JP2014521088A5 - - Google Patents
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- JP2014521088A5 JP2014521088A5 JP2014520221A JP2014520221A JP2014521088A5 JP 2014521088 A5 JP2014521088 A5 JP 2014521088A5 JP 2014520221 A JP2014520221 A JP 2014520221A JP 2014520221 A JP2014520221 A JP 2014520221A JP 2014521088 A5 JP2014521088 A5 JP 2014521088A5
- Authority
- JP
- Japan
- Prior art keywords
- hours
- subject
- serum creatinine
- assigning
- future
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 claims 80
- 229940109239 creatinine Drugs 0.000 claims 40
- 210000002966 serum Anatomy 0.000 claims 40
- 210000002700 urine Anatomy 0.000 claims 36
- 238000003556 assay Methods 0.000 claims 27
- 238000000034 method Methods 0.000 claims 27
- 210000001124 body fluid Anatomy 0.000 claims 24
- 230000003907 kidney function Effects 0.000 claims 21
- 208000009304 Acute Kidney Injury Diseases 0.000 claims 16
- 208000033626 Renal failure acute Diseases 0.000 claims 16
- 201000011040 acute kidney failure Diseases 0.000 claims 16
- 208000012998 acute renal failure Diseases 0.000 claims 15
- 239000003153 chemical reaction reagent Substances 0.000 claims 12
- 239000010839 body fluid Substances 0.000 claims 11
- 210000003734 kidney Anatomy 0.000 claims 11
- 230000006378 damage Effects 0.000 claims 9
- 102000004169 proteins and genes Human genes 0.000 claims 9
- 108090000623 proteins and genes Proteins 0.000 claims 9
- 102000005623 HSP27 Heat-Shock Proteins Human genes 0.000 claims 8
- 108010045100 HSP27 Heat-Shock Proteins Proteins 0.000 claims 8
- 101000595923 Homo sapiens Placenta growth factor Proteins 0.000 claims 8
- 102100035194 Placenta growth factor Human genes 0.000 claims 8
- 230000002438 mitochondrial effect Effects 0.000 claims 8
- 102000011022 Chorionic Gonadotropin Human genes 0.000 claims 7
- 108010062540 Chorionic Gonadotropin Proteins 0.000 claims 7
- 239000000090 biomarker Substances 0.000 claims 7
- 229940015047 chorionic gonadotropin Drugs 0.000 claims 7
- 108010004889 Heat-Shock Proteins Proteins 0.000 claims 5
- 102000002812 Heat-Shock Proteins Human genes 0.000 claims 5
- 239000012530 fluid Substances 0.000 claims 5
- 206010061481 Renal injury Diseases 0.000 claims 4
- 230000007423 decrease Effects 0.000 claims 4
- 230000003247 decreasing effect Effects 0.000 claims 4
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 3
- 230000027455 binding Effects 0.000 claims 3
- 238000003745 diagnosis Methods 0.000 claims 3
- 230000002485 urinary effect Effects 0.000 claims 3
- 230000006870 function Effects 0.000 claims 2
- 238000004393 prognosis Methods 0.000 claims 2
- 238000012959 renal replacement therapy Methods 0.000 claims 2
- 238000002054 transplantation Methods 0.000 claims 2
- 206010007559 Cardiac failure congestive Diseases 0.000 claims 1
- 101000884675 Coxiella burnetii (strain RSA 493 / Nine Mile phase I) Co-chaperonin GroES Proteins 0.000 claims 1
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 1
- 108010036949 Cyclosporine Proteins 0.000 claims 1
- 206010016654 Fibrosis Diseases 0.000 claims 1
- 102000006771 Gonadotropins Human genes 0.000 claims 1
- 108010086677 Gonadotropins Proteins 0.000 claims 1
- 206010019280 Heart failures Diseases 0.000 claims 1
- 102000001554 Hemoglobins Human genes 0.000 claims 1
- 108010054147 Hemoglobins Proteins 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims 1
- 102000036675 Myoglobin Human genes 0.000 claims 1
- 108010062374 Myoglobin Proteins 0.000 claims 1
