JP2013535422A5 - - Google Patents
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- Publication number
- JP2013535422A5 JP2013535422A5 JP2013518498A JP2013518498A JP2013535422A5 JP 2013535422 A5 JP2013535422 A5 JP 2013535422A5 JP 2013518498 A JP2013518498 A JP 2013518498A JP 2013518498 A JP2013518498 A JP 2013518498A JP 2013535422 A5 JP2013535422 A5 JP 2013535422A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition
- posaconazole
- composition according
- cyclodextrin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 19
- 239000008194 pharmaceutical composition Substances 0.000 claims 16
- RAGOYPUPXAKGKH-XAKZXMRKSA-N posaconazole Chemical compound O=C1N([C@H]([C@H](C)O)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@H]3C[C@@](CN4N=CN=C4)(OC3)C=3C(=CC(F)=CC=3)F)=CC=2)C=C1 RAGOYPUPXAKGKH-XAKZXMRKSA-N 0.000 claims 9
- 229960001589 posaconazole Drugs 0.000 claims 9
- 208000015181 infectious disease Diseases 0.000 claims 7
- 238000001802 infusion Methods 0.000 claims 4
- 229940097346 sulfobutylether-beta-cyclodextrin Drugs 0.000 claims 4
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims 3
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical class OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims 3
- 239000012458 free base Substances 0.000 claims 3
- VVJKKWFAADXIJK-UHFFFAOYSA-N Allylamine Chemical compound NCC=C VVJKKWFAADXIJK-UHFFFAOYSA-N 0.000 claims 2
- 241000222122 Candida albicans Species 0.000 claims 2
- 206010007134 Candida infections Diseases 0.000 claims 2
- 241000233866 Fungi Species 0.000 claims 2
- 206010030154 Oesophageal candidiasis Diseases 0.000 claims 2
- 206010050346 Oropharyngeal candidiasis Diseases 0.000 claims 2
- 229940121375 antifungal agent Drugs 0.000 claims 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims 2
- 201000003984 candidiasis Diseases 0.000 claims 2
- 239000002738 chelating agent Substances 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 201000005655 esophageal candidiasis Diseases 0.000 claims 2
- 238000001990 intravenous administration Methods 0.000 claims 2
- FRPZMMHWLSIFAZ-UHFFFAOYSA-N 10-undecenoic acid Chemical compound OC(=O)CCCCCCCCC=C FRPZMMHWLSIFAZ-UHFFFAOYSA-N 0.000 claims 1
- KAESVJOAVNADME-UHFFFAOYSA-N 1H-pyrrole Natural products C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 claims 1
- 206010001935 American trypanosomiasis Diseases 0.000 claims 1
- KLSJWNVTNUYHDU-UHFFFAOYSA-N Amitrole Chemical group NC1=NC=NN1 KLSJWNVTNUYHDU-UHFFFAOYSA-N 0.000 claims 1
- 239000005711 Benzoic acid Substances 0.000 claims 1
- 208000024699 Chagas disease Diseases 0.000 claims 1
- IIUZTXTZRGLYTI-UHFFFAOYSA-N Dihydrogriseofulvin Natural products COC1CC(=O)CC(C)C11C(=O)C(C(OC)=CC(OC)=C2Cl)=C2O1 IIUZTXTZRGLYTI-UHFFFAOYSA-N 0.000 claims 1
- 108010049047 Echinocandins Proteins 0.000 claims 1
- 206010017533 Fungal infection Diseases 0.000 claims 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- UXWOXTQWVMFRSE-UHFFFAOYSA-N Griseoviridin Natural products O=C1OC(C)CC=C(C(NCC=CC=CC(O)CC(O)C2)=O)SCC1NC(=O)C1=COC2=N1 UXWOXTQWVMFRSE-UHFFFAOYSA-N 0.000 claims 1
