NO331773B1 - Mangankelater, sammensetninger omfattende slike og anvendelse av disse som kontrastmidler for magnettomografi (MR) - Google Patents

Mangankelater, sammensetninger omfattende slike og anvendelse av disse som kontrastmidler for magnettomografi (MR) Download PDF

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Publication number
NO331773B1
NO331773B1 NO20093555A NO20093555A NO331773B1 NO 331773 B1 NO331773 B1 NO 331773B1 NO 20093555 A NO20093555 A NO 20093555A NO 20093555 A NO20093555 A NO 20093555A NO 331773 B1 NO331773 B1 NO 331773B1
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Norway
Prior art keywords
compound according
compound
linker
mmol
formula
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NO20093555A
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English (en)
Norwegian (no)
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NO20093555A1 (no
Inventor
Andreas Meijer
Original Assignee
Ge Healthcare As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ge Healthcare As filed Critical Ge Healthcare As
Priority to NO20093555A priority Critical patent/NO331773B1/no
Priority to PCT/EP2010/070029 priority patent/WO2011073371A1/en
Priority to JP2012543778A priority patent/JP5879268B2/ja
Priority to HUE10805224A priority patent/HUE032152T2/en
Priority to HRP20161627TT priority patent/HRP20161627T1/hr
Priority to EP10805224.2A priority patent/EP2512524B1/en
Priority to ES10805224.2T priority patent/ES2606165T3/es
Priority to RU2012124266/04A priority patent/RU2561718C2/ru
Priority to CN201080056567.0A priority patent/CN102639152B/zh
Priority to PT108052242T priority patent/PT2512524T/pt
Priority to PL10805224T priority patent/PL2512524T3/pl
Priority to BR112012013761A priority patent/BR112012013761A2/pt
Priority to CA2781228A priority patent/CA2781228A1/en
Priority to US13/510,064 priority patent/US9486544B2/en
Priority to LTEP10805224.2T priority patent/LT2512524T/lt
Priority to MX2012007041A priority patent/MX2012007041A/es
Priority to AU2010332760A priority patent/AU2010332760B2/en
Priority to DK10805224.2T priority patent/DK2512524T3/en
Priority to KR1020127015488A priority patent/KR101860160B1/ko
Publication of NO20093555A1 publication Critical patent/NO20093555A1/no
Publication of NO331773B1 publication Critical patent/NO331773B1/no

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/12—Macromolecular compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F17/00—Metallocenes
    • C07F17/02—Metallocenes of metals of Groups 8, 9 or 10 of the Periodic Table
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
NO20093555A 2009-12-18 2009-12-18 Mangankelater, sammensetninger omfattende slike og anvendelse av disse som kontrastmidler for magnettomografi (MR) NO331773B1 (no)

Priority Applications (19)

