JP2021039112A5 - - Google Patents
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- JP2021039112A5 JP2021039112A5 JP2020185705A JP2020185705A JP2021039112A5 JP 2021039112 A5 JP2021039112 A5 JP 2021039112A5 JP 2020185705 A JP2020185705 A JP 2020185705A JP 2020185705 A JP2020185705 A JP 2020185705A JP 2021039112 A5 JP2021039112 A5 JP 2021039112A5
- Authority
- JP
- Japan
- Prior art keywords
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- aki
- hours
- body fluid
- fluid sample
- Prior art date
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- Granted
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- 238000000034 method Methods 0.000 claims 20
- 208000033626 Renal failure acute Diseases 0.000 claims 14
- 201000011040 acute kidney failure Diseases 0.000 claims 14
- 208000009304 Acute Kidney Injury Diseases 0.000 claims 13
- 210000001124 body fluid Anatomy 0.000 claims 11
- 239000010839 body fluid Substances 0.000 claims 11
- 230000002688 persistence Effects 0.000 claims 9
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 claims 8
- 229940109239 creatinine Drugs 0.000 claims 4
- 210000002966 serum Anatomy 0.000 claims 4
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 3
- 238000003556 assay Methods 0.000 claims 3
- 210000002700 urine Anatomy 0.000 claims 3
- 208000001647 Renal Insufficiency Diseases 0.000 claims 2
- 201000006370 kidney failure Diseases 0.000 claims 2
- 201000011461 pre-eclampsia Diseases 0.000 claims 2
- 201000003126 Anuria Diseases 0.000 claims 1
- 206010007559 Cardiac failure congestive Diseases 0.000 claims 1
- 102000019034 Chemokines Human genes 0.000 claims 1
- 108010012236 Chemokines Proteins 0.000 claims 1
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 1
- 108010036949 Cyclosporine Proteins 0.000 claims 1
- 206010019280 Heart failures Diseases 0.000 claims 1
- 102000001554 Hemoglobins Human genes 0.000 claims 1
- 108010054147 Hemoglobins Proteins 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims 1
- 102000036675 Myoglobin Human genes 0.000 claims 1
- 108010062374 Myoglobin Proteins 0.000 claims 1
- 206010040047 Sepsis Diseases 0.000 claims 1
- ZSJLQEPLLKMAKR-UHFFFAOYSA-N Streptozotocin Natural products O=NN(C)C(=O)NC1C(O)OC(CO)C(O)C1O ZSJLQEPLLKMAKR-UHFFFAOYSA-N 0.000 claims 1
- QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 claims 1
- 229940126575 aminoglycoside Drugs 0.000 claims 1
- 230000037396 body weight Effects 0.000 claims 1
- 238000007675 cardiac surgery Methods 0.000 claims 1
- 229960001265 ciclosporin Drugs 0.000 claims 1
- 208000019425 cirrhosis of liver Diseases 0.000 claims 1
- 239000002872 contrast media Substances 0.000 claims 1
- 208000029078 coronary artery disease Diseases 0.000 claims 1
- 210000004351 coronary vessel Anatomy 0.000 claims 1
- 229930182912 cyclosporin Natural products 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 230000024924 glomerular filtration Effects 0.000 claims 1
- 229910001385 heavy metal Inorganic materials 0.000 claims 1
- HOMGKSMUEGBAAB-UHFFFAOYSA-N ifosfamide Chemical compound ClCCNP1(=O)OCCCN1CCCl HOMGKSMUEGBAAB-UHFFFAOYSA-N 0.000 claims 1
- 229960001101 ifosfamide Drugs 0.000 claims 1
- 229960000485 methotrexate Drugs 0.000 claims 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 1
- 201000001474 proteinuria Diseases 0.000 claims 1
- 230000008085 renal dysfunction Effects 0.000 claims 1
- 201000003068 rheumatic fever Diseases 0.000 claims 1
- ZSJLQEPLLKMAKR-GKHCUFPYSA-N streptozocin Chemical compound O=NN(C)C(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O ZSJLQEPLLKMAKR-GKHCUFPYSA-N 0.000 claims 1