- 208000002250 Hematologic Neoplasms Diseases 0.000 claims 1
- 208000004554 Leishmaniasis Diseases 0.000 claims 1
- 208000031888 Mycoses Diseases 0.000 claims 1
- DDUHZTYCFQRHIY-UHFFFAOYSA-N Negwer: 6874 Natural products COC1=CC(=O)CC(C)C11C(=O)C(C(OC)=CC(OC)=C2Cl)=C2O1 DDUHZTYCFQRHIY-UHFFFAOYSA-N 0.000 claims 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 1
- 241000223109 Trypanosoma cruzi Species 0.000 claims 1
- 206010061418 Zygomycosis Diseases 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 208000024340 acute graft versus host disease Diseases 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 230000003474 anti-emetic effect Effects 0.000 claims 1
- 230000000843 anti-fungal effect Effects 0.000 claims 1
- 229940125683 antiemetic agent Drugs 0.000 claims 1
- 239000002111 antiemetic agent Substances 0.000 claims 1
- 239000003429 antifungal agent Substances 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 239000003443 antiviral agent Substances 0.000 claims 1
- 235000010233 benzoic acid Nutrition 0.000 claims 1
- 229960004365 benzoic acid Drugs 0.000 claims 1
- 210000001185 bone marrow Anatomy 0.000 claims 1
- KHAVLLBUVKBTBG-UHFFFAOYSA-N caproleic acid Natural products OC(=O)CCCCCCCC=C KHAVLLBUVKBTBG-UHFFFAOYSA-N 0.000 claims 1
- 208000017760 chronic graft versus host disease Diseases 0.000 claims 1
- SCKYRAXSEDYPSA-UHFFFAOYSA-N ciclopirox Chemical compound ON1C(=O)C=C(C)C=C1C1CCCCC1 SCKYRAXSEDYPSA-UHFFFAOYSA-N 0.000 claims 1
- 229960003749 ciclopirox Drugs 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- XRECTZIEBJDKEO-UHFFFAOYSA-N flucytosine Chemical compound NC1=NC(=O)NC=C1F XRECTZIEBJDKEO-UHFFFAOYSA-N 0.000 claims 1
- 229960004413 flucytosine Drugs 0.000 claims 1
- DDUHZTYCFQRHIY-RBHXEPJQSA-N griseofulvin Chemical compound COC1=CC(=O)C[C@@H](C)[C@@]11C(=O)C(C(OC)=CC(OC)=C2Cl)=C2O1 DDUHZTYCFQRHIY-RBHXEPJQSA-N 0.000 claims 1
- 229960002867 griseofulvin Drugs 0.000 claims 1
- 238000002650 immunosuppressive therapy Methods 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 238000011368 intensive chemotherapy Methods 0.000 claims 1
- 230000009545 invasion Effects 0.000 claims 1
- 201000009085 invasive aspergillosis Diseases 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 201000007524 mucormycosis Diseases 0.000 claims 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 244000045947 parasite Species 0.000 claims 1
- 210000005259 peripheral blood Anatomy 0.000 claims 1
- 239000011886 peripheral blood Substances 0.000 claims 1
- 150000004291 polyenes Chemical class 0.000 claims 1
- 238000001556 precipitation Methods 0.000 claims 1
- 238000001959 radiotherapy Methods 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 238000011476 stem cell transplantation Methods 0.000 claims 1
- 150000003431 steroids Chemical class 0.000 claims 1
- 206010052366 systemic mycosis Diseases 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
- 229960002703 undecylenic acid Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35970110P | 2010-06-29 | 2010-06-29 | |
