JP2013539861A5 - - Google Patents
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- JP2013539861A5 JP2013539861A5 JP2013532937A JP2013532937A JP2013539861A5 JP 2013539861 A5 JP2013539861 A5 JP 2013539861A5 JP 2013532937 A JP2013532937 A JP 2013532937A JP 2013532937 A JP2013532937 A JP 2013532937A JP 2013539861 A5 JP2013539861 A5 JP 2013539861A5
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- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 claims 38
- 210000002700 urine Anatomy 0.000 claims 33
- 210000001124 body fluid Anatomy 0.000 claims 26
- 229940109239 creatinine Drugs 0.000 claims 19
- 238000005259 measurement Methods 0.000 claims 19
- 238000000034 method Methods 0.000 claims 19
- 210000002966 serum Anatomy 0.000 claims 19
- 238000003556 assay Methods 0.000 claims 16
- 102000005706 Keratin-6 Human genes 0.000 claims 12
- 108010070557 Keratin-6 Proteins 0.000 claims 12
- 230000036470 plasma concentration Effects 0.000 claims 12
- 239000010839 body fluid Substances 0.000 claims 10
- 208000009304 Acute Kidney Injury Diseases 0.000 claims 9
- 208000033626 Renal failure acute Diseases 0.000 claims 9
- 201000011040 acute kidney failure Diseases 0.000 claims 9
- 208000012998 acute renal failure Diseases 0.000 claims 9
- 108010025020 Nerve Growth Factor Proteins 0.000 claims 7
- 230000003907 kidney function Effects 0.000 claims 7
- 108090000765 processed proteins & peptides Proteins 0.000 claims 7
- VOUAQYXWVJDEQY-QENPJCQMSA-N 33017-11-7 Chemical compound OC(=O)CC[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)CCC1 VOUAQYXWVJDEQY-QENPJCQMSA-N 0.000 claims 6
- 102000054930 Agouti-Related Human genes 0.000 claims 6
- 101710127426 Agouti-related protein Proteins 0.000 claims 6
- 101710111255 Appetite-regulating hormone Proteins 0.000 claims 6
- 102000017284 Collagenase 3 Human genes 0.000 claims 6
- 108010014612 Follistatin Proteins 0.000 claims 6
- 102000016970 Follistatin Human genes 0.000 claims 6
- 102100040977 Follitropin subunit beta Human genes 0.000 claims 6
- 101710203050 Follitropin subunit beta Proteins 0.000 claims 6
- 108010004460 Gastric Inhibitory Polypeptide Proteins 0.000 claims 6
- 102100039994 Gastric inhibitory polypeptide Human genes 0.000 claims 6
- 102000012004 Ghrelin Human genes 0.000 claims 6
- 102000051325 Glucagon Human genes 0.000 claims 6
- 108060003199 Glucagon Proteins 0.000 claims 6
- 101800000224 Glucagon-like peptide 1 Proteins 0.000 claims 6
- DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 claims 6
- 108010034219 Insulin Receptor Substrate Proteins Proteins 0.000 claims 6
- 102000009433 Insulin Receptor Substrate Proteins Human genes 0.000 claims 6
- 102000013691 Interleukin-17 Human genes 0.000 claims 6
- 108050003558 Interleukin-17 Proteins 0.000 claims 6
- 102000036770 Islet Amyloid Polypeptide Human genes 0.000 claims 6
- 108010041872 Islet Amyloid Polypeptide Proteins 0.000 claims 6
- 102100023970 Keratin, type I cytoskeletal 10 Human genes 0.000 claims 6
- 102100022905 Keratin, type II cytoskeletal 1 Human genes 0.000 claims 6
- 108010070514 Keratin-1 Proteins 0.000 claims 6
