JP2013512962A5 - - Google Patents
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- Publication number
- JP2013512962A5 JP2013512962A5 JP2012543213A JP2012543213A JP2013512962A5 JP 2013512962 A5 JP2013512962 A5 JP 2013512962A5 JP 2012543213 A JP2012543213 A JP 2012543213A JP 2012543213 A JP2012543213 A JP 2012543213A JP 2013512962 A5 JP2013512962 A5 JP 2013512962A5
- Authority
- JP
- Japan
- Prior art keywords
- sulfonamide
- alkyl
- aryl
- benzene
- methanesulfonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26740109P | 2009-12-07 | 2009-12-07 | |
| US61/267,401 | 2009-12-07 | ||
| US29122409P | 2009-12-30 | 2009-12-30 | |
| US61/291,224 | 2009-12-30 | ||
| PCT/US2010/059335 WO2011071951A2 (en) | 2009-12-07 | 2010-12-07 | N-acyloxysulfonamide and n-hydroxy-n-acylsulfonamide derivatives |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015203216A Division JP2016094394A (ja) | 2009-12-07 | 2015-10-14 | N−アシルオキシスルホンアミドおよびn−ヒドロキシ−n−アシルスルホンアミド誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013512962A JP2013512962A (ja) | 2013-04-18 |
| JP2013512962A5 true JP2013512962A5 (cg-RX-API-DMAC7.html) | 2014-01-23 |
| JP5826762B2 JP5826762B2 (ja) | 2015-12-02 |
Family
ID=43877339
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012543213A Expired - Fee Related JP5826762B2 (ja) | 2009-12-07 | 2010-12-07 | N−アシルオキシスルホンアミドおよびn−ヒドロキシ−n−アシルスルホンアミド誘導体 |
| JP2015203216A Pending JP2016094394A (ja) | 2009-12-07 | 2015-10-14 | N−アシルオキシスルホンアミドおよびn−ヒドロキシ−n−アシルスルホンアミド誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015203216A Pending JP2016094394A (ja) | 2009-12-07 | 2015-10-14 | N−アシルオキシスルホンアミドおよびn−ヒドロキシ−n−アシルスルホンアミド誘導体 |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US20110144067A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2509941B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP5826762B2 (cg-RX-API-DMAC7.html) |
| CN (2) | CN102753520B (cg-RX-API-DMAC7.html) |
| AU (2) | AU2010328234B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2782110A1 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2719101T3 (cg-RX-API-DMAC7.html) |
| IN (1) | IN2012DN05025A (cg-RX-API-DMAC7.html) |
| MX (1) | MX2012006349A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2011071951A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0817562A2 (pt) | 2007-09-26 | 2017-05-02 | Cardioxyl Pharmaceuticals Inc | derivados de n-hidroxilsulfonamida como novos doadores de niltroxil fisiologicamente úteis |
| US20110160200A1 (en) * | 2009-11-23 | 2011-06-30 | Cardioxyl Pharmaceuticals, Inc. | Nitroxyl Progenitors for the Treatment of Pulmonary Hypertension |
| CN105130855B (zh) | 2009-12-07 | 2018-05-25 | 约翰斯霍普金斯大学 | 二酰基化的羟基胺衍生物及其用途 |
| EP2776402B1 (en) | 2011-10-17 | 2017-07-26 | The Johns Hopkins University | Meldrum's acid, barbituric acid and pyrazolone derivatives substituted with hydroxylamine as hno donors |
| EP2914579A1 (en) * | 2012-11-01 | 2015-09-09 | The Johns Hopkins University | Controlled hno release through intramolecular cyclization-elimination |
| EP3427728B1 (en) * | 2013-01-18 | 2021-07-07 | Cardioxyl Pharmaceuticals, Inc. | Pharmaceutical compositions comprising nitroxyl donors |
| ES2734060T3 (es) | 2014-01-17 | 2019-12-04 | Cardioxyl Pharmaceuticals Inc | Donadores de nitroxilo de N-hidroximetanosulfonamida |
| US9464061B2 (en) | 2014-05-27 | 2016-10-11 | The Johns Hopkins University | N-hydroxylamino-barbituric acid derivatives |
| WO2015183839A1 (en) | 2014-05-27 | 2015-12-03 | Cardioxyl Pharmaceuticals, Inc. | Pyrazolone derivatives as nitroxyl donors |
