JP2013513802A5 - - Google Patents
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- Publication number
- JP2013513802A5 JP2013513802A5 JP2012543290A JP2012543290A JP2013513802A5 JP 2013513802 A5 JP2013513802 A5 JP 2013513802A5 JP 2012543290 A JP2012543290 A JP 2012543290A JP 2012543290 A JP2012543290 A JP 2012543290A JP 2013513802 A5 JP2013513802 A5 JP 2013513802A5
- Authority
- JP
- Japan
- Prior art keywords
- vitamin
- ions
- sample
- ion
- fragment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000002500 ions Chemical class 0.000 claims 66
- 239000002243 precursor Substances 0.000 claims 22
- 239000000523 sample Substances 0.000 claims 20
- MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 claims 19
- 238000000034 method Methods 0.000 claims 18
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 claims 17
- 239000012634 fragment Substances 0.000 claims 11
- 238000004949 mass spectrometry Methods 0.000 claims 10
- -1 vitamin D 2 ions Chemical class 0.000 claims 9
- 238000000605 extraction Methods 0.000 claims 8
- 238000000065 atmospheric pressure chemical ionisation Methods 0.000 claims 4
- 239000012472 biological sample Substances 0.000 claims 4
- 238000002414 normal-phase solid-phase extraction Methods 0.000 claims 4
- 238000004885 tandem mass spectrometry Methods 0.000 claims 4
- 238000004458 analytical method Methods 0.000 claims 2
- 238000013467 fragmentation Methods 0.000 claims 2
- 238000006062 fragmentation reaction Methods 0.000 claims 2
- 238000004128 high performance liquid chromatography Methods 0.000 claims 2
- 238000004811 liquid chromatography Methods 0.000 claims 2
- 238000002552 multiple reaction monitoring Methods 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- 238000004611 spectroscopical analysis Methods 0.000 claims 1
- 239000011710 vitamin D Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28594309P | 2009-12-11 | 2009-12-11 | |
| US28593809P | 2009-12-11 | 2009-12-11 | |
| US61/285,943 | 2009-12-11 | ||
| US61/285,938 | 2009-12-11 | ||
| PCT/US2010/059765 WO2011072163A1 (en) | 2009-12-11 | 2010-12-09 | Mass spectrometric determination of non-derivatized, non-metabolized vitamin d |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015152480A Division JP6290145B2 (ja) | 2009-12-11 | 2015-07-31 | 非誘導体化非代謝化ビタミンｄの質量分析法による決定 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013513802A JP2013513802A (ja) | 2013-04-22 |
| JP2013513802A5 true JP2013513802A5 (enExample) | 2014-01-30 |
| JP6113504B2 JP6113504B2 (ja) | 2017-04-12 |
Family
ID=44145925
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012543290A Active JP6113504B2 (ja) | 2009-12-11 | 2010-12-09 | 非誘導体化非代謝化ビタミンｄの質量分析法による決定 |
| JP2015152480A Active JP6290145B2 (ja) | 2009-12-11 | 2015-07-31 | 非誘導体化非代謝化ビタミンｄの質量分析法による決定 |
| JP2018020278A Active JP6728254B2 (ja) | 2009-12-11 | 2018-02-07 | 非誘導体化非代謝化ビタミンｄの質量分析法による決定 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015152480A Active JP6290145B2 (ja) | 2009-12-11 | 2015-07-31 | 非誘導体化非代謝化ビタミンｄの質量分析法による決定 |
| JP2018020278A Active JP6728254B2 (ja) | 2009-12-11 | 2018-02-07 | 非誘導体化非代謝化ビタミンｄの質量分析法による決定 |
Country Status (6)
| Country | Link |
|---|---|
| US (8) | US20120025067A1 (enExample) |
| EP (1) | EP2510339B1 (enExample) |
| JP (3) | JP6113504B2 (enExample) |
| CN (1) | CN102753964A (enExample) |
| CA (1) | CA2783797C (enExample) |
| WO (2) | WO2011072163A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7745226B2 (en) | 2005-04-06 | 2010-06-29 | Quest Diagnostics Investments Incorporated | Methods for detecting vitamin D metabolites |
| US7972868B2 (en) | 2007-11-28 | 2011-07-05 | Quest Diagnostics Investments Incorporated | Methods for detecting dihydroxyvitamin D metabolites by mass spectrometry |
