JP2013525330A5 - - Google Patents
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- JP2013525330A5 JP2013525330A5 JP2013505466A JP2013505466A JP2013525330A5 JP 2013525330 A5 JP2013525330 A5 JP 2013525330A5 JP 2013505466 A JP2013505466 A JP 2013505466A JP 2013505466 A JP2013505466 A JP 2013505466A JP 2013525330 A5 JP2013525330 A5 JP 2013525330A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- conjugate
- reuptake inhibitor
- serotonin
- norepinephrine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 0 Cc1cc(C(C(*)(*)C2(*)**(*N*)C3=O)c4ccccc4C2N3I)ccc1 Chemical compound Cc1cc(C(C(*)(*)C2(*)**(*N*)C3=O)c4ccccc4C2N3I)ccc1 0.000 description 3
- YVVVQVSPNGMJAX-QCDSWUKFSA-N CN([C@@H](CC1)c2ccccc2[C@@H]1c(cc1)cc(Cl)c1Cl)C(CCCCCNC(CCC(NCCCCCCOP(O)(O)=O)=O)=O)=O Chemical compound CN([C@@H](CC1)c2ccccc2[C@@H]1c(cc1)cc(Cl)c1Cl)C(CCCCCNC(CCC(NCCCCCCOP(O)(O)=O)=O)=O)=O YVVVQVSPNGMJAX-QCDSWUKFSA-N 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32551510P | 2010-04-19 | 2010-04-19 | |
| EP10382087.4 | 2010-04-19 | ||
| EP10382087A EP2380595A1 (en) | 2010-04-19 | 2010-04-19 | Compositions and methods for selective delivery of oligonucleotide molecules to specific neuron types |
| US61/325,515 | 2010-04-19 | ||
| EP11382031 | 2011-02-09 | ||
| EP11382031.0 | 2011-02-09 | ||
| PCT/EP2011/056270 WO2011131693A2 (en) | 2010-04-19 | 2011-04-19 | Compositions and methods for selective delivery of oligonucleotide molecules to specific neuron types |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013525330A JP2013525330A (ja) | 2013-06-20 |
| JP2013525330A5 true JP2013525330A5 (enExample) | 2014-06-19 |
| JP5819401B2 JP5819401B2 (ja) | 2015-11-24 |
Family
ID=44063382
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013505466A Active JP5819401B2 (ja) | 2010-04-19 | 2011-04-19 | 組成物及びオリゴヌクレオチド分子を特異的なニューロンのタイプに選択的に送達する方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US9193969B2 (enExample) |
| EP (2) | EP2560687B1 (enExample) |
| JP (1) | JP5819401B2 (enExample) |
| KR (1) | KR20130103662A (enExample) |
| AR (1) | AR083715A1 (enExample) |
| AU (4) | AU2011244321A1 (enExample) |
| BR (1) | BR112012026471A2 (enExample) |
| CA (1) | CA2796722C (enExample) |
| DK (1) | DK2560687T3 (enExample) |
| ES (1) | ES2638309T3 (enExample) |
| LT (1) | LT2560687T (enExample) |
| MX (1) | MX342764B (enExample) |
| RU (1) | RU2664452C2 (enExample) |
| WO (1) | WO2011131693A2 (enExample) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006506317A (ja) | 2002-01-11 | 2006-02-23 | バイオマリン ファーマシューティカル インコーポレイテッド | 治療用リソソーム酵素の送達のための酵素送達系としてのｐ９７の使用 |
| KR20130103662A (ko) | 2010-04-19 | 2013-09-24 | 엔라이프 떼라퓨틱스, 에스.엘. | 올리고뉴클레오티드 분자들의 특정 뉴런 유형들로의 선택적인 전달을 위한 조성물들 및 방법 |
| WO2012068405A2 (en) | 2010-11-17 | 2012-05-24 | Isis Pharmaceuticals, Inc. | Modulation of alpha synuclein expression |
| AU2012278944B2 (en) | 2011-07-05 | 2015-09-17 | Bioasis Technologies Inc. | p97-antibody conjugates and methods of use |
| JP6309450B2 (ja) | 2011-08-04 | 2018-04-11 | イェダ リサーチ アンド デベロップメント カンパニー リミテッド | セロトニン関連の医学的状態、アドレナリン関連の医学的状態、ノルアドレナリン関連の医学的状態、グルタミン酸関連の医学的状態および副腎皮質刺激ホルモン放出ホルモン関連の医学的状態の処置および診断のためのミクロｒｎａおよび該ミクロｒｎａを含む組成物 |
