JP2013515243A5 - - Google Patents
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- JP2013515243A5 JP2013515243A5 JP2012544950A JP2012544950A JP2013515243A5 JP 2013515243 A5 JP2013515243 A5 JP 2013515243A5 JP 2012544950 A JP2012544950 A JP 2012544950A JP 2012544950 A JP2012544950 A JP 2012544950A JP 2013515243 A5 JP2013515243 A5 JP 2013515243A5
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- binding protein
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- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 claims 80
- 102100029228 Insulin-like growth factor-binding protein 7 Human genes 0.000 claims 73
- 108010008598 insulin-like growth factor binding protein-related protein 1 Proteins 0.000 claims 73
- 102000016799 Leukocyte elastase Human genes 0.000 claims 70
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 66
- 229920002674 hyaluronan Polymers 0.000 claims 66
- 229960003160 hyaluronic acid Drugs 0.000 claims 66
- 108010028275 Leukocyte Elastase Proteins 0.000 claims 64
- 108010050122 alpha 1-Antitrypsin Proteins 0.000 claims 62
- 102000015395 alpha 1-Antitrypsin Human genes 0.000 claims 62
- 229940024142 alpha 1-antitrypsin Drugs 0.000 claims 62
- 239000003475 metalloproteinase inhibitor Substances 0.000 claims 50
- 101000998548 Yersinia ruckeri Alkaline proteinase inhibitor Proteins 0.000 claims 49
- 229940109239 creatinine Drugs 0.000 claims 40
- 210000002966 serum Anatomy 0.000 claims 40
- 238000000034 method Methods 0.000 claims 37
- 210000002700 urine Anatomy 0.000 claims 35
- 108010045517 Serum Amyloid P-Component Proteins 0.000 claims 29
- 102100036202 Serum amyloid P-component Human genes 0.000 claims 29
- 102100030802 Beta-2-glycoprotein 1 Human genes 0.000 claims 27
- 101710180007 Beta-2-glycoprotein 1 Proteins 0.000 claims 27
- 238000003556 assay Methods 0.000 claims 25
- 230000003907 kidney function Effects 0.000 claims 25
- 102000003745 Hepatocyte Growth Factor Human genes 0.000 claims 24
- 108090000100 Hepatocyte Growth Factor Proteins 0.000 claims 24
- 208000009304 Acute Kidney Injury Diseases 0.000 claims 19
- 208000033626 Renal failure acute Diseases 0.000 claims 19
- 201000011040 acute kidney failure Diseases 0.000 claims 19
- 208000012998 acute renal failure Diseases 0.000 claims 17
- 210000001124 body fluid Anatomy 0.000 claims 16
- 229940099472 immunoglobulin a Drugs 0.000 claims 16
- 102000003908 Cathepsin D Human genes 0.000 claims 14
- 108090000258 Cathepsin D Proteins 0.000 claims 14
- 102000003815 Interleukin-11 Human genes 0.000 claims 14
- 108090000177 Interleukin-11 Proteins 0.000 claims 14
- 229940074383 interleukin-11 Drugs 0.000 claims 14
- 108060003951 Immunoglobulin Proteins 0.000 claims 11
- 102100032236 Tumor necrosis factor receptor superfamily member 11B Human genes 0.000 claims 11
- 101710178443 Tumor necrosis factor receptor superfamily member 11B Proteins 0.000 claims 11
- 230000006378 damage Effects 0.000 claims 11
- 102000018358 immunoglobulin Human genes 0.000 claims 11
- 210000003734 kidney Anatomy 0.000 claims 11
- 102000019034 Chemokines Human genes 0.000 claims 10
- 108010012236 Chemokines Proteins 0.000 claims 10
- 239000010839 body fluid Substances 0.000 claims 10
- 239000012530 fluid Substances 0.000 claims 10
- 102000018866 Hyaluronan Receptors Human genes 0.000 claims 7
- 108010013214 Hyaluronan Receptors Proteins 0.000 claims 7
- 108010000303 Secretory Proteinase Inhibitory Proteins Proteins 0.000 claims 6
- 239000003591 leukocyte elastase inhibitor Substances 0.000 claims 6