- 108010065038 Keratin-10 Proteins 0.000 claims 6
- 108010076503 Matrix Metalloproteinase 13 Proteins 0.000 claims 6
- 102000003945 NF-kappa B Human genes 0.000 claims 6
- 108010057466 NF-kappa B Proteins 0.000 claims 6
- 102000015336 Nerve Growth Factor Human genes 0.000 claims 6
- 102000004067 Osteocalcin Human genes 0.000 claims 6
- 108090000573 Osteocalcin Proteins 0.000 claims 6
- 108010071690 Prealbumin Proteins 0.000 claims 6
- 102100040918 Pro-glucagon Human genes 0.000 claims 6
- 102000009190 Transthyretin Human genes 0.000 claims 6
- 102000050760 Vitamin D-binding protein Human genes 0.000 claims 6
- 101710179590 Vitamin D-binding protein Proteins 0.000 claims 6
- 230000003436 cytoskeletal effect Effects 0.000 claims 6
- 210000004292 cytoskeleton Anatomy 0.000 claims 6
- 239000002158 endotoxin Substances 0.000 claims 6
- MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 claims 6
- 229960004666 glucagon Drugs 0.000 claims 6
- 239000003112 inhibitor Substances 0.000 claims 6
- 102000007236 involucrin Human genes 0.000 claims 6
- 108010033564 involucrin Proteins 0.000 claims 6
- 229920006008 lipopolysaccharide Polymers 0.000 claims 6
- 229920001184 polypeptide Polymers 0.000 claims 6
- 102000004196 processed proteins & peptides Human genes 0.000 claims 6
- 210000000952 spleen Anatomy 0.000 claims 6
- 230000002485 urinary effect Effects 0.000 claims 6
- YNXLOPYTAAFMTN-SBUIBGKBSA-N C([C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(N)=O)C1=CC=C(O)C=C1 Chemical compound C([C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(N)=O)C1=CC=C(O)C=C1 YNXLOPYTAAFMTN-SBUIBGKBSA-N 0.000 claims 5
- 108010005939 Ciliary Neurotrophic Factor Proteins 0.000 claims 5
- 102100031614 Ciliary neurotrophic factor Human genes 0.000 claims 5
- 102000016550 Complement Factor H Human genes 0.000 claims 5
- 108010053085 Complement Factor H Proteins 0.000 claims 5
- 108010088847 Peptide YY Proteins 0.000 claims 5
- 102100029909 Peptide YY Human genes 0.000 claims 5
- 239000003153 chemical reaction reagent Substances 0.000 claims 4
- 210000003734 kidney Anatomy 0.000 claims 4
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 3
- 206010061481 Renal injury Diseases 0.000 claims 3
- 239000000090 biomarker Substances 0.000 claims 3
- 230000027455 binding Effects 0.000 claims 2
- 230000006378 damage Effects 0.000 claims 2
- 230000003247 decreasing effect Effects 0.000 claims 2
- 238000003745 diagnosis Methods 0.000 claims 2
- 238000012959 renal replacement therapy Methods 0.000 claims 2
- 238000002054 transplantation Methods 0.000 claims 2
- 201000003126 Anuria Diseases 0.000 claims 1
- 206010007559 Cardiac failure congestive Diseases 0.000 claims 1
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 1
- 108010036949 Cyclosporine Proteins 0.000 claims 1
- 206010016654 Fibrosis Diseases 0.000 claims 1
- 102100030386 Granzyme A Human genes 0.000 claims 1
- 206010019280 Heart failures Diseases 0.000 claims 1
- 102000001554 Hemoglobins Human genes 0.000 claims 1
- 108010054147 Hemoglobins Proteins 0.000 claims 1
