JP2013521300A5 - - Google Patents
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- JP2013521300A5 JP2013521300A5 JP2012556198A JP2012556198A JP2013521300A5 JP 2013521300 A5 JP2013521300 A5 JP 2013521300A5 JP 2012556198 A JP2012556198 A JP 2012556198A JP 2012556198 A JP2012556198 A JP 2012556198A JP 2013521300 A5 JP2013521300 A5 JP 2013521300A5
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Families Citing this family (94)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2498603B1 (en) * | 2009-11-12 | 2016-07-13 | Signum Biosciences, Inc. | Use of anti-bacterial agents for the treatment of epithelial-related conditions |
| CA2790682C (en) | 2010-03-03 | 2020-11-24 | Neocutis Sa | Compositions and methods for the treatment of skin diseases and disorders using antimicrobial peptide sequestering compounds |
| CA2810746A1 (en) * | 2010-06-30 | 2012-01-05 | Galderma Research & Development | Method for preventing or treating skin tumor |
| US8236288B2 (en) * | 2011-01-07 | 2012-08-07 | Skinmedica, Inc. | Melanin modification compositions and methods of use |
| AU2012275292B2 (en) | 2011-06-28 | 2015-11-12 | Chemo Research, S.L. | High dosage mucoadhesive metronidazole aqueous-based gel formulations their use to treat bacterial vaginosis |
| FR2984126B1 (fr) * | 2011-12-20 | 2014-08-22 | Oreal | Polysaccharides sulfates agent antipelliculaire |
| CN102614298B (zh) * | 2012-04-26 | 2013-10-30 | 肖连元 | 一种烫伤喷剂及其制备方法 |
| DE102012214038A1 (de) * | 2012-08-08 | 2014-02-13 | Beiersdorf Ag | Verwendung von Wirkstoffkombinationen aus Harnstoff und Car-ni-tin und/oder einem oder mehreren Acyl-Carnitinen zur Behandlung und Prophylaxe von Neurodermitis sowie des diabetischen Fußes |
| GEAP201913925A (en) * | 2013-01-30 | 2019-07-10 | Boris Gorinshteyn | Compositions and methods for treating surface wounds |
| WO2014124458A1 (en) * | 2013-02-11 | 2014-08-14 | The Regents Of The University Of California | Compositions and methods for treating neurodegenerative diseases |
| FR3002452B1 (fr) * | 2013-02-28 | 2016-02-12 | Dermaconcept Jmc | Composition dermatologique antimicrobienne topique |
| GB201304041D0 (en) * | 2013-03-06 | 2013-04-17 | Water Jel Europ Llp | Treatment and prophylaxis of radiation dermatitis |
| WO2014140890A2 (en) | 2013-03-13 | 2014-09-18 | Neocutis Sa | Peptides for skin rejuvenation and methods of using the same |
| CN103263476B (zh) * | 2013-05-30 | 2015-05-13 | 广州市绿乔生物科技有限公司 | 一种用于减少刺激的复合抑菌剂 |
| US9193852B2 (en) * | 2013-12-27 | 2015-11-24 | L'oreal | Stable aerated compositions |
| CN104138397A (zh) * | 2014-01-13 | 2014-11-12 | 北京德默高科医药技术有限公司 | 一种预防和辅助治疗痔疮的组合物 |
| ES2919024T3 (es) | 2014-02-11 | 2022-07-21 | Mitokinin Inc | Composiciones y procedimientos que utilizan las mismas para el tratamiento de enfermedades neurodegenerativas y mitocondriales |
| CN103816089A (zh) * | 2014-03-11 | 2014-05-28 | 广州市洋林生物科技开发有限公司 | 一种皮肤粘膜抗菌液及皮肤粘膜抗菌湿巾 |