- 229960001052 streptozocin Drugs 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 229960001967 tacrolimus Drugs 0.000 claims 1
- QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021211779A JP7217796B2 (ja) | 2014-10-20 | 2021-12-27 | 腎障害および腎不全の診断および予後のための方法および組成物 |
| JP2023008480A JP2023052587A (ja) | 2014-10-20 | 2023-01-24 | 腎障害および腎不全の診断および予後のための方法および組成物 |
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462066316P | 2014-10-20 | 2014-10-20 | |
| US201462066313P | 2014-10-20 | 2014-10-20 | |
| US201462066310P | 2014-10-20 | 2014-10-20 | |
| US62/066,313 | 2014-10-20 | ||
| US62/066,316 | 2014-10-20 | ||
| US62/066,310 | 2014-10-20 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017521231A Division JP6792553B2 (ja) | 2014-10-20 | 2015-10-20 | 腎障害および腎不全の診断および予後のための方法および組成物 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021211779A Division JP7217796B2 (ja) | 2014-10-20 | 2021-12-27 | 腎障害および腎不全の診断および予後のための方法および組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021039112A JP2021039112A (ja) | 2021-03-11 |
| JP2021039112A5 true JP2021039112A5 (https=) | 2021-09-24 |
| JP7002623B2 JP7002623B2 (ja) | 2022-02-10 |
Family
ID=55761743
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017521231A Active JP6792553B2 (ja) | 2014-10-20 | 2015-10-20 | 腎障害および腎不全の診断および予後のための方法および組成物 |
| JP2020185705A Active JP7002623B2 (ja) | 2014-10-20 | 2020-11-06 | 腎障害および腎不全の診断および予後のための方法および組成物 |
| JP2021211779A Active JP7217796B2 (ja) | 2014-10-20 | 2021-12-27 | 腎障害および腎不全の診断および予後のための方法および組成物 |
| JP2023008480A Pending JP2023052587A (ja) | 2014-10-20 | 2023-01-24 | 腎障害および腎不全の診断および予後のための方法および組成物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017521231A Active JP6792553B2 (ja) | 2014-10-20 | 2015-10-20 | 腎障害および腎不全の診断および予後のための方法および組成物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021211779A Active JP7217796B2 (ja) | 2014-10-20 | 2021-12-27 | 腎障害および腎不全の診断および予後のための方法および組成物 |
| JP2023008480A Pending JP2023052587A (ja) | 2014-10-20 | 2023-01-24 | 腎障害および腎不全の診断および予後のための方法および組成物 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US11333671B2 (https=) |
| EP (2) | EP3968022A1 (https=) |
| JP (4) | JP6792553B2 (https=) |
| KR (1) | KR102431003B1 (https=) |
| CN (2) | CN107003301B (https=) |
| AU (2) | AU2015336069B2 (https=) |
| BR (1) | BR112017008218A2 (https=) |
| CA (1) | CA2965153C (https=) |
| EA (1) | EA201790696A1 (https=) |
| ES (1) | ES2907551T3 (https=) |
| MX (1) | MX388231B (https=) |
| PT (1) | PT3210018T (https=) |
| WO (1) | WO2016064877A2 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107003301B (zh) | 2014-10-20 | 2019-11-01 | 阿斯图特医药公司 | 用于诊断和预后肾损伤和肾衰竭的方法和组合物 |
| JP2020504157A (ja) * | 2017-01-12 | 2020-02-06 | アスチュート メディカル，インコーポレイテッド | Ｃ−ｃモチーフケモカインリガンド１４の測定に基づく腎損傷および腎不全の評価および処置のための方法および組成物 |
| US11346846B2 (en) | 2017-02-06 | 2022-05-31 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| US11891439B2 (en) | 2017-12-28 | 2024-02-06 | Astute Medical, Inc. | Antibodies and assays for CCL14 |
| US12114978B2 (en) | 2018-04-02 | 2024-10-15 | Potrero Medical, Inc. | Systems, devices and methods for draining and analyzing bodily fluids and assessing health |
| CN119454032A (zh) * | 2018-04-02 | 2025-02-18 | 波特雷罗医疗公司 | 用于排出和分析体液并评估健康的系统、设备和方法 |
| CN114207436A (zh) * | 2019-05-24 | 2022-03-18 | 机敏医药股份有限公司 | 基于c-c基序趋化因子配体14测量而评估和治疗肾损伤的方法 |
| US20230290457A1 (en) * | 2020-03-23 | 2023-09-14 | Biocogniv Inc. | Artificial intelligence medical device |