- 101001009599 Homo sapiens Granzyme A Proteins 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims 1
- 102000036675 Myoglobin Human genes 0.000 claims 1
- 108010062374 Myoglobin Proteins 0.000 claims 1
- 102000007072 Nerve Growth Factors Human genes 0.000 claims 1
- 208000001647 Renal Insufficiency Diseases 0.000 claims 1
- 206010040047 Sepsis Diseases 0.000 claims 1
- ZSJLQEPLLKMAKR-UHFFFAOYSA-N Streptozotocin Natural products O=NN(C)C(=O)NC1C(O)OC(CO)C(O)C1O ZSJLQEPLLKMAKR-UHFFFAOYSA-N 0.000 claims 1
- QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 claims 1
- 208000027418 Wounds and injury Diseases 0.000 claims 1
- 229940126575 aminoglycoside Drugs 0.000 claims 1
- 238000007675 cardiac surgery Methods 0.000 claims 1
- 229960001265 ciclosporin Drugs 0.000 claims 1
- 210000004240 ciliary body Anatomy 0.000 claims 1
- 230000007882 cirrhosis Effects 0.000 claims 1
- 208000019425 cirrhosis of liver Diseases 0.000 claims 1
- 238000012875 competitive assay Methods 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 239000002131 composite material Substances 0.000 claims 1
- 239000002872 contrast media Substances 0.000 claims 1
- 208000029078 coronary artery disease Diseases 0.000 claims 1
- 210000004351 coronary vessel Anatomy 0.000 claims 1
- 229930182912 cyclosporin Natural products 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 208000002296 eclampsia Diseases 0.000 claims 1
- 238000011156 evaluation Methods 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- 230000006870 function Effects 0.000 claims 1
- 230000024924 glomerular filtration Effects 0.000 claims 1
- 229910001385 heavy metal Inorganic materials 0.000 claims 1
- HOMGKSMUEGBAAB-UHFFFAOYSA-N ifosfamide Chemical compound ClCCNP1(=O)OCCCN1CCCl HOMGKSMUEGBAAB-UHFFFAOYSA-N 0.000 claims 1
- 229960001101 ifosfamide Drugs 0.000 claims 1
- 230000001771 impaired effect Effects 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 201000006370 kidney failure Diseases 0.000 claims 1
- 229960000485 methotrexate Drugs 0.000 claims 1
- 239000003900 neurotrophic factor Substances 0.000 claims 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 1
- -1 one or more of YY Proteins 0.000 claims 1
- 201000011461 pre-eclampsia Diseases 0.000 claims 1
- 238000004393 prognosis Methods 0.000 claims 1
- 201000001474 proteinuria Diseases 0.000 claims 1
- 230000002829 reductive effect Effects 0.000 claims 1
- 238000012493 sandwich binding assay Methods 0.000 claims 1
- ZSJLQEPLLKMAKR-GKHCUFPYSA-N streptozocin Chemical compound O=NN(C)C(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O ZSJLQEPLLKMAKR-GKHCUFPYSA-N 0.000 claims 1
- 229960001052 streptozocin Drugs 0.000 claims 1
- 229960001967 tacrolimus Drugs 0.000 claims 1
- QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 claims 1
- 238000007631 vascular surgery Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39099910P | 2010-10-07 | 2010-10-07 | |
| US61/390,999 | 2010-10-07 | ||
| PCT/US2011/055055 WO2012048082A2 (en) | 2010-10-07 | 2011-10-06 | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016118970A Division JP6321080B2 (ja) | 2010-10-07 | 2016-06-15 | 腎損傷および腎不全の診断および予後診断のための方法ならびに組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013539861A JP2013539861A (ja) | 2013-10-28 |
