JP2013514329A5 - - Google Patents
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- Publication number
- JP2013514329A5 JP2013514329A5 JP2012543778A JP2012543778A JP2013514329A5 JP 2013514329 A5 JP2013514329 A5 JP 2013514329A5 JP 2012543778 A JP2012543778 A JP 2012543778A JP 2012543778 A JP2012543778 A JP 2012543778A JP 2013514329 A5 JP2013514329 A5 JP 2013514329A5
- Authority
- JP
- Japan
- Prior art keywords
- linker
- compound
- compound according
- alkyl
- peg
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 14
- 125000005647 linker group Chemical group 0.000 claims 8
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 239000000412 dendrimer Substances 0.000 claims 2
- 229920000736 dendritic polymer Polymers 0.000 claims 2
- 239000000032 diagnostic agent Substances 0.000 claims 2
- 229940039227 diagnostic agent Drugs 0.000 claims 2
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 238000003384 imaging method Methods 0.000 claims 1
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 claims 1
- 229960000367 inositol Drugs 0.000 claims 1
- 150000002634 lipophilic molecules Chemical class 0.000 claims 1
- 239000002105 nanoparticle Substances 0.000 claims 1
- 229920005615 natural polymer Polymers 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000000816 peptidomimetic Substances 0.000 claims 1
- 229910052698 phosphorus Inorganic materials 0.000 claims 1
- 229920000768 polyamine Polymers 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 229920001059 synthetic polymer Polymers 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NO20093555A NO331773B1 (no) | 2009-12-18 | 2009-12-18 | Mangankelater, sammensetninger omfattende slike og anvendelse av disse som kontrastmidler for magnettomografi (MR) |
| NO20093555 | 2009-12-18 | ||
| PCT/EP2010/070029 WO2011073371A1 (en) | 2009-12-18 | 2010-12-17 | Manganese chelates and their use as contrast agents in magnetic resonance imaging (mri) |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013514329A JP2013514329A (ja) | 2013-04-25 |
| JP2013514329A5 true JP2013514329A5 (enExample) | 2014-02-06 |
| JP5879268B2 JP5879268B2 (ja) | 2016-03-08 |
Family
ID=43770529
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012543778A Active JP5879268B2 (ja) | 2009-12-18 | 2010-12-17 | マンガンキレート並びに磁気共鳴イメージング（ｍｒｉ）における造影剤としての使用 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US9486544B2 (enExample) |
| EP (1) | EP2512524B1 (enExample) |
| JP (1) | JP5879268B2 (enExample) |
| KR (1) | KR101860160B1 (enExample) |
| CN (1) | CN102639152B (enExample) |
| AU (1) | AU2010332760B2 (enExample) |
| BR (1) | BR112012013761A2 (enExample) |
| CA (1) | CA2781228A1 (enExample) |
| DK (1) | DK2512524T3 (enExample) |
| ES (1) | ES2606165T3 (enExample) |
| HR (1) | HRP20161627T1 (enExample) |
| HU (1) | HUE032152T2 (enExample) |
| LT (1) | LT2512524T (enExample) |
| MX (1) | MX2012007041A (enExample) |
| NO (1) | NO331773B1 (enExample) |
| PL (1) | PL2512524T3 (enExample) |
| PT (1) | PT2512524T (enExample) |
| RU (1) | RU2561718C2 (enExample) |
| WO (1) | WO2011073371A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2988756T4 (da) | 2013-04-26 | 2022-08-08 | Guerbet Sa | Formulering af kontraststof og dertil knyttet fremstillingsfremgangsmåde |
| EP3101012A1 (en) | 2015-06-04 | 2016-12-07 | Bayer Pharma Aktiengesellschaft | New gadolinium chelate compounds for use in magnetic resonance imaging |
| EP3380484A1 (en) | 2015-11-26 | 2018-10-03 | Debreceni Egyetem | New 6-oxa-3,9, 15-triaza-bicyclo[9.3.1 ]pentadec a- 1 ( 14), 1 1 ( 15), 12-triene derivatives based compounds and their application as ligands of essential metal ion based mri and 52mn based pet contrast agents |
| WO2017089847A1 (en) | 2015-11-26 | 2017-06-01 | Debreceni Egyetem | New 3,6,9, 15-tetraaza-bicyclo [9.3.1 ]pentadeca- 1(14), 11(15), 12-triene based compounds and their application as ligands of essential metal ion based mri and 52mn based pet contrast agents |
| US10968224B2 (en) | 2015-11-26 | 2021-04-06 | Debreceni Egyetem | 2,11-diaza-[3.3](2,6)pyridinophane compounds and their application as ligands of essential metal ion based MRI contrast agents and 52MN based PET contrast agents |
