ES2655916T3 - Aminoglucósidos y usos de los mismos para tratar trastornos genéticos - Google Patents

Aminoglucósidos y usos de los mismos para tratar trastornos genéticos Download PDF

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Publication number
ES2655916T3
ES2655916T3 ES11799501.9T ES11799501T ES2655916T3 ES 2655916 T3 ES2655916 T3 ES 2655916T3 ES 11799501 T ES11799501 T ES 11799501T ES 2655916 T3 ES2655916 T3 ES 2655916T3
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Spain
Prior art keywords
carbon atoms
alkyl
group
compound
aminoglycosides
Prior art date
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Active
Application number
ES11799501.9T
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English (en)
Spanish (es)
Inventor
Timor Baasov
Dana Atia-Glikin
Jeyakumar Kandasamy
Valery Belakhov
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Technion Research and Development Foundation Ltd
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Technion Research and Development Foundation Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D79/00—Kinds or details of packages, not otherwise provided for
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/228—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings
    • C07H15/23—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings with only two saccharide radicals in the molecule, e.g. ambutyrosin, butyrosin, xylostatin, ribostamycin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
    • C07H5/06—Aminosugars

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Mechanical Engineering (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
ES11799501.9T 2010-11-18 2011-11-17 Aminoglucósidos y usos de los mismos para tratar trastornos genéticos Active ES2655916T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US414956P 2002-09-30
US41495610P 2010-11-18 2010-11-18
PCT/IL2011/000889 WO2012066546A1 (en) 2010-11-18 2011-11-17 Aminoglycosides and uses thereof in treating genetic disorders

Publications (1)

Publication Number Publication Date
ES2655916T3 true ES2655916T3 (es) 2018-02-22

Family

ID=45390144

Family Applications (2)

Application Number Title Priority Date Filing Date
ES11799501.9T Active ES2655916T3 (es) 2010-11-18 2011-11-17 Aminoglucósidos y usos de los mismos para tratar trastornos genéticos
ES17192028T Active ES2833938T3 (es) 2010-11-18 2011-11-17 Aminoglucósidos y usos de los mismos en el tratamiento de trastornos genéticos

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES17192028T Active ES2833938T3 (es) 2010-11-18 2011-11-17 Aminoglucósidos y usos de los mismos en el tratamiento de trastornos genéticos

Country Status (18)

Country Link
US (7) US8895519B2 (enExample)
EP (2) EP3296311B1 (enExample)
JP (3) JP5960712B2 (enExample)
CA (1) CA2816789C (enExample)
CY (1) CY1120082T1 (enExample)
DK (1) DK2640734T3 (enExample)
ES (2) ES2655916T3 (enExample)
HR (1) HRP20180056T1 (enExample)
HU (1) HUE036248T2 (enExample)
IL (3) IL266495B (enExample)
LT (1) LT2640734T (enExample)
NO (1) NO2640734T3 (enExample)
PL (1) PL2640734T3 (enExample)
PT (1) PT2640734T (enExample)
RS (1) RS56739B1 (enExample)
SI (1) SI2640734T1 (enExample)
SM (1) SMT201800019T1 (enExample)
WO (1) WO2012066546A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE036248T2 (hu) 2010-11-18 2018-06-28 Technion Res & Dev Foundation Aminoglükozidok és alkalmazásaik genetikai rendellenességek kezelésére
KR101703137B1 (ko) 2014-05-30 2017-02-07 선문대학교 산학협력단 당 부가 아미노글리코사이드 화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 약학적 조성물
EP3151840A1 (en) * 2014-06-05 2017-04-12 Eloxx Pharmaceuticals Ltd. Use of aminoglycoside analogs in the treatment of rett syndrome
HK1257935A1 (zh) * 2015-09-02 2019-11-01 Eloxx Pharmaceuticals Ltd. 氨基糖苷衍生物及其在治疗遗传性病症中的应用
EP3344640A4 (en) * 2015-09-02 2019-05-01 Eloxx Pharmaceuticals Ltd. AMINO-LIKES DERIVATIVES AND USES THEREOF FOR THE TREATMENT OF GENETIC DISEASES
WO2017037718A1 (en) * 2015-09-02 2017-03-09 Eloxx Pharmaceuticals Ltd. Aminoglycoside derivatives and uses thereof in treating genetic disorders
WO2017118968A1 (en) * 2016-01-05 2017-07-13 Eloxx Pharmaceuticals Ltd. Aminoglycoside derivatives and uses thereof in treating genetic disorders
JP7187471B2 (ja) * 2017-03-15 2022-12-12 エロックス ファーマシューティカルズ リミテッド 擬似三糖アミノグリコシドおよびその中間体の大規模調製
WO2019237076A1 (en) * 2018-06-07 2019-12-12 Eloxx Pharmaceuticals, Inc. Methods, compositions, and kits for inducing readthrough
KR102067477B1 (ko) * 2018-06-20 2020-01-17 고려대학교 산학협력단 스킬로이노사민을 포함하는 아미노사이클리톨 화합물, 이의 제조방법 및 이를 함유하는 약학 조성물
WO2020113124A1 (en) * 2018-11-29 2020-06-04 Eloxx Pharmaceuticals Methods, compositions, and kits for treating ocular diseases
WO2021061873A1 (en) * 2019-09-23 2021-04-01 Eloxx Pharmaceuticals, Inc. Methods, compositions, and kits for treating polycystic kidney disease
EP4230196A1 (en) 2022-02-21 2023-08-23 Som Innovation Biotech, S.A. Compounds for use in the treatment of dystrophinopathies

