CN102639152B - 锰螯合物及其作为磁共振成像(mri)中造影剂的用途 - Google Patents

锰螯合物及其作为磁共振成像(mri)中造影剂的用途 Download PDF

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CN102639152B
CN102639152B CN201080056567.0A CN201080056567A CN102639152B CN 102639152 B CN102639152 B CN 102639152B CN 201080056567 A CN201080056567 A CN 201080056567A CN 102639152 B CN102639152 B CN 102639152B
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CN102639152A (zh
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A.梅杰
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GE Healthcare AS
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GE Healthcare AS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/12—Macromolecular compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F17/00—Metallocenes
    • C07F17/02—Metallocenes of metals of Groups 8, 9 or 10 of the Periodic Table
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN201080056567.0A 2009-12-18 2010-12-17 锰螯合物及其作为磁共振成像(mri)中造影剂的用途 Active CN102639152B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
NO20093555A NO331773B1 (no) 2009-12-18 2009-12-18 Mangankelater, sammensetninger omfattende slike og anvendelse av disse som kontrastmidler for magnettomografi (MR)
NO20093555 2009-12-18
PCT/EP2010/070029 WO2011073371A1 (en) 2009-12-18 2010-12-17 Manganese chelates and their use as contrast agents in magnetic resonance imaging (mri)

Publications (2)

Publication Number Publication Date
CN102639152A CN102639152A (zh) 2012-08-15
CN102639152B true CN102639152B (zh) 2015-11-25

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CN201080056567.0A Active CN102639152B (zh) 2009-12-18 2010-12-17 锰螯合物及其作为磁共振成像(mri)中造影剂的用途

Country Status (19)

Country Link
US (1) US9486544B2 (enExample)
EP (1) EP2512524B1 (enExample)
JP (1) JP5879268B2 (enExample)
KR (1) KR101860160B1 (enExample)
CN (1) CN102639152B (enExample)
AU (1) AU2010332760B2 (enExample)
BR (1) BR112012013761A2 (enExample)
CA (1) CA2781228A1 (enExample)
DK (1) DK2512524T3 (enExample)
ES (1) ES2606165T3 (enExample)
HR (1) HRP20161627T1 (enExample)
HU (1) HUE032152T2 (enExample)
LT (1) LT2512524T (enExample)
MX (1) MX2012007041A (enExample)
NO (1) NO331773B1 (enExample)
PL (1) PL2512524T3 (enExample)
PT (1) PT2512524T (enExample)
RU (1) RU2561718C2 (enExample)
WO (1) WO2011073371A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2988756T4 (da) 2013-04-26 2022-08-08 Guerbet Sa Formulering af kontraststof og dertil knyttet fremstillingsfremgangsmåde
EP3101012A1 (en) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft New gadolinium chelate compounds for use in magnetic resonance imaging
EP3380484A1 (en) 2015-11-26 2018-10-03 Debreceni Egyetem New 6-oxa-3,9, 15-triaza-bicyclo[9.3.1 ]pentadec a- 1 ( 14), 1 1 ( 15), 12-triene derivatives based compounds and their application as ligands of essential metal ion based mri and 52mn based pet contrast agents
WO2017089847A1 (en) 2015-11-26 2017-06-01 Debreceni Egyetem New 3,6,9, 15-tetraaza-bicyclo [9.3.1 ]pentadeca- 1(14), 11(15), 12-triene based compounds and their application as ligands of essential metal ion based mri and 52mn based pet contrast agents
US10968224B2 (en) 2015-11-26 2021-04-06 Debreceni Egyetem 2,11-diaza-[3.3](2,6)pyridinophane compounds and their application as ligands of essential metal ion based MRI contrast agents and 52MN based PET contrast agents
GB201610738D0 (en) * 2016-06-20 2016-08-03 Ge Healthcare As Chelate compounds
WO2018096082A1 (en) 2016-11-28 2018-05-31 Bayer Pharma Aktiengesellschaft High relaxivity gadolinium chelate compounds for use in magnetic resonance imaging
PL3558394T3 (pl) * 2016-12-21 2020-11-16 Ge Healthcare As Oparte na tetraazabicyklo-makrocyklu związki chelatowe manganu odpowiednie jako środki do obrazowania metodą MRI
EP3728168B1 (en) * 2017-12-20 2022-03-30 General Electric Company Anionic chelate compounds
MY208484A (en) 2018-11-23 2025-05-13 Bayer Pharma AG Formulation of contrast media and process of preparation thereof
CN111233982B (zh) * 2018-11-28 2023-03-03 深圳先进技术研究院 一种小分子蛋白质及其应用
HUE069750T2 (hu) 2019-09-03 2025-04-28 Ge Healthcare As Mangán-kelát izomerek
CN114874214B (zh) * 2022-05-31 2023-03-21 南京航空航天大学 可偶联巯基的双功能大环螯合剂衍生物及其制备方法

