JP2013512962A5 - - Google Patents

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Publication number
JP2013512962A5
JP2013512962A5 JP2012543213A JP2012543213A JP2013512962A5 JP 2013512962 A5 JP2013512962 A5 JP 2013512962A5 JP 2012543213 A JP2012543213 A JP 2012543213A JP 2012543213 A JP2012543213 A JP 2012543213A JP 2013512962 A5 JP2013512962 A5 JP 2013512962A5
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JP
Japan
Prior art keywords
sulfonamide
alkyl
aryl
benzene
methanesulfonyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2012543213A
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English (en)
Japanese (ja)
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JP2013512962A (ja
JP5826762B2 (ja
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Priority claimed from PCT/US2010/059335 external-priority patent/WO2011071951A2/en
Publication of JP2013512962A publication Critical patent/JP2013512962A/ja
Publication of JP2013512962A5 publication Critical patent/JP2013512962A5/ja
Application granted granted Critical
Publication of JP5826762B2 publication Critical patent/JP5826762B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2012543213A 2009-12-07 2010-12-07 N−アシルオキシスルホンアミドおよびn−ヒドロキシ−n−アシルスルホンアミド誘導体 Expired - Fee Related JP5826762B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US26740109P 2009-12-07 2009-12-07
US61/267,401 2009-12-07
US29122409P 2009-12-30 2009-12-30
US61/291,224 2009-12-30
PCT/US2010/059335 WO2011071951A2 (en) 2009-12-07 2010-12-07 N-acyloxysulfonamide and n-hydroxy-n-acylsulfonamide derivatives

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015203216A Division JP2016094394A (ja) 2009-12-07 2015-10-14 N−アシルオキシスルホンアミドおよびn−ヒドロキシ−n−アシルスルホンアミド誘導体

Publications (3)

Publication Number Publication Date
JP2013512962A JP2013512962A (ja) 2013-04-18
JP2013512962A5 true JP2013512962A5 (https=) 2014-01-23
JP5826762B2 JP5826762B2 (ja) 2015-12-02

Family

ID=43877339

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2012543213A Expired - Fee Related JP5826762B2 (ja) 2009-12-07 2010-12-07 N−アシルオキシスルホンアミドおよびn−ヒドロキシ−n−アシルスルホンアミド誘導体
JP2015203216A Pending JP2016094394A (ja) 2009-12-07 2015-10-14 N−アシルオキシスルホンアミドおよびn−ヒドロキシ−n−アシルスルホンアミド誘導体

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2015203216A Pending JP2016094394A (ja) 2009-12-07 2015-10-14 N−アシルオキシスルホンアミドおよびn−ヒドロキシ−n−アシルスルホンアミド誘導体

Country Status (10)

