-23 Theodore B Tinker Flexible valve structure
US2922613A (en) 1951-06-01 1960-01-26 Cutter Lab Pinch valve
FR78023E (fr) 1960-07-04 1962-05-26 Bruneau & Cie Lab Dispositif de réglage de débit dans un tube déformable
US3103335A (en) 1961-03-28 1963-09-10 Resiflex Lab Inc Unitary clamp means for flexible tubes
DE1479899A1 (de) * 1962-01-16 1969-05-29 Fassfabrik Diener & Roth Plastikbehaelter mit faserverstaerkter Armierung
US3190497A (en) 1962-05-28 1965-06-22 Warner Lambert Pharmaceutical Liquid collecting apparatus and a valve therefor
US3329389A (en) 1964-03-09 1967-07-04 Plastronics Inc Valve for controlling flow through a flexible tube
GB1270272A (en) 1969-04-03 1972-04-12 Riker Laboratories Inc Improved dispensing devices for use with or including aerosol dispensing containers
US3598288A (en) 1969-06-26 1971-08-10 Edward S Posgate Flexible tube-metering devices
US3746196A (en) * 1971-01-29 1973-07-17 Green Cross Corp Coated plastic container for liquid medicine
US4142651A (en) 1977-04-29 1979-03-06 Norbert Leopoldi Fluid dispenser with flexible outlet tube and pinching valve
US4370368A (en) * 1980-05-07 1983-01-25 Toyo Seikan Kaisha, Ltd. Plastic bottles and process for preparation thereof
US4486378A (en) * 1980-05-07 1984-12-04 Toyo Seikan Kaisha Ltd. Plastic bottles and process for preparation thereof
US4393106A (en) * 1980-10-31 1983-07-12 Toyo Seikan Kaisha Ltd. Laminated plastic container and process for preparation thereof
JPS5775855A (en) * 1980-10-31 1982-05-12 Toyo Seikan Kaisha Ltd Laminated plastic vessel and its manufacture
US4361148A (en) 1980-12-03 1982-11-30 Cutter Laboratories, Inc. Flexible conduit with releasable sealing means
US4576157A (en) 1983-10-24 1986-03-18 Raghuprasad Puthalath K Oral inhalation apparatus
GB8328808D0 (en) 1983-10-28 1983-11-30 Riker Laboratories Inc Inhalation responsive dispensers
CH658636A5 (fr) 1983-11-02 1986-11-28 Serge Michielin Dispositif d'obturation etanche adaptable a toute forme d'emballage ou appareillage contenant des fluides.
CA1258054A (en) 1986-04-25 1989-08-01 Robert E. Newell Indicating device
GB2195544A (en) 1986-08-04 1988-04-13 Universal Precision Moulders L Inhaler
US5119806A (en) 1987-05-12 1992-06-09 Glaxo Inc. Inhalation device
US5031610A (en) 1987-05-12 1991-07-16 Glaxo Inc. Inhalation device
JPH0426328Y2 (ja) * 1987-06-17 1992-06-24
US4984158A (en) 1988-10-14 1991-01-08 Hillsman Dean Metered dose inhaler biofeedback training and evaluation system
GB8824804D0 (en) 1988-10-22 1988-11-30 Fisons Plc Device
US5049345A (en) * 1988-11-01 1991-09-17 Continental Pet Technologies, Inc. Method of forming a multi-layer preform
US5299701A (en) 1989-02-03 1994-04-05 Senetics, Inc. Indicator cap
US5718355A (en) 1989-02-03 1998-02-17 Senetics, Inc. Indicator device responsive to axial force for use with inhaler
US5421482A (en) 1989-02-03 1995-06-06 Senetics, Inc. Indicator device responsive to axial force
AU5270490A (en) 1989-03-07 1990-10-09 Karl Holm An atomizing nozzle device for atomizing a fluid and an inhaler
US4955371A (en) 1989-05-08 1990-09-11 Transtech Scientific, Inc. Disposable inhalation activated, aerosol device for pulmonary medicine
JPH02305841A (ja) * 1989-05-18 1990-12-19 Terumo Corp ガスバリヤー性材料及びそれを用いた収容体並びにその製造方法
US5042685A (en) 1989-08-10 1991-08-27 Moulding Jr Thomas S Dispensing having a compartment for detecting and counting the dispensed objects especially adapted for dispensing medication and method of using the same
GB8919131D0 (en) 1989-08-23 1989-10-04 Riker Laboratories Inc Inhaler
GB8925707D0 (en) 1989-11-14 1990-01-04 Riker Laboratories Inc Device
FR2654627B1 (fr) 1989-11-23 1992-02-28 Micro Mega Sa Dispositif regulateur de debit en particulier a usage medical ou dentaire.