- LOGFVTREOLYCPF-KXNHARMFSA-N (2s,3r)-2-[[(2r)-1-[(2s)-2,6-diaminohexanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxybutanoic acid Chemical compound C[C@@H](O)[C@@H](C(O)=O)NC(=O)[C@H]1CCCN1C(=O)[C@@H](N)CCCCN LOGFVTREOLYCPF-KXNHARMFSA-N 0.000 claims 5
- 201000003126 Anuria Diseases 0.000 claims 5
- 102100039398 C-X-C motif chemokine 2 Human genes 0.000 claims 5
- 101710085496 C-X-C motif chemokine 2 Proteins 0.000 claims 5
- 102100036189 C-X-C motif chemokine 3 Human genes 0.000 claims 5
- 101710085501 C-X-C motif chemokine 3 Proteins 0.000 claims 5
- 102100034221 Growth-regulated alpha protein Human genes 0.000 claims 5
- 101710163784 Growth-regulated alpha protein Proteins 0.000 claims 5
- 102000015271 Intercellular Adhesion Molecule-1 Human genes 0.000 claims 5
- 108010064593 Intercellular Adhesion Molecule-1 Proteins 0.000 claims 5
- 102000003777 Interleukin-1 beta Human genes 0.000 claims 5
- 108090000193 Interleukin-1 beta Proteins 0.000 claims 5
- 102000004318 Matrilysin Human genes 0.000 claims 5
- 108090000855 Matrilysin Proteins 0.000 claims 5
- 102100023702 C-C motif chemokine 13 Human genes 0.000 claims 4
- 101710112613 C-C motif chemokine 13 Proteins 0.000 claims 4
- 102100036153 C-X-C motif chemokine 6 Human genes 0.000 claims 4
- 101710085504 C-X-C motif chemokine 6 Proteins 0.000 claims 4
- 102000007351 Interleukin-2 Receptor alpha Subunit Human genes 0.000 claims 4
- 108010032774 Interleukin-2 Receptor alpha Subunit Proteins 0.000 claims 4
- 102100028123 Macrophage colony-stimulating factor 1 Human genes 0.000 claims 4
- 101710127797 Macrophage colony-stimulating factor 1 Proteins 0.000 claims 4
- 206010061481 Renal injury Diseases 0.000 claims 4
- 239000003153 chemical reaction reagent Substances 0.000 claims 4
- 230000007423 decrease Effects 0.000 claims 4
- 210000000440 neutrophil Anatomy 0.000 claims 4
- 102000006395 Globulins Human genes 0.000 claims 3
- 108010044091 Globulins Proteins 0.000 claims 3
- 108090000965 Insulin-like growth factor binding protein 3 Proteins 0.000 claims 3
- 102000004374 Insulin-like growth factor binding protein 3 Human genes 0.000 claims 3
- 102000016387 Pancreatic elastase Human genes 0.000 claims 3
- 108010067372 Pancreatic elastase Proteins 0.000 claims 3
- 230000027455 binding Effects 0.000 claims 3
- 239000000090 biomarker Substances 0.000 claims 3
- 230000003247 decreasing effect Effects 0.000 claims 3
- 230000036039 immunity Effects 0.000 claims 3
- 230000002608 insulinlike Effects 0.000 claims 3
- 208000037806 kidney injury Diseases 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 206010007559 Cardiac failure congestive Diseases 0.000 claims 2
- 102000014914 Carrier Proteins Human genes 0.000 claims 2
- 206010019280 Heart failures Diseases 0.000 claims 2
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 claims 2
- 208000001647 Renal Insufficiency Diseases 0.000 claims 2
- 102000013275 Somatomedins Human genes 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 108091008324 binding proteins Proteins 0.000 claims 2
- 208000029078 coronary artery disease Diseases 0.000 claims 2
- 206010012601 diabetes mellitus Diseases 0.000 claims 2
- 238000003745 diagnosis Methods 0.000 claims 2
- 208000002296 eclampsia Diseases 0.000 claims 2
- 238000011156 evaluation Methods 0.000 claims 2
- 230000006870 function Effects 0.000 claims 2
- 210000003494 hepatocyte Anatomy 0.000 claims 2
- 201000006370 kidney failure Diseases 0.000 claims 2
- 201000011461 pre-eclampsia Diseases 0.000 claims 2
- 238000004393 prognosis Methods 0.000 claims 2
- 201000001474 proteinuria Diseases 0.000 claims 2
- 238000012959 renal replacement therapy Methods 0.000 claims 2