| US7977117B2 (en) | 2009-12-03 | 2011-07-12 | Quest Diagnostics Investments Incorprated | Vitamin D metabolite determination utilizing mass spectrometry following derivatization |
| JP5739903B2 (ja) | 2009-12-11 | 2015-06-24 | クエスト ダイアグノスティックス インヴェストメンツ インコーポレイテッド | 複合試料中のステロイド化合物の質量分析 |
| CN102753964A (zh) | 2009-12-11 | 2012-10-24 | 奎斯特诊断投资公司 | 非衍生的、非代谢的维生素d的质谱测定 |
| WO2011091436A1 (en) * | 2010-01-25 | 2011-07-28 | Dh Technologies Development Pte. Ltd. | Quantitative analysis of vitamin d3, vitamin d2, and metabolites thereof |
| WO2014149847A2 (en) | 2013-03-15 | 2014-09-25 | Riaz Abrar | Ionization within ion trap using photoionization and electron ionization |
| US20160282371A1 (en) * | 2015-03-28 | 2016-09-29 | Quantalytical Labs Inc. | Solid Phase Extraction, Derivatization with Crown Ethers, and Mass Spectrometry, Methods, Reagents and Kits |
| CN105403631B (zh) * | 2015-10-28 | 2017-12-08 | 浙江省疾病预防控制中心 | 一种快速检测保健食品中维生素d3含量的方法 |
| WO2018198043A1 (en) * | 2017-04-28 | 2018-11-01 | Waters Technologies Corporation | Methods for quantifying total vitamin d |
| US20210088486A1 (en) * | 2018-01-29 | 2021-03-25 | Dh Technologies Development Pte. Ltd. | Methods and systems for detection of vitamin d metabolites |
| CN111999372A (zh) * | 2020-07-09 | 2020-11-27 | 山东师范大学 | 可高通量筛选喹喔啉衍生物合成条件的微液滴电喷雾装置及方法 |
| WO2023155000A1 (en) * | 2022-02-15 | 2023-08-24 | Mcmaster University | High throughput rapid screening of vitamin d |
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| JP5739903B2 (ja) | 2009-12-11 | 2015-06-24 | クエスト ダイアグノスティックス インヴェストメンツ インコーポレイテッド | 複合試料中のステロイド化合物の質量分析 |
| CN102753964A (zh) | 2009-12-11 | 2012-10-24 | 奎斯特诊断投资公司 | 非衍生的、非代谢的维生素d的质谱测定 |
| WO2011091436A1 (en) | 2010-01-25 | 2011-07-28 | Dh Technologies Development Pte. Ltd. | Quantitative analysis of vitamin d3, vitamin d2, and metabolites thereof |
| EP2548015A1 (en) | 2010-03-15 | 2013-01-23 | Anderson Forschung Group, Inc. | Improved mass spectrometric assays for peptides |
| US9063159B2 (en) | 2010-10-29 | 2015-06-23 | Cohesive Technologies Inc. | LC-MS separation and detection of vitamin D metabolites |
| WO2012111249A1 (ja) | 2011-02-14 | 2012-08-23 | 学校法人麻布獣医学園 | 質量分析法における質量変化を検出する方法及び安定同位体標識タンパク質の絶対量の定量方法 |
| US9140695B2 (en) | 2012-01-18 | 2015-09-22 | University Of Utah Research Foundation | Methods for analysis of free and autoantibody-bound biomarkers and associated compositions, devices, and systems |
| CN104797715A (zh) | 2012-09-20 | 2015-07-22 | 奎斯特诊断投资公司 | 通过质谱法定量甲状腺球蛋白 |
| JP7209363B2 (ja) | 2020-04-13 | 2023-01-20 | リオモ インク | スタビリティ評価システム、プログラム及び方法 |
-
2010
- 2010-12-09 CN CN2010800635404A patent/CN102753964A/zh active Pending
- 2010-12-09 CA CA2783797A patent/CA2783797C/en active Active
- 2010-12-09 US US12/964,710 patent/US20120025067A1/en not_active Abandoned
- 2010-12-09 US US12/964,717 patent/US20110240840A1/en not_active Abandoned
- 2010-12-09 JP JP2012543290A patent/JP6113504B2/ja active Active
- 2010-12-09 WO PCT/US2010/059765 patent/WO2011072163A1/en not_active Ceased
- 2010-12-09 WO PCT/US2010/059771 patent/WO2011072168A1/en not_active Ceased
- 2010-12-09 EP EP10836711.1A patent/EP2510339B1/en not_active Not-in-force
-
2015
- 2015-07-31 JP JP2015152480A patent/JP6290145B2/ja active Active
-
2016
- 2016-06-27 US US15/194,009 patent/US20170115314A1/en not_active Abandoned
-
2018
- 2018-02-07 JP JP2018020278A patent/JP6728254B2/ja active Active
- 2018-08-01 US US16/051,849 patent/US10753950B2/en active Active
-
2020
- 2020-08-24 US US17/001,425 patent/US11280799B2/en active Active
-
2022
- 2022-03-21 US US17/700,320 patent/US11549954B2/en active Active
- 2022-12-30 US US18/091,726 patent/US11852636B2/en active Active
-
2023
- 2023-11-07 US US18/503,388 patent/US20240077503A1/en not_active Abandoned
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