Country Link
US (4) US20110144067A1 (https=)
EP (1) EP2509941B1 (https=)
JP (2) JP5826762B2 (https=)
CN (2) CN102753520B (https=)
AU (2) AU2010328234B2 (https=)
CA (1) CA2782110A1 (https=)
ES (1) ES2719101T3 (https=)
IN (1) IN2012DN05025A (https=)
MX (1) MX2012006349A (https=)
WO (1) WO2011071951A2 (https=)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ584036A (en) 2007-09-26 2012-06-29 Univ Johns Hopkins N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors
WO2011063339A1 (en) * 2009-11-23 2011-05-26 Cardioxyl Pharmaceuticals, Inc. Nitroxyl donors for the treatment of pulmonary hypertension
WO2011071947A2 (en) 2009-12-07 2011-06-16 Johns Hopkins University Bis-acylated hydroxylamine derivatives
AU2013201929B2 (en) 2011-10-17 2015-07-23 The Johns Hopkins University N-substituted hydroxylamine derivatives with carbon-based leaving groups
WO2014070919A1 (en) 2012-11-01 2014-05-08 The Johns Hopkins University Controlled hno release through intramolecular cyclization-elimination
HRP20180121T1 (hr) * 2013-01-18 2018-02-23 Cardioxyl Pharmaceuticals Inc. Donori nitroksila s poboljšanim terapijskim indeksom
EP3126329B1 (en) 2014-01-17 2019-05-29 Cardioxyl Pharmaceuticals Inc. N-hydroxymethanesulfonamide nitroxyl donors
US9464061B2 (en) 2014-05-27 2016-10-11 The Johns Hopkins University N-hydroxylamino-barbituric acid derivatives
EP3148983A1 (en) 2014-05-27 2017-04-05 The Johns Hopkins University N-hydroxylamino-barbituric acid derivatives as nitroxyl donors
EP3148972B1 (en) 2014-05-27 2019-08-21 Cardioxyl Pharmaceuticals, Inc. Pyrazolone derivatives as nitroxyl donors
CN107922371B (zh) * 2015-06-26 2022-04-19 约翰斯霍普金斯大学 作为有效的hno供体的具有碳基离去基团的n-取代的异羟肟酸及其用途
US10456405B2 (en) 2015-09-07 2019-10-29 Zhejiang Huahai Pharmaceutical Co., Ltd Nitric oxide-releasing prodrug molecule of substituted quinazolines
KR20180063326A (ko) 2015-10-19 2018-06-11 카르디옥실 파마슈티칼스 인코포레이티드 니트록실 공여자로서의 피라졸론 유도체
US10730828B2 (en) 2015-10-19 2020-08-04 Cardioxyl Pharmaceuticals, Inc. N-hydroxylsulfonamide derivatives as nitroxyl donors
US10913728B2 (en) 2016-07-28 2021-02-09 The Johns Hopkins University O-substituted hydroxamic acids
US11083704B2 (en) 2017-01-03 2021-08-10 Bristol-Myers Squibb Company Method of administering nitroxyl donating compounds
CN108318615A (zh) * 2018-03-16 2018-07-24 湖北亿诺瑞生物制药有限公司 顶空气相色谱法检测肝素钠中残留溶剂的方法
CN113621098B (zh) * 2020-05-09 2022-11-04 中国石油天然气股份有限公司 丙烯聚合催化剂、丙烯聚合催化剂体系及其制备与应用
CN114195731A (zh) * 2021-11-24 2022-03-18 海南大学 一种氢化亚硝酰供体化合物及其制备方法
WO2025043108A1 (en) 2023-08-23 2025-02-27 Bristol -Myers S Quibb Company Co-crystals of nitroxyl donating compounds