US5152456A (en) 1989-12-12 1992-10-06 Bespak, Plc Dispensing apparatus having a perforate outlet member and a vibrating device
US5020527A (en) 1990-02-20 1991-06-04 Texax-Glynn Corporation Inhaler device with counter/timer means
FR2660630B1 (fr) 1990-04-10 1993-06-04 Bielsteiner France Dispositif pour distribuer un produit fluide ou pateux contenu dans un tube ecrasable.
GB9015077D0 (en) 1990-07-09 1990-08-29 Riker Laboratories Inc Inhaler
GB9020555D0 (en) 1990-09-20 1990-10-31 Bespak Plc Dispensing apparatus
GB9024760D0 (en) * 1990-11-14 1991-01-02 Riker Laboratories Inc Inhalation device and medicament carrier
US5217004A (en) 1990-12-13 1993-06-08 Tenax Corporation Inhalation actuated dispensing apparatus
DE69127826T2 (de) 1990-12-17 1998-04-09 Minnesota Mining & Mfg Inhalationsgerät
DE4105939A1 (de) 1991-02-26 1992-08-27 Sigismund Laskowski Verfahren und vorrichtung zum dosieren von fluessigen substanzen aus einem spendegutbehaelter
DE4111895C2 (de) 1991-04-12 1994-10-13 Sigismund Laskowski Verfahren und Vorrichtung zum Verschließen und Ausgießen von flüssigen Substanzen
AU650873B2 (en) 1991-04-15 1994-07-07 Leiras Oy Device intended for measuring a dose of powdered medicament for inhalation
FR2676929B1 (fr) 1991-05-30 1994-02-11 Aerosols Bouchage Ste Fse Inhalateur de poudres.
DE4136985C1 (ja) 1991-11-11 1993-05-13 Marsteller & Killmann Gmbh & Co Kg, 4300 Essen, De
GB2262452B (en) 1991-12-19 1995-12-20 Minnesota Mining & Mfg Inhalation device
DE4142238A1 (de) 1991-12-20 1993-06-24 Boehringer Ingelheim Kg Pulverinhalator mit pulvertraeger aus regelmaessigen mikrostrukturen
EP0632734B1 (en) 1992-03-25 1998-06-10 Tebro S.A. Powder jet dispenser for medicament inhalation therapies
GB2266466B (en) 1992-04-08 1995-12-20 Bespak Plc Inhalation apparatus
SE9201411D0 (sv) 1992-05-05 1992-05-05 Astra Ab Dosage inhalator with indicating/interupting means
GB2263873A (en) 1992-05-29 1993-08-11 Norton Healthcare Ltd Medicament dispensing device
GB2264238A (en) 1992-05-29 1993-08-25 Norton Healthcare Ltd Medicament inhalor device
GB9214819D0 (en) * 1992-07-13 1992-08-26 Minnesota Mining & Mfg Valve assemblies
GB9217545D0 (en) 1992-08-18 1992-09-30 Minnesota Mining & Mfg Inhalation device
FR2701399B1 (fr) 1993-02-16 1995-03-31 Valois Dispositif portatif de pulvérisation à actionnement déclenché par l'inhalation.
FR2701653B1 (fr) 1993-02-18 1995-04-07 Valois Dispositif doseur pour l'inhalation de poudre sèche.