| EP3148983A1 (en) | 2014-05-27 | 2017-04-05 | The Johns Hopkins University | N-hydroxylamino-barbituric acid derivatives as nitroxyl donors |
| EP3313831B1 (en) | 2015-06-26 | 2021-03-10 | The Johns Hopkins University | N-substituted hydroxamic acids with carbon-based leaving groups as efficient hno donors and uses thereof |
| US10456405B2 (en) | 2015-09-07 | 2019-10-29 | Zhejiang Huahai Pharmaceutical Co., Ltd | Nitric oxide-releasing prodrug molecule of substituted quinazolines |
| EP3365325A1 (en) * | 2015-10-19 | 2018-08-29 | Cardioxyl Pharmaceuticals Inc. | N-hydroxylsulfonamide derivatives as nitroxyl donors |
| EP3365328A1 (en) | 2015-10-19 | 2018-08-29 | Cardioxyl Pharmaceuticals, Inc. | Pyrazolone derivatives as nitroxyl donors |
| US10913728B2 (en) | 2016-07-28 | 2021-02-09 | The Johns Hopkins University | O-substituted hydroxamic acids |
| SG11201906145YA (en) | 2017-01-03 | 2019-08-27 | Cardioxyl Pharmaceuticals Inc | Method of administering nitroxyl donating compounds |
| CN108318615A (zh) * | 2018-03-16 | 2018-07-24 | 湖北亿诺瑞生物制药有限公司 | 顶空气相色谱法检测肝素钠中残留溶剂的方法 |
| CN113621098B (zh) * | 2020-05-09 | 2022-11-04 | 中国石油天然气股份有限公司 | 丙烯聚合催化剂、丙烯聚合催化剂体系及其制备与应用 |
| CN114195731A (zh) * | 2021-11-24 | 2022-03-18 | 海南大学 | 一种氢化亚硝酰供体化合物及其制备方法 |
| WO2025043108A1 (en) | 2023-08-23 | 2025-02-27 | Bristol -Myers S Quibb Company | Co-crystals of nitroxyl donating compounds |
Family Cites Families (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1283890A (fr) * | 1959-12-28 | 1962-02-09 | Ajinomoto Kk | Procédé de préparation d'inosinate de sodium |
| US3219428A (en) * | 1961-04-17 | 1965-11-23 | Hooker Chemical Corp | O,n-diacylated-3,4-dihalophenylhydroxylamines as herbicides |
| US3382243A (en) * | 1965-05-17 | 1968-05-07 | American Home Prod | Acetamides and their preparation |
| US3458570A (en) * | 1966-07-28 | 1969-07-29 | Stauffer Chemical Co | N-substituted phenylsulfonyl-hydroxylamines |
| US3948967A (en) * | 1968-01-03 | 1976-04-06 | Velsicol Chemical Corporation | Aryl urea carbonates |
| US3661944A (en) * | 1970-07-01 | 1972-05-09 | Smith Kline French Lab | 4-(n-lower alkanoyl)hydroxylamino-4'-aminodiphenylsulfone compounds |
| US3746727A (en) * | 1971-06-07 | 1973-07-17 | Shell Oil Co | Benzenesulfhydroxamic acids and their derivatives |
| FR2344050A1 (fr) * | 1976-03-09 | 1977-10-07 | Agfa Gevaert Ag | Technique d'introduction d'additifs photographiques dans des emulsions d'un sel d'argent |
| JPS567710A (en) * | 1979-06-28 | 1981-01-27 | Sansho Seiyaku Kk | Whitening cosmetic |
| US4405357A (en) * | 1980-06-02 | 1983-09-20 | Fmc Corporation | Herbicidal 3-isoxazolidinones and hydroxamic acids |
| US4539321A (en) * | 1981-10-26 | 1985-09-03 | William H. Rorer, Inc. | 5-Diaza-aryl-3-substituted pyridone compounds |
| EP0188040B1 (en) * | 1985-01-11 | 1991-08-14 | Abbott Laboratories Limited | Slow release solid preparation |
| US4663351A (en) * | 1985-08-23 | 1987-05-05 | Berlex Laboratories, Inc. | Dobutamine tri-isobutyric acid ester and the use thereof as a cardiotonic agent |
| US4798824A (en) | 1985-10-03 | 1989-01-17 | Wisconsin Alumni Research Foundation | Perfusate for the preservation of organs |
| US4954526A (en) * | 1989-02-28 | 1990-09-04 | The United States Of America As Represented By The Department Of Health And Human Services | Stabilized nitric oxide - primary amine complexes useful as cardiovascular agents |
| US5039705A (en) * | 1989-09-15 | 1991-08-13 | The United States Of America As Represented By The Department Of Health And Human Services | Anti-hypertensive compositions of secondary amine-nitric oxide adducts and use thereof |