| US61/359,701 | 2010-06-29 | ||
| PCT/US2011/041715 WO2012005973A1 (en) | 2010-06-29 | 2011-06-24 | Posaconazole intravenous solution formulations stabilized by substituted beta-cyclodextrin |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013535422A JP2013535422A (ja) | 2013-09-12 |
| JP2013535422A5 true JP2013535422A5 (enExample) | 2014-07-17 |
| JP6008849B2 JP6008849B2 (ja) | 2016-10-19 |
Family
ID=45441500
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013518498A Active JP6008849B2 (ja) | 2010-06-29 | 2011-06-24 | 置換β−シクロデキストリンにより安定化されたポサコナゾール静脈注射用溶液製剤 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US9023790B2 (enExample) |
| EP (3) | EP2588116A4 (enExample) |
| JP (1) | JP6008849B2 (enExample) |
| KR (1) | KR101834024B1 (enExample) |
| CN (2) | CN102958528A (enExample) |
| AU (1) | AU2011276680B2 (enExample) |
| BR (1) | BR112012033077B8 (enExample) |
| CA (1) | CA2802929C (enExample) |
| CY (1) | CY1124690T1 (enExample) |
| DK (1) | DK3391890T3 (enExample) |
| ES (1) | ES2893444T3 (enExample) |
| HR (1) | HRP20211686T1 (enExample) |
| HU (1) | HUE056581T2 (enExample) |
| LT (1) | LT3391890T (enExample) |
| MX (2) | MX338685B (enExample) |
| PL (1) | PL3391890T3 (enExample) |
| PT (1) | PT3391890T (enExample) |
| RS (1) | RS62583B1 (enExample) |
| SI (1) | SI3391890T1 (enExample) |
| WO (1) | WO2012005973A1 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090175810A1 (en) | 2008-01-03 | 2009-07-09 | Gareth Winckle | Compositions and methods for treating diseases of the nail |
| US7635773B2 (en) | 2008-04-28 | 2009-12-22 | Cydex Pharmaceuticals, Inc. | Sulfoalkyl ether cyclodextrin compositions |
| JP6008849B2 (ja) | 2010-06-29 | 2016-10-19 | メルク・シャープ・エンド・ドーム・コーポレイション | 置換β−シクロデキストリンにより安定化されたポサコナゾール静脈注射用溶液製剤 |
| US8039494B1 (en) | 2010-07-08 | 2011-10-18 | Dow Pharmaceutical Sciences, Inc. | Compositions and methods for treating diseases of the nail |
| EP4083075A1 (en) | 2012-02-15 | 2022-11-02 | CyDex Pharmaceuticals, Inc. | Manufacturing process for cyclodextrin derivatives |
| KR102320051B1 (ko) | 2013-10-03 | 2021-10-29 | 다우 파마슈티컬 사이언시즈, 인코포레이티드 | 안정화된 에피나코나졸 조성물 |
| CN104546724A (zh) * | 2013-10-12 | 2015-04-29 | 博瑞生物医药技术(苏州)有限公司 | 一种抗真菌药的固体分散体 |
| CA3052643A1 (en) | 2013-11-22 | 2015-05-28 | Bausch Health Ireland Limited | Anti-infective methods, compositions, and devices |
| CN105879041A (zh) * | 2014-11-14 | 2016-08-24 | 北京赛林泰医药技术有限公司 | 一种泊沙康唑口服液及其制备方法 |
| EA201791100A1 (ru) * | 2014-11-19 | 2017-11-30 | Гуфик Байосайенсиз Лимитед | Способ получения парентерального состава на основе анидулафунгина |
| CN104473871B (zh) * | 2014-11-28 | 2017-03-08 | 济南康和医药科技有限公司 | 一种泊沙康唑脂肪乳注射液及其制备方法 |
| CN106265534A (zh) * | 2015-05-25 | 2017-01-04 | 江苏正大丰海制药有限公司 | 一种泊沙康唑冻干粉针剂的制备方法 |
| CN106511262A (zh) * | 2015-09-11 | 2017-03-22 | 上海美悦生物科技发展有限公司 | 一种泊沙康唑口服溶液剂及其制备方法 |
| US10517867B2 (en) | 2016-02-04 | 2019-12-31 | Wuhan Ll Science And Technology Development Co., Ltd. | Posaconazole derivative, pharmaceutical composition and use thereof |