| GB2596142B (en) * | 2020-06-19 | 2023-11-29 | Secr Defence | Methods and associated uses, kits and systems for assessing sepsis |
| AU2021381364A1 (en) * | 2020-11-18 | 2023-06-22 | Astute Medical, Inc. | Methods and compositions for treatment of renal injury and renal failure |
| WO2023168299A1 (en) * | 2022-03-03 | 2023-09-07 | Astute Medical, Inc. | Methods and compositions for assessing and treating persistent acute kidney injury based on c-c motif chemokine ligand 14 measurement |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US5028535A (en) | 1989-01-10 | 1991-07-02 | Biosite Diagnostics, Inc. | Threshold ligand-receptor assay |
| US5939272A (en) | 1989-01-10 | 1999-08-17 | Biosite Diagnostics Incorporated | Non-competitive threshold ligand-receptor assays |
| US5922615A (en) | 1990-03-12 | 1999-07-13 | Biosite Diagnostics Incorporated | Assay devices comprising a porous capture membrane in fluid-withdrawing contact with a nonabsorbent capillary network |
| CA2072758A1 (en) | 1990-09-14 | 1992-03-15 | Kenneth Francis Buechler | Antibodies to complexes of ligand receptors and ligands and their utility in ligand-receptor assays |
| US5955377A (en) | 1991-02-11 | 1999-09-21 | Biostar, Inc. | Methods and kits for the amplification of thin film based assays |
| CA2107894C (en) | 1991-04-10 | 2003-10-14 | Kenneth F. Buechler | Crosstalk inhibitors and their uses |
| EP0579767B1 (en) | 1991-04-11 | 2000-08-23 | Biosite Diagnostics Inc. | Novel conjugates and assays for simultaneous detection of multiple ligands |
| US6019944A (en) | 1992-05-21 | 2000-02-01 | Biosite Diagnostics, Inc. | Diagnostic devices and apparatus for the controlled movement of reagents without membranes |
| US6143576A (en) | 1992-05-21 | 2000-11-07 | Biosite Diagnostics, Inc. | Non-porous diagnostic devices for the controlled movement of reagents |
| US5494829A (en) | 1992-07-31 | 1996-02-27 | Biostar, Inc. | Devices and methods for detection of an analyte based upon light interference |
| US5824799A (en) | 1993-09-24 | 1998-10-20 | Biosite Diagnostics Incorporated | Hybrid phthalocyanine derivatives and their uses |
| US6811773B1 (en) | 1993-12-22 | 2004-11-02 | Human Genome Sciences, Inc. | Human monocyte colony inhibitory factor (M-CIF) polypeptides |
| US6113855A (en) | 1996-11-15 | 2000-09-05 | Biosite Diagnostics, Inc. | Devices comprising multiple capillarity inducing surfaces |
| US5947124A (en) | 1997-03-11 | 1999-09-07 | Biosite Diagnostics Incorporated | Diagnostic for determining the time of a heart attack |
| US6057098A (en) | 1997-04-04 | 2000-05-02 | Biosite Diagnostics, Inc. | Polyvalent display libraries |
| IL163547A0 (en) * | 2002-02-12 | 2005-12-18 | Quark Biotech Inc | Use of the axl receptor for diagnosis and treatment of renal disease |
| US20120064089A1 (en) * | 2002-11-15 | 2012-03-15 | Morehouse School Of Medicine | Anti-cxcl16 and anti-cxcr6 antibodies for the prevention and treatment of cancer and cancer cell migration |
| AU2006272913B2 (en) | 2005-07-21 | 2012-01-19 | The Johns Hopkins University | Methods of detecting and treating acute kidney injury |
| CA2663749A1 (en) | 2005-09-21 | 2007-03-29 | Dask Technologies, Llc | Methods and compositions for organ and tissue functionality |
| US20110059537A1 (en) | 2007-09-20 | 2011-03-10 | Caritas St. Elizabeth's Medical Center Of Boston, Inc. | Method for estimating risk of acute kidney injury |
| WO2009114110A1 (en) | 2008-03-08 | 2009-09-17 | Immungene, Inc. | Engineered fusion molecules immunotherapy in cancer and inflammatory diseases |
