JP2014062126A5 - - Google Patents
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- Publication number
- JP2014062126A5 JP2014062126A5 JP2014000383A JP2014000383A JP2014062126A5 JP 2014062126 A5 JP2014062126 A5 JP 2014062126A5 JP 2014000383 A JP2014000383 A JP 2014000383A JP 2014000383 A JP2014000383 A JP 2014000383A JP 2014062126 A5 JP2014062126 A5 JP 2014062126A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- pharmaceutically acceptable
- acceptable salt
- propyl
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- FWWOWPGPERBCNJ-UHFFFAOYSA-N 2-hydroxy-4-(2-hydroxyethoxy)-4-oxobutanoic acid Chemical compound OCCOC(=O)CC(O)C(O)=O FWWOWPGPERBCNJ-UHFFFAOYSA-N 0.000 claims 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 claims 1
- 239000013078 crystal Substances 0.000 claims 1
- 150000004677 hydrates Chemical class 0.000 claims 1
- 201000003631 narcolepsy Diseases 0.000 claims 1
- 230000003287 optical effect Effects 0.000 claims 1
- MUBZPKHOEPUJKR-UHFFFAOYSA-M oxalate(1-) Chemical compound OC(=O)C([O-])=O MUBZPKHOEPUJKR-UHFFFAOYSA-M 0.000 claims 1
- NNACHAUCXXVJSP-UHFFFAOYSA-N pitolisant Chemical compound C1=CC(Cl)=CC=C1CCCOCCCN1CCCCC1 NNACHAUCXXVJSP-UHFFFAOYSA-N 0.000 claims 1
- 208000007590 Disorders of Excessive Somnolence Diseases 0.000 description 1
- 239000000556 agonist Substances 0.000 description 1
- 239000005557 antagonist Substances 0.000 description 1
- 230000004622 sleep time Effects 0.000 description 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05290727A EP1707203A1 (en) | 2005-04-01 | 2005-04-01 | Treatment of parkinson's disease obstructive sleep apnea, dementia with lewy bodies, vascular dementia with non-imidazole alkylamines histamine H3- receptor ligands |
| EP05290727.6 | 2005-04-01 | ||
| US66861805P | 2005-04-06 | 2005-04-06 | |
| US60/668,618 | 2005-04-06 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008503613A Division JP5546761B2 (ja) | 2005-04-01 | 2006-03-30 | 非イミダゾールアルキルアミンヒスタミンｈ３−受容体リガンドによるパーキンソン病、閉塞性睡眠時無呼吸、レビー小体型認知症、血管性認知症の治療 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016045424A Division JP2016106142A (ja) | 2005-04-01 | 2016-03-09 | 非イミダゾールアルキルアミンヒスタミンｈ３−受容体リガンドによるパーキンソン病、閉塞性睡眠時無呼吸、レビー小体型認知症、血管性認知症の治療 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014062126A JP2014062126A (ja) | 2014-04-10 |
| JP2014062126A5 true JP2014062126A5 (enExample) | 2016-04-28 |
| JP5955872B2 JP5955872B2 (ja) | 2016-07-20 |
Family
ID=35169680
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008503613A Active JP5546761B2 (ja) | 2005-04-01 | 2006-03-30 | 非イミダゾールアルキルアミンヒスタミンｈ３−受容体リガンドによるパーキンソン病、閉塞性睡眠時無呼吸、レビー小体型認知症、血管性認知症の治療 |
| JP2014000383A Active JP5955872B2 (ja) | 2005-04-01 | 2014-01-06 | 非イミダゾールアルキルアミンヒスタミンｈ３−受容体リガンドによるパーキンソン病、閉塞性睡眠時無呼吸、レビー小体型認知症、血管性認知症の治療 |
| JP2016045424A Pending JP2016106142A (ja) | 2005-04-01 | 2016-03-09 | 非イミダゾールアルキルアミンヒスタミンｈ３−受容体リガンドによるパーキンソン病、閉塞性睡眠時無呼吸、レビー小体型認知症、血管性認知症の治療 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008503613A Active JP5546761B2 (ja) | 2005-04-01 | 2006-03-30 | 非イミダゾールアルキルアミンヒスタミンｈ３−受容体リガンドによるパーキンソン病、閉塞性睡眠時無呼吸、レビー小体型認知症、血管性認知症の治療 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016045424A Pending JP2016106142A (ja) | 2005-04-01 | 2016-03-09 | 非イミダゾールアルキルアミンヒスタミンｈ３−受容体リガンドによるパーキンソン病、閉塞性睡眠時無呼吸、レビー小体型認知症、血管性認知症の治療 |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US8486947B2 (enExample) |
| EP (2) | EP1707203A1 (enExample) |
| JP (3) | JP5546761B2 (enExample) |
