JP2013542981A5 - - Google Patents
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- Publication number
- JP2013542981A5 JP2013542981A5 JP2013539397A JP2013539397A JP2013542981A5 JP 2013542981 A5 JP2013542981 A5 JP 2013542981A5 JP 2013539397 A JP2013539397 A JP 2013539397A JP 2013539397 A JP2013539397 A JP 2013539397A JP 2013542981 A5 JP2013542981 A5 JP 2013542981A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- hydrogen
- group
- protecting group
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 18
- 229910052739 hydrogen Inorganic materials 0.000 claims 9
- 239000001257 hydrogen Substances 0.000 claims 9
- 125000000217 alkyl group Chemical group 0.000 claims 7
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 6
- 125000006239 protecting group Chemical group 0.000 claims 6
- 150000002431 hydrogen Chemical class 0.000 claims 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims 4
- 241000894006 Bacteria Species 0.000 claims 3
- 208000026350 Inborn Genetic disease Diseases 0.000 claims 3
- 208000016361 genetic disease Diseases 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 201000003883 Cystic fibrosis Diseases 0.000 claims 2
- 206010013801 Duchenne Muscular Dystrophy Diseases 0.000 claims 2
- 230000005764 inhibitory process Effects 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 239000000178 monomer Substances 0.000 claims 2
- 239000005022 packaging material Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- -1 (S) -4-amino-2-hydroxybutyryl Chemical group 0.000 claims 1
- 206010003591 Ataxia Diseases 0.000 claims 1
- 102100022548 Beta-hexosaminidase subunit alpha Human genes 0.000 claims 1
- 102100022641 Coagulation factor IX Human genes 0.000 claims 1
- 102100026735 Coagulation factor VIII Human genes 0.000 claims 1
- 241000206602 Eukaryota Species 0.000 claims 1
- 201000003542 Factor VIII deficiency Diseases 0.000 claims 1
- 208000009292 Hemophilia A Diseases 0.000 claims 1
- 101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 claims 1
- 108020004485 Nonsense Codon Proteins 0.000 claims 1
- 208000022292 Tay-Sachs disease Diseases 0.000 claims 1
- 206010043189 Telangiectasia Diseases 0.000 claims 1
- 208000014769 Usher Syndromes Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000009429 hemophilia B Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 230000006337 proteolytic cleavage Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 208000009056 telangiectasis Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41495610P | 2010-11-18 | 2010-11-18 | |
| US61/414,956 | 2010-11-18 | ||
| PCT/IL2011/000889 WO2012066546A1 (en) | 2010-11-18 | 2011-11-17 | Aminoglycosides and uses thereof in treating genetic disorders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016011038A Division JP2016121168A (ja) | 2010-11-18 | 2016-01-22 | アミノグリコシドおよび遺伝性障害の処置におけるその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013542981A JP2013542981A (ja) | 2013-11-28 |
| JP2013542981A5 true JP2013542981A5 (enExample) | 2014-12-11 |
| JP5960712B2 JP5960712B2 (ja) | 2016-08-02 |
Family
ID=45390144
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013539397A Active JP5960712B2 (ja) | 2010-11-18 | 2011-11-17 | アミノグリコシドおよび遺伝性障害の処置におけるその使用 |
| JP2016011038A Pending JP2016121168A (ja) | 2010-11-18 | 2016-01-22 | アミノグリコシドおよび遺伝性障害の処置におけるその使用 |
| JP2018036281A Active JP6758338B2 (ja) | 2010-11-18 | 2018-03-01 | アミノグリコシドおよび遺伝性障害の処置におけるその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016011038A Pending JP2016121168A (ja) | 2010-11-18 | 2016-01-22 | アミノグリコシドおよび遺伝性障害の処置におけるその使用 |
| JP2018036281A Active JP6758338B2 (ja) | 2010-11-18 | 2018-03-01 | アミノグリコシドおよび遺伝性障害の処置におけるその使用 |
Country Status (18)
| Country | Link |
|---|---|
| US (7) | US8895519B2 (enExample) |
| EP (2) | EP2640734B1 (enExample) |
| JP (3) | JP5960712B2 (enExample) |
| CA (1) | CA2816789C (enExample) |
| CY (1) | CY1120082T1 (enExample) |
| DK (1) | DK2640734T3 (enExample) |
| ES (2) | ES2833938T3 (enExample) |
| HR (1) | HRP20180056T1 (enExample) |
| HU (1) | HUE036248T2 (enExample) |
| IL (3) | IL266495B (enExample) |
| LT (1) | LT2640734T (enExample) |
| NO (1) | NO2640734T3 (enExample) |
| PL (1) | PL2640734T3 (enExample) |
| PT (1) | PT2640734T (enExample) |
| RS (1) | RS56739B1 (enExample) |
| SI (1) | SI2640734T1 (enExample) |
| SM (1) | SMT201800019T1 (enExample) |
| WO (1) | WO2012066546A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI2640734T1 (en) * | 2010-11-18 | 2018-02-28 | Technion Research & Development Foundation Ltd. | Aminoglycosides and their uses in the treatment of genetic disorders |
| KR101703137B1 (ko) | 2014-05-30 | 2017-02-07 | 선문대학교 산학협력단 | 당 부가 아미노글리코사이드 화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 약학적 조성물 |
