JP2013508282A5 - - Google Patents

Info

Publication number

JP2013508282A5

JP2013508282A5 JP2012534324A JP2012534324A JP2013508282A5 JP 2013508282 A5 JP2013508282 A5 JP 2013508282A5 JP 2012534324 A JP2012534324 A JP 2012534324A JP 2012534324 A JP2012534324 A JP 2012534324A JP 2013508282 A5 JP2013508282 A5 JP 2013508282A5

Authority

JP

Japan

Prior art keywords

use according

antiviral agent

receptor agonist

hydroxy

methyl

Prior art date

2010-10-13

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• 239000003443 antiviral agent Substances 0.000 claims 16
• 101150109738 Ptger4 gene Proteins 0.000 claims 13
• 239000000018 receptor agonist Substances 0.000 claims 13
• 229940044601 receptor agonist Drugs 0.000 claims 13
• 201000010099 disease Diseases 0.000 claims 6
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
• 239000003814 drug Substances 0.000 claims 5
• 239000008194 pharmaceutical composition Substances 0.000 claims 5
• 230000003612 virological effect Effects 0.000 claims 4
• OJIGXQJDLFUVFM-MBLRWRSDSA-N (5e)-5-[(3ar,4r,5r,6as)-5-hydroxy-4-[(e,3s)-3-hydroxy-4-methyloct-1-enyl]-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-2-ylidene]-5-cyanopentanoic acid Chemical group O1\C(=C(/CCCC(O)=O)C#N)C[C@@H]2[C@@H](/C=C/[C@@H](O)C(C)CCCC)[C@H](O)C[C@@H]21 OJIGXQJDLFUVFM-MBLRWRSDSA-N 0.000 claims 2
• YASAKCUCGLMORW-UHFFFAOYSA-N Rosiglitazone Chemical compound C=1C=CC=NC=1N(C)CCOC(C=C1)=CC=C1CC1SC(=O)NC1=O YASAKCUCGLMORW-UHFFFAOYSA-N 0.000 claims 2
• 239000002260 anti-inflammatory agent Substances 0.000 claims 2
• 229940121363 anti-inflammatory agent Drugs 0.000 claims 2
• 229960002890 beraprost Drugs 0.000 claims 2
• YTCZZXIRLARSET-VJRSQJMHSA-M beraprost sodium Chemical group [Na+].O([C@H]1C[C@@H](O)[C@@H]([C@@H]21)/C=C/[C@@H](O)C(C)CC#CC)C1=C2C=CC=C1CCCC([O-])=O YTCZZXIRLARSET-VJRSQJMHSA-M 0.000 claims 2
• 239000003112 inhibitor Substances 0.000 claims 2
• 229960003752 oseltamivir Drugs 0.000 claims 2
• VSZGPKBBMSAYNT-RRFJBIMHSA-N oseltamivir Chemical group CCOC(=O)C1=C[C@@H](OC(CC)CC)[C@H](NC(C)=O)[C@@H](N)C1 VSZGPKBBMSAYNT-RRFJBIMHSA-N 0.000 claims 2
• HYAFETHFCAUJAY-UHFFFAOYSA-N pioglitazone Chemical compound N1=CC(CC)=CC=C1CCOC(C=C1)=CC=C1CC1C(=O)NC(=O)S1 HYAFETHFCAUJAY-UHFFFAOYSA-N 0.000 claims 2
• 229910052708 sodium Inorganic materials 0.000 claims 2
• 239000011734 sodium Substances 0.000 claims 2
• NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 claims 2
• OJIGXQJDLFUVFM-AGCJUELTSA-N (5e)-5-[(3ar,4r,5r,6as)-5-hydroxy-4-[(e,3s,4s)-3-hydroxy-4-methyloct-1-enyl]-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-2-ylidene]-5-cyanopentanoic acid Chemical compound O1\C(=C(/CCCC(O)=O)C#N)C[C@@H]2[C@@H](/C=C/[C@@H](O)[C@@H](C)CCCC)[C@H](O)C[C@@H]21 OJIGXQJDLFUVFM-AGCJUELTSA-N 0.000 claims 1
• UBCHPRBFMUDMNC-UHFFFAOYSA-N 1-(1-adamantyl)ethanamine Chemical compound C1C(C2)CC3CC2CC1(C(N)C)C3 UBCHPRBFMUDMNC-UHFFFAOYSA-N 0.000 claims 1
• XBYGDAGWXPBGNY-UHFFFAOYSA-N 4-(1-benzofuran-5-yl)butanoic acid Chemical compound OC(=O)CCCC1=CC=C2OC=CC2=C1 XBYGDAGWXPBGNY-UHFFFAOYSA-N 0.000 claims 1
• 241000711573 Coronaviridae Species 0.000 claims 1
• IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical group N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 claims 1
• 108010067390 Viral Proteins Proteins 0.000 claims 1
• 239000002253 acid Substances 0.000 claims 1
• DKNWSYNQZKUICI-UHFFFAOYSA-N amantadine Chemical group C1C(C2)CC3CC2CC1(N)C3 DKNWSYNQZKUICI-UHFFFAOYSA-N 0.000 claims 1
• 229960003805 amantadine Drugs 0.000 claims 1
• 239000001273 butane Substances 0.000 claims 1
• 229940042406 direct acting antivirals neuraminidase inhibitors Drugs 0.000 claims 1
• 239000002552 dosage form Substances 0.000 claims 1
• ZCGNOVWYSGBHAU-UHFFFAOYSA-N favipiravir Chemical group NC(=O)C1=NC(F)=CNC1=O ZCGNOVWYSGBHAU-UHFFFAOYSA-N 0.000 claims 1
• 229940126181 ion channel inhibitor Drugs 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 229950004935 nileprost Drugs 0.000 claims 1
• 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 1
• 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 1
• XRQDFNLINLXZLB-CKIKVBCHSA-N peramivir Chemical compound CCC(CC)[C@H](NC(C)=O)[C@@H]1[C@H](O)[C@@H](C(O)=O)C[C@H]1NC(N)=N XRQDFNLINLXZLB-CKIKVBCHSA-N 0.000 claims 1
• 229960001084 peramivir Drugs 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 229960005095 pioglitazone Drugs 0.000 claims 1
• 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
• 230000010076 replication Effects 0.000 claims 1
• 229960000329 ribavirin Drugs 0.000 claims 1
• HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 claims 1
• 229960000888 rimantadine Drugs 0.000 claims 1
• 229960004586 rosiglitazone Drugs 0.000 claims 1
• 150000003839 salts Chemical class 0.000 claims 1
• 239000002911 sialidase inhibitor Substances 0.000 claims 1
• 159000000000 sodium salts Chemical class 0.000 claims 1
• 150000003431 steroids Chemical class 0.000 claims 1
• 230000000153 supplemental effect Effects 0.000 claims 1
• 230000035897 transcription Effects 0.000 claims 1
• 238000013518 transcription Methods 0.000 claims 1
• 241000712461 unidentified influenza virus Species 0.000 claims 1
• 229960001028 zanamivir Drugs 0.000 claims 1
• ARAIBEBZBOPLMB-UFGQHTETSA-N zanamivir Chemical compound CC(=O)N[C@@H]1[C@@H](N=C(N)N)C=C(C(O)=O)O[C@H]1[C@H](O)[C@H](O)CO ARAIBEBZBOPLMB-UFGQHTETSA-N 0.000 claims 1