| US9725716B2 (en) * | 2011-12-06 | 2017-08-08 | Ohio State Innovation Foundation and Research Institute at Nationwide Children's Hospital | Non-ionic, low osmolar contrast agents for delivery of antisense oligonucleotides and treatment of disease |
| US10273474B2 (en) | 2012-03-30 | 2019-04-30 | Washington University | Methods for modulating Tau expression for reducing seizure and modifying a neurodegenerative syndrome |
| CN104662150B (zh) | 2012-07-31 | 2018-07-10 | 比奥阿赛斯技术有限公司 | 脱磷酸化的溶酶体贮积症蛋白及其使用方法 |
| WO2014064258A1 (en) * | 2012-10-26 | 2014-05-01 | Nlife Therapeutics, S.L. | Compositions and methods for selective delivery of oligonucleotide molecules to cell types |
| HK1214179A1 (zh) * | 2012-10-26 | 2016-07-22 | 恩莱弗医疗有限公司 | 通过选择性递送寡核苷酸分子至特定神经元类型治疗帕金森病的组合物和方法 |
| JP6452614B2 (ja) | 2012-11-15 | 2019-01-16 | ロシュ イノベーション センター コペンハーゲン エーエス | オリゴヌクレオチドコンジュゲート |
| EP2743695A1 (en) | 2012-12-12 | 2014-06-18 | Nanogap Sub NM Powder, S.A. | Methods and reagents for the detection of biomolecules using luminescence |
| JP6586412B2 (ja) | 2013-03-13 | 2019-10-02 | バイオアシス テクノロジーズ インコーポレイテッド | ｐ９７のフラグメントおよびその使用 |
| RU2745324C2 (ru) | 2013-03-14 | 2021-03-23 | Ионис Фармасьютикалз, Инк. | Композиции и способы модулирования экспрессии tau |
| WO2014187313A1 (zh) * | 2013-05-21 | 2014-11-27 | 成都先导药物开发有限公司 | 一种化合物的细胞透膜的方法 |
| JP6262848B2 (ja) * | 2013-05-21 | 2018-01-17 | 成都先導薬物開発有限公司 | 薬物標的の捕獲方法 |
| EP3029059B1 (en) * | 2013-05-21 | 2018-07-04 | Hitgen Ltd. | Compound administration precursor and medicament carrier preparation |
| TWI772856B (zh) | 2013-07-19 | 2022-08-01 | 美商百健Ｍａ公司 | 用於調節τ蛋白表現之組合物 |
| ES2764973T3 (es) | 2014-02-03 | 2020-06-05 | Bioasis Technologies Inc | Proteínas de fusión de P97 |
| JP2017506228A (ja) | 2014-02-05 | 2017-03-02 | イェダ リサーチ アンド ディベロップメント カンパニー リミテッドＹｅｄａ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｄｅｖｅｌｏｐｍｅｎｔ Ｃｏ．Ｌｔｄ． | セロトニン放出ホルモン、アドレナリン放出ホルモン、ノルアドレナリン放出ホルモン、グルタミン酸放出ホルモンおよび副腎皮質刺激ホルモン放出ホルモン関連の医学的状態の処置および診断のためのマイクロｒｎａおよび該マイクロｒｎａを含む組成物 |
| ES2762672T3 (es) | 2014-02-19 | 2020-05-25 | Bioasis Technologies Inc | Proteínas de fusión de P97-IDS |
| WO2015168521A2 (en) * | 2014-05-01 | 2015-11-05 | Bioasis Technologies, Inc. | P97-polynucleotide conjugates |
| GB201410693D0 (en) | 2014-06-16 | 2014-07-30 | Univ Southampton | Splicing modulation |
| AU2015327836B2 (en) | 2014-10-03 | 2021-07-01 | Cold Spring Harbor Laboratory | Targeted augmentation of nuclear gene output |
| CN108025089A (zh) | 2015-07-22 | 2018-05-11 | 波涛生命科学有限公司 | 寡核苷酸组合物及其方法 |
| US10733023B1 (en) * | 2015-08-06 | 2020-08-04 | D2Iq, Inc. | Oversubscription scheduling |
| DK3133166T4 (da) * | 2015-08-21 | 2023-03-20 | 42 Life Sciences Gmbh & Co Kg | Sammensætning og fremgangsmåde til hybridisering |
| CN108603230A (zh) | 2015-10-09 | 2018-09-28 | 南安普敦大学 | 基因表达的调节与蛋白质表达失调的筛选 |
| US11096956B2 (en) | 2015-12-14 | 2021-08-24 | Stoke Therapeutics, Inc. | Antisense oligomers and uses thereof |
| EP3390636B1 (en) | 2015-12-14 | 2021-05-19 | Cold Spring Harbor Laboratory | Antisense oligomers for treatment of dravet syndrome |
| GB2545898B (en) | 2015-12-21 | 2019-10-09 | Sutura Therapeutics Ltd | Improved drug delivery by conjugating oligonucleotides to stitched/stapled peptides |