| KR (1) | KR101308527B1 (enExample) |
| CN (1) | CN101171009B (enExample) |
| AU (1) | AU2006228413C1 (enExample) |
| BR (1) | BRPI0612216B1 (enExample) |
| CA (1) | CA2603656C (enExample) |
| CY (1) | CY1114636T1 (enExample) |
| DK (1) | DK1863487T4 (enExample) |
| EA (1) | EA016007B1 (enExample) |
| ES (1) | ES2426008T5 (enExample) |
| HR (1) | HRP20130748T4 (enExample) |
| MA (1) | MA29353B1 (enExample) |
| ME (1) | ME01713B (enExample) |
| MX (1) | MX2007012162A (enExample) |
| NO (1) | NO343603B1 (enExample) |
| NZ (1) | NZ561940A (enExample) |
| PL (1) | PL1863487T5 (enExample) |
| PT (1) | PT1863487E (enExample) |
| RS (1) | RS52911B2 (enExample) |
| SG (1) | SG147415A1 (enExample) |
| SI (1) | SI1863487T2 (enExample) |
| TN (1) | TNSN07365A1 (enExample) |
| UA (1) | UA94902C2 (enExample) |
| WO (1) | WO2006103546A2 (enExample) |
| ZA (1) | ZA200708086B (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9108948B2 (en) | 2006-06-23 | 2015-08-18 | Abbvie Inc. | Cyclopropyl amine derivatives |
| CN101472887A (zh) | 2006-06-23 | 2009-07-01 | 艾博特公司 | 作为组胺h3受体调节物的环丙胺衍生物 |
| FR2903904A1 (fr) * | 2006-07-21 | 2008-01-25 | Bioprojet Soc Civ Ile | Association de modafinil et d'un antagoniste ou agoniste inverse du recepteur h3 |
| NZ574873A (en) | 2006-07-25 | 2012-03-30 | Cephalon Inc | Pyridazinone derivatives as h3 inhibitors |
| US8153813B2 (en) | 2007-12-20 | 2012-04-10 | Abbott Laboratories | Benzothiazole and benzooxazole derivatives and methods of use |
| CA2712897A1 (en) | 2008-01-30 | 2009-08-06 | Pharmacopeia, Inc. | Substituted spirocyclic piperidine derivatives as histamine-3 (h3) receptor ligands |
| FR2932479A1 (fr) | 2008-06-13 | 2009-12-18 | Servier Lab | Nouveaux derives azabicycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| US9186353B2 (en) | 2009-04-27 | 2015-11-17 | Abbvie Inc. | Treatment of osteoarthritis pain |
| WO2012037258A1 (en) | 2010-09-16 | 2012-03-22 | Abbott Laboratories | Processes for preparing 1,2-substituted cyclopropyl derivatives |
| US9181275B2 (en) | 2011-08-11 | 2015-11-10 | Abbvie Inc. | Mercaptoamidine derivatives and methods of use |
| WO2013151982A1 (en) | 2012-04-03 | 2013-10-10 | Arena Pharmaceuticals, Inc. | Methods and compounds useful in treating pruritus, and methods for identifying such compounds |
| SG11201502210VA (en) * | 2012-10-05 | 2015-04-29 | Vtvx Holdings I Llc | Treatment of mild and moderate alzheimer's disease |
| EP3391886A1 (en) | 2017-04-19 | 2018-10-24 | Novartis AG | The use of a h3r inverse agonist for the treatment of shift work disorder |
| US20200281522A1 (en) | 2019-03-06 | 2020-09-10 | Medtronic Xomed, LLC | System and method for improved obstructive sleep apnea diagnostic for implantable devices |
| EP4248969A1 (en) | 2022-03-23 | 2023-09-27 | Bioprojet | Use of pitolisant for treating severe fatigue |
| WO2024201139A1 (en) | 2023-03-31 | 2024-10-03 | Bioprojet Pharma | Polymorph form of pitolisant hydrochloride |
| TW202535385A (zh) | 2023-10-16 | 2025-09-16 | 法商拜爾普羅傑特醫藥有限公司 | 必托里賽（ｐｉｔｏｌｉｓａｎｔ）之新穎調配物及使用方法 |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5815945A (ja) * | 1981-07-21 | 1983-01-29 | Teikoku Hormone Mfg Co Ltd | 新規なフエノキシアルキルアミン誘導体 |
| FR2579596B1 (fr) | 1985-03-26 | 1987-11-20 | Inst Nat Sante Rech Med | (imidazolyl-4) piperidines, leur preparation et leur application en therapeutique |
| FR2671083B1 (fr) | 1990-12-31 | 1994-12-23 | Inst Nat Sante Rech Med | Nouvelles 4-(4-imidazolyl) piperidines substituees en 1, leur preparation ainsi que leurs applications therapeutiques. |
