BR112012013761A2 - quelatos de manganês e seu uso como os agentes de contraste na formação de imagem pela ressonância magnética (mri) - Google Patents

quelatos de manganês e seu uso como os agentes de contraste na formação de imagem pela ressonância magnética (mri)

Info

Publication number
BR112012013761A2
BR112012013761A2 BR112012013761A BR112012013761A BR112012013761A2 BR 112012013761 A2 BR112012013761 A2 BR 112012013761A2 BR 112012013761 A BR112012013761 A BR 112012013761A BR 112012013761 A BR112012013761 A BR 112012013761A BR 112012013761 A2 BR112012013761 A2 BR 112012013761A2
Authority
BR
Brazil
Prior art keywords
magnetic resonance
resonance imaging
mri
contrast agents
manganese chelates
Prior art date
Application number
BR112012013761A
Other languages
English (en)
Portuguese (pt)
Inventor
Andreas Meijer
Original Assignee
Ge Healthcare As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ge Healthcare As filed Critical Ge Healthcare As
Publication of BR112012013761A2 publication Critical patent/BR112012013761A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/12—Macromolecular compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F17/00—Metallocenes
    • C07F17/02—Metallocenes of metals of Groups 8, 9 or 10 of the Periodic Table
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
BR112012013761A 2009-12-18 2010-12-17 quelatos de manganês e seu uso como os agentes de contraste na formação de imagem pela ressonância magnética (mri) BR112012013761A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NO20093555A NO331773B1 (no) 2009-12-18 2009-12-18 Mangankelater, sammensetninger omfattende slike og anvendelse av disse som kontrastmidler for magnettomografi (MR)
PCT/EP2010/070029 WO2011073371A1 (en) 2009-12-18 2010-12-17 Manganese chelates and their use as contrast agents in magnetic resonance imaging (mri)

Publications (1)

Publication Number Publication Date
BR112012013761A2 true BR112012013761A2 (pt) 2016-04-26

Family

ID=43770529

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012013761A BR112012013761A2 (pt) 2009-12-18 2010-12-17 quelatos de manganês e seu uso como os agentes de contraste na formação de imagem pela ressonância magnética (mri)

Country Status (19)