- 238000002054 transplantation Methods 0.000 claims 2
- 206010002329 Aneurysm Diseases 0.000 claims 1
- 206010016654 Fibrosis Diseases 0.000 claims 1
- 208000031886 HIV Infections Diseases 0.000 claims 1
- 208000037357 HIV infectious disease Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 208000001953 Hypotension Diseases 0.000 claims 1
- 208000019693 Lung disease Diseases 0.000 claims 1
- 102000007651 Macrophage Colony-Stimulating Factor Human genes 0.000 claims 1
- 108010046938 Macrophage Colony-Stimulating Factor Proteins 0.000 claims 1
- 102100026262 Metalloproteinase inhibitor 2 Human genes 0.000 claims 1
- 108050006602 Metalloproteinase inhibitor 2 Proteins 0.000 claims 1
- 102000018315 Parkinson Disease Associated Proteins Human genes 0.000 claims 1
- 108010066305 Parkinson Disease Associated Proteins Proteins 0.000 claims 1
- 206010040047 Sepsis Diseases 0.000 claims 1
- 206010069351 acute lung injury Diseases 0.000 claims 1
- 238000007675 cardiac surgery Methods 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 230000007882 cirrhosis Effects 0.000 claims 1
- 208000019425 cirrhosis of liver Diseases 0.000 claims 1
- 238000012875 competitive assay Methods 0.000 claims 1
- 239000002131 composite material Substances 0.000 claims 1
- 210000004351 coronary vessel Anatomy 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003602 elastase inhibitor Substances 0.000 claims 1
- 229920001971 elastomer Polymers 0.000 claims 1
- 239000000806 elastomer Substances 0.000 claims 1
- 230000024924 glomerular filtration Effects 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- 102000028718 growth factor binding proteins Human genes 0.000 claims 1
- 108091009353 growth factor binding proteins Proteins 0.000 claims 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims 1
- 230000036543 hypotension Effects 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 108091022911 insulin-like growth factor binding Proteins 0.000 claims 1
- 102000028416 insulin-like growth factor binding Human genes 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 230000003589 nefrotoxic effect Effects 0.000 claims 1
- 231100000381 nephrotoxic Toxicity 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 238000012493 sandwich binding assay Methods 0.000 claims 1
- 230000035939 shock Effects 0.000 claims 1
- 238000013517 stratification Methods 0.000 claims 1
- 230000036325 urinary excretion Effects 0.000 claims 1
- 238000007631 vascular surgery Methods 0.000 claims 1
Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28832709P | 2009-12-20 | 2009-12-20 | |
| US61/288,327 | 2009-12-20 | ||
| US30886110P | 2010-02-26 | 2010-02-26 | |
| US61/308,861 | 2010-02-26 | ||
| US41087510P | 2010-11-06 | 2010-11-06 | |
| US41087810P | 2010-11-06 | 2010-11-06 | |
| US41088010P | 2010-11-06 | 2010-11-06 | |
| US41087910P | 2010-11-06 | 2010-11-06 | |
| US61/410,878 | 2010-11-06 | ||
| US61/410,879 | 2010-11-06 | ||
| US61/410,875 | 2010-11-06 | ||
| US61/410,880 | 2010-11-06 | ||
| PCT/US2010/061377 WO2011075744A1 (en) | 2009-12-20 | 2010-12-20 | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014237875A Division JP6309434B2 (ja) | 2009-12-20 | 2014-11-25 | 腎損傷および腎不全の診断および予後診断のための方法ならびに組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013515243A JP2013515243A (ja) | 2013-05-02 |
| JP2013515243A5 true JP2013515243A5 (https=) | 2014-01-23 |
| JP5763098B2 JP5763098B2 (ja) | 2015-08-12 |
Family
ID=44167738
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012544950A Active JP5763098B2 (ja) | 2009-12-20 | 2010-12-20 | 腎損傷および腎不全の診断および予後診断のための方法ならびに組成物 |