| GB2574525B (en) * | 2015-12-21 | 2020-09-02 | Sutura Therapeutics Ltd | Improved drug delivery by conjugating oligonucleotides to stitched/stapled peptides |
| WO2017221883A1 (ja) * | 2016-06-20 | 2017-12-28 | 武田薬品工業株式会社 | 抗体－薬物コンジュゲート |
| KR101916652B1 (ko) * | 2016-06-29 | 2018-11-08 | 올릭스 주식회사 | 작은 간섭 rna의 rna 간섭효과 증진용 화합물 및 이의 용도 |
| US10208098B2 (en) * | 2016-09-15 | 2019-02-19 | Council Of Scientific & Industrial Research | Recombinant protein-based method for the delivery of silencer RNA to target the brain |
| JOP20190065A1 (ar) | 2016-09-29 | 2019-03-28 | Ionis Pharmaceuticals Inc | مركبات وطرق لتقليل التعبير عن tau |
| EP3673080B1 (en) | 2017-08-25 | 2023-10-18 | Stoke Therapeutics, Inc. | Antisense oligomers for treatment of conditions and diseases |
| JP2020537636A (ja) * | 2017-09-22 | 2020-12-24 | マンセル、ジョン | 敗血症関連障害の処置のための組成物及び方法 |
| EP3461487A1 (en) * | 2017-09-29 | 2019-04-03 | Nlife Therapeutics S.L. | Compositions and methods for the delivery of mrna to hepatic cells |
| RS66633B1 (sr) | 2017-10-23 | 2025-08-29 | Stoke Therapeutics Inc | Antisens oligomeri za lečenje bolesti i stanja na bazi besmisleno posredovanog raspadanja rnk |
| EP3700556A2 (en) | 2017-10-25 | 2020-09-02 | Janssen Pharmaceuticals, Inc. | Compositions of phosphorylated tau peptides and uses thereof |
| TWI809004B (zh) | 2017-11-09 | 2023-07-21 | 美商Ionis製藥公司 | 用於降低snca表現之化合物及方法 |
| KR20200109338A (ko) | 2018-01-12 | 2020-09-22 | 로슈 이노베이션 센터 코펜하겐 에이/에스 | 알파-시누클레인 안티센스 올리고뉴클레오티드 및 이의 용도 |
| MX2020007433A (es) | 2018-01-12 | 2020-09-14 | Bristol Myers Squibb Co | Oligonucleotidos antisentido que actuan sobre alfa-sinucleina, y usos de estos. |
| EA202091693A1 (ru) | 2018-01-12 | 2021-04-14 | Бристол-Маерс Сквибб Компани | Антисмысловые олигонуклеотиды, целенаправленно воздействующие на альфа-синуклеин, и их применения |
| JP2021523227A (ja) | 2018-05-04 | 2021-09-02 | ストーク セラピューティクス，インク． | コレステリルエステル蓄積症の処置のための方法及び組成物 |
| CN112218877B (zh) | 2018-08-27 | 2025-07-25 | 瑞泽恩制药公司 | 拉曼光谱在下游纯化中的应用 |
| ES2698565B2 (es) * | 2018-12-12 | 2019-07-16 | Univ Madrid Complutense | Procedimiento para la elaboración de nanopartículas lipídicas, y nanopartículas lipídicas con los macrófagos cerebrales como células diana |
| MY206596A (en) | 2019-02-08 | 2024-12-25 | Janssen Pharmaceuticals Inc | Method of safe administration of phosphorylated tau peptide vaccine |
| CN113748209A (zh) | 2019-02-27 | 2021-12-03 | 斯托克制药公司 | 用于治疗病况和疾病的反义寡聚体 |
| US12478684B2 (en) | 2019-04-11 | 2025-11-25 | Northeastern University | Oligonucleotide-polymer miktoarm conjugates and methods of use |
| EP3983077A4 (en) * | 2019-06-17 | 2023-12-20 | Alnylam Pharmaceuticals, Inc. | DELIVERY OF OLIGONUCLEOTIDES TO THE STRIATUM |
| AU2021270720A1 (en) | 2020-05-11 | 2022-12-08 | Stoke Therapeutics, Inc. | OPA1 antisense oligomers for treatment of conditions and diseases |
| CA3204415A1 (en) * | 2021-01-18 | 2022-07-21 | Alon Chen | Modified mir-135, conjugated form thereof, and uses of same |
| WO2024069229A2 (en) | 2022-08-03 | 2024-04-04 | Sutura Therapeutics Ltd | Biologically active compounds |
