JP2013510122A5 - - Google Patents
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- Publication number
- JP2013510122A5 JP2013510122A5 JP2012537380A JP2012537380A JP2013510122A5 JP 2013510122 A5 JP2013510122 A5 JP 2013510122A5 JP 2012537380 A JP2012537380 A JP 2012537380A JP 2012537380 A JP2012537380 A JP 2012537380A JP 2013510122 A5 JP2013510122 A5 JP 2013510122A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- methyl
- alkyl
- triazolo
- benzodiazepin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 125000000217 alkyl group Chemical group 0.000 claims 33
- -1 nitro, cyano, dimethylamino, benzoyl Chemical group 0.000 claims 16
- 150000003839 salts Chemical class 0.000 claims 15
- 125000003545 alkoxy group Chemical group 0.000 claims 13
- 150000001875 compounds Chemical class 0.000 claims 13
- 125000000623 heterocyclic group Chemical group 0.000 claims 11
- 125000004452 carbocyclyl group Chemical group 0.000 claims 10
- 229910052736 halogen Inorganic materials 0.000 claims 7
- 125000005843 halogen group Chemical group 0.000 claims 7
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims 6
- 150000002367 halogens Chemical class 0.000 claims 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
- 125000004093 cyano group Chemical group *C#N 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 4
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 4
- 125000004429 atom Chemical group 0.000 claims 3
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 claims 2
- 150000001540 azides Chemical class 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 1
- NOXULISRIXJOPU-DTQAZKPQSA-N (e)-3-(4-chlorophenyl)-n-(1-methyl-6-phenyl-4h-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl)prop-2-enamide Chemical compound N1=C(C=2C=CC=CC=2)C2=CC=CC=C2N2C(C)=NN=C2C1NC(=O)\C=C\C1=CC=C(Cl)C=C1 NOXULISRIXJOPU-DTQAZKPQSA-N 0.000 claims 1
- HQXKNLNBUWKEHU-DTQAZKPQSA-N (e)-3-(4-fluorophenyl)-n-(1-methyl-6-phenyl-4h-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl)prop-2-enamide Chemical compound N1=C(C=2C=CC=CC=2)C2=CC=CC=C2N2C(C)=NN=C2C1NC(=O)\C=C\C1=CC=C(F)C=C1 HQXKNLNBUWKEHU-DTQAZKPQSA-N 0.000 claims 1
- XOBMKWPZTPKYHP-SAPNQHFASA-N (e)-3-(4-methoxyphenyl)-n-(1-methyl-6-phenyl-4h-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl)prop-2-enamide Chemical compound C1=CC(OC)=CC=C1\C=C\C(=O)NC1C2=NN=C(C)N2C2=CC=CC=C2C(C=2C=CC=CC=2)=N1 XOBMKWPZTPKYHP-SAPNQHFASA-N 0.000 claims 1
- AIBGAEDELSKJMK-UHFFFAOYSA-N 1-(1-methyl-6-phenyl-4h-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl)-3-phenylurea Chemical compound N1=C(C=2C=CC=CC=2)C2=CC=CC=C2N2C(C)=NN=C2C1NC(=O)NC1=CC=CC=C1 AIBGAEDELSKJMK-UHFFFAOYSA-N 0.000 claims 1
- YKHPDEJRXBTLOU-UHFFFAOYSA-N 1-[(4-methoxyphenyl)methyl]-3-(1-methyl-6-phenyl-4h-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl)urea Chemical compound C1=CC(OC)=CC=C1CNC(=O)NC1C2=NN=C(C)N2C2=CC=CC=C2C(C=2C=CC=CC=2)=N1 YKHPDEJRXBTLOU-UHFFFAOYSA-N 0.000 claims 1
- RATMGGWUORWQNG-UHFFFAOYSA-N 1-benzyl-3-(1-methyl-6-phenyl-4h-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl)urea Chemical compound N1=C(C=2C=CC=CC=2)C2=CC=CC=C2N2C(C)=NN=C2C1NC(=O)NCC1=CC=CC=C1 RATMGGWUORWQNG-UHFFFAOYSA-N 0.000 claims 1
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 claims 1
- NOIUHLVGASAAKC-UHFFFAOYSA-N 3-bromo-n-(1-methyl-6-phenyl-4h-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl)benzamide Chemical compound N1=C(C=2C=CC=CC=2)C2=CC=CC=C2N2C(C)=NN=C2C1NC(=O)C1=CC=CC(Br)=C1 NOIUHLVGASAAKC-UHFFFAOYSA-N 0.000 claims 1