DE4313319B4 (de) 1993-04-23 2006-09-28 C. Ehrensperger Ag Vorrichtung für Betätigungsvorrichtungen für Treibmitteldosen
GB2278979B (en) 1993-06-12 1997-01-08 Northern Telecom Ltd Communications system
GB2279571A (en) 1993-06-14 1995-01-11 Minnesota Mining & Mfg Inhaler
GB9312494D0 (en) 1993-06-17 1993-08-04 Lilly Industries Ltd Improvements in or relating to devices for dispensing articles
GB2279879B (en) 1993-07-14 1997-10-08 Bespak Plc Medicament inhalers
US6596260B1 (en) * 1993-08-27 2003-07-22 Novartis Corporation Aerosol container and a method for storage and administration of a predetermined amount of a pharmaceutically active aerosol
US5415161A (en) 1993-09-15 1995-05-16 Ryder; Steven L. Intermittant demand aerosol control device
KR960704770A (ko) 1993-09-22 1996-10-09 게이지 엘. 가아비 축력 감응 지시장치
US5388572A (en) 1993-10-26 1995-02-14 Tenax Corporation (A Connecticut Corp.) Dry powder medicament inhalator having an inhalation-activated piston to aerosolize dose and deliver same
US5839429A (en) 1994-03-25 1998-11-24 Astra Aktiebolag Method and apparatus in connection with an inhaler
US5501375A (en) 1994-05-12 1996-03-26 Cenova Innovations & Produktions Ab Dispenser valve for dispensing a pressurized liquid
US5564414A (en) 1994-05-26 1996-10-15 Walker; William F. Pressurized and metered medication dose counter on removable sleeve
FR2721106B1 (fr) 1994-06-10 1996-09-13 Step Compteur de doses pour inhalateurs.
US5482030A (en) 1994-06-13 1996-01-09 Klein; David Aerosol and non-aerosol spray counter
GB2292891A (en) 1994-09-07 1996-03-13 Norton Healthcare Ltd Actuator for breath-actuated medicament dispenser
US5544657A (en) 1994-09-09 1996-08-13 Siemens Medical Systems, Inc. Ultrasound blood flow monitor of the non-doppler type
US5622163A (en) 1994-11-29 1997-04-22 Iep Group, Inc. Counter for fluid dispensers
US5544647A (en) 1994-11-29 1996-08-13 Iep Group, Inc. Metered dose inhalator
EP0813490B1 (en) * 1995-03-10 2000-07-12 Minnesota Mining And Manufacturing Company Aerosol valves
US6205999B1 (en) 1995-04-05 2001-03-27 Aerogen, Inc. Methods and apparatus for storing chemical compounds in a portable inhaler
US6014970A (en) 1998-06-11 2000-01-18 Aerogen, Inc. Methods and apparatus for storing chemical compounds in a portable inhaler
PL180895B1 (pl) 1995-04-14 2001-04-30 Glaxo Wellcome Inc Inhalator z dozymetrem
US5809997A (en) 1995-05-18 1998-09-22 Medtrac Technologies, Inc. Electronic medication chronolog device
US6357442B1 (en) 1995-06-08 2002-03-19 Innovative Devices, Llc Inhalation actuated device for use with metered dose inhalers (MDIS)
US6672304B1 (en) 1995-06-08 2004-01-06 Innovative Devices, Llc Inhalation actuated device for use with metered dose inhalers (MDIs)
DE19525546C2 (de) * 1995-07-13 2002-05-02 Schott Glas Vorrichtung zur Verabreichung von Substanzen, insbesondere Inhalationspräparate
JP3317823B2 (ja) * 1995-08-11 2002-08-26 株式会社ユニシアジェックス 投薬器
DE19549033C1 (de) 1995-12-28 1997-05-28 Boehringer Ingelheim Int Mechanisches Zählwerk für ein Dosiergerät
US6470884B2 (en) 1996-01-29 2002-10-29 Aventis Pharma Limited Capsule opening arrangement for use in a powder inhaler
