EA201390293A1 - Способы и композиции для диагностики и прогнозирования повреждений почек и почечной недостаточности - Google Patents

Способы и композиции для диагностики и прогнозирования повреждений почек и почечной недостаточности

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Publication number
EA201390293A1
EA201390293A1 EA201390293A EA201390293A EA201390293A1 EA 201390293 A1 EA201390293 A1 EA 201390293A1 EA 201390293 A EA201390293 A EA 201390293A EA 201390293 A EA201390293 A EA 201390293A EA 201390293 A1 EA201390293 A1 EA 201390293A1
Authority
EA
Eurasian Patent Office
Prior art keywords
peptide
compositions
keratin
methods
kidney damage
Prior art date
Application number
EA201390293A
Other languages
English (en)
Inventor
Джозеф Андерберг
Джефф Грей
Пол Макферсон
Кевин Накамура
Джеймс Патрик Кампф
Original Assignee
Астьют Медикал, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Астьют Медикал, Инк. filed Critical Астьют Медикал, Инк.
Publication of EA201390293A1 publication Critical patent/EA201390293A1/ru

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/34—Genitourinary disorders
    • G01N2800/347—Renal failures; Glomerular diseases; Tubulointerstitial diseases, e.g. nephritic syndrome, glomerulonephritis; Renovascular diseases, e.g. renal artery occlusion, nephropathy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/56—Staging of a disease; Further complications associated with the disease

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Настоящее изобретение относится к способам и композициям для наблюдения за состоянием, диагностики, прогнозирования и определения схемы лечения субъектов, страдающих повреждением почек или предположительно имеющих повреждение почек. В частности, настоящее изобретение относится к применению анализов, позволяющих обнаружить один или более биомаркеров, выбранных из группы, состоящей из фактора роста нервов β, интерлейкина-17А, β-субъединицы фоллитропина, коллагеназы 3, фоллистатина, белка, связывающего витамин D, островкового амилоидного полипептида, С-пептида инсулина, фактора комплемента Н, желудочного ингибиторного полипептида, глюкагоноподобного пептида 1, глюкагона, инволюкрина, кератина-1/кератина-10 цитоскелета II типа, кератина-6А/6В/6С цитоскелета II типа, остеокальцина, липополисахарида, прогормона поджелудочной железы, пептида YY, агути-родственного белка, цилиарного нейротрофического фактора, гормона, регулирующего аппетит, транстиретина, субстрата 1 рецептора инсулина и α-ингибитора NF-κ-В, в качестве анализов диагностических и прогностических биомаркеров при повреждениях почек.
EA201390293A 2010-10-07 2011-10-06 Способы и композиции для диагностики и прогнозирования повреждений почек и почечной недостаточности EA201390293A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39099910P 2010-10-07 2010-10-07
PCT/US2011/055055 WO2012048082A2 (en) 2010-10-07 2011-10-06 Methods and compositions for diagnosis and prognosis of renal injury and renal failure

Publications (1)

Publication Number Publication Date
EA201390293A1 true EA201390293A1 (ru) 2013-09-30

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Family Applications (1)

Application Number Title Priority Date Filing Date
EA201390293A EA201390293A1 (ru) 2010-10-07 2011-10-06 Способы и композиции для диагностики и прогнозирования повреждений почек и почечной недостаточности

Country Status (12)

Country Link
US (1) US20130316370A1 (ru)
EP (2) EP3249402A1 (ru)
JP (3) JP2013539861A (ru)
CN (1) CN103238068B (ru)
AU (1) AU2011311997A1 (ru)
CA (1) CA2811438A1 (ru)
EA (1) EA201390293A1 (ru)
HK (1) HK1186248A1 (ru)
IN (1) IN2013MN00441A (ru)
MX (1) MX2013003662A (ru)
NZ (1) NZ608316A (ru)
WO (1) WO2012048082A2 (ru)

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CN114264828B (zh) * 2022-01-28 2023-09-08 中国科学院基础医学与肿瘤研究所(筹) 鉴别良性甲状腺结节与甲状腺癌的生物标志物及其应用

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Also Published As

Publication number Publication date
WO2012048082A3 (en) 2012-06-21
WO2012048082A2 (en) 2012-04-12
JP6321080B2 (ja) 2018-05-09
EP2625524A2 (en) 2013-08-14
HK1186248A1 (zh) 2014-03-07
JP2013539861A (ja) 2013-10-28
EP2625524A4 (en) 2014-05-07
CA2811438A1 (en) 2012-04-12
AU2011311997A1 (en) 2013-04-04
CN103238068A (zh) 2013-08-07
EP3249402A1 (en) 2017-11-29
US20130316370A1 (en) 2013-11-28
JP2016180762A (ja) 2016-10-13
IN2013MN00441A (ru) 2015-05-29
JP2018141793A (ja) 2018-09-13
MX2013003662A (es) 2013-05-01
CN103238068B (zh) 2016-06-08
NZ608316A (en) 2015-03-27

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