| CN103830303B (zh) * | 2014-03-11 | 2016-03-02 | 北京德默高科医药技术有限公司 | 一种预防褥疮的组合物 |
| CN116515924A (zh) * | 2014-04-16 | 2023-08-01 | 青岛惠诺德生物科技有限公司 | 一种生物活性透明质酸片段、其生产方法、应用、制剂及含有该制剂的物品 |
| FR3020570B1 (fr) * | 2014-04-30 | 2017-07-21 | Pierre Fabre Dermo Cosmetique | Association d'un acide hyaluronique et d'un polysaccharide sulfate |
| WO2016022066A1 (en) | 2014-08-04 | 2016-02-11 | Jerry Tan Eye Surgery Pte Ltd | Pharmaceutical compositions for demodex related blepharitis and eyelid crusting |
| US10912811B1 (en) * | 2014-10-28 | 2021-02-09 | Felician Stancioiu | Composition for improving peripheral circulation and healing of hematomas |
| WO2016090494A1 (en) * | 2014-12-12 | 2016-06-16 | Oceans Ltd. | Anti-microbial seaweed extracts, compositions and uses thereof |
| GB2536072A (en) * | 2014-12-13 | 2016-09-07 | Berezin Anatoljevieh Vadim | Method for determination of the choice of the active ingredients of biological and chemical composition against infectious, oncology, skin diseases, which are |
| WO2016137513A1 (en) * | 2015-02-27 | 2016-09-01 | Sutich Paul | Method and topical composition for the treatment of rosacea and skin erythema using selenium sulfide |
| CN104761629B (zh) * | 2015-03-05 | 2017-12-26 | 大连理工大学 | 一种广谱高效抗微生物肽Pb‑CATH‑OH1及其基因、制备方法和应用 |
| KR101721228B1 (ko) * | 2015-04-03 | 2017-03-30 | 사회복지법인 삼성생명공익재단 | 지방유래 줄기세포의 배양액을 유효성분으로 포함하는 발모촉진용 조성물 |
| CN104721129A (zh) * | 2015-04-13 | 2015-06-24 | 上海东晟源日化有限公司 | 微乳化生物科技护肤品 |
| CN106267168A (zh) * | 2015-05-12 | 2017-01-04 | 浙江海汇医疗科技有限公司 | 一种哺乳期妇女用乳头皲裂贴 |
| CN104928081B (zh) * | 2015-05-26 | 2018-01-16 | 广州瑞嘉精细化工有限公司 | 一种抑螨除螨的马油和植物组合物及其在制皂中的用途 |
| CN105254736B (zh) * | 2015-09-02 | 2018-06-08 | 大连理工大学 | 源于缅甸蟒的cathelicidin家族广谱抗微生物肽Pb-CATH4及其基因、制备与应用 |
| CN105085647B (zh) * | 2015-09-07 | 2018-06-08 | 大连理工大学 | 天然抗感染抗氧化双功能肽Pb-CATH2及其基因与应用 |
| US11702523B2 (en) | 2015-09-09 | 2023-07-18 | Bloom Holdings, Llc | Algae-derived flexible foam, and method of manufacturing the same |
| KR102463131B1 (ko) * | 2015-09-30 | 2022-11-04 | (주)아모레퍼시픽 | Aha, 우레아, 및 니아신아마이드를 포함하는 각질 연화용 및 미백용 화장료 조성물 |
| CN105287629B (zh) * | 2015-10-23 | 2018-04-17 | 四川农业大学 | 一种动物脱毛治疗剂的制备方法及其药用用途 |
| EP3380549A4 (en) | 2015-11-19 | 2019-09-11 | Bloom Holdings, LLC | SOFT FLEXIBLE FOAM DERIVED FROM ALGAE AND METHOD FOR THE PRODUCTION THEREOF |
| WO2017105413A1 (en) | 2015-12-15 | 2017-06-22 | Medicell Technologies, Llc | Stem cell stimulating compositions and methods of treating melasma |
| ITUB20160058A1 (it) * | 2016-01-19 | 2017-07-19 | Farm S R L C U S | Composizione di un preparato per il trattamento delle punture di insetto con attivita’ vasocostrittiva, lenitiva, disinfiammante e disarrossante |
| CN105622720B (zh) * | 2016-02-23 | 2020-09-08 | 浙江海洋学院 | 一种激活Nrf2-ARE通路的双髻鲨鱼肉抗氧化肽 |
| CN106075334A (zh) * | 2016-06-23 | 2016-11-09 | 贝亲管理（上海）有限公司 | 一种组合物在辅助治疗婴儿湿疹中的用途 |