| JP2014237875A Active JP6309434B2 (ja) | 2009-12-20 | 2014-11-25 | 腎損傷および腎不全の診断および予後診断のための方法ならびに組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014237875A Active JP6309434B2 (ja) | 2009-12-20 | 2014-11-25 | 腎損傷および腎不全の診断および予後診断のための方法ならびに組成物 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US10830773B2 (https=) |
| EP (2) | EP3112871B1 (https=) |
| JP (2) | JP5763098B2 (https=) |
| KR (2) | KR102003258B1 (https=) |
| CN (2) | CN104698161A (https=) |
| AU (2) | AU2010330735B2 (https=) |
| CA (1) | CA2784889C (https=) |
| EA (1) | EA201290387A1 (https=) |
| ES (2) | ES2592386T3 (https=) |
| HK (1) | HK1211082A1 (https=) |
| MX (1) | MX342967B (https=) |
| NZ (3) | NZ600828A (https=) |
| WO (1) | WO2011075744A1 (https=) |
Families Citing this family (58)
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|---|---|---|---|---|
| NZ610356A (en) | 2008-08-28 | 2015-03-27 | Astute Medical Inc | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| CA2735590A1 (en) | 2008-08-29 | 2010-03-04 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| NZ607703A (en) | 2008-10-21 | 2014-09-26 | Astute Medical Inc | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| CN102264230B (zh) | 2008-11-10 | 2014-12-10 | 阿斯图特医药公司 | 用于诊断和预后肾损伤和肾衰竭的方法和组合物 |
| US9229010B2 (en) | 2009-02-06 | 2016-01-05 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
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| NZ630277A (en) * | 2009-09-21 | 2015-02-27 | Astute Medical Inc | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| EP2496942B1 (en) | 2009-11-07 | 2017-03-22 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| JP5763098B2 (ja) | 2009-12-20 | 2015-08-12 | アスチュート メディカル，インコーポレイテッド | 腎損傷および腎不全の診断および予後診断のための方法ならびに組成物 |
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| NZ605698A (en) | 2010-06-23 | 2015-03-27 | Astute Medical Inc | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| IN2012MN02812A (https=) | 2010-06-23 | 2015-05-22 | Astute Medical Inc | |
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| US10557856B2 (en) * | 2010-09-24 | 2020-02-11 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Biomarkers of renal injury |
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| EP3617234A1 (en) | 2013-08-07 | 2020-03-04 | Astute Medical, Inc. | Assays for timp2 having improved performance in biological samples |
| US9822172B2 (en) | 2013-11-06 | 2017-11-21 | Astute Medical, Inc. | Assays for IGFBP7 having improved performance in biological samples |
| US10300108B2 (en) | 2013-12-03 | 2019-05-28 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| US11243202B2 (en) | 2015-04-09 | 2022-02-08 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| JP6859334B2 (ja) | 2015-10-08 | 2021-04-14 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 手術前に測定した際にａｋｉのリスクを予測するためのｉｇｆｂｐ７ |
| EP3465201A4 (en) | 2016-06-06 | 2020-08-26 | Astute Medical, Inc. | MANAGEMENT OF ACUTE KIDNEY DAMAGE USING INSULINOMIMETIC GROWTH FACTOR BINDING PROTEIN 7 AND TISSUE METALLOPROTEINASE 2 INHIBITOR |
| CN110352073A (zh) | 2016-10-28 | 2019-10-18 | 机敏医药股份有限公司 | 针对timp-2的抗体用于改善肾功能的用途 |
| US11346846B2 (en) | 2017-02-06 | 2022-05-31 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| US11718682B2 (en) | 2017-04-05 | 2023-08-08 | Astute Medical, Inc. | Assays for TIMP2 having improved performance in biological samples |
| WO2018208684A1 (en) | 2017-05-07 | 2018-11-15 | Astute Medical, Inc. | Use of insulin-like growth factor-binding protein 7 and tissue inhibitor of metalloproteinase 2 in the management of renal replacement therapy |
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