- 206010037660 Pyrexia Diseases 0.000 claims 1
- 208000001647 Renal Insufficiency Diseases 0.000 claims 1
- 108700004754 S pombe hsp9 Proteins 0.000 claims 1
- 206010040047 Sepsis Diseases 0.000 claims 1
- ZSJLQEPLLKMAKR-UHFFFAOYSA-N Streptozotocin Natural products O=NN(C)C(=O)NC1C(O)OC(CO)C(O)C1O ZSJLQEPLLKMAKR-UHFFFAOYSA-N 0.000 claims 1
- QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 claims 1
- 229940126575 aminoglycoside Drugs 0.000 claims 1
- 238000007675 cardiac surgery Methods 0.000 claims 1
- 229960001265 ciclosporin Drugs 0.000 claims 1
- 230000007882 cirrhosis Effects 0.000 claims 1
- 208000019425 cirrhosis of liver Diseases 0.000 claims 1
- 238000012875 competitive assay Methods 0.000 claims 1
- 239000002872 contrast media Substances 0.000 claims 1
- 208000029078 coronary artery disease Diseases 0.000 claims 1
- 210000004351 coronary vessel Anatomy 0.000 claims 1
- 229930182912 cyclosporin Natural products 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 208000002296 eclampsia Diseases 0.000 claims 1
- 230000024924 glomerular filtration Effects 0.000 claims 1
- 239000002622 gonadotropin Substances 0.000 claims 1
- 229910001385 heavy metal Inorganic materials 0.000 claims 1
- HOMGKSMUEGBAAB-UHFFFAOYSA-N ifosfamide Chemical compound ClCCNP1(=O)OCCCN1CCCl HOMGKSMUEGBAAB-UHFFFAOYSA-N 0.000 claims 1
- 229960001101 ifosfamide Drugs 0.000 claims 1
- 201000006370 kidney failure Diseases 0.000 claims 1
- 229960000485 methotrexate Drugs 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 1
- 201000011461 pre-eclampsia Diseases 0.000 claims 1
- 201000001474 proteinuria Diseases 0.000 claims 1
- 238000012493 sandwich binding assay Methods 0.000 claims 1
- 230000035939 shock Effects 0.000 claims 1
- 230000009870 specific binding Effects 0.000 claims 1
- 238000013517 stratification Methods 0.000 claims 1
- ZSJLQEPLLKMAKR-GKHCUFPYSA-N streptozocin Chemical compound O=NN(C)C(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O ZSJLQEPLLKMAKR-GKHCUFPYSA-N 0.000 claims 1
- 229960001052 streptozocin Drugs 0.000 claims 1
- 229960001967 tacrolimus Drugs 0.000 claims 1
- QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 claims 1
- 238000007631 vascular surgery Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161506038P | 2011-07-09 | 2011-07-09 | |
| US61/506,038 | 2011-07-09 | ||
| PCT/US2012/045583 WO2013009573A1 (en) | 2011-07-09 | 2012-07-05 | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014521088A JP2014521088A (ja) | 2014-08-25 |
| JP2014521088A5 true JP2014521088A5 (https=) | 2015-08-20 |
Family
ID=47506416
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014520221A Pending JP2014521088A (ja) | 2011-07-09 | 2012-07-05 | 腎損傷および腎不全の診断および予後診断のための方法ならびに組成物 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20140171522A1 (https=) |
| EP (1) | EP2729803A4 (https=) |
| JP (1) | JP2014521088A (https=) |
| CN (1) | CN103858008B (https=) |
| AU (1) | AU2012282918A1 (https=) |
| CA (1) | CA2841880A1 (https=) |
| EA (1) | EA201490105A1 (https=) |
| MX (1) | MX2014000283A (https=) |
| WO (1) | WO2013009573A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014120569A1 (en) * | 2013-01-25 | 2014-08-07 | Beth Israel Deaconess Medical Center, Inc. | Methods and compositions for human epididymis protein-4 (he4) |
| WO2015081102A1 (en) | 2013-11-27 | 2015-06-04 | Gnubio, Inc. | Microfluidic droplet packing |
| CN104045453B (zh) * | 2014-06-11 | 2016-08-24 | 句容市鑫诚果业家庭农场 | 一种石榴专用有机肥料及其制备方法 |
