JP2013535210A5 - - Google Patents

Download PDF

Info

Publication number
JP2013535210A5
JP2013535210A5 JP2013522292A JP2013522292A JP2013535210A5 JP 2013535210 A5 JP2013535210 A5 JP 2013535210A5 JP 2013522292 A JP2013522292 A JP 2013522292A JP 2013522292 A JP2013522292 A JP 2013522292A JP 2013535210 A5 JP2013535210 A5 JP 2013535210A5
Authority
JP
Japan
Prior art keywords
seq
dna
primer
sequence
amplification
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2013522292A
Other languages
English (en)
Japanese (ja)
Other versions
JP2013535210A (ja
Filing date
Publication date
Priority claimed from GBGB1013153.0A external-priority patent/GB201013153D0/en
Application filed filed Critical
Publication of JP2013535210A publication Critical patent/JP2013535210A/ja
Publication of JP2013535210A5 publication Critical patent/JP2013535210A5/ja
Pending legal-status Critical Current

Links

JP2013522292A 2010-08-04 2011-08-04 パリンドローム配列を用いた閉鎖型直鎖状dnaの生成 Pending JP2013535210A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1013153.0 2010-08-04
GBGB1013153.0A GB201013153D0 (en) 2010-08-04 2010-08-04 Primer for production of closed linear DNA
PCT/GB2011/001175 WO2012017210A1 (en) 2010-08-04 2011-08-04 Production of closed linear dna using a palindromic sequence

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2016202277A Division JP6689726B2 (ja) 2010-08-04 2016-10-14 パリンドローム配列を用いた閉鎖型直鎖状dnaの生成

Publications (2)

Publication Number Publication Date
JP2013535210A JP2013535210A (ja) 2013-09-12
JP2013535210A5 true JP2013535210A5 (https=) 2014-09-18

Family

ID=42931209

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2013522292A Pending JP2013535210A (ja) 2010-08-04 2011-08-04 パリンドローム配列を用いた閉鎖型直鎖状dnaの生成
JP2016202277A Active JP6689726B2 (ja) 2010-08-04 2016-10-14 パリンドローム配列を用いた閉鎖型直鎖状dnaの生成

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2016202277A Active JP6689726B2 (ja) 2010-08-04 2016-10-14 パリンドローム配列を用いた閉鎖型直鎖状dnaの生成

Country Status (6)

Country Link
US (1) US9499847B2 (https=)
EP (1) EP2601312B1 (https=)
JP (2) JP2013535210A (https=)
CN (1) CN103080337B (https=)
GB (1) GB201013153D0 (https=)
WO (1) WO2012017210A1 (https=)

