JP2013513802A5 - - Google Patents
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- JP2013513802A5 JP2013513802A5 JP2012543290A JP2012543290A JP2013513802A5 JP 2013513802 A5 JP2013513802 A5 JP 2013513802A5 JP 2012543290 A JP2012543290 A JP 2012543290A JP 2012543290 A JP2012543290 A JP 2012543290A JP 2013513802 A5 JP2013513802 A5 JP 2013513802A5
- Authority
- JP
- Japan
- Prior art keywords
- vitamin
- ions
- sample
- ion
- fragment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000002500 ions Chemical class 0.000 claims 66
- 239000002243 precursor Substances 0.000 claims 22
- 239000000523 sample Substances 0.000 claims 20
- MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 claims 19
- 238000000034 method Methods 0.000 claims 18
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 claims 17
- 239000012634 fragment Substances 0.000 claims 11
- 238000004949 mass spectrometry Methods 0.000 claims 10
- -1 vitamin D 2 ions Chemical class 0.000 claims 9
- 238000000605 extraction Methods 0.000 claims 8
- 238000000065 atmospheric pressure chemical ionisation Methods 0.000 claims 4
- 239000012472 biological sample Substances 0.000 claims 4
- 238000002414 normal-phase solid-phase extraction Methods 0.000 claims 4
- 238000004885 tandem mass spectrometry Methods 0.000 claims 4
- 238000004458 analytical method Methods 0.000 claims 2
- 238000013467 fragmentation Methods 0.000 claims 2
- 238000006062 fragmentation reaction Methods 0.000 claims 2
- 238000004128 high performance liquid chromatography Methods 0.000 claims 2
- 238000004811 liquid chromatography Methods 0.000 claims 2
- 238000002552 multiple reaction monitoring Methods 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- 238000004611 spectroscopical analysis Methods 0.000 claims 1
- 239000011710 vitamin D Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28593809P | 2009-12-11 | 2009-12-11 | |
| US28594309P | 2009-12-11 | 2009-12-11 | |
| US61/285,943 | 2009-12-11 | ||
| US61/285,938 | 2009-12-11 | ||
| PCT/US2010/059765 WO2011072163A1 (en) | 2009-12-11 | 2010-12-09 | Mass spectrometric determination of non-derivatized, non-metabolized vitamin d |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015152480A Division JP6290145B2 (ja) | 2009-12-11 | 2015-07-31 | 非誘導体化非代謝化ビタミンｄの質量分析法による決定 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013513802A JP2013513802A (ja) | 2013-04-22 |
| JP2013513802A5 true JP2013513802A5 (enExample) | 2014-01-30 |
| JP6113504B2 JP6113504B2 (ja) | 2017-04-12 |
Family
ID=44145925
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012543290A Active JP6113504B2 (ja) | 2009-12-11 | 2010-12-09 | 非誘導体化非代謝化ビタミンｄの質量分析法による決定 |
| JP2015152480A Active JP6290145B2 (ja) | 2009-12-11 | 2015-07-31 | 非誘導体化非代謝化ビタミンｄの質量分析法による決定 |
| JP2018020278A Active JP6728254B2 (ja) | 2009-12-11 | 2018-02-07 | 非誘導体化非代謝化ビタミンｄの質量分析法による決定 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015152480A Active JP6290145B2 (ja) | 2009-12-11 | 2015-07-31 | 非誘導体化非代謝化ビタミンｄの質量分析法による決定 |
| JP2018020278A Active JP6728254B2 (ja) | 2009-12-11 | 2018-02-07 | 非誘導体化非代謝化ビタミンｄの質量分析法による決定 |
Country Status (6)
| Country | Link |
|---|---|
| US (8) | US20120025067A1 (enExample) |
| EP (1) | EP2510339B1 (enExample) |
| JP (3) | JP6113504B2 (enExample) |
| CN (1) | CN102753964A (enExample) |
| CA (1) | CA2783797C (enExample) |
| WO (2) | WO2011072163A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7745226B2 (en) | 2005-04-06 | 2010-06-29 | Quest Diagnostics Investments Incorporated | Methods for detecting vitamin D metabolites |
| US7972868B2 (en) | 2007-11-28 | 2011-07-05 | Quest Diagnostics Investments Incorporated | Methods for detecting dihydroxyvitamin D metabolites by mass spectrometry |
| US7977117B2 (en) | 2009-12-03 | 2011-07-12 | Quest Diagnostics Investments Incorprated | Vitamin D metabolite determination utilizing mass spectrometry following derivatization |