PT883415E (pt) 1996-02-21 2002-10-31 Schering Corp Inalador para medicacao em po
FR2750780B1 (fr) 1996-07-05 1998-10-30 Valois Compteur de doses
GB2320489A (en) 1996-12-20 1998-06-24 Norton Healthcare Ltd Inhaler dose counter
US6427683B1 (en) 1997-01-17 2002-08-06 Bo Drachmann Aerosol inhaler device
GB9705657D0 (en) 1997-03-19 1997-05-07 Bacon Raymond J Dispenser
US6085742A (en) * 1997-04-02 2000-07-11 Aeromax Technologies, Inc. Intrapulmonary delivery device
US5794612A (en) 1997-04-02 1998-08-18 Aeromax Technologies, Inc. MDI device with ultrasound sensor to detect aerosol dispensing
AU729716B2 (en) * 1997-05-23 2001-02-08 Pa Knowledge Limited Inhaler mechanism
TW533865U (en) 1997-06-10 2003-05-21 Glaxo Group Ltd Dispenser for dispensing medicament and actuation indicating device
DE19745513A1 (de) 1997-10-15 1999-04-22 Walz Karl Heinz Ablaufventil
AU777488B2 (en) 1997-10-17 2004-10-21 Systemic Pulmonary Delivery, Ltd. Method and apparatus for delivering aerosolized medication
SE9704185D0 (sv) 1997-11-14 1997-11-14 Astra Pharma Prod Inhalation device
US20060213505A1 (en) 1997-11-14 2006-09-28 Astrazeneca Ab Inhalation device
US7743765B2 (en) 1997-11-14 2010-06-29 Astrazeneca Ab Inhalation device
US7967011B2 (en) 1997-11-14 2011-06-28 Astrazeneca Ab Inhalation device
EP1449557B1 (en) 1998-01-16 2016-09-07 Trudell Medical International Dispensing device kit
JPH11197249A (ja) * 1998-01-16 1999-07-27 Hitachi Cable Ltd カテーテルチューブの製造方法
FR2775668B1 (fr) 1998-03-04 2000-05-19 Tebro Dispositif de distribution de produit fluide declenche par l'inhalation
KR100620338B1 (ko) * 1998-03-16 2006-09-13 넥타르 테라퓨틱스 에어로졸형 활성 제제 전달 방법
SE9801077D0 (sv) 1998-03-27 1998-03-27 Shl Medical Ab Inhalator
GB9807558D0 (en) 1998-04-09 1998-06-10 Bason Neil P An indicator device
US20040005475A1 (en) * 1998-04-17 2004-01-08 Curie Kevin James Transparent multilayer polypropylene container with barrier protection
US6336453B1 (en) 1999-04-30 2002-01-08 Trudell Medical International Indicating device for aerosol container
US6729330B2 (en) * 1998-05-05 2004-05-04 Trudell Medical International Indicating device for aerosol container
US6082358A (en) 1998-05-05 2000-07-04 1263152 Ontario Inc. Indicating device for aerosol container
US20020104530A1 (en) 1998-06-11 2002-08-08 Aerogen, Inc. Piezoelectric polymer flow sensor and methods
US5960609A (en) 1998-06-12 1999-10-05 Microdose Technologies, Inc. Metering and packaging method and device for pharmaceuticals and drugs
US6152130A (en) 1998-06-12 2000-11-28 Microdose Technologies, Inc. Inhalation device with acoustic control
US6142146A (en) 1998-06-12 2000-11-07 Microdose Technologies, Inc. Inhalation device
US6260549B1 (en) 1998-06-18 2001-07-17 Clavius Devices, Inc. Breath-activated metered-dose inhaler
SE9802398D0 (sv) 1998-07-03 1998-07-03 Astra Pharma Prod Inhalation device
DE29814647U1 (de) 1998-08-14 1999-12-23 Wischerath Josef Gmbh Co Kg Inhalator mit einer Dosierzähleinrichtung
US20020088458A1 (en) 1998-09-24 2002-07-11 Astrazeneca Ab Inhaler
CA2344382C (en) 1998-09-24 2008-01-29 Astrazeneca Ab Inhaler
DE29818662U1 (de) 1998-10-20 2000-03-02 Wischerath Josef Gmbh Co Kg Inhalator
