CA2783797C - Mass spectrometric determination of non-derivatized, non-metabolized vitamin d - Google Patents

Mass spectrometric determination of non-derivatized, non-metabolized vitamin d Download PDF

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Publication number
CA2783797C
CA2783797C CA2783797A CA2783797A CA2783797C CA 2783797 C CA2783797 C CA 2783797C CA 2783797 A CA2783797 A CA 2783797A CA 2783797 A CA2783797 A CA 2783797A CA 2783797 C CA2783797 C CA 2783797C
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vitamin
ions
sample
column
metabolized
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French (fr)
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CA2783797A1 (en
Inventor
Brett Holmquist
Nigel J. Clarke
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Quest Diagnostics Investments LLC
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Quest Diagnostics Investments LLC
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/82—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving vitamins or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/14—Ion sources; Ion guns using particle bombardment, e.g. ionisation chambers
    • H01J49/145—Ion sources; Ion guns using particle bombardment, e.g. ionisation chambers using chemical ionisation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N2030/009—Extraction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N2030/022—Column chromatography characterised by the kind of separation mechanism
    • G01N2030/027—Liquid chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Plasma & Fusion (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
CA2783797A 2009-12-11 2010-12-09 Mass spectrometric determination of non-derivatized, non-metabolized vitamin d Active CA2783797C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US28594309P 2009-12-11 2009-12-11
US28593809P 2009-12-11 2009-12-11
US61/285,943 2009-12-11
US61/285,938 2009-12-11
PCT/US2010/059765 WO2011072163A1 (en) 2009-12-11 2010-12-09 Mass spectrometric determination of non-derivatized, non-metabolized vitamin d

Publications (2)

Publication Number Publication Date
CA2783797A1 CA2783797A1 (en) 2011-06-16
CA2783797C true CA2783797C (en) 2021-06-08

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Family Applications (1)

Application Number Title Priority Date Filing Date
CA2783797A Active CA2783797C (en) 2009-12-11 2010-12-09 Mass spectrometric determination of non-derivatized, non-metabolized vitamin d

Country Status (6)

Country Link
US (8) US20120025067A1 (enExample)
EP (1) EP2510339B1 (enExample)
JP (3) JP6113504B2 (enExample)
CN (1) CN102753964A (enExample)
CA (1) CA2783797C (enExample)
WO (2) WO2011072163A1 (enExample)

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CN102753964A (zh) 2009-12-11 2012-10-24 奎斯特诊断投资公司 非衍生的、非代谢的维生素d的质谱测定
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CN105403631B (zh) * 2015-10-28 2017-12-08 浙江省疾病预防控制中心 一种快速检测保健食品中维生素d3含量的方法
WO2018198043A1 (en) * 2017-04-28 2018-11-01 Waters Technologies Corporation Methods for quantifying total vitamin d
US20210088486A1 (en) * 2018-01-29 2021-03-25 Dh Technologies Development Pte. Ltd. Methods and systems for detection of vitamin d metabolites
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WO2023155000A1 (en) * 2022-02-15 2023-08-24 Mcmaster University High throughput rapid screening of vitamin d

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Also Published As

Publication number Publication date
CN102753964A (zh) 2012-10-24
US20240077503A1 (en) 2024-03-07
JP6113504B2 (ja) 2017-04-12
US11852636B2 (en) 2023-12-26
US20110240840A1 (en) 2011-10-06
US10753950B2 (en) 2020-08-25
JP6728254B2 (ja) 2020-07-22
EP2510339A4 (en) 2013-11-27
US20210041464A1 (en) 2021-02-11
US20120025067A1 (en) 2012-02-02
JP2013513802A (ja) 2013-04-22
WO2011072168A1 (en) 2011-06-16
US20170115314A1 (en) 2017-04-27
JP2018105878A (ja) 2018-07-05
WO2011072163A1 (en) 2011-06-16
EP2510339B1 (en) 2019-09-18
US20220214366A1 (en) 2022-07-07
US11549954B2 (en) 2023-01-10
US11280799B2 (en) 2022-03-22
JP2016026287A (ja) 2016-02-12
US20230146212A1 (en) 2023-05-11
JP6290145B2 (ja) 2018-03-07
EP2510339A1 (en) 2012-10-17
US20180348236A1 (en) 2018-12-06
CA2783797A1 (en) 2011-06-16

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