Application Number Priority Date Filing Date Title
NO20093555A NO331773B1 (no) 2009-12-18 2009-12-18 Mangankelater, sammensetninger omfattende slike og anvendelse av disse som kontrastmidler for magnettomografi (MR)
PCT/EP2010/070029 WO2011073371A1 (en) 2009-12-18 2010-12-17 Manganese chelates and their use as contrast agents in magnetic resonance imaging (mri)
JP2012543778A JP5879268B2 (ja) 2009-12-18 2010-12-17 マンガンキレート並びに磁気共鳴イメージング（ｍｒｉ）における造影剤としての使用
HUE10805224A HUE032152T2 (en) 2009-12-18 2010-12-17 Manganese chelates and their use as contrast agents in magnetic nuclear resonance imaging (MRI)
HRP20161627TT HRP20161627T1 (hr) 2009-12-18 2010-12-17 Kelati mangana i njihova uporaba kao kontrastnih sredstava u magnetskoj rezonanciji (mri)
EP10805224.2A EP2512524B1 (en) 2009-12-18 2010-12-17 Manganese chelates and their use as contrast agents in magnetic resonance imaging (mri)
ES10805224.2T ES2606165T3 (es) 2009-12-18 2010-12-17 Quelatos de manganeso y su uso como agentes de contraste en estudios de imagen por resonacia magnética (IRM)
RU2012124266/04A RU2561718C2 (ru) 2009-12-18 2010-12-17 Хелаты марганца и их применение в качестве контрастных агентов в магнитно-резонансной визуализации (mpb)
CN201080056567.0A CN102639152B (zh) 2009-12-18 2010-12-17 锰螯合物及其作为磁共振成像(mri)中造影剂的用途
PT108052242T PT2512524T (pt) 2009-12-18 2010-12-17 Quelatos de manganês e sua utilização como agentes de contraste em imagiologia de ressonância magnética (irm)
PL10805224T PL2512524T3 (pl) 2009-12-18 2010-12-17 Chelaty manganu i ich zastosowanie jako środki kontrastowe w obrazowaniu metodą rezonansu magnetycznego (mri)
BR112012013761A BR112012013761A2 (pt) 2009-12-18 2010-12-17 quelatos de manganês e seu uso como os agentes de contraste na formação de imagem pela ressonância magnética (mri)
CA2781228A CA2781228A1 (en) 2009-12-18 2010-12-17 Manganese chelates and their use as contrast agents in magnetic resonance imaging (mri)
US13/510,064 US9486544B2 (en) 2009-12-18 2010-12-17 Manganese chelates and their use as contrast agents in magnetic resonance imaging (MRI)
LTEP10805224.2T LT2512524T (lt) 2009-12-18 2010-12-17 Mangano chelatai ir jų, kaip kontrastinių medžiagų magnetinio rezonanso tomografijai (mrt), panaudojimas
MX2012007041A MX2012007041A (es) 2009-12-18 2010-12-17 Quelados de manganeso y su uso como agentes de contraste en elaboracion de imagen de resonancia magnetica (mri).
AU2010332760A AU2010332760B2 (en) 2009-12-18 2010-12-17 Manganese chelates and their use as contrast agents in magnetic resonance imaging (MRI)
DK10805224.2T DK2512524T3 (en) 2009-12-18 2010-12-17 Manganchelater and their use as contrast agents in magnetic resonance imaging (mri)
KR1020127015488A KR101860160B1 (ko) 2009-12-18 2010-12-17 망가니즈 킬레이트 및 자기 공명 영상화 （ｍｒｉ） 조영제로서의 그의 용도

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NO20093555A NO331773B1 (no) 2009-12-18 2009-12-18 Mangankelater, sammensetninger omfattende slike og anvendelse av disse som kontrastmidler for magnettomografi (MR)

Publications (2)

Publication Number Publication Date
NO20093555A1 NO20093555A1 (no) 2011-06-20
NO331773B1 true NO331773B1 (no) 2012-03-26

Family

ID=43770529

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20093555A NO331773B1 (no) 2009-12-18 2009-12-18 Mangankelater, sammensetninger omfattende slike og anvendelse av disse som kontrastmidler for magnettomografi (MR)

Country Status (19)

Country Link
US (1) US9486544B2 (enExample)
EP (1) EP2512524B1 (enExample)
JP (1) JP5879268B2 (enExample)
KR (1) KR101860160B1 (enExample)
CN (1) CN102639152B (enExample)
AU (1) AU2010332760B2 (enExample)
BR (1) BR112012013761A2 (enExample)
CA (1) CA2781228A1 (enExample)
DK (1) DK2512524T3 (enExample)
ES (1) ES2606165T3 (enExample)
HR (1) HRP20161627T1 (enExample)
HU (1) HUE032152T2 (enExample)
LT (1) LT2512524T (enExample)
MX (1) MX2012007041A (enExample)
NO (1) NO331773B1 (enExample)
PL (1) PL2512524T3 (enExample)
PT (1) PT2512524T (enExample)
RU (1) RU2561718C2 (enExample)
WO (1) WO2011073371A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2988756T4 (da) 2013-04-26 2022-08-08 Guerbet Sa Formulering af kontraststof og dertil knyttet fremstillingsfremgangsmåde
EP3101012A1 (en) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft New gadolinium chelate compounds for use in magnetic resonance imaging
EP3380484A1 (en) 2015-11-26 2018-10-03 Debreceni Egyetem New 6-oxa-3,9, 15-triaza-bicyclo[9.3.1 ]pentadec a- 1 ( 14), 1 1 ( 15), 12-triene derivatives based compounds and their application as ligands of essential metal ion based mri and 52mn based pet contrast agents
WO2017089847A1 (en) 2015-11-26 2017-06-01 Debreceni Egyetem New 3,6,9, 15-tetraaza-bicyclo [9.3.1 ]pentadeca- 1(14), 11(15), 12-triene based compounds and their application as ligands of essential metal ion based mri and 52mn based pet contrast agents
US10968224B2 (en) 2015-11-26 2021-04-06 Debreceni Egyetem 2,11-diaza-[3.3](2,6)pyridinophane compounds and their application as ligands of essential metal ion based MRI contrast agents and 52MN based PET contrast agents
GB201610738D0 (en) * 2016-06-20 2016-08-03 Ge Healthcare As Chelate compounds
WO2018096082A1 (en) 2016-11-28 2018-05-31 Bayer Pharma Aktiengesellschaft High relaxivity gadolinium chelate compounds for use in magnetic resonance imaging
PL3558394T3 (pl) * 2016-12-21 2020-11-16 Ge Healthcare As Oparte na tetraazabicyklo-makrocyklu związki chelatowe manganu odpowiednie jako środki do obrazowania metodą MRI
EP3728168B1 (en) * 2017-12-20 2022-03-30 General Electric Company Anionic chelate compounds
MY208484A (en) 2018-11-23 2025-05-13 Bayer Pharma AG Formulation of contrast media and process of preparation thereof
CN111233982B (zh) * 2018-11-28 2023-03-03 深圳先进技术研究院 一种小分子蛋白质及其应用
HUE069750T2 (hu) 2019-09-03 2025-04-28 Ge Healthcare As Mangán-kelát izomerek
CN114874214B (zh) * 2022-05-31 2023-03-21 南京航空航天大学 可偶联巯基的双功能大环螯合剂衍生物及其制备方法

