AU2010332760B2 - Manganese chelates and their use as contrast agents in magnetic resonance imaging (MRI) - Google Patents

Manganese chelates and their use as contrast agents in magnetic resonance imaging (MRI) Download PDF

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Publication number
AU2010332760B2
AU2010332760B2 AU2010332760A AU2010332760A AU2010332760B2 AU 2010332760 B2 AU2010332760 B2 AU 2010332760B2 AU 2010332760 A AU2010332760 A AU 2010332760A AU 2010332760 A AU2010332760 A AU 2010332760A AU 2010332760 B2 AU2010332760 B2 AU 2010332760B2
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AU2010332760A
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AU2010332760A1 (en
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Andreas Meijer
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GE Healthcare AS
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GE Healthcare AS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/12—Macromolecular compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F17/00—Metallocenes
    • C07F17/02—Metallocenes of metals of Groups 8, 9 or 10 of the Periodic Table
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AU2010332760A 2009-12-18 2010-12-17 Manganese chelates and their use as contrast agents in magnetic resonance imaging (MRI) Ceased AU2010332760B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
NO20093555 2009-12-18
NO20093555A NO331773B1 (no) 2009-12-18 2009-12-18 Mangankelater, sammensetninger omfattende slike og anvendelse av disse som kontrastmidler for magnettomografi (MR)
PCT/EP2010/070029 WO2011073371A1 (en) 2009-12-18 2010-12-17 Manganese chelates and their use as contrast agents in magnetic resonance imaging (mri)

Publications (2)

Publication Number Publication Date
AU2010332760A1 AU2010332760A1 (en) 2012-06-07
AU2010332760B2 true AU2010332760B2 (en) 2016-01-07

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Application Number Title Priority Date Filing Date
AU2010332760A Ceased AU2010332760B2 (en) 2009-12-18 2010-12-17 Manganese chelates and their use as contrast agents in magnetic resonance imaging (MRI)

Country Status (19)

Country Link
US (1) US9486544B2 (enExample)
EP (1) EP2512524B1 (enExample)
JP (1) JP5879268B2 (enExample)
KR (1) KR101860160B1 (enExample)
CN (1) CN102639152B (enExample)
AU (1) AU2010332760B2 (enExample)
BR (1) BR112012013761A2 (enExample)
CA (1) CA2781228A1 (enExample)
DK (1) DK2512524T3 (enExample)
ES (1) ES2606165T3 (enExample)
HR (1) HRP20161627T1 (enExample)
HU (1) HUE032152T2 (enExample)
LT (1) LT2512524T (enExample)
MX (1) MX2012007041A (enExample)
NO (1) NO331773B1 (enExample)
PL (1) PL2512524T3 (enExample)
PT (1) PT2512524T (enExample)
RU (1) RU2561718C2 (enExample)
WO (1) WO2011073371A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2909919C (fr) 2013-04-26 2022-07-12 Guerbet Formulation de produit de contraste et son procede de preparation associe
EP3101012A1 (en) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft New gadolinium chelate compounds for use in magnetic resonance imaging
US10494379B2 (en) 2015-11-26 2019-12-03 Debreceni Egyetem 6-oxa-3,9,15-triaza-bicyclo[9.3.1]pentadeca-1(14),11(15),12-triene derivatives based compounds and their application as ligands of essential metal ion based MRI and 52MN based PET contrast agents
EP3380472A1 (en) 2015-11-26 2018-10-03 Debreceni Egyetem New 3,6,9, 15-tetraaza-bicyclo [9.3.1 ]pentadeca- 1(14), 11(15), 12-triene based compounds and their application as ligands of essential metal ion based mri and 52mn based pet contrast agents
EP3380473A1 (en) 2015-11-26 2018-10-03 Debreceni Egyetem New 2, 1 l -diaza-[3.3](2,6)pyridinophane compounds and their application as ligands of essential metal ion based mri contrast agents and 52mn based pet contrast agents
GB201610738D0 (en) * 2016-06-20 2016-08-03 Ge Healthcare As Chelate compounds
EP3544964B1 (en) 2016-11-28 2020-06-17 Bayer Pharma Aktiengesellschaft High relaxivity gadolinium chelate compounds for use in magnetic resonance imaging
CN110290815A (zh) 2016-12-21 2019-09-27 通用电气医疗集团股份有限公司 适合作为mri显像剂的基于四氮杂双环-大环的锰螯合化合物
US11110186B2 (en) 2017-12-20 2021-09-07 General Electric Company Anionic chelate compounds
IL321215B2 (en) 2018-11-23 2026-05-01 Bayer Ag Contrast media formulation and process for its preparation
CN111233982B (zh) * 2018-11-28 2023-03-03 深圳先进技术研究院 一种小分子蛋白质及其应用
PT4025259T (pt) 2019-09-03 2025-01-24 Ge Healthcare As Isómeros do quelato de manganês
CN114874214B (zh) * 2022-05-31 2023-03-21 南京航空航天大学 可偶联巯基的双功能大环螯合剂衍生物及其制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994026313A1 (en) * 1993-05-06 1994-11-24 The Dow Chemical Company Bicyclopolyazamacrocyclocarboxylic acid complexes, their conjugates, processes for their preparation, and use as contrast agents
WO2006080022A2 (en) * 2005-01-31 2006-08-03 Yeda Research And Development Co. Ltd. Mri contrast agents for diagnosis and prognosis of tumors