Families Citing this family (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0901593D0 (en) * 2009-01-30 2009-03-11 Touchlight Genetics Ltd Production of closed linear DNA
EP2692870A1 (en) 2012-08-03 2014-02-05 Alacris Theranostics GmbH Method for nucleic acid amplification
AU2014233145A1 (en) * 2013-03-15 2015-09-17 Theranos Ip Company, Llc Nucleic acid amplification
AU2014233152A1 (en) 2013-03-15 2015-09-17 Theranos Ip Company, Llc Nucleic acid amplification
JP2016521120A (ja) 2013-03-15 2016-07-21 セラノス, インコーポレイテッド 核酸増幅
US10450595B2 (en) 2013-03-15 2019-10-22 Theranos Ip Company, Llc Nucleic acid amplification
US9290800B2 (en) 2013-03-15 2016-03-22 Pacific Biosciences Of California, Inc. Targeted rolling circle amplification
WO2015035260A1 (en) 2013-09-06 2015-03-12 Theranos, Inc. Systems and methods for detecting infectious diseases
WO2015134812A1 (en) 2014-03-05 2015-09-11 Editas Medicine, Inc. Crispr/cas-related methods and compositions for treating usher syndrome and retinitis pigmentosa
US11141493B2 (en) 2014-03-10 2021-10-12 Editas Medicine, Inc. Compositions and methods for treating CEP290-associated disease
US11339437B2 (en) 2014-03-10 2022-05-24 Editas Medicine, Inc. Compositions and methods for treating CEP290-associated disease
WO2015138510A1 (en) 2014-03-10 2015-09-17 Editas Medicine., Inc. Crispr/cas-related methods and compositions for treating leber's congenital amaurosis 10 (lca10)
US11242525B2 (en) 2014-03-26 2022-02-08 Editas Medicine, Inc. CRISPR/CAS-related methods and compositions for treating sickle cell disease
US12460231B2 (en) 2014-04-02 2025-11-04 Editas Medicine, Inc. Crispr/CAS-related methods and compositions for treating primary open angle glaucoma
GB201415789D0 (en) * 2014-09-05 2014-10-22 Touchlight Genetics Ltd Synthesis of DNA
GB201502645D0 (en) 2015-02-17 2015-04-01 Touchlight Genetics Ltd Method
CA2982966C (en) 2015-04-24 2024-02-20 Editas Medicine, Inc. Evaluation of cas9 molecule/guide rna molecule complexes
FR3042121A1 (fr) * 2015-10-08 2017-04-14 Jean-Marc Limacher Composition anti-tumorale
WO2017165862A1 (en) 2016-03-25 2017-09-28 Editas Medicine, Inc. Systems and methods for treating alpha 1-antitrypsin (a1at) deficiency
WO2018015995A1 (ja) * 2016-07-19 2018-01-25 株式会社バイオダイナミクス研究所 長鎖一本鎖dnaを調製する方法
WO2018026976A1 (en) 2016-08-02 2018-02-08 Editas Medicine, Inc. Compositions and methods for treating cep290 associated disease
DK3500682T3 (da) * 2016-08-16 2020-08-24 Touchlight Ip Ltd Fremstilling af lukket, lineært dna
EP3596217A1 (en) 2017-03-14 2020-01-22 Editas Medicine, Inc. Systems and methods for the treatment of hemoglobinopathies
EP3622070A2 (en) 2017-05-10 2020-03-18 Editas Medicine, Inc. Crispr/rna-guided nuclease systems and methods
US11866726B2 (en) 2017-07-14 2024-01-09 Editas Medicine, Inc. Systems and methods for targeted integration and genome editing and detection thereof using integrated priming sites
US10350307B2 (en) * 2017-09-18 2019-07-16 General Electric Company In vivo RNA or protein expression using double-stranded concatemeric DNA including phosphorothioated nucleotides
DK3701028T3 (da) 2017-10-24 2024-11-11 Editas Medicine Inc Systemer og fremgangsmåder til behandling af hyper-igm-syndrom
US20200263206A1 (en) 2017-11-07 2020-08-20 Editas Medicine, Inc. Targeted integration systems and methods for the treatment of hemoglobinopathies
WO2019118516A1 (en) 2017-12-11 2019-06-20 Editas Medicine, Inc. Cpf1-related methods and compositions for gene editing
WO2019118806A1 (en) * 2017-12-14 2019-06-20 Solid Biosciences Inc. Non-viral production and delivery of genes
WO2019178426A1 (en) 2018-03-14 2019-09-19 Editas Medicine, Inc. Systems and methods for the treatment of hemoglobinopathies
CN108531496B (zh) * 2018-04-04 2020-11-06 江南大学 一种提高外源基因mRNA数量的DNA及其应用
GB201805683D0 (en) 2018-04-05 2018-05-23 Touchlight Ip Ltd Reprogramming vectors
EP3810782A2 (en) * 2018-06-22 2021-04-28 Asklepios Biopharmaceutical, Inc. Vectors for gene delivery that persist within cells
JP2022536850A (ja) 2019-06-18 2022-08-19 ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー B型肝炎ウイルス(hbv)ワクチンおよび抗pd-1または抗pd-l1抗体の組合せ
MA56533A (fr) 2019-06-18 2022-04-27 Janssen Sciences Ireland Unlimited Co Combinaison de vaccins contre le virus de l'hépatite b (vhb) et d'anticorps anti-pd-1
WO2020254876A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Virus-like particle delivery of hepatitis b virus (hbv) vaccines
WO2020255010A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combination of recombinant interleukin 12 construct and hepatitis b virus (hbv) vaccines
CA3143679A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and hbv-targeting rnai