| JP2013539861A5 true JP2013539861A5 (https=) | 2014-11-13 |
Family
ID=45928428
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013532937A Pending JP2013539861A (ja) | 2010-10-07 | 2011-10-06 | 腎損傷および腎不全の診断および予後診断のための方法ならびに組成物 |
| JP2016118970A Active JP6321080B2 (ja) | 2010-10-07 | 2016-06-15 | 腎損傷および腎不全の診断および予後診断のための方法ならびに組成物 |
| JP2018072166A Ceased JP2018141793A (ja) | 2010-10-07 | 2018-04-04 | 腎損傷および腎不全の診断および予後診断のための方法ならびに組成物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016118970A Active JP6321080B2 (ja) | 2010-10-07 | 2016-06-15 | 腎損傷および腎不全の診断および予後診断のための方法ならびに組成物 |
| JP2018072166A Ceased JP2018141793A (ja) | 2010-10-07 | 2018-04-04 | 腎損傷および腎不全の診断および予後診断のための方法ならびに組成物 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20130316370A1 (https=) |
| EP (2) | EP3249402A1 (https=) |
| JP (3) | JP2013539861A (https=) |
| CN (1) | CN103238068B (https=) |
| AU (1) | AU2011311997A1 (https=) |
| CA (1) | CA2811438A1 (https=) |
| EA (1) | EA201390293A1 (https=) |
| IN (1) | IN2013MN00441A (https=) |
| MX (1) | MX2013003662A (https=) |
| NZ (1) | NZ608316A (https=) |
| WO (1) | WO2012048082A2 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105556308B (zh) * | 2013-09-20 | 2018-05-29 | 阿斯图特医药公司 | 用于阑尾炎的诊断和预后及腹痛病因的区分的方法和组合物 |
| CA2939366A1 (en) * | 2014-02-20 | 2015-08-27 | Immundiagnostik Ag | In vitro diagnostic and prognosis of contrast induced nephropathy (cin) in patients undergoing coronary angiography |
| JP2018518676A (ja) * | 2015-06-11 | 2018-07-12 | アスチュート メディカル，インコーポレイテッド | 腎損傷および腎不全の診断および予後診断のための方法ならびに組成物 |
| CN106405064B (zh) * | 2016-08-30 | 2018-10-26 | 嘉兴行健生物科技有限公司 | 一种40岁以上女性骨转换率的评估方法 |
| WO2018165936A1 (zh) * | 2017-03-16 | 2018-09-20 | 深圳先进技术研究院 | 调节能量代谢的多肽及其用途 |
| CN109468357A (zh) * | 2018-12-25 | 2019-03-15 | 河北肽都生物科技有限公司 | 一种脾氨肽的制备方法 |
| MX2022001087A (es) * | 2019-07-26 | 2022-04-07 | Fundacio Inst Dinvestigacio Biomedica De Bellvitge Idibell | Ergotioneina, s-metil-ergotioneina, y usos de las mismas. |
| CN113092768A (zh) * | 2019-12-23 | 2021-07-09 | 首都医科大学附属北京世纪坛医院 | 尿液角蛋白,ii型细胞骨架1及其多肽片段在过敏性疾病中的应用 |
| JP6895148B1 (ja) * | 2020-03-31 | 2021-06-30 | クラシエホールディングス株式会社 | 冷え保有者における冷えの原因が、腎機能低下、水分代謝異常又は副腎疲労にあることを判定する判定用マーカー、冷え保有者における冷えの原因が、腎機能低下、水分代謝異常又は副腎疲労にあることを判定する判定方法、及び冷え保有者における冷えの原因が、腎機能低下、水分代謝異常又は副腎疲労にあることを判定するための判定用キット |
| CN113777304A (zh) * | 2020-06-09 | 2021-12-10 | 张曼 | 尿液纤维蛋白溶解酶原及其多肽片段在烧伤中的应用 |
| CN114264828B (zh) * | 2022-01-28 | 2023-09-08 | 中国科学院基础医学与肿瘤研究所(筹) | 鉴别良性甲状腺结节与甲状腺癌的生物标志物及其应用 |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US5028535A (en) | 1989-01-10 | 1991-07-02 | Biosite Diagnostics, Inc. | Threshold ligand-receptor assay |
| US5939272A (en) | 1989-01-10 | 1999-08-17 | Biosite Diagnostics Incorporated | Non-competitive threshold ligand-receptor assays |
| US5922615A (en) | 1990-03-12 | 1999-07-13 | Biosite Diagnostics Incorporated | Assay devices comprising a porous capture membrane in fluid-withdrawing contact with a nonabsorbent capillary network |
