MA33661B1 - Polypeptides pour liaison au "récepteur des produits finaux de glycation avancée" et compositions et procédés mettant en oeuvre ceux-ci - Google Patents

Polypeptides pour liaison au "récepteur des produits finaux de glycation avancée" et compositions et procédés mettant en oeuvre ceux-ci

Info

Publication number
MA33661B1
MA33661B1 MA34756A MA34756A MA33661B1 MA 33661 B1 MA33661 B1 MA 33661B1 MA 34756 A MA34756 A MA 34756A MA 34756 A MA34756 A MA 34756A MA 33661 B1 MA33661 B1 MA 33661B1
Authority
MA
Morocco
Prior art keywords
polypeptide
rabies
advanced glycation
glycation end
polypeptides
Prior art date
Application number
MA34756A
Other languages
Arabic (ar)
English (en)
Inventor
Ingo Focken
Kathrin Heermeier
Jochen Kruip
Christian Lange
Jochen Huber
Francis Blanche
Tarik Dabdoubi
Fabienne Soubrier
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP09290778A external-priority patent/EP2308896A1/fr
Priority claimed from EP09290845A external-priority patent/EP2319871A1/fr
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of MA33661B1 publication Critical patent/MA33661B1/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physics & Mathematics (AREA)

Abstract

La présente invention concerne un polypeptide ou complexe polypeptidique comprenant au moins les deux séquences d'acides aminés conçues pour permettre une liaison spécifique au « récepteur de produits terminaux de glycation avancée » (rage), un ou plusieurs acides nucléiques codant pour le polypeptide ou complexe polypeptidique, une cellule produisant un anticorps dirigé contre rage, une composition pharmaceutique comprenant au moins un polypeptide ou acide nucléique tel que défini ci-dessus, facultativement pour traiter une maladie ou un trouble lié à rage. L'invention concerne également un procédé de diagnostic d'une maladie ou d'un trouble lié à rage.
MA34756A 2009-10-09 2012-04-04 Polypeptides pour liaison au "récepteur des produits finaux de glycation avancée" et compositions et procédés mettant en oeuvre ceux-ci MA33661B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09290778A EP2308896A1 (fr) 2009-10-09 2009-10-09 Polypeptides pour liaison au récepteur des produits finaux de la glycosylation avancée et compositions et procédés les impliquant
EP09290845A EP2319871A1 (fr) 2009-11-05 2009-11-05 Polypeptides pour liaison au récepteur des produits finaux de la glycosylation avancée et compositions et procédés les impliquant
PCT/EP2010/065124 WO2011042548A1 (fr) 2009-10-09 2010-10-08 Polypeptides de liaison au « récepteur de produits terminaux de glycation avancée » ainsi que compositions et procédés les mettant en jeu

Publications (1)

Publication Number Publication Date
MA33661B1 true MA33661B1 (fr) 2012-10-01

Family

ID=43448431

Family Applications (1)

Application Number Title Priority Date Filing Date
MA34756A MA33661B1 (fr) 2009-10-09 2012-04-04 Polypeptides pour liaison au "récepteur des produits finaux de glycation avancée" et compositions et procédés mettant en oeuvre ceux-ci

Country Status (19)

Country Link
US (1) US20120282637A1 (fr)
EP (1) EP2486058A1 (fr)
JP (1) JP2013507115A (fr)
KR (1) KR20120089863A (fr)
CN (1) CN102686611A (fr)
AU (1) AU2010305374A1 (fr)
BR (1) BR112012007821A2 (fr)
CA (1) CA2777237A1 (fr)
CL (1) CL2012000886A1 (fr)
CR (1) CR20120139A (fr)
EC (1) ECSP12011787A (fr)
IL (1) IL218968A0 (fr)
MA (1) MA33661B1 (fr)
MX (1) MX2012004090A (fr)
PE (1) PE20121689A1 (fr)
RU (1) RU2558301C2 (fr)
TN (1) TN2012000138A1 (fr)
WO (1) WO2011042548A1 (fr)
ZA (1) ZA201202099B (fr)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA112434C2 (uk) 2011-05-27 2016-09-12 Ґлаксо Ґруп Лімітед Антигензв'язувальний білок, який специфічно зв'язується з всма
GB201200563D0 (en) * 2012-01-13 2012-02-29 Imp Innovations Ltd Binding molecule
WO2014167826A1 (fr) * 2013-04-08 2014-10-16 株式会社免疫生物研究所 ANTICORPS RECONNAISSANT SPÉCIFIQUEMENT LA SURFACE DE CLIVAGE DU FRAGMENT C-TERMINAL APRÈS CLIVAGE DU PRÉCURSEUR DE LA PROTÉINE AMYLOÏDE PAR L'α-SÉCRÉTASE ET SON UTILISATION
US11668721B2 (en) 2013-06-04 2023-06-06 The Trustees Of The University Of Pennsylvania Methods for diagnosing and treating bicuspid aortic valve and/or aortopathies
WO2015031815A2 (fr) 2013-08-30 2015-03-05 Immunogen, Inc. Anticorps et dosages pour la détection du récepteur 1 du folate
EP3633381A3 (fr) 2013-12-05 2020-07-29 The Broad Institute, Inc. Compositions et procédés d'identification et de traitement de la cachexie ou de la pré-cachexie
WO2016061532A1 (fr) * 2014-10-16 2016-04-21 The Broad Institute Inc. Compositions et méthodes pour identifier et traiter la cachexie ou la pré-cachexie
JP6679096B2 (ja) * 2014-10-21 2020-04-15 学校法人 久留米大学 Rageアプタマーおよびその用途
WO2016070001A1 (fr) * 2014-10-31 2016-05-06 Jounce Therapeutics, Inc. Méthodes de traitement d'états pathologiques avec des anticorps qui se lient à b7-h4
EP3294335B1 (fr) * 2015-05-12 2023-07-05 Syntimmune Inc. Anticorps anti-fcrn à maturation d'affinité humanisés
WO2016187356A1 (fr) * 2015-05-18 2016-11-24 Agensys, Inc. Anticorps qui se lient aux protéines axl
JP6857138B2 (ja) 2015-05-18 2021-04-14 アジェンシス,インコーポレイテッド Axlタンパク質に結合する抗体
EP3307781B8 (fr) 2015-06-10 2020-12-02 The Broad Institute, Inc. Anticorps, composés et écrans permettant l'identification et le traitement la cachexie ou pré-cachexie
WO2016201319A1 (fr) * 2015-06-10 2016-12-15 The Broad Institute Inc. Anticorps, composés et écrans d'identification et de traitement de cachexie ou pré-cachexie
JP6578595B2 (ja) * 2015-08-28 2019-09-25 国立研究開発法人科学技術振興機構 抗アセチル化ヒストンh4抗体
BR112018003494A2 (pt) * 2015-09-08 2018-09-18 Eisai R&D Management Co., Ltd anticorpo anti-epha4
WO2017049149A1 (fr) 2015-09-17 2017-03-23 Immunogen, Inc. Combinaisons thérapeutiques comprenant des immunoconjugués anti-folr1
US11111296B2 (en) 2015-12-14 2021-09-07 The Broad Institute, Inc. Compositions and methods for treating cardiac dysfunction
CN108570106B (zh) * 2017-03-10 2021-07-16 北京天广实生物技术股份有限公司 抗埃博拉病毒单克隆抗体、其制备方法及用途
US11401329B2 (en) * 2017-08-02 2022-08-02 Phanes Therapeutics, Inc. Anti-CD47 antibodies and uses thereof
WO2019195770A1 (fr) 2018-04-06 2019-10-10 Atyr Pharma, Inc. Compositions et procédés comprenant des anticorps anti-nrp2
US11345744B2 (en) 2019-05-07 2022-05-31 William R Church Antibody specific to Staphylococcus aureus, therapeutic method and detection method using same
BR112021025476A2 (pt) * 2019-06-26 2022-10-11 Glaxosmithkline Ip Dev Ltd Proteínas de ligação à il1rap
CN114746120A (zh) * 2019-10-03 2022-07-12 Atyr 医药公司 包含抗nrp2抗体的组合物和方法
WO2022019924A1 (fr) * 2020-07-23 2022-01-27 Church William R Anticorps spécifique de staphylococcus aureus, méthode thérapeutique et méthode de détection de celui-ci
CN113956363B (zh) * 2021-10-13 2023-03-31 宜明昂科生物医药技术(上海)股份有限公司 靶向cd47和cd24的重组融合蛋白及其制备和用途
CN116554311B (zh) * 2023-05-04 2023-11-21 中国人民解放军军事科学院军事医学研究院 抗CD2v-N的特异性抗体及其应用

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5859205A (en) * 1989-12-21 1999-01-12 Celltech Limited Humanised antibodies
ATE420171T1 (de) 1994-07-15 2009-01-15 Univ Iowa Res Found Immunomodulatorische oligonukleotide
US5864018A (en) * 1996-04-16 1999-01-26 Schering Aktiengesellschaft Antibodies to advanced glycosylation end-product receptor polypeptides and uses therefor
ZA988461B (en) * 1997-09-18 1999-03-30 Idec Pharma Corp Synergistic composition and methods for treating neoplastic or cancerous growths and for restoring or boosting hematopoiesis
AT409085B (de) 2000-01-28 2002-05-27 Cistem Biotechnologies Gmbh Pharmazeutische zusammensetzung zur immunmodulation und herstellung von vakzinen
AT410173B (de) 2000-06-08 2003-02-25 Cistem Biotechnologies Gmbh Antigene zusammensetzung
SK287689B6 (sk) 2000-06-08 2011-06-06 Intercell Ag Použitie molekuly oligodeoxynukleovej kyseliny na výrobu imunostimulačnej farmaceutickej kompozície a farmaceutický prípravok
CA2418854A1 (fr) 2000-08-17 2002-02-21 Jorg Fritz Vaccin comprenant au moins un antigene et un peptide antimicrobien a base de cathelicidine ou un derive de ce peptide
AT410635B (de) 2000-10-18 2003-06-25 Cistem Biotechnologies Gmbh Vakzin-zusammensetzung
US7858588B2 (en) 2001-05-21 2010-12-28 Intercell Ag Immunostimulatory oligodeoxynucleic molecules
US7425328B2 (en) * 2003-04-22 2008-09-16 Purdue Pharma L.P. Tissue factor antibodies and uses thereof
US20080008719A1 (en) * 2004-07-10 2008-01-10 Bowdish Katherine S Methods and compositions for the treatment of prostate cancer
RU2008139098A (ru) * 2006-03-02 2010-04-10 Онкотерапи Сайенс, Инк. (Jp) Способы диагностики рака поджелудочной железы с применением белка reg4
EP2001907A2 (fr) * 2006-03-21 2008-12-17 Wyeth a Corporation of the State of Delaware Procédés et compositions destinés à un antagonisme de rage
CN101448857A (zh) * 2006-03-21 2009-06-03 惠氏公司 预防和治疗淀粉样蛋白生成疾病的方法
WO2007147901A1 (fr) * 2006-06-22 2007-12-27 Novo Nordisk A/S Production d'anticorps bispécifiques
CN100586960C (zh) * 2006-06-23 2010-02-03 陈志南 HAb18GC2单抗和其轻、重链可变区基因及应用
WO2008137552A2 (fr) * 2007-05-02 2008-11-13 Medimmune, Llc Anticorps anti-rage et procédés d'utilisation de ceux-ci
BRPI0911758A8 (pt) * 2008-05-09 2017-10-10 Abbott Lab Anticorpos para receptor de produtos finais de glicação avançada (rage) e utilizações dos mesmos

Also Published As

Publication number Publication date
IL218968A0 (en) 2012-07-31
RU2012118598A (ru) 2013-11-20
ECSP12011787A (es) 2012-10-30
CA2777237A1 (fr) 2011-04-14
ZA201202099B (en) 2012-11-28
AU2010305374A1 (en) 2012-05-03
CL2012000886A1 (es) 2012-12-14
RU2558301C2 (ru) 2015-07-27
CN102686611A (zh) 2012-09-19
PE20121689A1 (es) 2012-12-14
EP2486058A1 (fr) 2012-08-15
MX2012004090A (es) 2012-04-20
WO2011042548A1 (fr) 2011-04-14
KR20120089863A (ko) 2012-08-14
CR20120139A (es) 2012-07-13
US20120282637A1 (en) 2012-11-08
TN2012000138A1 (en) 2013-09-19
BR112012007821A2 (pt) 2017-05-30
JP2013507115A (ja) 2013-03-04

Similar Documents

Publication Publication Date Title
MA33661B1 (fr) Polypeptides pour liaison au "récepteur des produits finaux de glycation avancée" et compositions et procédés mettant en oeuvre ceux-ci
Chung et al. Effects of antibody disulfide bond reduction on purification process performance and final drug substance stability
MA34475B1 (fr) Peptide ou complexe de peptide se liant a l'integrine a2 et procedes et utilisation mettant en oeuvre ceux-ci
WO2009017679A3 (fr) Anticorps spécifiques de igf-1r utiles dans la détection et le diagnostic de troubles de prolifération cellulaire
WO2010037836A3 (fr) Anticorps monocaténaire bispécifique psmaxcd3, spécifique d'espèces croisées
CN1596371A (zh) 新的自组装分子
GEP20146112B (en) Binding proteins, including antibodies, antibody derivatives and antibody fragments, that specifically bind cd154 and usage thereof
IL210485A (en) An isolated antibody or its functional protein, a process for making it, a pharmaceutical preparation containing it, and an isolated amino acid encoding an antibody or a functional protein
MX348360B (es) Anticuerpo biespecifico psmaxcd3 de simple cadena especifico de especies cruzadas.
WO2008054543A3 (fr) Oligonucléotides pour l'assemblage mutiplexé d'acides nucléiques
WO2007042261A3 (fr) Compositions comportant des anticorps specifiques d'especes croisees et leurs utilisations
AU2020247918B2 (en) Modified cleavases, uses thereof and related kits
UA102061C2 (ru) Агонистическое антитело к notch3 и его применение для лечения notch3- ассоциированных заболеваний
WO2007010080A3 (fr) Nouveaux dendrimeres carbosilanes, leur preparation et leur utilisation
MA34053B1 (fr) Polypeptides agonistes de liaison à dr5
WO2008135446A3 (fr) Antigènes de la klebsiella
CN103201288A (zh) 通过混合模式层析捕捉抗体的优化方法
EP3162895A1 (fr) Protéine de liaison au récepteur fc améliorée, procédé de production de ladite protéine, anticorps adsorbant utilisant ladite protéine, et procédés de séparation d'anticorps au moyen dudit adsorbant
WO2010092176A3 (fr) Antigènes haemophilus influenzae non typables
WO2011053065A3 (fr) Dérivé de poly(éthylèneglycol) avec catéchol et conjugués protéiques ou peptidiques, et leur procédé de préparation
WO2004094476A3 (fr) Compositions et methodes se rapportant a stop-1
WO2009138494A3 (fr) Séquences d'acides aminés dirigées contre des récepteurs du type toll et polypeptides comprenant celles-ci pour le traitement de maladies apparentées aux récepteurs du type toll
JP2015083558A (ja) 抗体吸着剤ならびにそれを用いた抗体の精製方法および識別方法
WO2009115508A3 (fr) Peptides luttant contre s. pneumoniae et compositions, méthodes et utilisations associées
WO2009093246A3 (fr) Nouveau peptide dérivé de clusterine