KR20220042116A (ko) 2019-06-18 2022-04-04 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 B형 간염 바이러스(HBV) 백신 및 HBV-타케팅 RNAi의 조합
WO2020255014A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Recombinant interleukin 12 construct and uses thereof
WO2020255062A1 (en) 2019-06-20 2020-12-24 Janssen Sciences Ireland Unlimited Company Lipid nanoparticle or liposome delivery of hepatitis b virus (hbv) vaccines
AU2020297019A1 (en) 2019-06-20 2022-02-17 Janssen Sciences Ireland Unlimited Company Carbohydrate nanocarrier delivery of hepatitis B virus (HBV) vaccines
EP3792367A1 (en) 2019-09-11 2021-03-17 Universität Bielefeld Method for the production of raav and method for the in vitro generation of genetically engineered, linear, single-stranded nucleic acid fragments containing itr sequences flanking a gene of interest
GB2700048B (en) 2019-09-18 2026-03-04 Aldevron Llc synthetic dna vectors and method of use
GB201915163D0 (en) 2019-10-18 2019-12-04 Univ Southampton Cancer vaccine
CN115023503A (zh) 2020-01-31 2022-09-06 泰瑞斯疗法公司 生产闭合线性dna的方法
GB202007428D0 (en) 2020-05-19 2020-07-01 Fabricnano Ltd Polynucleotide synthesis
EP4165183A1 (en) * 2020-06-12 2023-04-19 University of Rochester Encoding and expression of ace-trnas
CN112111544B (zh) * 2020-09-23 2022-04-01 复旦大学附属肿瘤医院 提高单链dna连接效率的方法
WO2022156188A1 (en) * 2021-01-22 2022-07-28 Nanjing GenScript Biotech Co., Ltd. Method for producing target dna sequence and cloning vector
EP4060049B1 (en) * 2021-03-18 2023-08-23 Genomill Health Oy Methods for accurate parallel quantification of nucleic acids in dilute or non-purified samples
US20250122528A1 (en) 2021-06-08 2025-04-17 Touchlight IP Limited Lentiviral vector
GB202108176D0 (en) 2021-06-08 2021-07-21 Touchlight Ip Ltd Vector
CA3223292A1 (en) 2021-06-25 2022-12-29 Laura Van Lieshout Adeno-associated virus packaging systems
CA3226725A1 (en) 2021-07-13 2023-01-19 Stonehaven Incubate AG Composition and uses thereof
GB202114105D0 (en) 2021-10-01 2021-11-17 Fabricnano Ltd Nucleotide synthesis
US20250027107A1 (en) 2021-10-18 2025-01-23 Flagship Pioneering Innovations Vii, Llc Dna compositions and related methods
WO2023114901A2 (en) 2021-12-15 2023-06-22 Oxford Biomedica Solutions Llc Methods and compositions for the production of adeno-associated virus
JP2025503470A (ja) 2021-12-20 2025-02-04 ゾエティス・サービシーズ・エルエルシー 細胞膜上に抗原を発現させるための組成物及び方法
EP4453008A1 (en) 2021-12-20 2024-10-30 Zoetis Services LLC Compositions and methods for prevention of piscine myocarditis
AU2022419971A1 (en) 2021-12-20 2024-07-04 Zoetis Services Llc Use of interferon as an adjuvant in vaccines
CN114561372B (zh) * 2022-04-27 2022-07-26 南京巨匠生物科技有限公司 Bst DNA聚合酶突变体及其应用和产品、基因、重组质粒和基因工程菌
EP4293101A1 (en) 2022-06-14 2023-12-20 Asklepios Biopharmaceutical, Inc. Reactor with temperature control and method of using the same
EP4570912A1 (en) * 2022-08-10 2025-06-18 Zhenjiang Probio Biotech Co., Ltd. Method for preparing linear closed dna and plasmid for use in the method
WO2024039652A1 (en) 2022-08-16 2024-02-22 Aldevron, L.L.C. Cell-free method of producing synthetic circular nucleic acid
WO2024058155A1 (ja) * 2022-09-12 2024-03-21 株式会社カネカ 二本鎖環状dnaベクター、直鎖状共有結合閉鎖dnaの作製方法、並びにプロテロメラーゼ及びエンドヌクレアーゼを含む融合ポリペプチド
US20260053907A1 (en) 2022-09-12 2026-02-26 Zoetis Services Llc Method of administration of aquaculture vaccines
CN117778498A (zh) * 2022-09-26 2024-03-29 深圳瑞吉生物科技有限公司 一种无细胞制备mRNA转录模板的方法
WO2024069549A1 (en) 2022-09-29 2024-04-04 Touchlight Aquaculture Limited Vaccine construct and uses thereof
WO2024121354A1 (en) * 2022-12-08 2024-06-13 Keygene N.V. Duplex sequencing with covalently closed dna ends
DK202370610A1 (en) 2022-12-13 2024-07-12 Zoetis Services Llc Methods of vaccine administration to salmonids
WO2024197081A1 (en) 2023-03-20 2024-09-26 Hc Bioscience, Inc. Minimally-sized dna threads for trna therapy
CN116606834A (zh) * 2023-04-10 2023-08-18 天津中合基因科技有限公司 多种具有切割连接活性的原端酶及其应用
WO2024256842A1 (en) 2023-06-16 2024-12-19 Touchlight IP Limited Therapeutic transfection
WO2025040001A1 (zh) 2023-08-18 2025-02-27 镇江蓬勃生物科技有限公司 纯化核酸分子的方法
US11981936B1 (en) 2023-09-29 2024-05-14 New England Biolabs, Inc. TelA variants, compositions, and methods
GB202319998D0 (en) 2023-12-22 2024-02-07 Touchlight Ip Ltd duplexing method
FR3160186A1 (fr) 2024-03-13 2025-09-19 Odimma Therapeutics Vecteur non-viral pour transcription augmentee
WO2025202929A1 (en) * 2024-03-29 2025-10-02 Pfizer Inc. Methods for producing nucleic acids
WO2025250742A1 (en) * 2024-05-30 2025-12-04 Aclarity Genomics, Inc. Amplification of macromolecules
WO2025264964A1 (en) 2024-06-20 2025-12-26 Zoetis Services Llc Vaccines against tenacibaculum finnmarkense
EP4729632A1 (en) 2024-10-18 2026-04-22 AskBio Inc. Method of synthesizing dna