| GB201610738D0 (en) * | 2016-06-20 | 2016-08-03 | Ge Healthcare As | Chelate compounds |
| WO2018096082A1 (en) | 2016-11-28 | 2018-05-31 | Bayer Pharma Aktiengesellschaft | High relaxivity gadolinium chelate compounds for use in magnetic resonance imaging |
| PL3558394T3 (pl) * | 2016-12-21 | 2020-11-16 | Ge Healthcare As | Oparte na tetraazabicyklo-makrocyklu związki chelatowe manganu odpowiednie jako środki do obrazowania metodą MRI |
| EP3728168B1 (en) * | 2017-12-20 | 2022-03-30 | General Electric Company | Anionic chelate compounds |
| MY208484A (en) | 2018-11-23 | 2025-05-13 | Bayer Pharma AG | Formulation of contrast media and process of preparation thereof |
| CN111233982B (zh) * | 2018-11-28 | 2023-03-03 | 深圳先进技术研究院 | 一种小分子蛋白质及其应用 |
| HUE069750T2 (hu) | 2019-09-03 | 2025-04-28 | Ge Healthcare As | Mangán-kelát izomerek |
| CN114874214B (zh) * | 2022-05-31 | 2023-03-21 | 南京航空航天大学 | 可偶联巯基的双功能大环螯合剂衍生物及其制备方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU608759B2 (en) | 1986-08-04 | 1991-04-18 | Amersham Health Salutar Inc | NMR imaging with paramagnetic polyvalents metal salts of poly-(acid-alkylene-amido)-alkanes |
| DE3640708C2 (de) | 1986-11-28 | 1995-05-18 | Schering Ag | Verbesserte metallhaltige Pharmazeutika |
| US5334371A (en) * | 1988-07-20 | 1994-08-02 | Schering Aktiengesellschaft | Marcocyclic polyaza bicyclo compounds containing 5 or 6 membered rings, and method for MRI |
| DE68908185T2 (de) | 1988-09-27 | 1993-11-25 | Nycomed Salutar Inc | Chelat-zusammensetzung. |
| ES2145041T3 (es) * | 1991-12-10 | 2000-07-01 | Dow Chemical Co | Complejos de acidos biciclopoliazamacrociclocarboxilicos, sus conjugados, preparacion y uso como agentes de contraste. |
| ZA929576B (en) * | 1991-12-10 | 1994-06-10 | Dow Chemical Co | Bicyclopolyazamacrocyclophosphonic acids their complexes and conjugates for use as contrast agents and processes for their preparation |
| US5428139A (en) * | 1991-12-10 | 1995-06-27 | The Dow Chemical Company | Bicyclopolyazamacrocyclophosphonic acid complexes for use as radiopharmaceuticals |
| FI933506A7 (fi) * | 1993-05-06 | 1994-11-07 | Dow Global Technologies Inc | Bisyklopolyatsamakrosyklokarboksyylihappokomplekseja, niiden konjugaat teja, menetelmä niiden valmistamiseksi ja käyttö varjoaineina |
| FR2836916B1 (fr) * | 2002-03-05 | 2004-06-11 | Guerbet Sa | Oligomeres de chelates de gadolinium, leur application comme produits de contraste en imagerie par resonance magnetique et leurs intermediaires de synthese |
| FR2856689A1 (fr) * | 2003-06-25 | 2004-12-31 | Guerbet Sa | Composes specifiques a forte relaxivite |
| US20080305049A1 (en) | 2005-01-31 | 2008-12-11 | Hadassa Degani | Mri Contrast Agents for Diagnosis and Prognosis of Tumors |
-
2009
- 2009-12-18 NO NO20093555A patent/NO331773B1/no unknown
-
2010
- 2010-12-17 CN CN201080056567.0A patent/CN102639152B/zh active Active
- 2010-12-17 MX MX2012007041A patent/MX2012007041A/es not_active Application Discontinuation
- 2010-12-17 ES ES10805224.2T patent/ES2606165T3/es active Active
- 2010-12-17 WO PCT/EP2010/070029 patent/WO2011073371A1/en not_active Ceased
- 2010-12-17 RU RU2012124266/04A patent/RU2561718C2/ru not_active IP Right Cessation
- 2010-12-17 AU AU2010332760A patent/AU2010332760B2/en not_active Ceased
- 2010-12-17 EP EP10805224.2A patent/EP2512524B1/en active Active
- 2010-12-17 KR KR1020127015488A patent/KR101860160B1/ko not_active Expired - Fee Related
- 2010-12-17 DK DK10805224.2T patent/DK2512524T3/en active
- 2010-12-17 US US13/510,064 patent/US9486544B2/en active Active
- 2010-12-17 HU HUE10805224A patent/HUE032152T2/en unknown
- 2010-12-17 HR HRP20161627TT patent/HRP20161627T1/hr unknown
- 2010-12-17 PL PL10805224T patent/PL2512524T3/pl unknown
- 2010-12-17 CA CA2781228A patent/CA2781228A1/en not_active Abandoned
- 2010-12-17 LT LTEP10805224.2T patent/LT2512524T/lt unknown
- 2010-12-17 PT PT108052242T patent/PT2512524T/pt unknown
- 2010-12-17 JP JP2012543778A patent/JP5879268B2/ja active Active
- 2010-12-17 BR BR112012013761A patent/BR112012013761A2/pt not_active Application Discontinuation