Family Cites Families (9)

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Publication number Priority date Publication date Assignee Title
AU608759B2 (en) 1986-08-04 1991-04-18 Amersham Health Salutar Inc NMR imaging with paramagnetic polyvalents metal salts of poly-(acid-alkylene-amido)-alkanes
DE3640708C2 (de) 1986-11-28 1995-05-18 Schering Ag Verbesserte metallhaltige Pharmazeutika
US5334371A (en) 1988-07-20 1994-08-02 Schering Aktiengesellschaft Marcocyclic polyaza bicyclo compounds containing 5 or 6 membered rings, and method for MRI
AU4317889A (en) 1988-09-27 1990-05-01 Salutar, Inc. Chelate compositions
US5428139A (en) * 1991-12-10 1995-06-27 The Dow Chemical Company Bicyclopolyazamacrocyclophosphonic acid complexes for use as radiopharmaceuticals
DK0570575T3 (da) * 1991-12-10 1998-08-24 Dow Chemical Co Bicykloazamakrocyklophosphonsyre, komplekser, konjugater, kontrastmidler og fremstilling heraf
DE69230970T2 (de) * 1991-12-10 2001-01-04 The Dow Chemical Co., Midland Bicylclische, polyazamakrocyclocarbonsäure-komplexe, konjugate, herstellung und verwendung als kontraststoffe
FR2836916B1 (fr) * 2002-03-05 2004-06-11 Guerbet Sa Oligomeres de chelates de gadolinium, leur application comme produits de contraste en imagerie par resonance magnetique et leurs intermediaires de synthese
FR2856689A1 (fr) * 2003-06-25 2004-12-31 Guerbet Sa Composes specifiques a forte relaxivite

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994026313A1 (en) * 1993-05-06 1994-11-24 The Dow Chemical Company Bicyclopolyazamacrocyclocarboxylic acid complexes, their conjugates, processes for their preparation, and use as contrast agents
WO2006080022A2 (en) * 2005-01-31 2006-08-03 Yeda Research And Development Co. Ltd. Mri contrast agents for diagnosis and prognosis of tumors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
AIME, S. et al, "[GdPCP2A(H2O)2]-: A Paramagnetic Contrast Agent Designed for Improved Applications in Magnetic Resonance Imaging." Journal of Medicinal Chemistry, 2000, 43, 4017-4024. *

Also Published As

Publication number Publication date
RU2561718C2 (ru) 2015-09-10
US9486544B2 (en) 2016-11-08
EP2512524A1 (en) 2012-10-24
WO2011073371A1 (en) 2011-06-23
AU2010332760A1 (en) 2012-06-07
PT2512524T (pt) 2016-12-15
BR112012013761A2 (pt) 2016-04-26
RU2012124266A (ru) 2014-01-27
CN102639152B (zh) 2015-11-25
JP5879268B2 (ja) 2016-03-08
PL2512524T3 (pl) 2017-08-31
KR101860160B1 (ko) 2018-05-21
HUE032152T2 (en) 2017-09-28
KR20120109505A (ko) 2012-10-08
CA2781228A1 (en) 2011-06-23
NO331773B1 (no) 2012-03-26
HRP20161627T1 (hr) 2017-01-13
DK2512524T3 (en) 2017-01-09
EP2512524B1 (en) 2016-10-05
US20120244081A1 (en) 2012-09-27
ES2606165T3 (es) 2017-03-23
LT2512524T (lt) 2016-12-12
MX2012007041A (es) 2012-07-20
JP2013514329A (ja) 2013-04-25
NO20093555A1 (no) 2011-06-20
CN102639152A (zh) 2012-08-15

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