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
JPH03236781A (ja) * 1990-02-13 1991-10-22 Takara Shuzo Co Ltd ランダムプライマーキット及びその使用方法
AU649066B2 (en) 1990-07-25 1994-05-12 Syngene, Inc. Circular extension for generating multiple nucleic acid complements
FR2675803B1 (fr) 1991-04-25 1996-09-06 Genset Sa Oligonucleotides fermes, antisens et sens et leurs applications.
US6953676B1 (en) 1992-05-01 2005-10-11 Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification device and method
WO1994003624A1 (en) * 1992-08-04 1994-02-17 Auerbach Jeffrey I Methods for the isothermal amplification of nucleic acid molecules
US5714320A (en) 1993-04-15 1998-02-03 University Of Rochester Rolling circle synthesis of oligonucleotides and amplification of select randomized circular oligonucleotides
EP0636413B1 (en) 1993-07-28 2001-11-14 PE Corporation (NY) Nucleic acid amplification reaction apparatus and method
CA2175380A1 (en) * 1993-10-29 1995-05-04 Lan Bo Chen A novel tumor marker and novel method of isolating same
FR2732971B1 (fr) 1995-04-13 1997-07-04 Genset Sa Oligonucleotide sens inhibiteur de virus herpes simplex (hsv) a structure en haltere
US5856174A (en) 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
AU714486B2 (en) 1995-11-21 2000-01-06 Yale University Unimolecular segment amplification and detection
DE19648625A1 (de) * 1996-11-13 1998-05-14 Soft Gene Gmbh Mikroprojektil für das Einbringen von Substanzen in Zellen durch ballistischen Transfer
JPH10234399A (ja) * 1997-02-28 1998-09-08 Shinkinrui Kinou Kaihatsu Kenkyusho:Kk ピシウム属菌検出用の核酸配列
US6054274A (en) 1997-11-12 2000-04-25 Hewlett-Packard Company Method of amplifying the signal of target nucleic acid sequence analyte
DK1179585T3 (da) 1997-12-24 2008-11-10 Cepheid Indretning og fremgangsmåde til lysis
WO1999035281A1 (en) 1998-01-09 1999-07-15 University Of Utah Research Foundation Method for in vitro amplification of circular dna
DE19826758C1 (de) 1998-06-15 1999-10-21 Soft Gene Gmbh Darstellung von linearen kovalent geschlossenen DNA-Molekülen als Expressionskonstrukte
EP1114184A2 (en) 1998-09-15 2001-07-11 Yale University Molecular cloning using rolling circle amplification
DE50010240D1 (de) 1999-07-08 2005-06-09 Mologen Forschungs Entwicklung Impfstoff gegen infektionen mit lentiviren, wie dem felinen immunschwäche-virus der katze
AU2001250572A1 (en) * 2000-04-07 2001-10-23 Epigenomics Ag Detection of single nucleotide polymorphisms (snp's) and cytosine-methylations
GB0018120D0 (en) 2000-07-24 2000-09-13 Fermentas Ab Nuclease
JP2002051784A (ja) * 2000-08-09 2002-02-19 Toyobo Co Ltd 核酸の増幅方法及び標識核酸の調製方法
US6977148B2 (en) 2001-10-15 2005-12-20 Qiagen Gmbh Multiple displacement amplification
US20030077611A1 (en) 2001-10-24 2003-04-24 Sention Methods and systems for dynamic gene expression profiling
US20030170693A1 (en) * 2001-12-21 2003-09-11 George Chaconas Assay for identifying modulators of Borrelia telomere resolvase
US7081339B2 (en) 2002-04-12 2006-07-25 Primera Biosystems, Inc. Methods for variation detection
AU2003251905A1 (en) 2002-07-12 2004-02-02 Affymetrix, Inc. Synthetic tag genes
AU2003281917A1 (en) 2002-09-23 2004-04-19 Mologen Ag Vaccine against infections caused by oncoviruses such as the feline leucosis virus of cats
US7955795B2 (en) 2003-06-06 2011-06-07 Qiagen Gmbh Method of whole genome amplification with reduced artifact production
US7452699B2 (en) 2003-01-15 2008-11-18 Dana-Farber Cancer Institute, Inc. Amplification of DNA in a hairpin structure, and applications
WO2004074503A2 (en) 2003-02-21 2004-09-02 Hoser Mark J Nucleic acid sequencing methods, kits and reagents
EP1706502A4 (en) 2003-11-26 2007-05-23 Eppendorf Ag METHODS AND COMPOSITIONS FOR IN VITRO AMPLIFICATION OF EXTRACHROMOSOMIC NUCLEIC ACID
JP3972106B2 (ja) * 2004-03-03 2007-09-05 大学共同利用機関法人情報・システム研究機構 ゲノムライブラリー作製方法、および同方法により作製されたゲノムライブラリー
US20080305142A1 (en) * 2004-12-11 2008-12-11 Cytogenix, Inc. Cell Free Biosynthesis of High-Quality Nucleic Acid and Uses Thereof
CN101103122A (zh) * 2004-12-11 2008-01-09 西托吉尼克斯公司 高质量核酸的无细胞生物合成及其用途
EP1871897B1 (en) 2005-04-12 2010-09-29 Olink AB Methods for production of oligonucleotides
DK1885880T3 (da) 2005-04-29 2010-11-08 Synthetic Genomics Inc Amplifikation og kloning af enkelte DNA-molekyler ved anvendelse af rolling circle-amplifikation
CA2636816C (en) 2006-01-12 2014-02-11 Lucigen Corporation Linear vectors, host cells and cloning methods
EP3527671A1 (en) 2006-10-06 2019-08-21 Applied DNA Sciences Inc. System for a continuous rapid thermal cycle system
US20080118917A1 (en) * 2006-11-21 2008-05-22 Applera Corporation Isothermal SNP Detection Method
US8921072B2 (en) 2008-09-02 2014-12-30 General Electric Compnay Methods to generate DNA mini-circles
GB0901593D0 (en) 2009-01-30 2009-03-11 Touchlight Genetics Ltd Production of closed linear DNA
JP5182949B2 (ja) * 2009-03-31 2013-04-17 浜名部品工業株式会社 ヨークの製造方法及び製造装置
US9114399B2 (en) 2010-08-31 2015-08-25 Canon U.S. Life Sciences, Inc. System and method for serial processing of multiple nucleic acid assays
EP2692870A1 (en) 2012-08-03 2014-02-05 Alacris Theranostics GmbH Method for nucleic acid amplification
KR102014989B1 (ko) 2013-04-15 2019-08-27 삼성전자주식회사 폴리뉴클레오티드 및 그의 용도