| JP2017516835A (ja) * | 2014-06-05 | 2017-06-22 | エロックス ファーマシューティカルズ リミテッド | レット症候群治療におけるアミノグリコシド類縁体の使用 |
| EP3344641A4 (en) * | 2015-09-02 | 2019-09-18 | Eloxx Pharmaceuticals Ltd. | AMINO-LIKES DERIVATIVES AND USES THEREOF FOR THE TREATMENT OF GENETIC DISEASES |
| US11306115B2 (en) | 2015-09-02 | 2022-04-19 | Eloxx Pharmaceuticals Ltd. | Aminoglycoside derivatives and uses thereof in treating genetic disorders |
| EP3350194A4 (en) | 2015-09-02 | 2019-04-24 | Eloxx Pharmaceuticals Ltd. | AMINO-LIKES DERIVATIVES AND USES THEREOF FOR THE TREATMENT OF GENETIC DISEASES |
| WO2017118968A1 (en) * | 2016-01-05 | 2017-07-13 | Eloxx Pharmaceuticals Ltd. | Aminoglycoside derivatives and uses thereof in treating genetic disorders |
| CN117466958A (zh) * | 2017-03-15 | 2024-01-30 | Eloxx制药有限公司 | 假三糖氨基糖苷及其中间体的大规模制备 |
| WO2019237076A1 (en) * | 2018-06-07 | 2019-12-12 | Eloxx Pharmaceuticals, Inc. | Methods, compositions, and kits for inducing readthrough |
| KR102067477B1 (ko) * | 2018-06-20 | 2020-01-17 | 고려대학교 산학협력단 | 스킬로이노사민을 포함하는 아미노사이클리톨 화합물, 이의 제조방법 및 이를 함유하는 약학 조성물 |
| AU2019387385A1 (en) * | 2018-11-29 | 2021-07-08 | Eloxx Pharmaceuticals | Methods, compositions, and kits for treating ocular diseases |
| WO2021061873A1 (en) * | 2019-09-23 | 2021-04-01 | Eloxx Pharmaceuticals, Inc. | Methods, compositions, and kits for treating polycystic kidney disease |
| EP4230196A1 (en) | 2022-02-21 | 2023-08-23 | Som Innovation Biotech, S.A. | Compounds for use in the treatment of dystrophinopathies |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5960712A (ja) | 1982-09-30 | 1984-04-06 | Toshiba Corp | デ−タ判別装置 |
| WO2005078099A1 (en) | 2004-02-17 | 2005-08-25 | The Hospital For Sick Children | Mecp2e1 gene |
| EP2390255B1 (en) * | 2006-04-03 | 2016-07-13 | Technion Research & Development Foundation Ltd. | Novel aminoglycosides and uses thereof in the treatment of genetic disorders |
| SI2640734T1 (en) * | 2010-11-18 | 2018-02-28 | Technion Research & Development Foundation Ltd. | Aminoglycosides and their uses in the treatment of genetic disorders |
| JP2017516835A (ja) * | 2014-06-05 | 2017-06-22 | エロックス ファーマシューティカルズ リミテッド | レット症候群治療におけるアミノグリコシド類縁体の使用 |
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2011
- 2011-11-17 SI SI201131387T patent/SI2640734T1/en unknown
- 2011-11-17 SM SM20180019T patent/SMT201800019T1/it unknown
- 2011-11-17 ES ES17192028T patent/ES2833938T3/es active Active
- 2011-11-17 CA CA2816789A patent/CA2816789C/en active Active
- 2011-11-17 DK DK11799501.9T patent/DK2640734T3/en active
- 2011-11-17 PL PL11799501T patent/PL2640734T3/pl unknown
- 2011-11-17 PT PT117995019T patent/PT2640734T/pt unknown
- 2011-11-17 HU HUE11799501A patent/HUE036248T2/hu unknown
- 2011-11-17 LT LTEP11799501.9T patent/LT2640734T/lt unknown
- 2011-11-17 EP EP11799501.9A patent/EP2640734B1/en active Active
- 2011-11-17 HR HRP20180056TT patent/HRP20180056T1/hr unknown
- 2011-11-17 US US13/885,715 patent/US8895519B2/en active Active
- 2011-11-17 JP JP2013539397A patent/JP5960712B2/ja active Active
- 2011-11-17 RS RS20180029A patent/RS56739B1/sr unknown
- 2011-11-17 EP EP17192028.3A patent/EP3296311B1/en active Active
- 2011-11-17 WO PCT/IL2011/000889 patent/WO2012066546A1/en not_active Ceased
- 2011-11-17 ES ES11799501.9T patent/ES2655916T3/es active Active
- 2011-11-17 NO NO11799501A patent/NO2640734T3/no unknown
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2014
- 2014-08-18 US US14/461,477 patent/US9175029B2/en active Active
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2015
- 2015-09-27 US US14/866,960 patent/US9616079B2/en active Active
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2016
- 2016-01-22 JP JP2016011038A patent/JP2016121168A/ja active Pending
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2017
- 2017-03-09 US US15/453,990 patent/US9943533B2/en active Active
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2018
- 2018-01-15 CY CY20181100039T patent/CY1120082T1/el unknown
- 2018-03-01 JP JP2018036281A patent/JP6758338B2/ja active Active
- 2018-03-07 US US15/914,045 patent/US10398718B2/en active Active
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2019
- 2019-05-07 IL IL266495A patent/IL266495B/en active IP Right Grant
- 2019-08-23 US US16/550,121 patent/US10973839B2/en active Active
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2020
- 2020-09-01 IL IL277063A patent/IL277063B/en unknown
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2021
- 2021-04-08 US US17/226,050 patent/US11865128B2/en active Active
- 2021-06-16 IL IL284067A patent/IL284067B/en unknown