| US11103544B2 (en) | 2016-12-30 | 2021-08-31 | Ann And Robert H. Lurie Children's Hospital Of Chicago | Application of honey and bacteria in methods of treating scalp conditions and hair conditions |
| US12337019B2 (en) | 2016-12-30 | 2025-06-24 | Northwestern University | Vehicles for applying bacteria to skin, scalp, and hair |
| CN108633253A (zh) * | 2017-01-19 | 2018-10-09 | 崔性铉 | 包括特应性疾病的血浆蛋白质的渗出性皮肤疾病的缓解及治疗用衬垫 |
| JP6900067B2 (ja) * | 2017-02-07 | 2021-07-07 | オンコクロス カンパニー，リミテッド | 癌の転移抑制および治療用組成物 |
| KR101859922B1 (ko) * | 2017-02-07 | 2018-05-21 | 주식회사 온코크로스 | 클로페네신을 포함하는 대장암 증식 및 전이 억제용 조성물 |
| CN106860401A (zh) * | 2017-02-09 | 2017-06-20 | 林映津 | 一种纯天然伤口修复剂 |
| CN106943594A (zh) * | 2017-03-29 | 2017-07-14 | 西安交通大学 | Psoriasin抗体和LL‑37抗体在制备防治银屑病的药物中的应用 |
| EA039464B1 (ru) * | 2017-04-26 | 2022-01-31 | Др. Редди'З Лабораториз Лимитед | Композиции для местного применения для ухода за кожей |
| AU2018290225A1 (en) | 2017-06-21 | 2020-01-23 | Mitokinin, Inc. | Compositions and methods using the same for treatment of neurodegenerative and mitochondrial disease |
| KR101983668B1 (ko) * | 2017-08-22 | 2019-05-29 | 건국대학교 산학협력단 | 그람 음성 박테리아에 대한 강한 항균 활성을 갖는 벌거숭이두더지쥐 유래의 항균성 폴리펩티드 및 이를 포함하는 약학 조성물 |
| MY210233A (en) * | 2017-10-11 | 2025-09-04 | Illustris Pharmaceuticals Inc | Methods and compositions for topical delivery |
| AU2018385766B2 (en) | 2017-12-15 | 2022-12-01 | Tarsus Pharmaceuticals, Inc. | Isoxazoline parasiticide formulations and methods for treating blepharitis |
| WO2019144116A1 (en) | 2018-01-22 | 2019-07-25 | Cancer Commons | Platforms for conducting virtual trials |
| WO2019167934A1 (ja) * | 2018-02-28 | 2019-09-06 | 三生医薬株式会社 | 皮膜組成物及び該皮膜組成物を用いたカプセル剤 |
| EP3765057A4 (en) * | 2018-03-13 | 2022-01-05 | Peptilogics, Inc. | TREATMENT OF IMPLANTS WITH GENERALLY MODIFIED AMPHIPHILIC PEPTIDES |
| CN108324926B (zh) * | 2018-03-23 | 2021-12-28 | 高志涛 | 干细胞提取物和抗菌肽的组合物及其用途 |
| CN108403582A (zh) * | 2018-04-08 | 2018-08-17 | 北京皓尔生物科技有限公司 | 一种含抗菌肽的防痘、祛痘组合物及其应用 |
| CN108294997A (zh) * | 2018-04-09 | 2018-07-20 | 青岛溯博生物技术有限公司 | 天然物质复合抗菌面膜粉、面膜及制备方法 |
| WO2019204729A1 (en) * | 2018-04-19 | 2019-10-24 | Worcester Polytechnic Institute | Compositions and methods for skin treatments |
| IT201800005585A1 (it) * | 2018-05-22 | 2019-11-22 | Composti per prevenire e trattare affezioni della pelle o della mucosa con componente infiammatoria | |
| CA3117657A1 (en) * | 2018-11-27 | 2020-06-04 | Colgate-Palmolive Company | Multi-benefit personal care compositions and methods for the same |
| CA3125456A1 (en) * | 2019-01-04 | 2020-07-09 | Dermata Therapeutics, Llc | Compositions and methods for the treatment of skin conditions |
| US12502377B2 (en) | 2019-04-04 | 2025-12-23 | Tarsus Pharmaceuticals, Inc. | Method of eradicating ticks that attach to humans using lotilaner formulations |