GB9825118D0 (en) 1998-11-16 1999-01-13 Minnesota Mining & Mfg Breath-actuated aerosol dispensers
JP2000157607A (ja) * 1998-11-25 2000-06-13 Material Eng Tech Lab Inc 医療容器
GB2344534B (en) * 1998-12-11 2000-10-18 Bespak Plc Inhalation apparatus
JP2000220794A (ja) * 1999-02-02 2000-08-08 Tsutsumi Yotaro 高圧容器
US6196218B1 (en) 1999-02-24 2001-03-06 Ponwell Enterprises Ltd Piezo inhaler
GB2348928B (en) 1999-04-07 2001-10-31 Bespak Plc Improvements in or relating to dispensing apparatus
US6202642B1 (en) 1999-04-23 2001-03-20 Medtrac Technologies, Inc. Electronic monitoring medication apparatus and method
GB9911388D0 (en) 1999-05-18 1999-07-14 Glaxo Group Ltd Dispenser
AU2003234746B2 (en) 1999-06-18 2005-03-03 Shl Medical Ab Inhaler
SE516826C2 (sv) 1999-06-18 2002-03-05 Shl Medical Ab Anordning i en inhalator med organ för aktivering och avaktivering av en kanister som svar på ett luftflöde
AU2003234745B2 (en) 1999-06-18 2005-03-03 Shl Medical Ab Inhaler
IT1312426B1 (it) 1999-06-30 2002-04-17 Microspray Delta Spa Distributore di dosi di un liquido,con dispositivo per il conteggio di un elevato numero di dosi erogate
SE9902672D0 (sv) 1999-07-12 1999-07-12 Astra Ab Delivery device
US6516799B1 (en) * 1999-09-08 2003-02-11 Sapphire Design, Inc. Inhalation counter device
US6615827B2 (en) 1999-09-08 2003-09-09 Sapphire Designs, Inc. Inhalation counter device
US20030192535A1 (en) 1999-09-24 2003-10-16 Astrazeneca Ab. Inhaler
FR2799858B1 (fr) 1999-10-19 2002-01-18 Valois Sa Compteur de doses et distributeur de produit fluide incorporant un tel compteur
SE9903990D0 (sv) 1999-11-02 1999-11-02 Shl Medical Ab Inhalator with aerosolizing unit
DK1229953T3 (da) 1999-11-10 2007-04-10 Innovative Devices Llc Inhalationsaktiveret anordning til anvendelse med inhalatorer med afmålt dosis (MDI)
GB0002798D0 (en) 2000-02-09 2000-03-29 Glaxo Group Ltd Actuator nozzle for metered dose inhaler
GB0006525D0 (en) 2000-03-18 2000-05-10 Astrazeneca Uk Ltd Inhaler
GB2360218A (en) 2000-03-18 2001-09-19 Astrazeneca Uk Ltd Inhaler
GB2360216A (en) * 2000-03-18 2001-09-19 Astrazeneca Uk Ltd Inhaler
US6823863B2 (en) 2000-03-18 2004-11-30 Astrazeneca Ab Inhaler
GB2360219A (en) 2000-03-18 2001-09-19 Astrazeneca Uk Ltd Inhaler
US6581590B1 (en) 2000-03-21 2003-06-24 Iep Pharmaceutical Devices Inc. Inhalation actuated device
US6637432B2 (en) 2000-05-09 2003-10-28 Iep Pharmaceutical Devices Inc. Inhalation actuated device
US6759108B1 (en) 2000-05-12 2004-07-06 Yoshino Kogyoshocco., Ltd. Laminated plastic molded body
US20020000225A1 (en) 2000-06-02 2002-01-03 Carlos Schuler Lockout mechanism for aerosol drug delivery devices
US6553988B1 (en) 2000-06-09 2003-04-29 Norton Healthcare, Inc. Medicament dispensing device with a multimaterial diaphragm bounding a pneumatic force chamber
GB0016123D0 (en) 2000-07-01 2000-08-23 Glaxo Group Ltd Valve for aerosol container
EP1301230A1 (en) 2000-07-15 2003-04-16 Glaxo Group Limited Medicament dispenser
GB2381462B (en) 2000-07-24 2005-02-23 Clinical Designs Ltd Dispenser
US7036505B2 (en) 2000-07-24 2006-05-02 Clinical Designs Ltd. Dispenser
ES2231540T3 (es) 2000-08-18 2005-05-16 Norton Healthcare Limited Dispositivo de pulverizacion medica.