| ES2108107T3 (es) | 1991-02-27 | 1997-12-16 | Seed Capital Investments | Derivados de imidazol que tienen actividad antagonista en el receptor h3 de histamina. |
| AU671092B2 (en) | 1991-12-18 | 1996-08-15 | Schering Corporation | Imidazolyl or imidazoylalkyl substituted with a four or five membered nitrogen containing heterocyclic ring |
| EP0619818B1 (en) | 1991-12-18 | 1996-07-10 | Schering Corporation | Imidazoylalkyl substituted with a six membered nitrogen containing heterocyclic ring |
| FR2686084B1 (fr) | 1992-01-10 | 1995-12-22 | Bioprojet Soc Civ | Nouveaux derives de l'imidazole, leur preparation et leurs applications therapeutiques. |
| US5486526A (en) * | 1992-04-01 | 1996-01-23 | The University Of Toledo | Histamine H3 -receptor antagonists and therapeutic uses thereof |
| US5380858A (en) | 1992-04-01 | 1995-01-10 | The University Of Toledo | Process for the preparation of intermediates useful for the synthesis of histamine receptor antagonists |
| US5639775A (en) | 1992-04-01 | 1997-06-17 | The University Of Toledo | 4-[4'-piperodinyl or 3'-pirrolidinyl] substituted imidazoles as H3 -receptor antagonists and therapeutic uses thereof |
| WO1994017058A1 (fr) | 1993-01-25 | 1994-08-04 | The Green Cross Corporation | Compose d'imidazole |
| JP3522790B2 (ja) | 1993-06-08 | 2004-04-26 | 花王株式会社 | Ｈ３−レセプター刺激薬 |
| WO1995006037A1 (en) | 1993-08-27 | 1995-03-02 | Vrije Universiteit | New imidazole derivatives having agonistic or antagonistic activity on the histamine h3 receptor |
| GB9319534D0 (en) * | 1993-09-22 | 1993-11-10 | Boots Co Plc | Therapeutic agents |
| AU693142B2 (en) | 1993-11-15 | 1998-06-25 | Schering Corporation | Phenyl-alkyl imidazoles as H3-receptor antagonists |
| GB9411045D0 (en) * | 1994-06-02 | 1994-07-20 | Smithkline Beecham Plc | Compounds and use |
| FR2732017B1 (fr) | 1995-03-21 | 2000-09-22 | Inst Nat Sante Rech Med | Nouveaux derives de l'imidazole antagonistes et/ou agonistes du recepteur h3 de l'histamine, leur preparation et leurs applications therapeutiques |
| CA2222099A1 (en) | 1995-05-30 | 1996-12-05 | Gliatech, Inc. | 1h-4(5)-substituted imidazole derivatives |
| US5652258A (en) | 1995-05-30 | 1997-07-29 | Gliatech, Inc. | 2-(4-imidazoyl) cyclopropyl derivatives |
| WO1996040126A1 (en) | 1995-06-07 | 1996-12-19 | Gliatech, Inc. | 1h-4(5)-substituted imidazole derivatives |
| PL328369A1 (en) | 1996-02-09 | 1999-01-18 | Black James Foundation | Ligands of histamin h receptor |
| JP3925579B2 (ja) | 1998-02-03 | 2007-06-06 | 日本精工株式会社 | 潤滑剤供給体、並びに前記潤滑剤供給体を備える転がり軸受、リニアガイド装置及びボールねじ装置 |
| EP0982300A3 (en) * | 1998-07-29 | 2000-03-08 | Societe Civile Bioprojet | Non-imidazole alkylamines as histamine H3 - receptor ligands and their therapeutic applications |
| US6136559A (en) * | 1998-10-07 | 2000-10-24 | Ortho Pharmaceutical Corporation | DNA encoding as human histamine receptor of the H3 subtype |
| EP1186594B1 (en) * | 1999-06-11 | 2009-08-05 | Toyama Chemical Co., Ltd. | N-alkoxyalkyl-n,n-dialkylamine derivatives or salts thereof, and remedies for nerve degeneration diseases containing the same |
| GB9924941D0 (en) * | 1999-10-22 | 1999-12-22 | Univ Manchester | Treatment of dyskinesia |
| US6620839B2 (en) * | 2000-07-13 | 2003-09-16 | Abbott Laboratories | 1,3-disubstituted and 1,3,3-trisubstituted pyrrolidines as histamine-3 receptor ligands and their therapeutic applications |