Family Cites Families (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1283890A (fr) * 1959-12-28 1962-02-09 Ajinomoto Kk Procédé de préparation d'inosinate de sodium
US3219428A (en) * 1961-04-17 1965-11-23 Hooker Chemical Corp O,n-diacylated-3,4-dihalophenylhydroxylamines as herbicides
US3382243A (en) * 1965-05-17 1968-05-07 American Home Prod Acetamides and their preparation
US3458570A (en) * 1966-07-28 1969-07-29 Stauffer Chemical Co N-substituted phenylsulfonyl-hydroxylamines
US3948967A (en) * 1968-01-03 1976-04-06 Velsicol Chemical Corporation Aryl urea carbonates
US3661944A (en) * 1970-07-01 1972-05-09 Smith Kline French Lab 4-(n-lower alkanoyl)hydroxylamino-4'-aminodiphenylsulfone compounds
US3746727A (en) * 1971-06-07 1973-07-17 Shell Oil Co Benzenesulfhydroxamic acids and their derivatives
FR2344050A1 (fr) * 1976-03-09 1977-10-07 Agfa Gevaert Ag Technique d'introduction d'additifs photographiques dans des emulsions d'un sel d'argent
JPS567710A (en) * 1979-06-28 1981-01-27 Sansho Seiyaku Kk Whitening cosmetic
US4405357A (en) * 1980-06-02 1983-09-20 Fmc Corporation Herbicidal 3-isoxazolidinones and hydroxamic acids
US4539321A (en) * 1981-10-26 1985-09-03 William H. Rorer, Inc. 5-Diaza-aryl-3-substituted pyridone compounds
DE3583799D1 (de) 1985-01-11 1991-09-19 Abbott Lab Ltd Feste zubereitung mit langsamer freisetzung.
US4663351A (en) 1985-08-23 1987-05-05 Berlex Laboratories, Inc. Dobutamine tri-isobutyric acid ester and the use thereof as a cardiotonic agent
US4798824A (en) * 1985-10-03 1989-01-17 Wisconsin Alumni Research Foundation Perfusate for the preservation of organs
US4954526A (en) * 1989-02-28 1990-09-04 The United States Of America As Represented By The Department Of Health And Human Services Stabilized nitric oxide - primary amine complexes useful as cardiovascular agents
US5039705A (en) * 1989-09-15 1991-08-13 The United States Of America As Represented By The Department Of Health And Human Services Anti-hypertensive compositions of secondary amine-nitric oxide adducts and use thereof
US5212204A (en) * 1989-10-18 1993-05-18 The United States Of America As Represented By The Department Of Health And Human Services Antihypertensive compositions and use thereof
JPH04235171A (ja) * 1990-07-26 1992-08-24 Sumitomo Chem Co Ltd スルホヒドロキサム酸誘導体、その製造法およびそれを有効成分とする除草剤
JP2773959B2 (ja) * 1990-07-10 1998-07-09 信越化学工業株式会社 大腸内放出性固形製剤
US5418212A (en) * 1990-11-30 1995-05-23 Kumiai Chemical Industry Co., Ltd. Alkanoic acid amide derivative or its salt, and herbicidal composition
JPH05341461A (ja) * 1992-06-05 1993-12-24 Fuji Photo Film Co Ltd ハロゲン化銀カラー写真感光材料
US5278192A (en) * 1992-07-02 1994-01-11 The Research Foundation Of State University Of New York Method of vasodilator therapy for treating a patient with a condition
ATE192922T1 (de) * 1993-11-02 2000-06-15 Us Health Verwendung von stickstoffoxid freisetzenden verbindungen zur herstellung eines arzneimittels zum schutz gegen die ischämischen reperfusionsschäden
US5532256A (en) * 1994-05-18 1996-07-02 American Home Products Corporation New azolidinediones and thiadiazolidinediones as antihyperglycemic agents
DE19533023B4 (de) * 1994-10-14 2007-05-16 Basf Ag Neue Carbonsäurederivate, ihre Herstellung und Verwendung
US6043232A (en) * 1997-07-23 2000-03-28 Nitromed, Inc. Nitroso esters of beta-oxo-amides and aryl propionic acid derivatives of non-steroidal antiinflammatory drugs
US5703073A (en) * 1995-04-19 1997-12-30 Nitromed, Inc. Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs
US5674894A (en) * 1995-05-15 1997-10-07 G.D. Searle & Co. Amidine derivatives useful as platelet aggregation inhibitors and vasodilators
US5714511A (en) * 1995-07-31 1998-02-03 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Selective prevention of organ injury in sepsis and shock using selection release of nitric oxide in vulnerable organs