Citations (3)

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US5334371A (en) * 1988-07-20 1994-08-02 Schering Aktiengesellschaft Marcocyclic polyaza bicyclo compounds containing 5 or 6 membered rings, and method for MRI
WO1994026313A1 (en) * 1993-05-06 1994-11-24 The Dow Chemical Company Bicyclopolyazamacrocyclocarboxylic acid complexes, their conjugates, processes for their preparation, and use as contrast agents
US20080305049A1 (en) * 2005-01-31 2008-12-11 Hadassa Degani Mri Contrast Agents for Diagnosis and Prognosis of Tumors

Family Cites Families (8)

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AU608759B2 (en) 1986-08-04 1991-04-18 Amersham Health Salutar Inc NMR imaging with paramagnetic polyvalents metal salts of poly-(acid-alkylene-amido)-alkanes
DE3640708C2 (de) 1986-11-28 1995-05-18 Schering Ag Verbesserte metallhaltige Pharmazeutika
DE68908185T2 (de) 1988-09-27 1993-11-25 Nycomed Salutar Inc Chelat-zusammensetzung.
ES2145041T3 (es) * 1991-12-10 2000-07-01 Dow Chemical Co Complejos de acidos biciclopoliazamacrociclocarboxilicos, sus conjugados, preparacion y uso como agentes de contraste.
ZA929576B (en) * 1991-12-10 1994-06-10 Dow Chemical Co Bicyclopolyazamacrocyclophosphonic acids their complexes and conjugates for use as contrast agents and processes for their preparation
US5428139A (en) * 1991-12-10 1995-06-27 The Dow Chemical Company Bicyclopolyazamacrocyclophosphonic acid complexes for use as radiopharmaceuticals
FR2836916B1 (fr) * 2002-03-05 2004-06-11 Guerbet Sa Oligomeres de chelates de gadolinium, leur application comme produits de contraste en imagerie par resonance magnetique et leurs intermediaires de synthese
FR2856689A1 (fr) * 2003-06-25 2004-12-31 Guerbet Sa Composes specifiques a forte relaxivite

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5334371A (en) * 1988-07-20 1994-08-02 Schering Aktiengesellschaft Marcocyclic polyaza bicyclo compounds containing 5 or 6 membered rings, and method for MRI
WO1994026313A1 (en) * 1993-05-06 1994-11-24 The Dow Chemical Company Bicyclopolyazamacrocyclocarboxylic acid complexes, their conjugates, processes for their preparation, and use as contrast agents
US20080305049A1 (en) * 2005-01-31 2008-12-11 Hadassa Degani Mri Contrast Agents for Diagnosis and Prognosis of Tumors

Also Published As

Publication number Publication date
JP2013514329A (ja) 2013-04-25
CA2781228A1 (en) 2011-06-23
HUE032152T2 (en) 2017-09-28
MX2012007041A (es) 2012-07-20
PT2512524T (pt) 2016-12-15
HRP20161627T1 (hr) 2017-01-13
NO331773B1 (no) 2012-03-26
US20120244081A1 (en) 2012-09-27
RU2561718C2 (ru) 2015-09-10
ES2606165T3 (es) 2017-03-23
JP5879268B2 (ja) 2016-03-08
CN102639152A (zh) 2012-08-15
AU2010332760A1 (en) 2012-06-07
KR20120109505A (ko) 2012-10-08
AU2010332760B2 (en) 2016-01-07
PL2512524T3 (pl) 2017-08-31
NO20093555A1 (no) 2011-06-20
DK2512524T3 (en) 2017-01-09
WO2011073371A1 (en) 2011-06-23
BR112012013761A2 (pt) 2016-04-26
LT2512524T (lt) 2016-12-12
EP2512524B1 (en) 2016-10-05
EP2512524A1 (en) 2012-10-24
US9486544B2 (en) 2016-11-08
KR101860160B1 (ko) 2018-05-21
RU2012124266A (ru) 2014-01-27

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