JP2013529472A5 - - Google Patents
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- Publication number
- JP2013529472A5 JP2013529472A5 JP2013516983A JP2013516983A JP2013529472A5 JP 2013529472 A5 JP2013529472 A5 JP 2013529472A5 JP 2013516983 A JP2013516983 A JP 2013516983A JP 2013516983 A JP2013516983 A JP 2013516983A JP 2013529472 A5 JP2013529472 A5 JP 2013529472A5
- Authority
- JP
- Japan
- Prior art keywords
- primer
- hla
- pcr
- pairs
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000012163 sequencing technique Methods 0.000 claims 27
- 108700024394 Exon Proteins 0.000 claims 22
- 239000000523 sample Substances 0.000 claims 22
- 238000000034 method Methods 0.000 claims 20
- 108020004414 DNA Proteins 0.000 claims 16
- 102100028972 HLA class I histocompatibility antigen, A alpha chain Human genes 0.000 claims 13
- 108010075704 HLA-A Antigens Proteins 0.000 claims 11
- 102100040485 HLA class II histocompatibility antigen, DRB1 beta chain Human genes 0.000 claims 10
- 108010039343 HLA-DRB1 Chains Proteins 0.000 claims 10
- 238000003205 genotyping method Methods 0.000 claims 10
- 102100036241 HLA class II histocompatibility antigen, DQ beta 1 chain Human genes 0.000 claims 7
- 108010065026 HLA-DQB1 antigen Proteins 0.000 claims 7
- 108020004707 nucleic acids Proteins 0.000 claims 6
- 150000007523 nucleic acids Chemical class 0.000 claims 6
- 102000039446 nucleic acids Human genes 0.000 claims 6
- 108010052199 HLA-C Antigens Proteins 0.000 claims 5
- 101150035071 HLA-C gene Proteins 0.000 claims 5
- 102100028971 HLA class I histocompatibility antigen, C alpha chain Human genes 0.000 claims 4
- 238000012408 PCR amplification Methods 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 3
- 239000002773 nucleotide Substances 0.000 claims 3
- 125000003729 nucleotide group Chemical group 0.000 claims 3
- 101150076489 B gene Proteins 0.000 claims 2
- 101150118346 HLA-A gene Proteins 0.000 claims 2
- 230000003321 amplification Effects 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 2
- 238000003199 nucleic acid amplification method Methods 0.000 claims 2
- 239000013074 reference sample Substances 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 101150046128 HLA-DQB1 gene Proteins 0.000 claims 1
- 101150018610 HLA-DRB1 gene Proteins 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 238000004458 analytical method Methods 0.000 claims 1
- 229960001716 benzalkonium Drugs 0.000 claims 1
- CYDRXTMLKJDRQH-UHFFFAOYSA-N benzododecinium Chemical compound CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 CYDRXTMLKJDRQH-UHFFFAOYSA-N 0.000 claims 1
- 238000010276 construction Methods 0.000 claims 1
- 238000005516 engineering process Methods 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 238000013467 fragmentation Methods 0.000 claims 1
- 238000006062 fragmentation reaction Methods 0.000 claims 1
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010213721.2 | 2010-06-30 | ||
| CN201010213717.6 | 2010-06-30 | ||
| CN 201010213721 CN101921842B (zh) | 2010-06-30 | 2010-06-30 | Hla-a,b基因分型用pcr引物及其使用方法 |
| CN201010213719.5 | 2010-06-30 | ||