| FR3094637A1 (fr) * | 2019-04-04 | 2020-10-09 | Pierre Fabre Dermo-Cosmetique | Sulfate de dextran dans les dermatoses inflammatoires |
| CN109916917B (zh) * | 2019-04-17 | 2021-07-13 | 湖北三环锻造有限公司 | 一种渗透探伤工艺 |
| US20210000910A1 (en) | 2019-07-03 | 2021-01-07 | Jysk Skin Solutions Pte Ltd | Topical compositions |
| CN114867464A (zh) * | 2019-08-06 | 2022-08-05 | 大自然化妆品股份有限公司 | 局部化妆品组合物、所述组合物和用于面部施用滋补剂的用途 |
| MY206715A (en) * | 2019-09-20 | 2025-01-03 | Univ Fukui | Pharmaceutical composition |
| EP4017470A1 (en) | 2019-12-16 | 2022-06-29 | Colgate-Palmolive Company | Personal care compositions and methods for the same |
| MX2022007079A (es) | 2019-12-16 | 2022-07-11 | Colgate Palmolive Co | Composiciones para el cuidado personal y metodos para estas. |
| CN111388740B (zh) * | 2020-05-21 | 2021-09-10 | 南通大学 | 一种促伤口愈合敷料及其制备方法 |
| KR102174084B1 (ko) * | 2020-06-01 | 2020-11-04 | 바이오닉랩 주식회사 | Afa 블루그린알지를 이용한 피부개선 및 피부재생용 화장품 조성물 |
| DE102020211389A1 (de) | 2020-09-10 | 2022-03-10 | Beiersdorf Aktiengesellschaft | Wirkstoffhaltige Wundverschlusszubereitung |
| CN112043817A (zh) * | 2020-09-14 | 2020-12-08 | 北京皓尔生物科技有限公司 | 一种抗螨虫的组合物及其应用 |
| KR20230048426A (ko) * | 2020-09-29 | 2023-04-11 | 로레알 | 다양한 화장품층을 갖는 피부 상의 선스크린을 검출하기 위한 방법 및 장치 |
| CN112220705B (zh) * | 2020-10-29 | 2021-07-06 | 芭芭多芦荟生物科技研究(广州)院 | 纯天然组分的保湿化妆品 |
| DE212020000280U1 (de) * | 2020-11-10 | 2021-01-07 | Nantong Youyuan art design Co.,Ltd. | Kryokonservierungsrohr für mesenchymale Plazentastammzellen mit Überzugsschicht aus Ginsengpolysaccharid |
| CN112603993A (zh) * | 2020-12-19 | 2021-04-06 | 江苏诺瓦立医疗用品有限公司 | 一种基于壳聚糖治疗炎性痤疮的凝胶及其制备方法 |
| KR102744422B1 (ko) * | 2021-03-08 | 2024-12-19 | 주식회사 엘지생활건강 | 카르니틴살리실레이트(ca-sa)를 유효성분으로 포함하는 화장료 조성물 |
| CN113527428B (zh) * | 2021-09-17 | 2021-12-21 | 渤海水产育苗(山东)有限公司 | 海参肽及其应用和产品 |
| CN114209809B (zh) * | 2021-12-24 | 2023-09-05 | 成都佩德生物医药有限公司 | 一种抗痤疮丙酸杆菌的联合用药物组合物及其应用 |
| WO2023129413A1 (en) * | 2021-12-31 | 2023-07-06 | Ingredient Fusion, Llc | Molecular complexing method, formulation and manufacturing for enhanced nutrient delivery |
| CA3249846A1 (en) | 2022-01-28 | 2023-08-03 | Kenvue Brands Llc | Predictive Biomarkers for Atopic Dermatitis |
| KR20250025597A (ko) | 2022-04-04 | 2025-02-24 | 존슨 앤드 존슨 컨수머 인코포레이티드 | 아토피성 피부염의 발병을 예방하거나 아토피성 피부염을 치료하기 위한 기회의 창 피부 치료 요법 및 조성물 |
| US11730694B1 (en) | 2022-05-25 | 2023-08-22 | L'oreal | Hair coloring compositions and methods |
| US12083204B2 (en) | 2022-06-02 | 2024-09-10 | L'oreal | Topical composition for homeostatic delivery of nitric oxide and uses thereof |
| CN115011659B (zh) * | 2022-07-19 | 2024-04-19 | 北京臻味坊食品有限公司 | 混合坚果肽的制备方法和设备 |
| US12201717B2 (en) | 2022-10-31 | 2025-01-21 | Skinfix Inc. | Compositions and methods for supporting skin barrier homeostasis |
| WO2024102456A1 (en) * | 2022-11-09 | 2024-05-16 | Cfd Research Corporation | Compositions and methods for controlled release of therapeutic agents from articles |