| WO2018091668A1 (en) | 2016-11-18 | 2018-05-24 | Aicuris Anti-Infective Cures Gmbh | Novel formulations of amidine substituted beta-lactam compounds on the basis of modified cyclodextrins and acidifying agents, their preparation and use as antimicrobial pharmaceutical compositions |
| CN111989121B (zh) | 2018-04-16 | 2024-08-13 | 默克专利股份有限公司 | 高浓缩蛋白质制剂的粘度降低 |
| CN110711174A (zh) * | 2018-07-11 | 2020-01-21 | 郑州泰丰制药有限公司 | 一种泊沙康唑注射液中间体溶液配制方法 |
| TR201820816A2 (tr) * | 2018-12-28 | 2020-07-21 | Polifarma Ilac Sanayi Ve Ticaret Anonim Sirketi | Si̇klodekstri̇n ve şeker i̇çeren stabi̇l enjekte edi̇lebi̇li̇r posakonazol formülasyonlari |
| US20230285391A1 (en) * | 2020-06-06 | 2023-09-14 | Inventia Healthcare Limited | Stable liquid compositions of posaconazole |
| CN115429748A (zh) * | 2021-06-02 | 2022-12-06 | 江苏奥赛康药业有限公司 | 一种泊沙康唑注射液的制备方法 |
| WO2023148763A1 (en) * | 2022-02-01 | 2023-08-10 | Cipla Limited | Injectable pharmaceutical compositions of azole antifungal agents |
| CN117783387A (zh) * | 2023-12-28 | 2024-03-29 | 郑州泰丰制药有限公司 | 一种测定泊沙康唑注射液包合常数的方法 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5257985A (en) | 1989-12-04 | 1993-11-02 | Richard Puhl | Multi-chamber intravenous bag apparatus |
| KR0166088B1 (ko) | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
| PL181193B1 (pl) | 1993-12-21 | 2001-06-29 | Schering Corp | Nowe pochodne tetrahydrofuranowe o działaniu przeciwgrzybicznym, kompozycja farmaceutyczna do leczenia infekcji grzybiczych oraz sposób wytwarzania tych związków |
| US5661151A (en) | 1993-12-21 | 1997-08-26 | Schering Corporation | Tetrahydrofuran antifungals |
| US5703079A (en) | 1993-12-21 | 1997-12-30 | Schering Corporation | Tetrahydrofuran antifungals |
| US5834472A (en) | 1996-05-24 | 1998-11-10 | Schering Corporation | Antifungal composition with enhanced bioavailability |
| US5972381A (en) | 1996-06-28 | 1999-10-26 | Schering Corporation | Solid solution of an antifungal agent with enhanced bioavailability |
| GB9713149D0 (en) | 1997-06-21 | 1997-08-27 | Pfizer Ltd | Pharmaceutical formulations |
| US6713481B1 (en) | 1997-10-17 | 2004-03-30 | David R. Andrews | Crystalline antifungal polymorph |
| US20030099674A1 (en) | 2001-08-11 | 2003-05-29 | Chen Andrew X. | Lyophilized injectable formulations containing paclitaxel or other taxoid drugs |
| CA2482520C (en) | 2002-04-30 | 2011-01-04 | Otsuka Pharmaceutical Factory, Inc. | Multiple-chamber medical container and bag for enclosing same |
| CA2528493C (en) * | 2003-06-06 | 2009-01-20 | Sankyo Company Limited | Medicinal composition containing triazole compound |
| KR20070027564A (ko) * | 2004-05-28 | 2007-03-09 | 쉐링 코포레이션 | 포사코나졸을 포함하는 주사가능한 약제학적 현탁액 |
| US20060009469A1 (en) * | 2004-05-28 | 2006-01-12 | Leonore Witchey-Lakshmanan | Particulate-stabilized injectable pharmacutical compositions of posaconazole |
| US20060160823A1 (en) | 2004-05-28 | 2006-07-20 | Leonore Witchey-Lakshmanan | Particulate-stabilized injectable pharmaceutical compositions of Posaconazole |
| PL1776109T3 (pl) * | 2004-08-13 | 2009-06-30 | Schering Plough Ltd | Farmaceutyczna formulacja zawierająca antybiotyk, triazol i kortykosteroid |