US20020043262A1 (en) * 2000-08-22 2002-04-18 Alan Langford Spray device
FR2813214B1 (fr) 2000-08-29 2003-05-02 Valois Sa Dispositif de distribution de produit fluide ameliore
GB2366519B (en) 2000-09-08 2002-11-20 Bespak Plc Improvements in or relating to dispensing apparatus
AU2001289126A1 (en) 2000-09-18 2002-04-02 Glaxo Group Limited Metered dose inhaler can coated two or more times with fluorocarbon polymers
SE517228C2 (sv) * 2000-09-25 2002-05-14 Microdrug Ag Inhalator för torrt pulver med andningsaktivering
JP4875826B2 (ja) 2000-09-29 2012-02-15 ファイザー・リミテッド 投薬装置
GB0023845D0 (en) 2000-09-29 2000-11-15 Pa Knowledge Ltd Dosing device
GB0025749D0 (en) 2000-10-20 2000-12-06 Glaxo Group Ltd Inhaler
GB0026646D0 (en) 2000-10-31 2000-12-13 Glaxo Group Ltd Medicament dispenser
GB0029612D0 (en) 2000-12-05 2001-01-17 Bacon Raymond J Drug dispenser
DE10061723C2 (de) 2000-12-12 2003-01-16 Eckert Rosemarie Zählwerk zum Zählen dosierter Abgaben flüssiger, pastöser oder fester Produkte sowie Einrichtung zum dosierten Abgeben solcher Produkte
SE0100034D0 (sv) 2001-01-04 2001-01-04 Astrazeneca Ab A delivery device
US6425385B1 (en) 2001-01-24 2002-07-30 Bear Archery Llc Archery bow having a swing arm cable guard with adjustably mounted cable saver
GB0101944D0 (en) 2001-01-25 2001-03-07 Bacon Raymond J Dispenser
ES2524912T3 (es) 2001-01-25 2014-12-15 Clinical Designs Limited Dispensador para medicamento
GB2385640B (en) 2001-02-23 2003-10-15 Bespak Plc Dosage counting devices
GB2372542B (en) 2001-02-23 2003-08-20 Bespak Plc Dosage counting devices
GB2372543B (en) 2001-02-23 2003-08-20 Bespak Plc Dosage counting devices
GB0106046D0 (en) * 2001-03-12 2001-05-02 Glaxo Group Ltd Canister
GB0108228D0 (en) 2001-04-02 2001-05-23 Glaxo Group Ltd Medicament dispenser
CA2444590C (en) * 2001-04-18 2009-12-01 Robert L. Mcginnis Stabilized hemoglobin solutions
GB0109717D0 (en) 2001-04-20 2001-06-13 Glaxo Group Ltd Medicament dispenser
EP2258429A1 (en) 2001-06-26 2010-12-08 Norton Healthcare Limited An improved aerosol actuator
ES2473591T3 (es) 2001-07-31 2014-07-07 Philip Morris Products S.A. Método y aparato para generar líquidos volatilizados
JP2003056254A (ja) 2001-08-10 2003-02-26 Tostem Corp 開口部装置
DE10159692A1 (de) 2001-11-29 2003-06-12 Pfeiffer Erich Gmbh & Co Kg Dosiervorrichtung
JP4482256B2 (ja) * 2001-12-26 2010-06-16 テイカ製薬株式会社 点眼剤容器
KR20030056326A (ko) * 2001-12-28 2003-07-04 주식회사 하이닉스반도체 반도체 소자의 루테늄 전하저장전극 형성 방법
FR2834277B1 (fr) * 2001-12-28 2004-06-11 Valois Sa Dispositif de distribution de produit fluide
PT1487523T (pt) 2002-03-22 2017-07-25 Clinical Designs Ltd Acessório de lata
EP1369139A1 (en) 2002-06-03 2003-12-10 3M Innovative Properties Company Dose indicators and dispensing canister-indicator assemblies
US20030234746A1 (en) * 2002-06-20 2003-12-25 Tang Minh Quyen Sub-reflector shaping in an unfurlable reflector antenna system
FR2842905B1 (fr) 2002-07-29 2005-05-13 Valois Sa Indicateur de doses pour dispositif de distribution de produit fluide
GB0315791D0 (en) 2003-07-07 2003-08-13 3M Innovative Properties Co Two component molded valve stems
CA2497869C (en) 2002-09-06 2013-06-04 Chrysalis Technologies Incorporated Aerosol generating device and method of use thereof
ATE532547T1 (de) 2002-09-06 2011-11-15 3M Innovative Properties Co Dosierventil für einen dosierinhalator mit konsistenter abgabe
US7497214B2 (en) 2002-09-16 2009-03-03 3M Innovative Properties Company Aerosol dispensers and adaptors therefor
US7322352B2 (en) 2002-09-21 2008-01-29 Aventis Pharma Limited Inhaler
US7296567B2 (en) 2002-09-25 2007-11-20 3M Innovative Properties Company Breath actuated aerosol dispensers
US7261701B2 (en) * 2002-10-03 2007-08-28 3M Innovative Properties Co. Skin antiseptic composition dispenser and methods of use
WO2004041339A2 (en) 2002-11-04 2004-05-21 Cambridge Consultants Limited Pressurised inhalers
GB0226021D0 (en) 2002-11-07 2002-12-18 Corporate Intellectual Propert A container
FR2850192B1 (fr) 2003-01-20 2005-05-06 Tebro Indicateur de doses pour dispositif de distribution de produit fluide.