Similar Documents

Publication Publication Date Title
JP2013535210A5 (https=)
JP2012516147A5 (https=)
US12116571B2 (en) Compositions and methods for detecting nucleic acid regions
AU2024278094A1 (en) Stabilized nucleic acids encoding messenger ribonucleic acid (mRNA)
EP3559269B1 (en) Single stranded circular dna libraries for circular consensus sequencing
JP2018537955A5 (https=)
JP2020512845A5 (https=)
JP2002272489A5 (https=)
JP2017504360A5 (https=)
KR101984700B1 (ko) 폴리뉴클레오티드 및 그의 용도
CN104114702A (zh) 模板转换用于dna合成的用途
KR20160036061A (ko) 뉴클레아제 프로파일링 시스템
AU2014363967A1 (en) Long nucleic acid sequences containing variable regions
CN117487801A (zh) Dna合成的方法
CN111893103A (zh) 可变换cas9核酸酶及其用途
JP2014527401A5 (https=)
JP2015533296A5 (https=)
JP2009530257A5 (https=)
US20230357790A1 (en) Self-targeting expression vector
US12157911B2 (en) Method for generating single-stranded circular DNA libraries for single molecule sequencing
JP2015532097A5 (https=)
JP2018533956A5 (https=)
JP2017532044A5 (https=)
JP2021526798A5 (https=)
WO2011142798A3 (en) Methods of preparing targeted aptamer prodrugs