- BOVHWQDJYASZCX-UHFFFAOYSA-N 5-methyl-n-(1-methyl-6-phenyl-4h-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl)-1h-indole-2-carboxamide Chemical compound C12=CC=CC=C2N2C(C)=NN=C2C(NC(=O)C=2NC3=CC=C(C)C=C3C=2)N=C1C1=CC=CC=C1 BOVHWQDJYASZCX-UHFFFAOYSA-N 0.000 claims 1
- AHGSTKPQVCTIHA-UHFFFAOYSA-N 6-methoxy-n-(1-methyl-6-phenyl-4h-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl)-1h-indole-2-carboxamide Chemical compound N1C2=CC(OC)=CC=C2C=C1C(=O)NC(C1=NN=C(C)N1C1=CC=CC=C11)N=C1C1=CC=CC=C1 AHGSTKPQVCTIHA-UHFFFAOYSA-N 0.000 claims 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 1
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical group CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 claims 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical group C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 230000005784 autoimmunity Effects 0.000 claims 1
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 1
- TUWDLUFFAHHNEF-UHFFFAOYSA-N benzyl n-(1-methyl-6-phenyl-4h-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl)carbamate Chemical compound N1=C(C=2C=CC=CC=2)C2=CC=CC=C2N2C(C)=NN=C2C1NC(=O)OCC1=CC=CC=C1 TUWDLUFFAHHNEF-UHFFFAOYSA-N 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 238000006073 displacement reaction Methods 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- YIIAEOSGRYXGSO-UHFFFAOYSA-N ethyl n-(1-methyl-6-phenyl-4h-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl)carbamate Chemical compound C12=CC=CC=C2N2C(C)=NN=C2C(NC(=O)OCC)N=C1C1=CC=CC=C1 YIIAEOSGRYXGSO-UHFFFAOYSA-N 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 230000004968 inflammatory condition Effects 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- BOHXEHCCMXOJMM-UHFFFAOYSA-N n-(1-methyl-6-phenyl-4h-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl)naphthalene-2-carboxamide Chemical compound C12=CC=CC=C2N2C(C)=NN=C2C(NC(=O)C=2C=C3C=CC=CC3=CC=2)N=C1C1=CC=CC=C1 BOHXEHCCMXOJMM-UHFFFAOYSA-N 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229930192474 thiophene Natural products 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0919426.7 | 2009-11-05 | ||
| GBGB0919426.7A GB0919426D0 (en) | 2009-11-05 | 2009-11-05 | Novel compounds |
| PCT/EP2010/066696 WO2011054844A1 (en) | 2009-11-05 | 2010-11-03 | Condensed azepine derivatives as bromodomain inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013510122A JP2013510122A (ja) | 2013-03-21 |
| JP2013510122A5 true JP2013510122A5 (cg-RX-API-DMAC7.html) | 2013-11-28 |
Family
ID=41501969
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012537380A Withdrawn JP2013510122A (ja) | 2009-11-05 | 2010-11-03 | ブロモドメイン阻害剤としての縮合アゼピン誘導体 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20120202799A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2496581A1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2013510122A (cg-RX-API-DMAC7.html) |
| GB (1) | GB0919426D0 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2011054844A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (75)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103154246B (zh) | 2010-05-14 | 2015-11-25 | 达那-法伯癌症研究所 | 用于治疗白血病的组合物和方法 |
| US9301962B2 (en) | 2010-05-14 | 2016-04-05 | Baylor College Of Medicine | Male contraceptive compositions and methods of use |
| BR122014024883A2 (pt) | 2010-05-14 | 2019-08-20 | Dana-Farber Cancer Institute, Inc. | Compostos no tratamento de neoplasia |
| WO2012075456A1 (en) | 2010-12-02 | 2012-06-07 | Constellation Pharmaceuticals | Bromodomain inhibitors and uses thereof |
| AR084070A1 (es) | 2010-12-02 | 2013-04-17 | Constellation Pharmaceuticals Inc | Inhibidores del bromodominio y usos de los mismos |
| US9422292B2 (en) | 2011-05-04 | 2016-08-23 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
| WO2012174487A2 (en) | 2011-06-17 | 2012-12-20 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
| WO2013027168A1 (en) | 2011-08-22 | 2013-02-28 | Pfizer Inc. | Novel heterocyclic compounds as bromodomain inhibitors |
| WO2013033269A1 (en) * | 2011-08-29 | 2013-03-07 | Coferon, Inc. | Bioorthogonal monomers capable of dimerizing and targeting bromodomains and methods of using same |
| WO2013033270A2 (en) * | 2011-08-29 | 2013-03-07 | Coferon, Inc. | Bromodomain ligands capable of dimerizing in an aqueous solution, and methods of using same |
| DE102011082013A1 (de) | 2011-09-01 | 2013-03-07 | Bayer Pharma AG | 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine |
| WO2013097052A1 (en) | 2011-12-30 | 2013-07-04 | Abbott Laboratories | Bromodomain inhibitors |
| JP5989229B2 (ja) | 2012-04-20 | 2016-09-07 | アッヴィ・インコーポレイテッド | イソインドロン誘導体 |
| WO2013184878A1 (en) | 2012-06-06 | 2013-12-12 | Constellation Pharmaceuticals, Inc. | Benzo [b] isoxazoloazepine bromodomain inhibitors and uses thereof |
| TWI602820B (zh) * | 2012-06-06 | 2017-10-21 | 星宿藥物公司 | 溴域抑制劑及其用途 |
| JP6215315B2 (ja) | 2012-06-12 | 2017-10-18 | アッヴィ・インコーポレイテッド | ピリジノンおよびピリダジノン誘導体 |
| WO2013192274A2 (en) | 2012-06-19 | 2013-12-27 | The Broad Institute, Inc. | Diagnostic and treatment methods in subjects having or at risk of developing resistance to cancer therapy |
| US9890147B2 (en) | 2012-08-16 | 2018-02-13 | Bayer Pharma Aktiengesellshaft | 2,3-benzodiazepines |
| WO2014048945A1 (de) | 2012-09-28 | 2014-04-03 | Bayer Pharma Aktiengesellschaft | Bet-proteininhibitorische 5-aryl-triazolo-azepine |
| JP6401773B2 (ja) | 2013-03-11 | 2018-10-10 | ザ リージェンツ オブ ザ ユニヴァシティ オブ ミシガン | Ｂｅｔブロモドメイン阻害剤およびこれを用いる治療方法 |
| CA2903910C (en) * | 2013-03-12 | 2023-08-15 | Steven D. FIDANZE | Triazadibenzo[cd,f]azulene derivatives and pharmaceutical compositions thereof useful as bromodomain inhibitors |
| WO2014159392A1 (en) | 2013-03-14 | 2014-10-02 | Dana-Farber Cancer Institute, Inc. | Bromodomain binding reagents and uses thereof |
| KR20150135359A (ko) | 2013-03-14 | 2015-12-02 | 컨버진 엘엘씨 | 브로모도메인-함유 단백질의 억제를 위한 방법 및 조성물 |
| EP2970282B1 (en) | 2013-03-15 | 2019-08-21 | Incyte Holdings Corporation | Tricyclic heterocycles as bet protein inhibitors |
| AU2014256750B2 (en) | 2013-04-26 | 2018-08-23 | Beigene, Ltd. | Substituted5-(3,5-dimethylisoxazol-4-yl)indoline-2-ones |
| AR096837A1 (es) | 2013-07-08 | 2016-02-03 | Incyte Corp | Heterociclos tricíclicos como inhibidores de proteínas bet |
| EP3024327B1 (en) | 2013-07-25 | 2019-09-04 | Dana-Farber Cancer Institute, Inc. | Inhibitors of transcription factors and uses thereof |
| EP3066101B1 (en) | 2013-11-08 | 2020-07-29 | Dana-Farber Cancer Institute, Inc. | Combination therapy for cancer using bromodomain and extra-terminal (bet) protein inhibitors |
| US9399640B2 (en) | 2013-11-26 | 2016-07-26 | Incyte Corporation | Substituted pyrrolo[2,3-c]pyridines and pyrazolo[3,4-c]pyridines as BET protein inhibitors |
| US9315501B2 (en) | 2013-11-26 | 2016-04-19 | Incyte Corporation | Bicyclic heterocycles as BET protein inhibitors |
| US9309246B2 (en) | 2013-12-19 | 2016-04-12 | Incyte Corporation | Tricyclic heterocycles as BET protein inhibitors |
| WO2015117087A1 (en) | 2014-01-31 | 2015-08-06 | Dana-Farber Cancer Institute, Inc. | Uses of diazepane derivatives |
| RU2016134947A (ru) | 2014-01-31 | 2018-03-01 | Дана-Фарбер Кансер Институт, Инк. | Производные диаминопиримидин бензолсульфона и их применение |
| WO2015117083A1 (en) | 2014-01-31 | 2015-08-06 | Dana-Farber Cancer Institute, Inc. | Diazepane derivatives and uses thereof |
| EP3110818B1 (en) | 2014-02-28 | 2019-10-23 | The Regents of The University of Michigan | 9h-pyrimido[4,5-b]indoles and related analogs as bet bromodomain inhibitors |
| MX377534B (es) * | 2014-02-28 | 2025-03-10 | Tensha Therapeutics Inc | Compuestos para usarse en el tratamiento de hiperinsulinemia. |
| ES2751642T3 (es) * | 2014-04-09 | 2020-04-01 | Kainos Medicine Inc | Compuestos inhibidores de bromodominios y composición farmacéutica que los comprende para prevenir o tratar un cáncer |
| MY207899A (en) | 2014-04-23 | 2025-03-27 | Incyte Holdings Corp | 1h-pyrrolo[2,3-c]pyridin-7(6h)-ones and pyrazolo[3,4-c]pyridin-7(6h)-ones as inhibitors of bet proteins |
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| MX2017001757A (es) | 2014-08-08 | 2017-05-30 | Dana Farber Cancer Inst Inc | Derivados de dihidropteridinona y sus usos. |
| WO2016022902A1 (en) | 2014-08-08 | 2016-02-11 | Dana-Farber Cancer Institute, Inc. | Diazepane derivatives and uses thereof |
| ES2855225T3 (es) | 2014-09-15 | 2021-09-23 | Incyte Corp | Heterociclos tricíclicos para su uso como inhibidores de proteínas BET |
| US10307407B2 (en) | 2015-02-27 | 2019-06-04 | The Regents Of The University Of Michigan | 9H-pyrimido [4,5-B] indoles as BET bromodomain inhibitors |
| GB201504694D0 (en) | 2015-03-19 | 2015-05-06 | Glaxosmithkline Ip Dev Ltd | Covalent conjugates |
| WO2016196065A1 (en) | 2015-05-29 | 2016-12-08 | Genentech, Inc. | Methods and compositions for assessing responsiveness of cancers to bet inhibitors |
| AU2016276963C1 (en) | 2015-06-12 | 2021-08-05 | Dana-Farber Cancer Institute, Inc. | Combination therapy of transcription inhibitors and kinase inhibitors |
| WO2016203335A1 (en) | 2015-06-18 | 2016-12-22 | Pfizer Inc. | Novel pyrido[2,3-b]pyrazinones as bet-family bromodomain inhibitors |
| US20180193350A1 (en) | 2015-06-26 | 2018-07-12 | Tensha Therapeutics, Inc. | Treatment of nut midline carcinoma |
| WO2017027571A1 (en) | 2015-08-10 | 2017-02-16 | Dana-Farber Cancer Institute, Inc. | Mechanism of resistance to bet bromodomain inhibitors |
| WO2017037567A1 (en) * | 2015-09-03 | 2017-03-09 | Pfizer Inc. | Regulators of frataxin |
| BR112018004618A2 (pt) | 2015-09-11 | 2018-09-25 | Dana-Farber Cancer Institute, Inc. | ciano tienotriazoldiazepinas e usos das mesmas |
| CR20180199A (es) | 2015-09-11 | 2018-05-25 | Dana Farber Cancer Inst Inc | Acetamida tienotriazolodiazepinas y usos de las mismas |
| US20170121347A1 (en) | 2015-10-29 | 2017-05-04 | Incyte Corporation | Amorphous solid form of a bet protein inhibitor |
| BR112018009798A8 (pt) | 2015-11-25 | 2019-02-26 | Dana Farber Cancer Inst Inc | inibidores de bromodomínio bivalentes e usos dos mesmos |
| CA3007037A1 (en) | 2015-12-03 | 2017-06-08 | Bayer Cropscience Aktiengesellschaft | Mesoionic halogenated 3-(acetyl)-1-[(1,3-thiazol-5-yl)methyl]-1h-imidazo[1,2-a]pyridin-4-ium-2-olate derivatives and related compounds as insecticides |
| AU2017219627B2 (en) | 2016-02-15 | 2021-08-05 | The Regents Of The University Of Michigan | Fused 1,4-oxazepines and related analogs as BET bromodomain inhibitors |
| EP3440066B1 (en) | 2016-04-06 | 2022-11-30 | The Regents of The University of Michigan | Mdm2 protein degraders |