| WO2006098345A1 (ja) | 2005-03-15 | 2006-09-21 | Ajinomoto Co., Inc. | 薬剤移送具 |
| US20070082870A1 (en) | 2005-10-11 | 2007-04-12 | Buchanan Charles M | Pharmaceutical formulations of cyclodextrins and antifungal azole compounds |
| US7629331B2 (en) | 2005-10-26 | 2009-12-08 | Cydex Pharmaceuticals, Inc. | Sulfoalkyl ether cyclodextrin compositions and methods of preparation thereof |
| CN101442987A (zh) * | 2005-12-14 | 2009-05-27 | 扎尔斯制药公司 | 喷雾制剂和皮肤给药方法 |
| CN101495096A (zh) * | 2006-05-30 | 2009-07-29 | 伊兰制药国际有限公司 | 纳米微粒泊沙康唑制剂 |
| US20080194519A1 (en) * | 2006-09-15 | 2008-08-14 | Regents Of The University Of Minnesota | Topiramate compositions and methods for their use |
| JP2010515762A (ja) | 2007-01-16 | 2010-05-13 | エンゾン ファーマスーティカルズ インコーポレイテッド | ポサコナゾール−ポリマー複合体、並びに、ポサコナゾールおよびそのポリマー複合体を使用した治療方法 |
| WO2009018069A2 (en) | 2007-07-30 | 2009-02-05 | Cydex Pharmaceuticals, Inc | Mixtures of cyclodextrin derivatives |
| US7635773B2 (en) * | 2008-04-28 | 2009-12-22 | Cydex Pharmaceuticals, Inc. | Sulfoalkyl ether cyclodextrin compositions |
| US7863309B2 (en) * | 2008-07-24 | 2011-01-04 | Theravance, Inc. | Dual-acting antihypertensive agents |
| JP6008849B2 (ja) | 2010-06-29 | 2016-10-19 | メルク・シャープ・エンド・ドーム・コーポレイション | 置換β−シクロデキストリンにより安定化されたポサコナゾール静脈注射用溶液製剤 |
-
2011
- 2011-06-24 JP JP2013518498A patent/JP6008849B2/ja active Active
- 2011-06-24 WO PCT/US2011/041715 patent/WO2012005973A1/en not_active Ceased
- 2011-06-24 EP EP11804061.7A patent/EP2588116A4/en not_active Withdrawn
- 2011-06-24 PL PL18171672T patent/PL3391890T3/pl unknown
- 2011-06-24 HR HRP20211686TT patent/HRP20211686T1/hr unknown
- 2011-06-24 PT PT181716721T patent/PT3391890T/pt unknown
- 2011-06-24 MX MX2012015168A patent/MX338685B/es active IP Right Grant
- 2011-06-24 CN CN2011800314889A patent/CN102958528A/zh active Pending
- 2011-06-24 EP EP18171672.1A patent/EP3391890B1/en active Active
- 2011-06-24 HU HUE18171672A patent/HUE056581T2/hu unknown
- 2011-06-24 RS RS20211325A patent/RS62583B1/sr unknown
- 2011-06-24 KR KR1020127034087A patent/KR101834024B1/ko active Active
- 2011-06-24 CA CA2802929A patent/CA2802929C/en active Active
- 2011-06-24 AU AU2011276680A patent/AU2011276680B2/en active Active
- 2011-06-24 EP EP21192006.1A patent/EP3960185A1/en active Pending
- 2011-06-24 US US13/704,145 patent/US9023790B2/en active Active
- 2011-06-24 SI SI201132006T patent/SI3391890T1/sl unknown
- 2011-06-24 DK DK18171672.1T patent/DK3391890T3/da active
- 2011-06-24 BR BR112012033077A patent/BR112012033077B8/pt not_active IP Right Cessation
- 2011-06-24 LT LTEP18171672.1T patent/LT3391890T/lt unknown
- 2011-06-24 ES ES18171672T patent/ES2893444T3/es active Active
- 2011-06-24 CN CN201710169203.7A patent/CN107049935A/zh active Pending
-
2012
- 2012-12-19 MX MX2016001250A patent/MX346901B/es unknown
-
2015
- 2015-03-25 US US14/668,683 patent/US9358297B2/en active Active
-
2021
- 2021-11-03 CY CY20211100950T patent/CY1124690T1/el unknown
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