| US5212204A (en) * | 1989-10-18 | 1993-05-18 | The United States Of America As Represented By The Department Of Health And Human Services | Antihypertensive compositions and use thereof |
| JPH04235171A (ja) * | 1990-07-26 | 1992-08-24 | Sumitomo Chem Co Ltd | スルホヒドロキサム酸誘導体、その製造法およびそれを有効成分とする除草剤 |
| JP2773959B2 (ja) * | 1990-07-10 | 1998-07-09 | 信越化学工業株式会社 | 大腸内放出性固形製剤 |
| US5418212A (en) * | 1990-11-30 | 1995-05-23 | Kumiai Chemical Industry Co., Ltd. | Alkanoic acid amide derivative or its salt, and herbicidal composition |
| JPH05341461A (ja) * | 1992-06-05 | 1993-12-24 | Fuji Photo Film Co Ltd | ハロゲン化銀カラー写真感光材料 |
| US5278192A (en) * | 1992-07-02 | 1994-01-11 | The Research Foundation Of State University Of New York | Method of vasodilator therapy for treating a patient with a condition |
| ES2149338T3 (es) * | 1993-11-02 | 2000-11-01 | Us Health | Utilizacion de compuestos que liberan oxido nitrico para la fabricacion de un medicamento destinado al tratamiento de lesiones por reperfusion isquemica. |
| US5532256A (en) * | 1994-05-18 | 1996-07-02 | American Home Products Corporation | New azolidinediones and thiadiazolidinediones as antihyperglycemic agents |
| DE19533023B4 (de) * | 1994-10-14 | 2007-05-16 | Basf Ag | Neue Carbonsäurederivate, ihre Herstellung und Verwendung |
| US5703073A (en) * | 1995-04-19 | 1997-12-30 | Nitromed, Inc. | Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs |
| US6043232A (en) * | 1997-07-23 | 2000-03-28 | Nitromed, Inc. | Nitroso esters of beta-oxo-amides and aryl propionic acid derivatives of non-steroidal antiinflammatory drugs |
| US5674894A (en) * | 1995-05-15 | 1997-10-07 | G.D. Searle & Co. | Amidine derivatives useful as platelet aggregation inhibitors and vasodilators |
| US5714511A (en) * | 1995-07-31 | 1998-02-03 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Selective prevention of organ injury in sepsis and shock using selection release of nitric oxide in vulnerable organs |
| DE19545878A1 (de) * | 1995-12-08 | 1997-06-12 | Basf Ag | Pyridylcarbamate, Verfahren und Zwischenprodukte zu ihrer Herstellung und ihre Verwendung |
| US5824669A (en) * | 1996-03-22 | 1998-10-20 | Nitromed, Inc. | Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders |
| WO1998007702A1 (en) * | 1996-08-23 | 1998-02-26 | Kowa Co., Ltd. | Diamide compounds and drugs containing the same |
| US5962521A (en) * | 1997-04-04 | 1999-10-05 | Guilford Pharmaceuticals Inc. | Hydroxamic acid derivatives |
| TW453999B (en) * | 1997-06-27 | 2001-09-11 | Fujisawa Pharmaceutical Co | Benzimidazole derivatives |
| GB9726989D0 (en) * | 1997-12-22 | 1998-02-18 | Ciba Geigy Ag | Organic compounds |
| UA73092C2 (uk) * | 1998-07-17 | 2005-06-15 | Брістол-Майерс Сквібб Компані | Таблетка з ентеросолюбільним покриттям і спосіб її приготування |
| DE69924735T2 (de) * | 1998-07-28 | 2006-01-19 | Tanabe Seiyaku Co., Ltd. | Zur wirkstoffabgabe an zielorten im darm fähige zubereitung |
| JP2002528495A (ja) * | 1998-10-30 | 2002-09-03 | ニトロメド インコーポレーテッド | ニトロソ化およびニトロシル化された非ステロイド抗炎症性化合物、組成物および使用方法 |
| ME00429B (me) * | 1999-08-30 | 2011-10-10 | Aventis Pharma Deutschland Gmbh | Upotreba inhibitora sistema renin-angiotenzin za prevenciju kardiovaskularnih slučajeva |
| WO2001093872A1 (de) * | 2000-06-08 | 2001-12-13 | Jomaa Pharmaka Gmbh | Verwendung von phosphororganischen hydroxamsäurederivaten zur herstellung von arzneimitteln |
| AU2001269958A1 (en) * | 2000-06-20 | 2002-01-02 | Richard A. Bond | Paradoxical pharmacology |
| CA2410632A1 (en) * | 2000-06-22 | 2001-12-27 | David S. Garvey | Nitrosated and nitrosylated taxanes, compositions and methods of use |