Country Link
US (1) US9486544B2 (enExample)
EP (1) EP2512524B1 (enExample)
JP (1) JP5879268B2 (enExample)
KR (1) KR101860160B1 (enExample)
CN (1) CN102639152B (enExample)
AU (1) AU2010332760B2 (enExample)
BR (1) BR112012013761A2 (enExample)
CA (1) CA2781228A1 (enExample)
DK (1) DK2512524T3 (enExample)
ES (1) ES2606165T3 (enExample)
HR (1) HRP20161627T1 (enExample)
HU (1) HUE032152T2 (enExample)
LT (1) LT2512524T (enExample)
MX (1) MX2012007041A (enExample)
NO (1) NO331773B1 (enExample)
PL (1) PL2512524T3 (enExample)
PT (1) PT2512524T (enExample)
RU (1) RU2561718C2 (enExample)
WO (1) WO2011073371A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2988756T4 (da) 2013-04-26 2022-08-08 Guerbet Sa Formulering af kontraststof og dertil knyttet fremstillingsfremgangsmåde
EP3101012A1 (en) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft New gadolinium chelate compounds for use in magnetic resonance imaging
EP3380484A1 (en) 2015-11-26 2018-10-03 Debreceni Egyetem New 6-oxa-3,9, 15-triaza-bicyclo[9.3.1 ]pentadec a- 1 ( 14), 1 1 ( 15), 12-triene derivatives based compounds and their application as ligands of essential metal ion based mri and 52mn based pet contrast agents
WO2017089847A1 (en) 2015-11-26 2017-06-01 Debreceni Egyetem New 3,6,9, 15-tetraaza-bicyclo [9.3.1 ]pentadeca- 1(14), 11(15), 12-triene based compounds and their application as ligands of essential metal ion based mri and 52mn based pet contrast agents
US10968224B2 (en) 2015-11-26 2021-04-06 Debreceni Egyetem 2,11-diaza-[3.3](2,6)pyridinophane compounds and their application as ligands of essential metal ion based MRI contrast agents and 52MN based PET contrast agents
GB201610738D0 (en) * 2016-06-20 2016-08-03 Ge Healthcare As Chelate compounds
WO2018096082A1 (en) 2016-11-28 2018-05-31 Bayer Pharma Aktiengesellschaft High relaxivity gadolinium chelate compounds for use in magnetic resonance imaging
PL3558394T3 (pl) * 2016-12-21 2020-11-16 Ge Healthcare As Oparte na tetraazabicyklo-makrocyklu związki chelatowe manganu odpowiednie jako środki do obrazowania metodą MRI
EP3728168B1 (en) * 2017-12-20 2022-03-30 General Electric Company Anionic chelate compounds
MY208484A (en) 2018-11-23 2025-05-13 Bayer Pharma AG Formulation of contrast media and process of preparation thereof
CN111233982B (zh) * 2018-11-28 2023-03-03 深圳先进技术研究院 一种小分子蛋白质及其应用
HUE069750T2 (hu) 2019-09-03 2025-04-28 Ge Healthcare As Mangán-kelát izomerek
CN114874214B (zh) * 2022-05-31 2023-03-21 南京航空航天大学 可偶联巯基的双功能大环螯合剂衍生物及其制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU608759B2 (en) 1986-08-04 1991-04-18 Amersham Health Salutar Inc NMR imaging with paramagnetic polyvalents metal salts of poly-(acid-alkylene-amido)-alkanes
DE3640708C2 (de) 1986-11-28 1995-05-18 Schering Ag Verbesserte metallhaltige Pharmazeutika
US5334371A (en) * 1988-07-20 1994-08-02 Schering Aktiengesellschaft Marcocyclic polyaza bicyclo compounds containing 5 or 6 membered rings, and method for MRI
DE68908185T2 (de) 1988-09-27 1993-11-25 Nycomed Salutar Inc Chelat-zusammensetzung.
ES2145041T3 (es) * 1991-12-10 2000-07-01 Dow Chemical Co Complejos de acidos biciclopoliazamacrociclocarboxilicos, sus conjugados, preparacion y uso como agentes de contraste.
ZA929576B (en) * 1991-12-10 1994-06-10 Dow Chemical Co Bicyclopolyazamacrocyclophosphonic acids their complexes and conjugates for use as contrast agents and processes for their preparation
US5428139A (en) * 1991-12-10 1995-06-27 The Dow Chemical Company Bicyclopolyazamacrocyclophosphonic acid complexes for use as radiopharmaceuticals
FI933506A7 (fi) * 1993-05-06 1994-11-07 Dow Global Technologies Inc Bisyklopolyatsamakrosyklokarboksyylihappokomplekseja, niiden konjugaat teja, menetelmä niiden valmistamiseksi ja käyttö varjoaineina
FR2836916B1 (fr) * 2002-03-05 2004-06-11 Guerbet Sa Oligomeres de chelates de gadolinium, leur application comme produits de contraste en imagerie par resonance magnetique et leurs intermediaires de synthese
FR2856689A1 (fr) * 2003-06-25 2004-12-31 Guerbet Sa Composes specifiques a forte relaxivite
US20080305049A1 (en) 2005-01-31 2008-12-11 Hadassa Degani Mri Contrast Agents for Diagnosis and Prognosis of Tumors

Also Published As

Publication number Publication date
JP2013514329A (ja) 2013-04-25
CA2781228A1 (en) 2011-06-23
HUE032152T2 (en) 2017-09-28
MX2012007041A (es) 2012-07-20
PT2512524T (pt) 2016-12-15
HRP20161627T1 (hr) 2017-01-13
NO331773B1 (no) 2012-03-26
US20120244081A1 (en) 2012-09-27
RU2561718C2 (ru) 2015-09-10
ES2606165T3 (es) 2017-03-23
CN102639152B (zh) 2015-11-25
JP5879268B2 (ja) 2016-03-08
CN102639152A (zh) 2012-08-15
AU2010332760A1 (en) 2012-06-07
KR20120109505A (ko) 2012-10-08
AU2010332760B2 (en) 2016-01-07
PL2512524T3 (pl) 2017-08-31
NO20093555A1 (no) 2011-06-20
DK2512524T3 (en) 2017-01-09
WO2011073371A1 (en) 2011-06-23
LT2512524T (lt) 2016-12-12
EP2512524B1 (en) 2016-10-05
EP2512524A1 (en) 2012-10-24
US9486544B2 (en) 2016-11-08
KR101860160B1 (ko) 2018-05-21
RU2012124266A (ru) 2014-01-27

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B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B04C Request for examination: application reinstated [chapter 4.3 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07G Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette]

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B06T Formal requirements before examination [chapter 6.20 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL