JP2013507115A5 - - Google Patents
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- Publication number
- JP2013507115A5 JP2013507115A5 JP2012532622A JP2012532622A JP2013507115A5 JP 2013507115 A5 JP2013507115 A5 JP 2013507115A5 JP 2012532622 A JP2012532622 A JP 2012532622A JP 2012532622 A JP2012532622 A JP 2012532622A JP 2013507115 A5 JP2013507115 A5 JP 2013507115A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- polypeptide
- amino acid
- polypeptide complex
- constant domain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 229920001184 polypeptide Polymers 0.000 claims 25
- 108090000765 processed proteins & peptides Proteins 0.000 claims 25
- 102000004196 processed proteins & peptides Human genes 0.000 claims 25
- 125000003275 alpha amino acid group Chemical group 0.000 claims 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 8
- 201000010099 disease Diseases 0.000 claims 4
- 208000035475 disorder Diseases 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 230000027455 binding Effects 0.000 claims 3
- 206010012601 diabetes mellitus Diseases 0.000 claims 3
- 208000027866 inflammatory disease Diseases 0.000 claims 3
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 2
- 201000001119 neuropathy Diseases 0.000 claims 2
- 230000007823 neuropathy Effects 0.000 claims 2
- 208000033808 peripheral neuropathy Diseases 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 206010007559 Cardiac failure congestive Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 208000002249 Diabetes Complications Diseases 0.000 claims 1
- 208000007342 Diabetic Nephropathies Diseases 0.000 claims 1
- 206010012655 Diabetic complications Diseases 0.000 claims 1
- 206010012689 Diabetic retinopathy Diseases 0.000 claims 1
- 208000010228 Erectile Dysfunction Diseases 0.000 claims 1
- 206010019280 Heart failures Diseases 0.000 claims 1
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- 206010024641 Listeriosis Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000018262 Peripheral vascular disease Diseases 0.000 claims 1
- 201000001263 Psoriatic Arthritis Diseases 0.000 claims 1
- 208000036824 Psoriatic arthropathy Diseases 0.000 claims 1
- 208000017442 Retinal disease Diseases 0.000 claims 1
- 206010038923 Retinopathy Diseases 0.000 claims 1
- 206010040047 Sepsis Diseases 0.000 claims 1
- 206010040070 Septic Shock Diseases 0.000 claims 1
- 206010047115 Vasculitis Diseases 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 206010002022 amyloidosis Diseases 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000007795 chemical reaction product Substances 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 208000033679 diabetic kidney disease Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 230000036252 glycation Effects 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 201000001881 impotence Diseases 0.000 claims 1
- 208000028774 intestinal disease Diseases 0.000 claims 1
- 208000017169 kidney disease Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 230000036303 septic shock Effects 0.000 claims 1
- 230000009870 specific binding Effects 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 208000019553 vascular disease Diseases 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09290778A EP2308896A1 (en) | 2009-10-09 | 2009-10-09 | Polypeptides for binding to the "receptor for advanced glycation endproducts" as well as compositions and methods involving the same |
| EP09290778.1 | 2009-10-09 | ||
| EP09290845.8 | 2009-11-05 | ||
| EP09290845A EP2319871A1 (en) | 2009-11-05 | 2009-11-05 | Polypeptides for binding to the "receptor for advanced glycation endproducts" as well as compositions and methods involving the same |
| PCT/EP2010/065124 WO2011042548A1 (en) | 2009-10-09 | 2010-10-08 | Polypeptides for binding to the "receptor for advanced glycation endproducts" as well as compositions and methods involving the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013507115A JP2013507115A (ja) | 2013-03-04 |
| JP2013507115A5 true JP2013507115A5 (enExample) | 2013-10-03 |
Family
ID=43448431
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012532622A Pending JP2013507115A (ja) | 2009-10-09 | 2010-10-08 | 「終末糖化産物受容体」への結合のためのポリペプチド、さらにはそれを含む組成物及び方法 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20120282637A1 (enExample) |
| EP (1) | EP2486058A1 (enExample) |
| JP (1) | JP2013507115A (enExample) |
| KR (1) | KR20120089863A (enExample) |
| CN (1) | CN102686611A (enExample) |
| AU (1) | AU2010305374A1 (enExample) |
| BR (1) | BR112012007821A2 (enExample) |
| CA (1) | CA2777237A1 (enExample) |
| CL (1) | CL2012000886A1 (enExample) |
| CR (1) | CR20120139A (enExample) |
| EC (1) | ECSP12011787A (enExample) |
| IL (1) | IL218968A0 (enExample) |
| MA (1) | MA33661B1 (enExample) |
| MX (1) | MX2012004090A (enExample) |
| PE (1) | PE20121689A1 (enExample) |
| PH (1) | PH12012500564A1 (enExample) |
| RU (1) | RU2558301C2 (enExample) |
| TN (1) | TN2012000138A1 (enExample) |
| WO (1) | WO2011042548A1 (enExample) |
| ZA (1) | ZA201202099B (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA112434C2 (uk) | 2011-05-27 | 2016-09-12 | Ґлаксо Ґруп Лімітед | Антигензв'язувальний білок, який специфічно зв'язується з всма |
| GB201200563D0 (en) * | 2012-01-13 | 2012-02-29 | Imp Innovations Ltd | Binding molecule |
| WO2014167826A1 (ja) * | 2013-04-08 | 2014-10-16 | 株式会社免疫生物研究所 | アミロイド前駆体タンパク質のα－セクレターゼ切断後のＣ末端側断片の切断面を特異的に認識する抗体及びその利用 |
| WO2014197460A1 (en) * | 2013-06-04 | 2014-12-11 | The Trustees Of The University Of Pennsylvania | Methods for diagnosing and treating bicuspid aortic valve and/or aortopathies |
| SG11201601037YA (en) | 2013-08-30 | 2016-03-30 | Immunogen Inc | Antibodies and assays for detection of folate receptor 1 |
| EP3633381A3 (en) | 2013-12-05 | 2020-07-29 | The Broad Institute, Inc. | Compositions and methods for identifying and treating cachexia or pre-cachexia |
| WO2016061532A1 (en) * | 2014-10-16 | 2016-04-21 | The Broad Institute Inc. | Compositions and methods for identifying and treating cachexia or pre-cachexia |
| JP6679096B2 (ja) * | 2014-10-21 | 2020-04-15 | 学校法人 久留米大学 | Ｒａｇｅアプタマーおよびその用途 |
| WO2016070001A1 (en) * | 2014-10-31 | 2016-05-06 | Jounce Therapeutics, Inc. | Methods of treating conditions with antibodies that bind b7-h4 |
| KR20180023900A (ko) * | 2015-05-12 | 2018-03-07 | 신티뮨, 인크. | 인간화된 친화성 성숙 항-FcRn 항체 |
| WO2016187356A1 (en) * | 2015-05-18 | 2016-11-24 | Agensys, Inc. | Antibodies that bind to axl proteins |
| US10787516B2 (en) | 2015-05-18 | 2020-09-29 | Agensys, Inc. | Antibodies that bind to AXL proteins |
| EP3307781B8 (en) | 2015-06-10 | 2020-12-02 | The Broad Institute, Inc. | Antibodies, compounds and screens for identifying and treating cachexia or pre-cachexia |
| WO2016201319A1 (en) * | 2015-06-10 | 2016-12-15 | The Broad Institute Inc. | Antibodies, compounds and screens for identifying and treating cachexia or pre-cachexia |
| JP6578595B2 (ja) * | 2015-08-28 | 2019-09-25 | 国立研究開発法人科学技術振興機構 | 抗アセチル化ヒストンｈ４抗体 |
| CN111320693B (zh) * | 2015-09-08 | 2023-04-07 | 卫材R&D管理有限公司 | 抗EphA4抗体 |
| JP6880006B2 (ja) | 2015-09-17 | 2021-06-02 | イミュノジェン， インコーポレイテッド | 抗ｆｏｌｒ１免疫複合体を含む治療組み合わせ |
| EP3389715A4 (en) | 2015-12-14 | 2019-06-12 | David K. Thomas | COMPOSITIONS AND METHODS FOR TREATING CARDIAL DYSFUNCTION |
| CN108570106B (zh) * | 2017-03-10 | 2021-07-16 | 北京天广实生物技术股份有限公司 | 抗埃博拉病毒单克隆抗体、其制备方法及用途 |
| BR112020001679A2 (pt) | 2017-08-02 | 2020-07-21 | Phanes Therapeutics, Inc. | anticorpos anti-cd47 e usos dos mesmos |
| EP3773718A4 (en) | 2018-04-06 | 2022-01-19 | aTyr Pharma, Inc. | COMPOSITIONS AND METHODS WITH ANTI-NRP2 ANTIBODIES |
| US11345744B2 (en) | 2019-05-07 | 2022-05-31 | William R Church | Antibody specific to Staphylococcus aureus, therapeutic method and detection method using same |
| WO2020261097A1 (en) * | 2019-06-26 | 2020-12-30 | Glaxosmithkline Intellectual Property Development Limited | Il1rap binding proteins |
| EP4037711A4 (en) * | 2019-10-03 | 2024-02-14 | Atyr Pharma, Inc. | COMPOSITIONS AND METHODS USING ANTI-NRP2 ANTIBODIES |
| WO2022019924A1 (en) * | 2020-07-23 | 2022-01-27 | Church William R | Antibody specific to staphylococcus aureus, therapeutic method and detection method using same |
| CN113956363B (zh) * | 2021-10-13 | 2023-03-31 | 宜明昂科生物医药技术（上海）股份有限公司 | 靶向cd47和cd24的重组融合蛋白及其制备和用途 |
| EP4433514A4 (en) * | 2021-11-18 | 2025-10-08 | Salavarx Llc | ANTIBODIES TO THE ADVANCED GLYCATION ENDPRODUCT RECEPTOR AND THEIR USES |
| CN116554311B (zh) * | 2023-05-04 | 2023-11-21 | 中国人民解放军军事科学院军事医学研究院 | 抗CD2v-N的特异性抗体及其应用 |
| KR20250001879A (ko) | 2023-06-28 | 2025-01-07 | 주식회사 세바바이오텍 | 완도호랑가시나무와 노루궁뎅이버섯 추출물을 유효성분으로 포함하는 최종당화산물 억제용 조성물 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5859205A (en) * | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| CA2560114A1 (en) | 1994-07-15 | 1996-02-01 | The University Of Iowa Research Foundation | Immunomodulatory oligonucleotides |
| US5864018A (en) * | 1996-04-16 | 1999-01-26 | Schering Aktiengesellschaft | Antibodies to advanced glycosylation end-product receptor polypeptides and uses therefor |
| MY131805A (en) * | 1997-09-18 | 2007-09-28 | Biogen Idec Inc | Synergistic composition and methods for treating neoplastic or cancerous growths and for restoring or boosting hematopoiesis. |
| AT409085B (de) | 2000-01-28 | 2002-05-27 | Cistem Biotechnologies Gmbh | Pharmazeutische zusammensetzung zur immunmodulation und herstellung von vakzinen |
| HU228264B1 (en) | 2000-06-08 | 2013-02-28 | Intercell Ag | Immunostimulatory oligodeoxynucleotides |
| AT410173B (de) | 2000-06-08 | 2003-02-25 | Cistem Biotechnologies Gmbh | Antigene zusammensetzung |
| CA2418854A1 (en) | 2000-08-17 | 2002-02-21 | Jorg Fritz | A vaccine which comprises at least one antigen and a cathelididin derived antimicrobial peptide or a derivative thereof |
| AT410635B (de) | 2000-10-18 | 2003-06-25 | Cistem Biotechnologies Gmbh | Vakzin-zusammensetzung |
| WO2002094845A2 (en) | 2001-05-21 | 2002-11-28 | Intercell Ag | Method for stabilising of nucleic acids |
| US7425328B2 (en) * | 2003-04-22 | 2008-09-16 | Purdue Pharma L.P. | Tissue factor antibodies and uses thereof |
| US20080008719A1 (en) * | 2004-07-10 | 2008-01-10 | Bowdish Katherine S | Methods and compositions for the treatment of prostate cancer |
| JP2009528507A (ja) * | 2006-03-02 | 2009-08-06 | オンコセラピー・サイエンス株式会社 | Ｒｅｇ４タンパク質を用いて膵癌を診断する方法 |
| MX2008012023A (es) * | 2006-03-21 | 2008-10-01 | Wyeth Corp | Metodos para prevenir y tratar enfermedades amiloidogenicas. |
| CN101405300A (zh) * | 2006-03-21 | 2009-04-08 | 惠氏公司 | 用于拮抗rage的方法及组合物 |
| WO2007147901A1 (en) * | 2006-06-22 | 2007-12-27 | Novo Nordisk A/S | Production of bispecific antibodies |
| CN100586960C (zh) * | 2006-06-23 | 2010-02-03 | 陈志南 | HAb18GC2单抗和其轻、重链可变区基因及应用 |
| WO2008137552A2 (en) * | 2007-05-02 | 2008-11-13 | Medimmune, Llc | Anti-rage antibodies and methods of use thereof |
| CA2723219A1 (en) * | 2008-05-09 | 2009-11-12 | Abbott Gmbh & Co. Kg | Antibodies to receptor of advanced glycation end products (rage) and uses thereof |
-
2010
- 2010-10-08 BR BR112012007821A patent/BR112012007821A2/pt not_active IP Right Cessation
- 2010-10-08 US US13/500,400 patent/US20120282637A1/en not_active Abandoned
- 2010-10-08 EP EP10771381A patent/EP2486058A1/en not_active Withdrawn
- 2010-10-08 WO PCT/EP2010/065124 patent/WO2011042548A1/en not_active Ceased
- 2010-10-08 AU AU2010305374A patent/AU2010305374A1/en not_active Abandoned
- 2010-10-08 PH PH1/2012/500564A patent/PH12012500564A1/en unknown
- 2010-10-08 CA CA2777237A patent/CA2777237A1/en not_active Abandoned
- 2010-10-08 JP JP2012532622A patent/JP2013507115A/ja active Pending
- 2010-10-08 RU RU2012118598/10A patent/RU2558301C2/ru not_active IP Right Cessation
- 2010-10-08 MX MX2012004090A patent/MX2012004090A/es not_active Application Discontinuation
- 2010-10-08 PE PE2012000444A patent/PE20121689A1/es not_active Application Discontinuation
- 2010-10-08 CN CN201080045826XA patent/CN102686611A/zh active Pending
- 2010-10-08 KR KR1020127011908A patent/KR20120089863A/ko not_active Withdrawn
-
2012
- 2012-03-22 CR CR20120139A patent/CR20120139A/es unknown
- 2012-03-22 ZA ZA2012/02099A patent/ZA201202099B/en unknown
- 2012-03-27 TN TNP2012000138A patent/TN2012000138A1/en unknown
- 2012-04-01 IL IL218968A patent/IL218968A0/en unknown
- 2012-04-04 MA MA34756A patent/MA33661B1/fr unknown
- 2012-04-05 EC ECSP12011787 patent/ECSP12011787A/es unknown
- 2012-04-05 CL CL2012000886A patent/CL2012000886A1/es unknown