| CA2783797C (en) | 2009-12-11 | 2021-06-08 | Quest Diagnostics Investments Incorporated | Mass spectrometric determination of non-derivatized, non-metabolized vitamin d |
| CA2783708C (en) | 2009-12-11 | 2018-09-18 | Quest Diagnostics Investments Incorporated | Mass spectrometry of steroidal compounds in multiplex samples |
| CA2787900C (en) * | 2010-01-25 | 2018-10-02 | Dh Technologies Development Pte. Ltd. | Quantitative analysis of vitamin d3, vitamin d2, and metabolites thereof |
| WO2014149847A2 (en) | 2013-03-15 | 2014-09-25 | Riaz Abrar | Ionization within ion trap using photoionization and electron ionization |
| CN108027353A (zh) * | 2015-03-28 | 2018-05-11 | 帝肯样品制备股份有限公司 | 固相萃取、用冠醚衍生化、以及质谱、方法、试剂和试剂盒 |
| CN105403631B (zh) * | 2015-10-28 | 2017-12-08 | 浙江省疾病预防控制中心 | 一种快速检测保健食品中维生素d3含量的方法 |
| WO2018198043A1 (en) * | 2017-04-28 | 2018-11-01 | Waters Technologies Corporation | Methods for quantifying total vitamin d |
| US20210088486A1 (en) * | 2018-01-29 | 2021-03-25 | Dh Technologies Development Pte. Ltd. | Methods and systems for detection of vitamin d metabolites |
| CN111999372A (zh) * | 2020-07-09 | 2020-11-27 | 山东师范大学 | 可高通量筛选喹喔啉衍生物合成条件的微液滴电喷雾装置及方法 |
| WO2023155000A1 (en) * | 2022-02-15 | 2023-08-24 | Mcmaster University | High throughput rapid screening of vitamin d |
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| US7972868B2 (en) | 2007-11-28 | 2011-07-05 | Quest Diagnostics Investments Incorporated | Methods for detecting dihydroxyvitamin D metabolites by mass spectrometry |
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| CA2783708C (en) | 2009-12-11 | 2018-09-18 | Quest Diagnostics Investments Incorporated | Mass spectrometry of steroidal compounds in multiplex samples |
| CA2783797C (en) | 2009-12-11 | 2021-06-08 | Quest Diagnostics Investments Incorporated | Mass spectrometric determination of non-derivatized, non-metabolized vitamin d |
| CA2787900C (en) | 2010-01-25 | 2018-10-02 | Dh Technologies Development Pte. Ltd. | Quantitative analysis of vitamin d3, vitamin d2, and metabolites thereof |
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| US9140695B2 (en) | 2012-01-18 | 2015-09-22 | University Of Utah Research Foundation | Methods for analysis of free and autoantibody-bound biomarkers and associated compositions, devices, and systems |
| WO2014047316A1 (en) | 2012-09-20 | 2014-03-27 | Quest Diagnostics Investments Incorporated | Thyroglobulin quantitation by mass spectroscopy |
| JP7209363B2 (ja) | 2020-04-13 | 2023-01-20 | リオモ インク | スタビリティ評価システム、プログラム及び方法 |
-
2010
- 2010-12-09 CA CA2783797A patent/CA2783797C/en active Active
- 2010-12-09 EP EP10836711.1A patent/EP2510339B1/en not_active Not-in-force
- 2010-12-09 CN CN2010800635404A patent/CN102753964A/zh active Pending
- 2010-12-09 WO PCT/US2010/059765 patent/WO2011072163A1/en not_active Ceased
- 2010-12-09 US US12/964,710 patent/US20120025067A1/en not_active Abandoned
- 2010-12-09 WO PCT/US2010/059771 patent/WO2011072168A1/en not_active Ceased
- 2010-12-09 US US12/964,717 patent/US20110240840A1/en not_active Abandoned
- 2010-12-09 JP JP2012543290A patent/JP6113504B2/ja active Active
-
2015
- 2015-07-31 JP JP2015152480A patent/JP6290145B2/ja active Active
-
2016
- 2016-06-27 US US15/194,009 patent/US20170115314A1/en not_active Abandoned
-
2018
- 2018-02-07 JP JP2018020278A patent/JP6728254B2/ja active Active
- 2018-08-01 US US16/051,849 patent/US10753950B2/en active Active
-
2020
- 2020-08-24 US US17/001,425 patent/US11280799B2/en active Active
-
2022
- 2022-03-21 US US17/700,320 patent/US11549954B2/en active Active
- 2022-12-30 US US18/091,726 patent/US11852636B2/en active Active
-
2023
- 2023-11-07 US US18/503,388 patent/US20240077503A1/en active Pending
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