| CN201010213717.6A CN101921840B (zh) | 2010-06-30 | 2010-06-30 | 一种基于dna分子标签技术和dna不完全打断策略的pcr测序方法 |
| CN201010213719.5A CN101921841B (zh) | 2010-06-30 | 2010-06-30 | 基于Illumina GA测序技术的HLA基因高分辨率分型方法 |
| CNPCT/CN2010/002149 | 2010-12-24 | ||
| PCT/CN2010/002149 WO2012083505A1 (zh) | 2010-12-24 | 2010-12-24 | Hla-c基因分型的方法及其相关引物 |
| CNPCT/CN2010/002150 | 2010-12-24 | ||
| PCT/CN2010/002150 WO2012083506A1 (zh) | 2010-12-24 | 2010-12-24 | Hla-dqb1基因分型的方法及其相关引物 |
| PCT/CN2011/076688 WO2012000445A1 (zh) | 2010-06-30 | 2011-06-30 | 新的的pcr测序方法及其在hla基因分型中的应用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013529472A JP2013529472A (ja) | 2013-07-22 |
| JP2013529472A5 true JP2013529472A5 (enExample) | 2014-08-14 |
| JP5968879B2 JP5968879B2 (ja) | 2016-08-10 |
Family
ID=45401405
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013516983A Active JP5968879B2 (ja) | 2010-06-30 | 2011-06-30 | Ｄｎａ分子タグ技術及びｄｎａ不完全断片化技術に基づいたｐｃｒシークエンシング法及びそれを用いたｈｌａ遺伝子タイピング法 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US9957564B2 (enExample) |
| EP (1) | EP2599877B1 (enExample) |
| JP (1) | JP5968879B2 (enExample) |
| KR (1) | KR101709826B1 (enExample) |
| AU (1) | AU2011274090B2 (enExample) |
| BR (1) | BR112012032586B1 (enExample) |
| CA (1) | CA2803940C (enExample) |
| DK (1) | DK2599877T3 (enExample) |
| MY (1) | MY173793A (enExample) |
| RU (1) | RU2587606C2 (enExample) |
| SG (1) | SG186876A1 (enExample) |
| WO (1) | WO2012000445A1 (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG10201708498VA (en) * | 2013-04-17 | 2017-11-29 | Agency Science Tech & Res | Method for generating extended sequence reads |
| JP6308724B2 (ja) | 2013-05-09 | 2018-04-11 | ジェノダイブファーマ株式会社 | Ｈｌａ遺伝子のマルチプレックスｄｎａタイピング方法及びキット |
| WO2015031385A1 (en) * | 2013-08-26 | 2015-03-05 | The Translational Genomics Research Institute | Single molecule-overlapping read analysis for minor variant mutation detection in pathogen samples |
| GB201409282D0 (en) | 2014-05-23 | 2014-07-09 | Univ Sydney Tech | Sequencing process |
| JP2017525369A (ja) * | 2014-09-05 | 2017-09-07 | キアゲン ゲーエムベーハー | アダプター連結アンプリコンの調製 |
| CN105400864B (zh) * | 2014-09-12 | 2020-04-14 | 深圳华大基因股份有限公司 | 用于基于血液样品构建测序文库的方法及其在确定胎儿遗传异常中的用途 |
| EP3192869B1 (en) * | 2014-09-12 | 2019-03-27 | MGI Tech Co., Ltd. | Isolated oligonucleotide and use thereof in nucleic acid sequencing |
| US10233490B2 (en) | 2014-11-21 | 2019-03-19 | Metabiotech Corporation | Methods for assembling and reading nucleic acid sequences from mixed populations |
| US9859394B2 (en) | 2014-12-18 | 2018-01-02 | Agilome, Inc. | Graphene FET devices, systems, and methods of using the same for sequencing nucleic acids |
| US9618474B2 (en) | 2014-12-18 | 2017-04-11 | Edico Genome, Inc. | Graphene FET devices, systems, and methods of using the same for sequencing nucleic acids |
| EP3235010A4 (en) | 2014-12-18 | 2018-08-29 | Agilome, Inc. | Chemically-sensitive field effect transistor |
| US10006910B2 (en) | 2014-12-18 | 2018-06-26 | Agilome, Inc. | Chemically-sensitive field effect transistors, systems, and methods for manufacturing and using the same |