| CA2432642A1 (en) * | 2000-12-21 | 2002-08-08 | Subhash P. Khanapure | Substituted aryl compounds as novel cyclooxygenase-2 selective inhibitors, compositions and methods of use |
| US20030068386A1 (en) | 2001-09-05 | 2003-04-10 | Stoyanovsky Detcho A. | Method of treating cancerous disease |
| US20040038947A1 (en) * | 2002-06-14 | 2004-02-26 | The Gov. Of The U.S. Of America As Represented By The Sec. Of The Dept. Of Health & Human Services | Method of treating ischemia/reperfusion injury with nitroxyl donors |
| US20040077691A1 (en) * | 2002-06-21 | 2004-04-22 | Medinox, Inc. | Hydroxamate derivatives of non-steroidal anti-inflammatory drugs |
| US6936639B2 (en) * | 2002-08-21 | 2005-08-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Nitroxyl progenitors in the treatment of heart failure |
| AU2005209843B2 (en) | 2004-01-30 | 2012-02-16 | The Johns Hopkins University | Nitroxyl progenitor compounds and methods of use |
| WO2007002444A1 (en) | 2005-06-23 | 2007-01-04 | Johns Hopkins University | Thiol-sensitive positive inotropes |
| TWI282084B (en) | 2005-07-08 | 2007-06-01 | Jeng-Tzung Chen | Guitar |
| WO2007045962A2 (en) * | 2005-10-18 | 2007-04-26 | Orchid Research Laboratories Limited | Novel hdac inhibitors |
| KR20080081310A (ko) * | 2005-12-08 | 2008-09-09 | 더 존스 홉킨스 유니버시티 | 항암 효과가 높고 항말라리아 활성이 오래 지속되는트리옥산 이량체 |
| EP2596785A1 (en) * | 2006-03-17 | 2013-05-29 | Johns Hopkins University School of Medicine | N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors |
| JP4783657B2 (ja) * | 2006-03-27 | 2011-09-28 | 富士フイルム株式会社 | ポジ型レジスト組成物及び該組成物を用いたパターン形成方法 |
| CA2648384A1 (en) | 2006-04-13 | 2007-10-25 | Wake Forest University Health Sciences | C-nitroso-derived nitroxyl donors |
| BRPI0817562A2 (pt) * | 2007-09-26 | 2017-05-02 | Cardioxyl Pharmaceuticals Inc | derivados de n-hidroxilsulfonamida como novos doadores de niltroxil fisiologicamente úteis |
| HUE030372T2 (en) | 2008-05-07 | 2017-05-29 | Cardioxyl Pharmaceuticals Inc | New nitroso compounds as nitroxyl donors and methods for their use |
| US20110160200A1 (en) * | 2009-11-23 | 2011-06-30 | Cardioxyl Pharmaceuticals, Inc. | Nitroxyl Progenitors for the Treatment of Pulmonary Hypertension |
| CN105130855B (zh) * | 2009-12-07 | 2018-05-25 | 约翰斯霍普金斯大学 | 二酰基化的羟基胺衍生物及其用途 |
-
2010
- 2010-12-07 JP JP2012543213A patent/JP5826762B2/ja not_active Expired - Fee Related
- 2010-12-07 CN CN201080063223.2A patent/CN102753520B/zh not_active Expired - Fee Related
- 2010-12-07 EP EP10793381.4A patent/EP2509941B1/en not_active Not-in-force
- 2010-12-07 WO PCT/US2010/059335 patent/WO2011071951A2/en not_active Ceased
- 2010-12-07 CN CN201610319052.4A patent/CN105919987B/zh not_active Expired - Fee Related
- 2010-12-07 AU AU2010328234A patent/AU2010328234B2/en not_active Ceased
- 2010-12-07 US US12/962,572 patent/US20110144067A1/en not_active Abandoned
- 2010-12-07 ES ES10793381T patent/ES2719101T3/es active Active
- 2010-12-07 MX MX2012006349A patent/MX2012006349A/es not_active Application Discontinuation
- 2010-12-07 CA CA2782110A patent/CA2782110A1/en not_active Abandoned
- 2010-12-07 IN IN5025DEN2012 patent/IN2012DN05025A/en unknown
-
2014
- 2014-04-25 US US14/262,223 patent/US20140235636A1/en not_active Abandoned
-
2015
- 2015-10-14 JP JP2015203216A patent/JP2016094394A/ja active Pending
- 2015-10-30 US US14/927,658 patent/US20160046570A1/en not_active Abandoned
-
2016
- 2016-07-22 AU AU2016206369A patent/AU2016206369B2/en not_active Ceased
-
2017
- 2017-10-24 US US15/792,352 patent/US20180050985A1/en not_active Abandoned
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