| HK1053110A1 (zh) | 2000-08-08 | 2003-10-10 | Ortho-Mcneil Pharmaceutical, Inc. | 作為h3受體配體的非咪唑芳氧基烷基胺 |
| WO2002013821A1 (en) | 2000-08-17 | 2002-02-21 | Gliatech, Inc. | Novel alicyclic imidazoles as h3 agents |
| JP2004506685A (ja) * | 2000-08-21 | 2004-03-04 | グリアテツク・インコーポレイテツド | 食欲の制御と肥満の治療のためのヒスタミンｈ３受容体逆アゴニストの使用 |
| EP1373218B9 (en) * | 2001-03-29 | 2008-12-03 | Ortho-McNeil-Janssen Pharmaceuticals, Inc. | Imidazolyl derivatives useful as histamine h3 receptor ligands |
| EP1451225A1 (en) * | 2001-11-15 | 2004-09-01 | Ortho-McNeil Pharmaceutical, Inc. | Agonists of recombinant human histamine h3 receptor |
| WO2003050099A1 (en) * | 2001-12-10 | 2003-06-19 | Ortho-Mcneil Pharmaceutical, Inc. | Phenylalkynes |
| JP2006505590A (ja) | 2002-10-23 | 2006-02-16 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ヒスタミンｈ３受容体調節物質としてのフェニルピペリジンおよびフェニルピロリジン |
| FR2856596B1 (fr) * | 2003-06-27 | 2007-04-27 | Bioprojet Soc Civ | Nouvelle association medicamenteuse psychiatrique et utilisation d'une antagoniste ou agoniste inverse du recepteur h3 de l'histamine pour preparer un medicament prevenant des effets indesirables de psychotropes. |
| WO2005007644A1 (ja) * | 2003-06-27 | 2005-01-27 | Banyu Pharmaceutical Co., Ltd | ヘテロアリールオキシ含窒素飽和へテロ環誘導体 |
| SE0302116D0 (sv) * | 2003-07-21 | 2003-07-21 | Astrazeneca Ab | Novel compounds |
| CA2551037A1 (en) | 2003-09-22 | 2005-03-31 | Banyu Pharmaceutical Co., Ltd. | Novel piperidine derivative |
-
2005
- 2005-04-01 EP EP05290727A patent/EP1707203A1/en not_active Withdrawn
-
2006
- 2006-03-29 AU AU2006228413A patent/AU2006228413C1/en active Active
- 2006-03-30 MX MX2007012162A patent/MX2007012162A/es active IP Right Grant
- 2006-03-30 JP JP2008503613A patent/JP5546761B2/ja active Active
- 2006-03-30 CN CN2006800157656A patent/CN101171009B/zh active Active
- 2006-03-30 SI SI200631636T patent/SI1863487T2/sl unknown
- 2006-03-30 SG SG200807447-8A patent/SG147415A1/en unknown
- 2006-03-30 EA EA200702135A patent/EA016007B1/ru not_active IP Right Cessation
- 2006-03-30 PT PT67444661T patent/PT1863487E/pt unknown
- 2006-03-30 BR BRPI0612216-7A patent/BRPI0612216B1/pt active IP Right Grant
- 2006-03-30 RS RS20130359 patent/RS52911B2/sr unknown
- 2006-03-30 ES ES06744466T patent/ES2426008T5/es active Active
- 2006-03-30 PL PL06744466T patent/PL1863487T5/pl unknown
- 2006-03-30 EP EP06744466.1A patent/EP1863487B2/en active Active
- 2006-03-30 WO PCT/IB2006/000739 patent/WO2006103546A2/en not_active Ceased
- 2006-03-30 NZ NZ561940A patent/NZ561940A/en unknown
- 2006-03-30 ME MEP-2013-98A patent/ME01713B/me unknown
- 2006-03-30 HR HRP20130748T patent/HRP20130748T4/hr unknown
- 2006-03-30 KR KR1020077025126A patent/KR101308527B1/ko active Active
- 2006-03-30 UA UAA200710712A patent/UA94902C2/ru unknown
- 2006-03-30 DK DK06744466.1T patent/DK1863487T4/da active
- 2006-03-30 CA CA2603656A patent/CA2603656C/en active Active
- 2006-03-30 US US11/909,778 patent/US8486947B2/en active Active
-
2007
- 2007-09-20 ZA ZA200708086A patent/ZA200708086B/xx unknown
- 2007-09-26 TN TNP2007000365A patent/TNSN07365A1/fr unknown
- 2007-09-27 MA MA30254A patent/MA29353B1/fr unknown
- 2007-10-09 NO NO20075086A patent/NO343603B1/no unknown
-
2013
- 2013-08-14 CY CY20131100705T patent/CY1114636T1/el unknown
-
2014
- 2014-01-06 JP JP2014000383A patent/JP5955872B2/ja active Active
-
2016
- 2016-03-09 JP JP2016045424A patent/JP2016106142A/ja active Pending
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