| CN117064811B (zh) * | 2023-09-18 | 2024-04-12 | 广东省华桑丽皙生物技术有限公司 | 含有蚕丝抗菌肽的组合物及其在化妆品中的应用 |
| WO2025174368A1 (en) * | 2024-02-14 | 2025-08-21 | Sonenblick Jaacov | Dermatological cream formulated for skin affected by wearable electronics |
| CN118243829B (zh) * | 2024-05-29 | 2024-08-30 | 南通大学附属医院 | 一种治疗腹泻的蒙脱石药物有效成分检测方法 |
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Family Cites Families (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2798053A (en) | 1952-09-03 | 1957-07-02 | Goodrich Co B F | Carboxylic polymers |
| US3238100A (en) | 1963-07-23 | 1966-03-01 | American Maize Prod Co | Starch phosphate film composition and method of dressing wounds with same |
| JPS5677294A (en) * | 1979-08-28 | 1981-06-25 | Maruko Seiyaku Kk | Aluminum compound substance of sucrose sulfate and dihydroxy aluminum allantoinate |
| AU556817B2 (en) * | 1982-02-03 | 1986-11-20 | Efamol Limited | Topical application of a lithium salt and dihomo-alpha- linolenic acid |
| US4509949A (en) | 1983-06-13 | 1985-04-09 | The B. F. Goodrich Company | Water thickening agents consisting of copolymers of crosslinked acrylic acids and esters |
| GB8401206D0 (en) | 1984-01-17 | 1984-02-22 | Allied Colloids Ltd | Polymers and aqueous solutions |
| GB8414950D0 (en) | 1984-06-12 | 1984-07-18 | Allied Colloids Ltd | Cationic polyelectrolytes |
| GB8531118D0 (en) | 1985-12-18 | 1986-01-29 | Allied Colloids Ltd | Copolymers |
| US4912093A (en) | 1986-10-01 | 1990-03-27 | Marion Laboratories, Inc. | Use of synthetic sulfated saccharides to enhance wound healing |
| GB8622797D0 (en) | 1986-09-22 | 1986-10-29 | Allied Colloids Ltd | Polymeric particles |
| ES2061508T3 (es) | 1986-10-01 | 1994-12-16 | Allied Colloids Ltd | Composiciones polimericas solubles en agua. |
| US4879282A (en) * | 1987-03-17 | 1989-11-07 | Saliba Jr Michael J | Medical application for heparin and related molecules |
| DK505488D0 (da) | 1987-12-21 | 1988-09-09 | Bar Shalom Daniel | Middel og anvendelse af samme |
| US5916880A (en) * | 1987-12-21 | 1999-06-29 | Bukh Meditec A/S | Reduction of skin wrinkling using sulphated sugars |
| GB8909095D0 (en) | 1989-04-21 | 1989-06-07 | Allied Colloids Ltd | Thickened aqueous compositions |
| DE3922170A1 (de) * | 1989-07-06 | 1991-01-10 | Giulini Chemie | Neue salze von poly(alkylvinylether-maleinsaeureanhydrid) und damit hergestellte zahnprothesehaftmittel |
| US5087445A (en) | 1989-09-08 | 1992-02-11 | Richardson-Vicks, Inc. | Photoprotection compositions having reduced dermal irritation |
| CA2146988A1 (en) * | 1992-10-13 | 1994-04-28 | Gideon Strassmann | Treatment of cachexia and inhibition of il-6 activity |
| SE9402531L (sv) | 1994-07-19 | 1996-01-20 | Medicarb Ab | Sårläkningsmedel |
| DE69621528T2 (de) * | 1995-02-07 | 2003-01-16 | Shiseido Co. Ltd., Tokio/Tokyo | Anti-inflamatorische agenzien |