GB2398251A (en) 2003-02-11 2004-08-18 Bespak Plc Dispensing apparatus with automatic bias removal
GB2398253B (en) 2003-02-11 2005-08-31 Bespak Plc Dispensing apparatus
GB2398503A (en) 2003-02-11 2004-08-25 Bespak Plc Inhaler with removable mouthpiece
GB2398254B (en) 2003-02-11 2005-12-07 Bespak Plc Dispensing Apparatus
GB2398252B (en) 2003-02-11 2005-09-21 Bespak Plc Dispensing apparatus
GB2398250A (en) 2003-02-11 2004-08-18 Bespak Plc Inhaler with display and single operating button
GB0304000D0 (en) 2003-02-21 2003-03-26 Clinical Designs Ltd Dispenser
NZ542712A (en) 2003-03-04 2008-11-28 Norton Healthcare Ltd Medicament dispensing device with a display indicative of the state of an internal medicament reservoir
WO2004080504A2 (en) * 2003-03-10 2004-09-23 Wilson-Cook Medical, Inc. Stent introducer apparatus
FR2854878B1 (fr) 2003-05-15 2006-03-31 Valois Sas Distributeur de produit fluide.
US20070017511A1 (en) 2003-05-28 2007-01-25 Hitachi, Ltd. Inhalation type dosing device
JP4266134B2 (ja) * 2003-06-27 2009-05-20 ブリヂストンフローテック株式会社 積層樹脂成型体及びその製造方法
GB0315509D0 (en) 2003-07-02 2003-08-06 Meridica Ltd Dispensing device
US20060131346A1 (en) 2003-07-07 2006-06-22 Purkins Graham R Two component molded valve stems
FR2857769B1 (fr) 2003-07-18 2005-10-21 Valois Sa Indicateur de doses ameliore pour dispositif de distribution de produit fluide.
FR2857770B1 (fr) 2003-07-18 2005-10-21 Valois Sas Indicateur de doses ameliore pour dispositif de distribution de produit fluide.
FR2858867B1 (fr) 2003-08-12 2005-11-04 Valois Sa Indicateur de doses pour dispositif de distribution de produit fluide
GB0322284D0 (en) 2003-09-23 2003-10-22 Glaxo Group Ltd Medicament dispenser
CA2540179A1 (en) 2003-09-24 2005-03-31 Medi-Stream Pty Ltd Medication holder
GB0323085D0 (en) 2003-10-02 2003-11-05 Norton Healthcare Ltd Dry powder inhalation apparatus
US7621273B2 (en) 2003-10-28 2009-11-24 Trudell Medical International Indicating device with warning dosage indicator
GB0328635D0 (en) 2003-12-10 2004-01-14 3M Innovative Properties Co Dose counter for dispensers
GB0328859D0 (en) 2003-12-12 2004-01-14 Clinical Designs Ltd Dispenser and counter
US7100530B2 (en) 2003-12-15 2006-09-05 Trudell Medical International, Inc. Dose indicating device
JP4708369B2 (ja) 2004-02-24 2011-06-22 マイクロドース セラピューテクス，インコーポレイテッド 合成ジェットに基づく薬剤投与装置
US20050263612A1 (en) 2004-05-26 2005-12-01 Hsing-Tzu Wang Paint spray gun
US7237727B2 (en) 2004-04-13 2007-07-03 Hsing-Tzu Wang Paint spray gun
JP4762230B2 (ja) 2004-04-29 2011-08-31 バルワー エス．アー．エス． 粉末または流体ディスペンサ装置用のインジケータおよび流体ディスペンサ装置
FR2869685B1 (fr) 2004-04-29 2006-07-28 Valois Sas Indicateur pour dispositif de distribution de produit fluide ou pulverulent
GB2414187B (en) 2004-05-21 2007-03-07 Bespak Plc Dispensing apparatus
FR2871450B1 (fr) 2004-06-14 2006-09-22 Valois Sas Dispositif de distribution de produit fluide
SE0401787D0 (sv) 2004-07-05 2004-07-05 Astrazeneca Ab Inhaler device counter
SE0401786D0 (sv) 2004-07-05 2004-07-05 Astrazeneca Ab Inhaler device
US7167776B2 (en) 2004-09-02 2007-01-23 Philip Morris Usa Inc. Method and system for controlling a vapor generator