DE19545878A1 (de) * 1995-12-08 1997-06-12 Basf Ag Pyridylcarbamate, Verfahren und Zwischenprodukte zu ihrer Herstellung und ihre Verwendung
US5824669A (en) * 1996-03-22 1998-10-20 Nitromed, Inc. Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders
AU3866897A (en) * 1996-08-23 1998-03-06 Kowa Co. Ltd. Diamide compounds and drugs containing the same
US5962521A (en) * 1997-04-04 1999-10-05 Guilford Pharmaceuticals Inc. Hydroxamic acid derivatives
TW453999B (en) * 1997-06-27 2001-09-11 Fujisawa Pharmaceutical Co Benzimidazole derivatives
GB9726989D0 (en) * 1997-12-22 1998-02-18 Ciba Geigy Ag Organic compounds
UA73092C2 (uk) 1998-07-17 2005-06-15 Брістол-Майерс Сквібб Компані Таблетка з ентеросолюбільним покриттям і спосіб її приготування
DE69924735T2 (de) * 1998-07-28 2006-01-19 Tanabe Seiyaku Co., Ltd. Zur wirkstoffabgabe an zielorten im darm fähige zubereitung
EP1126838A4 (en) * 1998-10-30 2005-02-16 Nitromed Inc NITROSIS AND NITROSYAL NON-STEROID ANTI-INFLAMMATORY COMPOUNDS, COMPOSITIONS AND METHODS OF USE
PL353199A1 (en) * 1999-08-30 2003-11-03 Aventis Pharma Deutschland Gmbh Use of inhibitors of the renin-angiotensin system in the prevention of cardiovascular events
WO2001093872A1 (de) * 2000-06-08 2001-12-13 Jomaa Pharmaka Gmbh Verwendung von phosphororganischen hydroxamsäurederivaten zur herstellung von arzneimitteln
US20010053795A1 (en) * 2000-06-20 2001-12-20 Bond Richard A. Paradoxical pharmacology
CA2410632A1 (en) * 2000-06-22 2001-12-27 David S. Garvey Nitrosated and nitrosylated taxanes, compositions and methods of use
JP4092203B2 (ja) * 2000-12-21 2008-05-28 ニトロメッド,インク. 新規のシクロオキシゲナーゼ2選択的阻害剤としての置換アリール化合物、組成物、および使用方法
US20030068386A1 (en) 2001-09-05 2003-04-10 Stoyanovsky Detcho A. Method of treating cancerous disease
US20040038947A1 (en) 2002-06-14 2004-02-26 The Gov. Of The U.S. Of America As Represented By The Sec. Of The Dept. Of Health & Human Services Method of treating ischemia/reperfusion injury with nitroxyl donors
US20040077691A1 (en) * 2002-06-21 2004-04-22 Medinox, Inc. Hydroxamate derivatives of non-steroidal anti-inflammatory drugs
US6936639B2 (en) 2002-08-21 2005-08-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Nitroxyl progenitors in the treatment of heart failure
CA2554771A1 (en) * 2004-01-30 2005-08-18 Johns Hopkins University Nitroxyl progenitor compounds and methods of use
EP1909779A1 (en) * 2005-06-23 2008-04-16 Johns Hopkins University Thiol-sensitive positive inotropes
TWI282084B (en) 2005-07-08 2007-06-01 Jeng-Tzung Chen Guitar
US20070088043A1 (en) * 2005-10-18 2007-04-19 Orchid Research Laboratories Limited. Novel HDAC inhibitors
EP1962596A4 (en) * 2005-12-08 2010-09-22 Univ Johns Hopkins TRIOXAN-DIMERE WITH HIGH ANTIMALARIA AND PERMANENT ANTIMALARIA ACTIVITY
BRPI0708804B8 (pt) * 2006-03-17 2021-05-25 Cardioxyl Pharmaceuticals Inc compostos derivados de n-hidroxilsulfonamida como doadores de nitroxil, composição farmacêutica e kit
JP4783657B2 (ja) * 2006-03-27 2011-09-28 富士フイルム株式会社 ポジ型レジスト組成物及び該組成物を用いたパターン形成方法
EP2010476A4 (en) 2006-04-13 2011-01-26 Univ Wake Forest Health Sciences NITROXYL DISPENSERS FROM C-NITROSO COMPOUNDS
NZ584036A (en) * 2007-09-26 2012-06-29 Univ Johns Hopkins N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors
LT2278975T (lt) 2008-05-07 2016-11-25 Cardioxyl Pharmaceuticals Inc. Nauji nitrozo junginiai kaip nitroksilo donorai, ir jų panaudojimo būdas
WO2011063339A1 (en) * 2009-11-23 2011-05-26 Cardioxyl Pharmaceuticals, Inc. Nitroxyl donors for the treatment of pulmonary hypertension
WO2011071947A2 (en) * 2009-12-07 2011-06-16 Johns Hopkins University Bis-acylated hydroxylamine derivatives

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