| US10020300B2 (en) | 2014-12-18 | 2018-07-10 | Agilome, Inc. | Graphene FET devices, systems, and methods of using the same for sequencing nucleic acids |
| US9857328B2 (en) | 2014-12-18 | 2018-01-02 | Agilome, Inc. | Chemically-sensitive field effect transistors, systems and methods for manufacturing and using the same |
| CN107002153B (zh) * | 2015-02-04 | 2020-10-27 | 深圳华大生命科学研究院 | 一种构建长片段测序文库的方法 |
| KR101651817B1 (ko) * | 2015-10-28 | 2016-08-29 | 대한민국 | Ngs 라이브러리 제작용 프라이머 세트 및 이를 이용한 ngs 라이브러리 제작방법 및 키트 |
| CN108699600A (zh) * | 2016-02-23 | 2018-10-23 | 诺维信公司 | 改进的新一代测序 |
| WO2017201081A1 (en) | 2016-05-16 | 2017-11-23 | Agilome, Inc. | Graphene fet devices, systems, and methods of using the same for sequencing nucleic acids |
| ES2870639T3 (es) | 2016-10-24 | 2021-10-27 | Geneinfosec Inc | Ocultación de información presente en los ácidos nucleicos |
| CN110167951A (zh) * | 2016-11-15 | 2019-08-23 | 奎斯特诊断投资有限责任公司 | 使用mitra尖端提取检测dna突变的方法 |
| JP2020501601A (ja) * | 2016-11-15 | 2020-01-23 | クエスト ダイアグノスティックス インヴェストメンツ エルエルシー | Ｍｉｔｒａチップ抽出を使用して嚢胞性線維症の変異を検出するための方法 |
| EP3626835A1 (en) | 2018-09-18 | 2020-03-25 | Sistemas Genómicos, S.L. | Method for genotypically identifying both alleles of at least one locus of a subject's hla gene |
| RU2703401C1 (ru) * | 2018-10-24 | 2019-10-16 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Кубанский государственный аграрный университет имени И.Т. Трубилина" | Тест-система для выявления и генотипирования РНК вируса репродуктивно-респираторного синдрома свиней |
| RU2703394C1 (ru) * | 2018-10-24 | 2019-10-16 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Кубанский государственный аграрный университет имени И.Т. Трубилина" | Способ выявления и генотипирования РНК вируса репродуктивно-респираторного синдрома свиней |
| FR3100820B1 (fr) | 2019-09-12 | 2024-06-28 | Bionobis | Procédé de génotypage adapté au traitement d’un grand nombre d’échantillons, notamment en cas de polymorphisme élevé |
| FR3106596B1 (fr) | 2020-01-27 | 2022-12-02 | Bionobis | Procede de genotypage hla simple et rapide |
| CN111235266B (zh) * | 2020-03-10 | 2023-12-01 | 广州医科大学附属第二医院 | Hla亚型检测试剂盒及其应用 |
| FR3110178B1 (fr) | 2020-05-18 | 2022-05-27 | Bionobis | Procédé de génotypage adapté au traitement simultané d’un grand nombre de patients |
| CN112553313A (zh) * | 2020-12-30 | 2021-03-26 | 武汉康圣达医学检验所有限公司 | 用于Sanger法的测序反应产物的变性方法 |
| KR102507110B1 (ko) * | 2022-02-15 | 2023-03-07 | 주식회사 네오젠티씨 | 주조직 적합성 복합체의 타입들을 분석하기 위한 방법 및 장치 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0656065A1 (en) * | 1991-10-31 | 1995-06-07 | University Of Pittsburgh | Reverse dot blot hybridization using tandem head-to-tail monomers containing probes synthesized by staggered complementary primers |
| US5580730A (en) * | 1994-08-19 | 1996-12-03 | Olympus America, Inc. | Enzyme digestion method for the detection of amplified DNA |
| AU6321998A (en) | 1997-02-11 | 1998-08-26 | William H. Hildebrand | Class i sequence based typing of hla-a, -b, and -c alleles by direct dna sequencing |
| EP0953650A1 (en) * | 1998-04-20 | 1999-11-03 | Innogenetics N.V. | Method for typing of HLA alleles |