| JPH08277224A (ja) * | 1995-02-07 | 1996-10-22 | Shiseido Co Ltd | 抗炎症剤 |
| FR2732221B1 (fr) | 1995-03-28 | 1997-04-25 | Oreal | Utilisation d'un antagoniste de cgrp pour traiter les rougeurs cutanees d'origine neurogene et composition obtenue |
| SE508760C2 (sv) * | 1997-04-29 | 1998-11-02 | Medicarb Ab | Användning av en komposition innefattande kitosan i kombination med en polysackarid, som aktiv komponent i ett lösningsmedel, för framställning av ett spendoppningsmedel för mjölkproducerande djur |
| BR9909801A (pt) * | 1998-04-21 | 2002-01-22 | Infectio Recherche Inc | Formulações para a prevenção ou o tratamento de doenças que afetam mucosas ou pele, ou para evitar gravidez, e um aplicador para a liberação de formulações tópicas para as cavidades mucosas |
| WO1999064469A1 (en) * | 1998-06-09 | 1999-12-16 | Ghen Corporation | FIXATION INHIBITORS FOR $i(HELICOBACTER PYLORI) |
| US5952372A (en) | 1998-09-17 | 1999-09-14 | Mcdaniel; William Robert | Method for treating rosacea using oral or topical ivermectin |
| JP2000178196A (ja) | 1998-12-11 | 2000-06-27 | Seikagaku Kogyo Co Ltd | 新規ヒアルロニダーゼ阻害剤及び外用剤 |
| US7816402B2 (en) * | 1999-03-19 | 2010-10-19 | Bioderm, Inc. | Compositions and methods for the treatment of skin |
| US6444647B1 (en) | 1999-04-19 | 2002-09-03 | The Procter & Gamble Company | Skin care compositions containing combination of skin care actives |
| GB9917092D0 (en) * | 1999-07-22 | 1999-09-22 | Ml Lab Plc | Treatment of angiogenesis-dependent conditions |
| FR2799369B1 (fr) * | 1999-10-08 | 2001-12-21 | Oreal | Association d'escine et de sulfate de dextran et son utilisation |
| US20070009586A1 (en) * | 2000-02-29 | 2007-01-11 | Cohen Kelman I | Wound dressings containing complexes of transition metals and alginate for elastase sequestering |
| US6440465B1 (en) * | 2000-05-01 | 2002-08-27 | Bioderm, Inc. | Topical composition for the treatment of psoriasis and related skin disorders |
| TWI320713B (https=) | 2001-06-01 | 2010-02-21 | Neochemir Inc | |
| US6680062B2 (en) | 2001-10-05 | 2004-01-20 | Color Access, Inc. | Anti-irritating rosacea treatment |
| JP2005060234A (ja) | 2003-08-08 | 2005-03-10 | Rohto Pharmaceut Co Ltd | 皮膚外用剤 |
| EP1784150A4 (en) * | 2004-09-01 | 2011-05-11 | Nexmed Holdings Inc | TRANSDERMAL DELIVERY SYSTEM FOR ANTIEMETIC COMPOSITION |
| FR2877565A1 (fr) * | 2004-11-09 | 2006-05-12 | Oreal | Utilisation d'un sulfate de dextran de haut poids moleculaire comme agent apaisant |
| US7384916B2 (en) * | 2005-03-16 | 2008-06-10 | Procyte Corporation | Methods and compositions for preventing and treating aging or photodamaged skin |
| WO2006111633A2 (fr) * | 2005-04-18 | 2006-10-26 | Sc Dicophar | Utilisation de la lecithine comme medicament dans le traitement du psoriasis |
| EP1885865A4 (en) | 2005-05-12 | 2010-12-22 | Univ North Carolina | ENZYMATIC SYNTHESIS OF SULFATED POLYSACCHARIDES |