| CA2072758A1 (en) | 1990-09-14 | 1992-03-15 | Kenneth Francis Buechler | Antibodies to complexes of ligand receptors and ligands and their utility in ligand-receptor assays |
| US5955377A (en) | 1991-02-11 | 1999-09-21 | Biostar, Inc. | Methods and kits for the amplification of thin film based assays |
| AU1772992A (en) | 1991-04-10 | 1992-11-17 | Biosite Diagnostics Incorporated | Crosstalk inhibitors and their uses |
| JP3290988B2 (ja) | 1991-04-11 | 2002-06-10 | バイオサイト・ダイアグノスティックス・インコーポレイテッド | 多重リガンドを同時検出する新規接合体及び検定法 |
| US5885527A (en) | 1992-05-21 | 1999-03-23 | Biosite Diagnostics, Inc. | Diagnostic devices and apparatus for the controlled movement of reagents without membrances |
| US6143576A (en) | 1992-05-21 | 2000-11-07 | Biosite Diagnostics, Inc. | Non-porous diagnostic devices for the controlled movement of reagents |
| US5494829A (en) | 1992-07-31 | 1996-02-27 | Biostar, Inc. | Devices and methods for detection of an analyte based upon light interference |
| US5824799A (en) | 1993-09-24 | 1998-10-20 | Biosite Diagnostics Incorporated | Hybrid phthalocyanine derivatives and their uses |
| US6113855A (en) | 1996-11-15 | 2000-09-05 | Biosite Diagnostics, Inc. | Devices comprising multiple capillarity inducing surfaces |
| US5947124A (en) | 1997-03-11 | 1999-09-07 | Biosite Diagnostics Incorporated | Diagnostic for determining the time of a heart attack |
| US6057098A (en) | 1997-04-04 | 2000-05-02 | Biosite Diagnostics, Inc. | Polyvalent display libraries |
| JP4487376B2 (ja) * | 2000-03-31 | 2010-06-23 | 味の素株式会社 | 腎疾患治療剤 |
| JP2002191398A (ja) * | 2000-12-26 | 2002-07-09 | Jenokkusu Soyaku Kenkyusho:Kk | アレルギー性疾患検査方法 |
| US20040253637A1 (en) * | 2001-04-13 | 2004-12-16 | Biosite Incorporated | Markers for differential diagnosis and methods of use thereof |
| US20030224386A1 (en) * | 2001-12-19 | 2003-12-04 | Millennium Pharmaceuticals, Inc. | Compositions, kits, and methods for identification, assessment, prevention, and therapy of rheumatoid arthritis |
| US7255860B2 (en) * | 2002-10-08 | 2007-08-14 | Rinat Neuroscience Corp. | Methods for treating post-surgical pain by administering an anti-nerve growth factor antagonist antibody |
| US6941172B2 (en) * | 2002-11-18 | 2005-09-06 | Zvi Nachum | Method and device for restoring kidney function using electromagnetic stimulation |
| EP1756301A4 (en) * | 2004-04-16 | 2008-01-23 | Univ Monash | METHOD FOR MONITORING THE PROGRESS OF A CANCER DISEASE |
| US20050272101A1 (en) * | 2004-06-07 | 2005-12-08 | Prasad Devarajan | Method for the early detection of renal injury |
| FR2872579B1 (fr) * | 2004-06-30 | 2006-11-24 | Pasteur Institut | Detection de la tuberculose et de l'infection par mycobacterium tuberculosis a l'aide de hbha |
| DE602005023216D1 (de) * | 2004-12-15 | 2010-10-07 | Beth Israel Hospital | Nukleinsäuren und polypeptide zur diagnose und behandlung von schwangerschaftskomplikationen |
| PL1831699T3 (pl) * | 2004-12-20 | 2010-04-30 | Antibodyshop As | Oznaczanie lipokaliny neutrofilowej związanej z żelatynazą (NGAL) jako markera diagnostycznego dla zaburzeń nerek |