| CA2513535C (en) * | 2003-01-29 | 2012-06-12 | 454 Corporation | Bead emulsion nucleic acid amplification |
| US7300755B1 (en) * | 2003-05-12 | 2007-11-27 | Fred Hutchinson Cancer Research Center | Methods for haplotyping genomic DNA |
| WO2005042764A2 (en) | 2003-10-28 | 2005-05-12 | Dynal Biotech Llc | Primers, methods and kits for amplifying or detecting human leukocyte antigen alleles |
| US9365893B2 (en) * | 2005-05-10 | 2016-06-14 | State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon | Methods of mapping polymorphisms and polymorphism microarrays |
| EP2477029A1 (en) * | 2005-06-02 | 2012-07-18 | Fluidigm Corporation | Analysis using microfluidic partitioning devices |
| AU2006295556B2 (en) | 2005-09-29 | 2012-07-05 | Keygene N.V. | High throughput screening of mutagenized populations |
| US8071310B2 (en) | 2005-11-14 | 2011-12-06 | Keygene Nv | Method for the high throughput screening of transposon tagging populations and massive parallel sequence identification of insertion sites |
| DK3404114T3 (da) * | 2005-12-22 | 2021-06-28 | Keygene Nv | Fremgangsmåde til detektering af AFLP-baseret polymorfisme med højt gennemløb |
| US20110002948A1 (en) | 2006-06-09 | 2011-01-06 | Conexio 4 Pty Ltd | Identification of a nucleic acid molecule |
| US20100086914A1 (en) * | 2008-10-03 | 2010-04-08 | Roche Molecular Systems, Inc. | High resolution, high throughput hla genotyping by clonal sequencing |
| JP2011500041A (ja) * | 2007-10-16 | 2011-01-06 | エフ．ホフマン−ラ ロシュ アーゲー | クローナルシークエンシングによる高分解能かつ高効率のｈｌａ遺伝子型決定法 |
| RU2393231C1 (ru) * | 2008-12-29 | 2010-06-27 | Федеральное государственное учреждение здравоохранения "Российский научно-исследовательский противочумный институт "Микроб" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека ("РосНИПЧИ "Микроб") | Способ определения генетического родства штаммов холерных вибрионов методом секвенирования генов, фланкирующих кластер генов биосинтеза о-антигена |
| CN101921840B (zh) | 2010-06-30 | 2014-06-25 | 深圳华大基因科技有限公司 | 一种基于dna分子标签技术和dna不完全打断策略的pcr测序方法 |
| CN101921841B (zh) | 2010-06-30 | 2014-03-12 | 深圳华大基因科技有限公司 | 基于Illumina GA测序技术的HLA基因高分辨率分型方法 |
| CN101921842B (zh) | 2010-06-30 | 2013-08-07 | 深圳华大基因科技有限公司 | Hla-a,b基因分型用pcr引物及其使用方法 |
-
2011
- 2011-06-30 EP EP11800190.8A patent/EP2599877B1/en active Active
- 2011-06-30 MY MYPI2012005591A patent/MY173793A/en unknown
- 2011-06-30 RU RU2013103795/10A patent/RU2587606C2/ru active IP Right Revival
- 2011-06-30 AU AU2011274090A patent/AU2011274090B2/en active Active
- 2011-06-30 SG SG2012096616A patent/SG186876A1/en unknown
- 2011-06-30 CA CA2803940A patent/CA2803940C/en active Active
- 2011-06-30 JP JP2013516983A patent/JP5968879B2/ja active Active
- 2011-06-30 BR BR112012032586-8A patent/BR112012032586B1/pt active IP Right Grant
- 2011-06-30 WO PCT/CN2011/076688 patent/WO2012000445A1/zh not_active Ceased
- 2011-06-30 US US13/807,660 patent/US9957564B2/en active Active
- 2011-06-30 DK DK11800190.8T patent/DK2599877T3/da active
- 2011-06-30 KR KR1020137002332A patent/KR101709826B1/ko active Active
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