US7543582B2 (en) 2004-09-20 2009-06-09 Trudell Medical International Dose indicating device with display elements attached to container
DE102005033398A1 (de) 2004-11-10 2006-05-11 Alfred Von Schuckmann Inhalier-Gerät
GB0425518D0 (en) 2004-11-19 2004-12-22 Clinical Designs Ltd Substance source
GB0426780D0 (en) 2004-12-07 2005-01-12 3M Innovative Properties Co Pressurized inhalation devices
GB0507100D0 (en) 2005-04-08 2005-05-11 Team Holdings Uk Ltd Improvements in or relating to inhalers
TWI442951B (zh) 2005-04-14 2014-07-01 Astrazeneca Ab 吸入器計量器
US7219664B2 (en) 2005-04-28 2007-05-22 Kos Life Sciences, Inc. Breath actuated inhaler
KR20080030563A (ko) 2005-05-12 2008-04-04 코스 라이프 싸이언시즈, 인크. 계측 복용량 흡입기용 복용량 계수기
JP2008541831A (ja) 2005-05-24 2008-11-27 レトセット・アクチボラグ ドーズカウンタ
EP1888155A4 (en) 2005-05-24 2012-08-22 Shl Group Ab DOSE COUNTER FOR INHALER
GB2429166A (en) 2005-07-27 2007-02-21 Cambridge Consultants Inhaler counter
AU2006276343B2 (en) 2005-08-01 2009-10-08 Astrazeneca Ab Inhaler valve
CN101247897B (zh) 2005-08-24 2013-06-12 贝林格尔·英格海姆国际有限公司 雾化器
GB0518355D0 (en) 2005-09-08 2005-10-19 Glaxo Group Ltd An inhaler
GB0518400D0 (en) 2005-09-09 2005-10-19 Clinical Designs Ltd Dispenser
GB0519151D0 (en) 2005-09-20 2005-10-26 Aventis Pharma Ltd Inhaler
GB2434753B (en) 2005-11-22 2008-03-12 Bespak Plc Aerosol dispensing apparatus
US7802569B2 (en) 2005-12-22 2010-09-28 Kaer Biotherapeutics Corporation Aerosol processing and inhalation method and system for high dose rate aerosol drug delivery
US8517019B2 (en) 2006-03-03 2013-08-27 3M Innovative Properties Company Method and apparatus for metered dose dispensing
US8875700B2 (en) 2006-03-21 2014-11-04 Shl Group Ab Dose information device
GB2438396B (en) 2006-05-26 2008-10-01 Bespak Plc Improvements in or relating to dispensing apparatus
FR2904228B1 (fr) 2006-07-25 2009-05-29 Valois Sas Dispositif de distribution de produit fluide.
US7953277B2 (en) * 2006-09-05 2011-05-31 Williams Robert C Background separated images for print and on-line use
WO2008030837A1 (en) 2006-09-06 2008-03-13 Abbott Respiratory Llc Variable dose aerosol drug canister
GB2451225B (en) 2007-05-15 2009-07-08 Bespak Plc Improvements in or relating to dispensing apparatus
GB0904059D0 (en) * 2009-03-10 2009-04-22 Euro Celtique Sa Counter
US8456586B2 (en) * 2009-06-11 2013-06-04 Apple Inc. Portable computer display structures

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5613337A (en) * 1979-07-05 1981-02-09 Toppan Printing Co Ltd Multilayer hollow container
JPH05293159A (ja) * 1991-07-22 1993-11-09 Daikyo Seiko:Kk 衛生品用容器
JPH0531154A (ja) * 1991-07-29 1993-02-09 Kyoraku Co Ltd 薬液用プラスチツク容器
JPH0857017A (ja) * 1994-08-25 1996-03-05 Terumo Corp 医薬液用遮光性プラスチック容器

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WO2006067383A1 (en) 2006-06-29
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PL1833540T3 (pl) 2012-07-31
EP1833540B1 (en) 2011-04-06
EP1833540A1 (en) 2007-09-19
ATE504327T1 (de) 2011-04-15
US20080107848A1 (en) 2008-05-08
US8329271B2 (en) 2012-12-11
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PT1833540E (pt) 2011-05-31
GB0428204D0 (en) 2005-01-26

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