Family Cites Families (11)

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AU608759B2 (en) 1986-08-04 1991-04-18 Amersham Health Salutar Inc NMR imaging with paramagnetic polyvalents metal salts of poly-(acid-alkylene-amido)-alkanes
DE3640708C2 (de) 1986-11-28 1995-05-18 Schering Ag Verbesserte metallhaltige Pharmazeutika
US5334371A (en) * 1988-07-20 1994-08-02 Schering Aktiengesellschaft Marcocyclic polyaza bicyclo compounds containing 5 or 6 membered rings, and method for MRI
DE68908185T2 (de) 1988-09-27 1993-11-25 Nycomed Salutar Inc Chelat-zusammensetzung.
ES2145041T3 (es) * 1991-12-10 2000-07-01 Dow Chemical Co Complejos de acidos biciclopoliazamacrociclocarboxilicos, sus conjugados, preparacion y uso como agentes de contraste.
ZA929576B (en) * 1991-12-10 1994-06-10 Dow Chemical Co Bicyclopolyazamacrocyclophosphonic acids their complexes and conjugates for use as contrast agents and processes for their preparation
US5428139A (en) * 1991-12-10 1995-06-27 The Dow Chemical Company Bicyclopolyazamacrocyclophosphonic acid complexes for use as radiopharmaceuticals
FI933506A7 (fi) * 1993-05-06 1994-11-07 Dow Global Technologies Inc Bisyklopolyatsamakrosyklokarboksyylihappokomplekseja, niiden konjugaat teja, menetelmä niiden valmistamiseksi ja käyttö varjoaineina
FR2836916B1 (fr) * 2002-03-05 2004-06-11 Guerbet Sa Oligomeres de chelates de gadolinium, leur application comme produits de contraste en imagerie par resonance magnetique et leurs intermediaires de synthese
FR2856689A1 (fr) * 2003-06-25 2004-12-31 Guerbet Sa Composes specifiques a forte relaxivite
US20080305049A1 (en) 2005-01-31 2008-12-11 Hadassa Degani Mri Contrast Agents for Diagnosis and Prognosis of Tumors

Also Published As

Publication number Publication date
JP2013514329A (ja) 2013-04-25
CA2781228A1 (en) 2011-06-23
HUE032152T2 (en) 2017-09-28
MX2012007041A (es) 2012-07-20
PT2512524T (pt) 2016-12-15
HRP20161627T1 (hr) 2017-01-13
US20120244081A1 (en) 2012-09-27
RU2561718C2 (ru) 2015-09-10
ES2606165T3 (es) 2017-03-23
CN102639152B (zh) 2015-11-25
JP5879268B2 (ja) 2016-03-08
CN102639152A (zh) 2012-08-15
AU2010332760A1 (en) 2012-06-07
KR20120109505A (ko) 2012-10-08
AU2010332760B2 (en) 2016-01-07
PL2512524T3 (pl) 2017-08-31
NO20093555A1 (no) 2011-06-20
DK2512524T3 (en) 2017-01-09
WO2011073371A1 (en) 2011-06-23
BR112012013761A2 (pt) 2016-04-26
LT2512524T (lt) 2016-12-12
EP2512524B1 (en) 2016-10-05
EP2512524A1 (en) 2012-10-24
US9486544B2 (en) 2016-11-08
KR101860160B1 (ko) 2018-05-21
RU2012124266A (ru) 2014-01-27

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