| CA3020281A1 (en) | 2016-04-06 | 2017-10-12 | The Regents Of The University Of Michigan | Monofunctional intermediates for ligand-dependent target protein degradation |
| CA3020541A1 (en) | 2016-04-12 | 2017-10-19 | The Regents Of The University Of Michigan | Bet protein degraders |
| BR112018071216A2 (pt) | 2016-04-15 | 2019-02-05 | Abbvie Inc | inibidores de bromodomínios |
| DK3472157T3 (da) | 2016-06-20 | 2023-05-01 | Incyte Corp | Krystallinske faste former af en bet-inhibitor |
| US10918647B2 (en) | 2016-07-26 | 2021-02-16 | University Of Southern California | Selective bromodomain inhibition of fungal Bdf1 |
| WO2018052949A1 (en) | 2016-09-13 | 2018-03-22 | The Regents Of The University Of Michigan | Fused 1,4-diazepines as bet protein degraders |
| JP6961684B2 (ja) | 2016-09-13 | 2021-11-05 | ザ リージェンツ オブ ザ ユニヴァシティ オブ ミシガン | Ｂｅｔタンパク質分解物質としての縮合１，４−オキサゼピン |
| US11046709B2 (en) | 2017-02-03 | 2021-06-29 | The Regents Of The University Of Michigan | Fused 1,4-diazepines as BET bromodomain inhibitors |
| CN108727380A (zh) * | 2017-04-13 | 2018-11-02 | 中国科学院上海药物研究所 | 一种brd4抑制剂及其制备和应用 |
| EP3638677A1 (en) | 2017-06-16 | 2020-04-22 | Basf Se | Mesoionic imidazolium compounds and derivatives for combating animal pests |
| WO2019055444A1 (en) | 2017-09-13 | 2019-03-21 | The Regents Of The University Of Michigan | DEGRADATION AGENTS OF BROMODOMAIN BET PROTEIN WITH CLEAR BINDERS |
| WO2019195634A1 (en) | 2018-04-04 | 2019-10-10 | Epiodyne, Inc. | Opioid receptor modulators and products and methods related thereto |
| WO2021175432A1 (en) | 2020-03-04 | 2021-09-10 | Boehringer Ingelheim International Gmbh | Method for administration of an anti cancer agent |
| US11833155B2 (en) | 2020-06-03 | 2023-12-05 | Incyte Corporation | Combination therapy for treatment of myeloproliferative neoplasms |
| AU2021297799A1 (en) | 2020-06-23 | 2022-12-22 | Genentech, Inc. | Macrocyclic compounds and methods of use thereof |
| TW202304869A (zh) | 2021-04-05 | 2023-02-01 | 美商艾碧奧戴股份有限公司 | 類鴉片受體調節劑 |
| EP4401715A1 (en) | 2021-09-17 | 2024-07-24 | Institut Curie | Bet inhibitors for treating pab1 deficient cancer |
| WO2023205251A1 (en) | 2022-04-19 | 2023-10-26 | Nuevolution A/S | Compounds active towards bromodomains |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9004781D0 (en) | 1990-03-02 | 1990-04-25 | Glaxo Group Ltd | Device |
| EP0638560A4 (en) * | 1991-10-11 | 1995-03-29 | Yoshitomi Pharmaceutical | MEDICINE FOR OSTEOPOROSIS AND DIAZEPINE COMPOUND *. |
| JPH06128257A (ja) * | 1992-10-13 | 1994-05-10 | Yoshitomi Pharmaceut Ind Ltd | ピリドジアゼピン化合物 |
| JP2840454B2 (ja) * | 1993-11-22 | 1998-12-24 | メルク エンド カンパニー インコーポレーテッド | ベンゾジアゼピン類 |
| CA2258053A1 (en) * | 1996-06-12 | 1997-12-18 | Yoshihisa Yamamoto | Cytokine production inhibitors, triazepine compounds, and intermediates thereof |
| EP1699512B1 (en) | 2003-11-03 | 2012-06-20 | Glaxo Group Limited | A fluid dispensing device |
| JP2008156311A (ja) | 2006-12-26 | 2008-07-10 | Institute Of Physical & Chemical Research | Ｂｒｄ２ブロモドメイン結合剤 |
| KR101600634B1 (ko) | 2007-12-28 | 2016-03-07 | 미쓰비시 타나베 파마 코퍼레이션 | 항암제 |
-
2009
- 2009-11-05 GB GBGB0919426.7A patent/GB0919426D0/en not_active Ceased
-
2010
- 2010-11-03 EP EP10773086A patent/EP2496581A1/en not_active Withdrawn
- 2010-11-03 JP JP2012537380A patent/JP2013510122A/ja not_active Withdrawn
- 2010-11-03 WO PCT/EP2010/066696 patent/WO2011054844A1/en not_active Ceased
- 2010-11-03 US US13/501,557 patent/US20120202799A1/en not_active Abandoned
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