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5960712A (ja) 1982-09-30 1984-04-06 Toshiba Corp デ−タ判別装置
JP5830213B2 (ja) 2004-02-17 2015-12-09 ザ ホスピタル フォー シック チルドレン Ｍｅｃｐ２ｅ１遺伝子
LT2390255T (lt) * 2006-04-03 2016-10-25 Technion Research & Development Foundation Ltd. Nauji aminoglikozidai ir jų panaudojimas genetinių sutrikimų gydyme
HUE036248T2 (hu) * 2010-11-18 2018-06-28 Technion Res & Dev Foundation Aminoglükozidok és alkalmazásaik genetikai rendellenességek kezelésére
EP3151840A1 (en) * 2014-06-05 2017-04-12 Eloxx Pharmaceuticals Ltd. Use of aminoglycoside analogs in the treatment of rett syndrome

Also Published As

Publication number Publication date
WO2012066546A1 (en) 2012-05-24
US20190224226A9 (en) 2019-07-25
US9616079B2 (en) 2017-04-11
US20210228608A1 (en) 2021-07-29
NO2640734T3 (enExample) 2018-03-17
CA2816789A1 (en) 2012-05-24
SI2640734T1 (en) 2018-02-28
EP2640734A1 (en) 2013-09-25
US20170182078A1 (en) 2017-06-29
IL266495A (en) 2019-07-31
PT2640734T (pt) 2018-01-22
HUE036248T2 (hu) 2018-06-28
IL284067B (en) 2022-03-01
SMT201800019T1 (it) 2018-03-08
CA2816789C (en) 2018-12-11
IL284067A (en) 2021-07-29
ES2833938T3 (es) 2021-06-16
US11865128B2 (en) 2024-01-09
JP2018123135A (ja) 2018-08-09
HK1248709A1 (en) 2018-10-19
JP5960712B2 (ja) 2016-08-02
US9943533B2 (en) 2018-04-17
US9175029B2 (en) 2015-11-03
JP2016121168A (ja) 2016-07-07
US20180200276A1 (en) 2018-07-19
IL277063A (en) 2020-10-29
LT2640734T (lt) 2018-02-12
IL266495B (en) 2020-09-30
US20130237489A1 (en) 2013-09-12
JP6758338B2 (ja) 2020-09-23
DK2640734T3 (en) 2018-01-22
US10398718B2 (en) 2019-09-03
JP2013542981A (ja) 2013-11-28
CY1120082T1 (el) 2018-12-12
PL2640734T3 (pl) 2018-04-30
US20140357590A1 (en) 2014-12-04
US20160074425A1 (en) 2016-03-17
EP2640734B1 (en) 2017-10-18
HRP20180056T1 (hr) 2018-02-09
US20200078386A1 (en) 2020-03-12
EP3296311A1 (en) 2018-03-21
US10973839B2 (en) 2021-04-13
EP3296311B1 (en) 2020-09-30
IL277063B (en) 2021-07-29
US8895519B2 (en) 2014-11-25
RS56739B1 (sr) 2018-03-30

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