| WO2010048347A2 (en) * | 2008-10-21 | 2010-04-29 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| US20110065599A1 (en) * | 2009-08-07 | 2011-03-17 | Rules-Based Medicine, Inc. | Methods and Devices for Detecting Kidney Damage |
| NZ630277A (en) * | 2009-09-21 | 2015-02-27 | Astute Medical Inc | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| EP2496942B1 (en) | 2009-11-07 | 2017-03-22 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| CA2779905A1 (en) | 2009-11-07 | 2011-05-12 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| US20120156701A1 (en) * | 2009-12-20 | 2012-06-21 | Joseph Anderberg | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| JP5763098B2 (ja) | 2009-12-20 | 2015-08-12 | アスチュート メディカル，インコーポレイテッド | 腎損傷および腎不全の診断および予後診断のための方法ならびに組成物 |
| PT2666872T (pt) * | 2010-02-05 | 2016-07-08 | Astute Medical Inc | Processos e composições para o diagnóstico e o prognóstico de lesões renais e de insuficiência renal |
| NZ605698A (en) * | 2010-06-23 | 2015-03-27 | Astute Medical Inc | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| EP2899545B1 (en) * | 2010-06-23 | 2018-08-22 | Astute Medical, Inc. | Methods for diagnosis and prognosis of renal injury and renal failure |
| IN2012MN02812A (https=) * | 2010-06-23 | 2015-05-22 | Astute Medical Inc | |
| UY33492A (es) * | 2010-07-09 | 2012-01-31 | Abbott Lab | Inmunoglobulinas con dominio variable dual y usos de las mismas |
| EP2694974B1 (en) | 2011-04-04 | 2015-10-21 | Universiteit Gent | Biomarkers for acute kidney injury |
| CN103874923B (zh) * | 2011-08-26 | 2016-09-14 | 阿斯图特医药公司 | 用于肾损伤和肾衰竭的诊断及预后的方法和组合物 |
| ES2734494T3 (es) * | 2011-12-08 | 2019-12-10 | Astute Medical Inc | Métodos y usos para el diagnóstico de una lesión renal y de una insuficiencia renal |
| WO2013096740A1 (en) * | 2011-12-21 | 2013-06-27 | Alere San Diego Inc. | Methods and compositions for assigning likelihood of chronic kidney disease progression |
| EP2962109A4 (en) | 2013-02-26 | 2016-12-07 | Astute Medical Inc | METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE |
| CN107003301B (zh) | 2014-10-20 | 2019-11-01 | 阿斯图特医药公司 | 用于诊断和预后肾损伤和肾衰竭的方法和组合物 |
-
2015
- 2015-10-20 CN CN201580068922.9A patent/CN107003301B/zh active Active
- 2015-10-20 MX MX2017005126A patent/MX388231B/es unknown
- 2015-10-20 EP EP21186630.6A patent/EP3968022A1/en active Pending
- 2015-10-20 WO PCT/US2015/056462 patent/WO2016064877A2/en not_active Ceased
- 2015-10-20 PT PT15853584T patent/PT3210018T/pt unknown
- 2015-10-20 US US15/520,817 patent/US11333671B2/en active Active
- 2015-10-20 ES ES15853584T patent/ES2907551T3/es active Active
- 2015-10-20 CN CN201910986041.5A patent/CN110702921B/zh active Active
- 2015-10-20 JP JP2017521231A patent/JP6792553B2/ja active Active
- 2015-10-20 AU AU2015336069A patent/AU2015336069B2/en active Active
- 2015-10-20 EA EA201790696A patent/EA201790696A1/ru unknown
- 2015-10-20 CA CA2965153A patent/CA2965153C/en active Active
- 2015-10-20 BR BR112017008218A patent/BR112017008218A2/pt not_active Application Discontinuation
- 2015-10-20 EP EP15853584.9A patent/EP3210018B1/en active Active
- 2015-10-20 KR KR1020177013539A patent/KR102431003B1/ko active Active
-
2020
- 2020-11-06 JP JP2020185705A patent/JP7002623B2/ja active Active
-
2021
- 2021-12-27 JP JP2021211779A patent/JP7217796B2/ja active Active
-
2022
- 2022-02-21 AU AU2022201130A patent/AU2022201130B2/en active Active
- 2022-03-31 US US17/710,832 patent/US12099067B2/en active Active
-
2023
- 2023-01-24 JP JP2023008480A patent/JP2023052587A/ja active Pending
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