| CN106536709A (zh) | 2014-06-16 | 2017-03-22 | 基纽拜奥股份有限公司 | 尺寸交替的注入到液滴中以促进分选 |
| CN104062294A (zh) * | 2014-07-11 | 2014-09-24 | 青岛千士医疗科技有限公司 | 一种支气管/肺上皮细胞线粒体损伤的检测方法 |
| CN104166003B (zh) * | 2014-08-06 | 2016-06-08 | 中国人民解放军第二军医大学 | 人附睾蛋白4在制备系统性红斑狼疮性肾病诊断试剂或试剂盒中的应用 |
| WO2016130802A1 (en) * | 2015-02-11 | 2016-08-18 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| TW201827070A (zh) * | 2016-12-19 | 2018-08-01 | 康鶴生醫科技股份有限公司 | 合成多肽、含該多肽的組合物、由其產生的抗體及其用途 |
| CN121186383B (zh) * | 2025-11-24 | 2026-03-13 | 华中科技大学 | 慢性肾病的蛋白质标志物的筛选及应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001016354A1 (en) * | 1999-09-02 | 2001-03-08 | Gene Logic, Inc. | Modulation of he4 in inflammatory and renal diseases |
| CN1791797A (zh) * | 2003-03-27 | 2006-06-21 | 儿童医院医疗中心 | 用于检测肾小管细胞损伤的早发的方法和试剂盒 |
| US7588892B2 (en) * | 2004-07-19 | 2009-09-15 | Entelos, Inc. | Reagent sets and gene signatures for renal tubule injury |
| US20070087387A1 (en) * | 2005-04-21 | 2007-04-19 | Prasad Devarajan | Method for the Early Detection of Renal Disease Using Proteomics |
| WO2008060607A2 (en) * | 2006-11-14 | 2008-05-22 | Biosite Incorporated | Methods and compositions for monitoring and risk prediction in cardiorenal syndrome |
| CN101802014A (zh) * | 2007-03-09 | 2010-08-11 | 三路影像公司 | He4单克隆抗体和它们的使用方法 |
| EP2479569A3 (en) * | 2007-03-26 | 2012-09-26 | Novartis AG | Predictive renal safety biomarkers and biomarker signatures to monitor kidney function |
| KR20100122495A (ko) * | 2008-02-29 | 2010-11-22 | 고쿠리츠 다이가쿠 호우징 나고야 다이가쿠 | 급성 신장 장해 및 예후 추정용 바이오마커 및 그 용도 |
| WO2009126380A2 (en) * | 2008-03-05 | 2009-10-15 | Singulex, Inc. | Methods and compositions for highly sensitive detection of molecules |
| CA2726563A1 (en) * | 2008-06-04 | 2009-12-10 | Proteosys Ag | Protein biomarkers for in vitro testing of developmental toxicity and embryotoxicity of chemical substances |
| JP2012501456A (ja) * | 2008-08-28 | 2012-01-19 | アスチュート メディカル，インコーポレイテッド | 腎損傷および腎不全の診断および予後のための方法および組成物 |
| AU2009316387B2 (en) * | 2008-11-22 | 2015-01-29 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| WO2011075744A1 (en) * | 2009-12-20 | 2011-06-23 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| WO2011109830A2 (en) * | 2010-03-05 | 2011-09-09 | Case Western Reserve University | Protein biomarkers and therapeutic targets for renal disorders |
| WO2012074888A2 (en) * | 2010-11-29 | 2012-06-07 | Alere San Diego, Inc. | Methods and compositions for diagnosis and risk prediction in heart failure |
| WO2013006629A1 (en) * | 2011-07-06 | 2013-01-10 | Alere San Diego Inc. | Methods and compositions for assigning likelihood of acute kidney injury progression |
-
2012
- 2012-07-05 US US14/131,678 patent/US20140171522A1/en not_active Abandoned
- 2012-07-05 MX MX2014000283A patent/MX2014000283A/es not_active Application Discontinuation
- 2012-07-05 AU AU2012282918A patent/AU2012282918A1/en not_active Abandoned
- 2012-07-05 WO PCT/US2012/045583 patent/WO2013009573A1/en not_active Ceased
- 2012-07-05 EP EP12810709.1A patent/EP2729803A4/en not_active Withdrawn
- 2012-07-05 CA CA2841880A patent/CA2841880A1/en not_active Abandoned
- 2012-07-05 JP JP2014520221A patent/JP2014521088A/ja active Pending
- 2012-07-05 EA EA201490105A patent/EA201490105A1/ru unknown
- 2012-07-05 CN CN201280039959.5A patent/CN103858008B/zh not_active Expired - Fee Related
-
2015
- 2015-12-09 US US14/964,410 patent/US20160097779A1/en not_active Abandoned
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