| GB0517236D0 (en) | 2005-08-23 | 2005-09-28 | Ricardo Uk Ltd | A split carburettor with offset throttle plate |
| CN101282708B (zh) * | 2005-10-05 | 2013-03-20 | 江崎格力高株式会社 | 含有磷酸化糖的皮肤外用剂 |
| EP2069377A4 (en) | 2006-09-27 | 2009-11-11 | Univ California | METHOD AND COMPOSITIONS FOR THE TREATMENT OF SKIN DISEASES AND SKIN FUNCTIONAL DISORDERS |
| WO2008047779A1 (fr) * | 2006-10-17 | 2008-04-24 | Glycoscience Laboratories, Inc. | Agent thérapeutique ou prophylactique pour la dermatite atopique |
| DE102006062438A1 (de) * | 2006-12-27 | 2008-07-03 | Henkel Kgaa | Kosmetische Zusammensetzungen zur Glättung und Straffung der Haut |
| WO2008134430A1 (en) * | 2007-04-24 | 2008-11-06 | Novelmed Therapeutics Inc. | Methods and compositions of inhibiting complement and cellular activation with dextran sulfate |
| WO2009015183A1 (en) * | 2007-07-23 | 2009-01-29 | University Of Utah Research Foundation | Method for blocking ligation of the receptor for advanced glycation end-products (rage) |
| US8802073B2 (en) * | 2007-11-15 | 2014-08-12 | Prelief Inc. | Methods and compositions for wound healing |
| US8114898B2 (en) | 2007-11-16 | 2012-02-14 | Allergan, Inc. | Compositions and methods for treating purpura |
| JP2009143863A (ja) * | 2007-12-14 | 2009-07-02 | Showa Denko Kk | 皮膚収斂剤 |
| AU2009231634B2 (en) | 2008-04-04 | 2014-05-15 | University Of Utah Research Foundation | Alkylated semi-synthetic glycosaminoglycosan ethers, and methods for making and using thereof |
| US7932237B2 (en) * | 2008-05-15 | 2011-04-26 | Consejo Nacional De Investigaciones Cientificas Y Technicas (CONICET) | Pharmaceutical compositions for use in the treatment of wounds |
| EP2201930A1 (en) * | 2008-12-23 | 2010-06-30 | Intendis GmbH | Hydrogel composition for the treatment of dermatological disorders |
| WO2010083368A2 (en) | 2009-01-16 | 2010-07-22 | Neocutis Sa | Calcium sequestration compositions and methods of treating skin pigmentation disorders and conditions |
| JO3676B1 (ar) * | 2009-07-27 | 2020-08-27 | Arc Medical Devices Inc | مركبات صيدلانية تضم فوكانات معدلة وطرق تتعلق بها |
| CA2790682C (en) | 2010-03-03 | 2020-11-24 | Neocutis Sa | Compositions and methods for the treatment of skin diseases and disorders using antimicrobial peptide sequestering compounds |
-
2011
- 2011-03-02 CA CA2790682A patent/CA2790682C/en active Active
- 2011-03-02 US US13/038,524 patent/US9629856B2/en active Active
- 2011-03-02 CN CN201180022095.1A patent/CN102985091B/zh active Active
- 2011-03-02 EP EP11707328A patent/EP2542246A1/en not_active Withdrawn
- 2011-03-02 JP JP2012556198A patent/JP2013521300A/ja active Pending
- 2011-03-02 WO PCT/US2011/026804 patent/WO2011109469A1/en not_active Ceased
- 2011-03-02 KR KR1020127025690A patent/KR20130018739A/ko not_active Ceased
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