| US20070087387A1 (en) * | 2005-04-21 | 2007-04-19 | Prasad Devarajan | Method for the Early Detection of Renal Disease Using Proteomics |
| JP2007057509A (ja) * | 2005-08-26 | 2007-03-08 | Toray Ind Inc | ネコアクチビンａの測定方法およびその測定キット |
| WO2007106781A2 (en) * | 2006-03-10 | 2007-09-20 | University Of Rochester | Ecg-based differentiation of lqt1 and lqt2 mutation |
| JP2009531332A (ja) * | 2006-03-23 | 2009-09-03 | ライフ テクノロジーズ コーポレーション | 癌細胞株のインビボイメージングのための方法及び試薬 |
| US7662578B2 (en) * | 2006-04-21 | 2010-02-16 | Children's Hospital Medical Center | Method and kit for the early detection of impaired renal status |
| US20090047694A1 (en) * | 2007-08-17 | 2009-02-19 | Shuber Anthony P | Clinical Intervention Directed Diagnostic Methods |
| EP2479569A3 (en) * | 2007-03-26 | 2012-09-26 | Novartis AG | Predictive renal safety biomarkers and biomarker signatures to monitor kidney function |
| WO2008150488A1 (en) * | 2007-06-01 | 2008-12-11 | Laboratory Corporation Of America Holdings | Methods and systems for quantification of peptides and other analytes |
| US8039227B2 (en) * | 2007-09-20 | 2011-10-18 | University Of Louisville Research Foundation, Inc. | Peptide biomarkers predictive of renal function decline and kidney disease |
| US7977110B2 (en) * | 2008-06-02 | 2011-07-12 | Children's Hospital Medical Center | Method for distinguishing between kidney dysfunctions |
| US20110287964A1 (en) * | 2008-11-17 | 2011-11-24 | The Brigham And Women's Hospital, Inc. | Urinary biomarkers for sensitive and specific detection of acute kidney injury in humans |
| AU2009316387B2 (en) * | 2008-11-22 | 2015-01-29 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| WO2010091233A1 (en) * | 2009-02-06 | 2010-08-12 | Astute Medical, Inc. | Diagnosis and prognosis of renal injury and renal failure |
| EP2394166B1 (en) * | 2009-02-06 | 2016-07-13 | Astute Medical, Inc. | Methods for diagnosis and prognosis of renal injury and failure |
| NZ701807A (en) * | 2010-02-26 | 2015-05-29 | Astute Medical Inc | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
-
2011
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- 2011-10-06 IN IN441MUN2013 patent/IN2013MN00441A/en unknown
- 2011-10-06 EA EA201390293A patent/EA201390293A1/ru unknown
- 2011-10-06 AU AU2011311997A patent/AU2011311997A1/en not_active Abandoned
- 2011-10-06 WO PCT/US2011/055055 patent/WO2012048082A2/en not_active Ceased
- 2011-10-06 NZ NZ60831611A patent/NZ608316A/en not_active IP Right Cessation
- 2011-10-06 EP EP17175396.5A patent/EP3249402A1/en not_active Withdrawn
- 2011-10-06 MX MX2013003662A patent/MX2013003662A/es not_active Application Discontinuation
- 2011-10-06 EP EP11831575.3A patent/EP2625524A4/en not_active Withdrawn
- 2011-10-06 CA CA2811438A patent/CA2811438A1/en not_active Abandoned
- 2011-10-06 JP JP2013532937A patent/JP2013539861A/ja active Pending
- 2011-10-06 CN CN201180050168.8A patent/CN103238068B/zh not_active Expired - Fee Related
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2016
- 2016-06-15 JP JP2016118970A patent/JP6321080B2/ja active Active
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