| US12396981B2 (en) | 2023-03-09 | 2025-08-26 | William Shulman | Methods of using DMT |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003042162A1 (en) * | 2001-11-17 | 2003-05-22 | Neurosearch A/S | Prodrugs of antidepressants and their use for treating depressions |
| EP1336406A1 (en) * | 2002-02-14 | 2003-08-20 | Solvay Pharmaceuticals B.V. | Partial dopamine-D2 receptor agonist plus serotonin and/or noradrenaline inhibitory activity |
| EP1711632A4 (en) * | 2004-01-19 | 2009-03-11 | Technion Res & Dev Foundation | DIAGNOSTIC TEST FOR PARKINSON |
| WO2007050789A2 (en) * | 2005-10-25 | 2007-05-03 | Nëdken Corporation | Glycosyl-oligonucleotide conjugates and methods |
| GB0605337D0 (en) | 2006-03-17 | 2006-04-26 | Genomica Sau | Treatment of CNS conditions |
| WO2008033285A2 (en) * | 2006-09-15 | 2008-03-20 | The Trustees Of Culumbia University In The City Of New York | Delivery of double-stranded rna into the central nervous system |
| CA2709635A1 (en) * | 2007-12-20 | 2009-07-02 | Angiochem Inc. | Polypeptide-nucleic acid conjugates and uses thereof |
| GB0809476D0 (en) | 2008-05-23 | 2008-07-02 | Cambridge Entpr Ltd | Treatment of neurodegenerative disorders |
| DE102009058769A1 (de) * | 2009-12-16 | 2011-06-22 | MagForce Nanotechnologies AG, 10589 | Temperaturabhängige Aktivierung von katalytischen Nukleinsäuren zur kontrollierten Wirkstofffreisetzung |
| KR20130103662A (ko) | 2010-04-19 | 2013-09-24 | 엔라이프 떼라퓨틱스, 에스.엘. | 올리고뉴클레오티드 분자들의 특정 뉴런 유형들로의 선택적인 전달을 위한 조성물들 및 방법 |
| WO2012068405A2 (en) * | 2010-11-17 | 2012-05-24 | Isis Pharmaceuticals, Inc. | Modulation of alpha synuclein expression |
| WO2014064258A1 (en) | 2012-10-26 | 2014-05-01 | Nlife Therapeutics, S.L. | Compositions and methods for selective delivery of oligonucleotide molecules to cell types |
| HK1214179A1 (zh) | 2012-10-26 | 2016-07-22 | 恩莱弗医疗有限公司 | 通过选择性递送寡核苷酸分子至特定神经元类型治疗帕金森病的组合物和方法 |
-
2011
- 2011-04-19 KR KR1020127030202A patent/KR20130103662A/ko not_active Ceased
- 2011-04-19 BR BR112012026471A patent/BR112012026471A2/pt not_active IP Right Cessation
- 2011-04-19 CA CA2796722A patent/CA2796722C/en active Active
- 2011-04-19 DK DK11718678.3T patent/DK2560687T3/en active
- 2011-04-19 AU AU2011244321A patent/AU2011244321A1/en not_active Abandoned
- 2011-04-19 RU RU2012149042A patent/RU2664452C2/ru active
- 2011-04-19 US US13/066,590 patent/US9193969B2/en active Active
- 2011-04-19 WO PCT/EP2011/056270 patent/WO2011131693A2/en not_active Ceased
- 2011-04-19 MX MX2012012214A patent/MX342764B/es active IP Right Grant
- 2011-04-19 EP EP11718678.3A patent/EP2560687B1/en active Active
- 2011-04-19 EP EP17172370.3A patent/EP3231446B1/en active Active
- 2011-04-19 ES ES11718678.3T patent/ES2638309T3/es active Active
- 2011-04-19 LT LTEP11718678.3T patent/LT2560687T/lt unknown
- 2011-04-19 JP JP2013505466A patent/JP5819401B2/ja active Active
- 2011-04-20 AR ARP110101361A patent/AR083715A1/es not_active Application Discontinuation
-
2015
- 2015-11-23 US US14/949,490 patent/US10071163B2/en active Active
-
2017
- 2017-06-30 AU AU2017204529A patent/AU2017204529A1/en not_active Abandoned
-
2019
- 2019-06-04 AU AU2019203887A patent/AU2019203887B2/en active Active
-
2020
- 2020-04-15 AU AU2020202533A patent/AU2020202533B2/en active Active
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