JP2013501055A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2013501055A5 JP2013501055A5 JP2012523678A JP2012523678A JP2013501055A5 JP 2013501055 A5 JP2013501055 A5 JP 2013501055A5 JP 2012523678 A JP2012523678 A JP 2012523678A JP 2012523678 A JP2012523678 A JP 2012523678A JP 2013501055 A5 JP2013501055 A5 JP 2013501055A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- alkyl
- alkenyl
- iii
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23093209P | 2009-08-03 | 2009-08-03 | |
| US61/230,932 | 2009-08-03 | ||
| US23288309P | 2009-08-11 | 2009-08-11 | |
| US61/232,883 | 2009-08-11 | ||
| PCT/US2010/044078 WO2011017249A1 (en) | 2009-08-03 | 2010-08-02 | Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013501055A JP2013501055A (ja) | 2013-01-10 |
| JP2013501055A5 true JP2013501055A5 (enExample) | 2013-09-05 |
| JP5859964B2 JP5859964B2 (ja) | 2016-02-16 |
Family
ID=42782224
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012523678A Expired - Fee Related JP5859964B2 (ja) | 2009-08-03 | 2010-08-02 | 抗増殖性化合物、その抱合体、そのための方法ならびにその使用 |
Country Status (28)
| Country | Link |
|---|---|
| US (6) | US8394922B2 (enExample) |
| EP (1) | EP2461830B1 (enExample) |
| JP (1) | JP5859964B2 (enExample) |
| KR (1) | KR101759359B1 (enExample) |
| CN (2) | CN102725001B (enExample) |
| AR (1) | AR077701A1 (enExample) |
| AU (1) | AU2010279674B2 (enExample) |
| BR (1) | BR112012002615A2 (enExample) |
| CA (1) | CA2770042C (enExample) |
| CL (1) | CL2012000302A1 (enExample) |
| CO (1) | CO6501196A2 (enExample) |
| DK (1) | DK2461830T3 (enExample) |
| EA (1) | EA022288B1 (enExample) |
| ES (1) | ES2525351T3 (enExample) |
| HR (1) | HRP20140976T1 (enExample) |
| HU (1) | HUE026997T2 (enExample) |
| IL (1) | IL217717A (enExample) |
| IN (1) | IN2012DN00860A (enExample) |
| MX (1) | MX2012001665A (enExample) |
| NZ (1) | NZ597985A (enExample) |
| PE (1) | PE20121087A1 (enExample) |
| PL (1) | PL2461830T3 (enExample) |
| PT (1) | PT2461830E (enExample) |
| SG (2) | SG10201503332XA (enExample) |
| SI (1) | SI2461830T1 (enExample) |
| SM (1) | SMT201400183B (enExample) |
| TW (1) | TWI469794B (enExample) |
| WO (1) | WO2011017249A1 (enExample) |
Families Citing this family (90)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5149620B2 (ja) | 2004-07-23 | 2013-02-20 | エンドサイト，インコーポレイテッド | ２価リンカーおよびその結合体 |
| NZ580132A (en) | 2007-03-14 | 2012-11-30 | Endocyte Inc | Binding ligand linked drug delivery conjugates of tubulysins to vitamins |
| CN104383553A (zh) | 2007-06-25 | 2015-03-04 | 恩多塞特公司 | 含有亲水性间隔区接头的共轭物 |
| US9877965B2 (en) | 2007-06-25 | 2018-01-30 | Endocyte, Inc. | Vitamin receptor drug delivery conjugates for treating inflammation |
| US9193763B2 (en) | 2007-08-17 | 2015-11-24 | Purdue Research Foundation | PSMA binding ligand-linker conjugates and methods for using |
| IT1394860B1 (it) * | 2009-07-22 | 2012-07-20 | Kemotech S R L | Composti farmaceutici |
| US8394922B2 (en) * | 2009-08-03 | 2013-03-12 | Medarex, Inc. | Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof |
| US9951324B2 (en) | 2010-02-25 | 2018-04-24 | Purdue Research Foundation | PSMA binding ligand-linker conjugates and methods for using |
| SG185428A1 (en) | 2010-06-08 | 2012-12-28 | Genentech Inc | Cysteine engineered antibodies and conjugates |
| ES2656167T5 (es) * | 2011-03-16 | 2021-03-26 | Hoffmann La Roche | Cromatografía de intercambio iónico con selectividad mejorada para la separación de monómeros, agregados y fragmentos polipeptídicos mediante la modulación de la fase móvil |
| CA2837840C (en) | 2011-06-10 | 2020-08-04 | Mersana Therapeutics, Inc. | Protein-polymer-drug conjugates |
| US10080805B2 (en) | 2012-02-24 | 2018-09-25 | Purdue Research Foundation | Cholecystokinin B receptor targeting for imaging and therapy |
| US20140080175A1 (en) | 2012-03-29 | 2014-03-20 | Endocyte, Inc. | Processes for preparing tubulysin derivatives and conjugates thereof |
| EP3925627A1 (en) * | 2012-05-15 | 2021-12-22 | Concortis Biosystems, Corp | Drug-conjugates and uses thereof |
| EP3210627B1 (en) * | 2012-07-12 | 2022-12-21 | Hangzhou Dac Biotech Co., Ltd | Conjugates of cell binding molecules with cytotoxic agents |
| US11873281B2 (en) | 2012-07-12 | 2024-01-16 | Hangzhou Dac Biotech Co., Ltd. | Conjugates of cell binding molecules with cytotoxic agents |
| EP2708243A1 (en) | 2012-09-17 | 2014-03-19 | OntoChem GmbH | Receptor ligand linked cytotoxic molecules |
| JP2015536323A (ja) | 2012-10-16 | 2015-12-21 | エンドサイト・インコーポレイテッドＥｎｄｏｃｙｔｅ， Ｉｎｃ． | 非天然アミノ酸を含む薬物送達結合体および使用方法 |
| AU2013344778C1 (en) | 2012-11-15 | 2024-06-27 | Endocyte, Inc. | Conjugates for treating diseases caused by PSMA expressing cells |
| AU2012395148B2 (en) | 2012-11-24 | 2016-10-27 | Hangzhou Dac Biotech Co., Ltd. | Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules |
| CA2892863C (en) | 2012-12-10 | 2022-03-15 | Mersana Therapeutics, Inc. | Polymeric scaffold based on phf for targeted drug delivery |
| EP2931316B1 (en) | 2012-12-12 | 2019-02-20 | Mersana Therapeutics, Inc. | Hydroxyl-polymer-drug-protein conjugates |
| LT2956173T (lt) | 2013-02-14 | 2017-06-26 | Bristol-Myers Squibb Company | Tubulizino junginiai, gavimo ir panaudojimo būdai |
| US20140249315A1 (en) * | 2013-03-01 | 2014-09-04 | Endocyte, Inc. | Processes for preparing tubulysins |
| US9522876B2 (en) | 2013-03-15 | 2016-12-20 | Zymeworks Inc. | Cytotoxic and anti-mitotic compounds, and methods of using the same |
| JP6171435B2 (ja) * | 2013-03-18 | 2017-08-02 | 富士通株式会社 | 半導体装置及びその製造方法、電源装置、高周波増幅器 |
| WO2014197866A1 (en) | 2013-06-06 | 2014-12-11 | Igenica Biotherapeutics, Inc. | Modified antibodies and related compounds, compositions, and methods of use |
| WO2015057585A1 (en) * | 2013-10-14 | 2015-04-23 | Regents Of The University Of Minnesota | Therapeutic compounds |
| EP3456700A1 (en) | 2013-10-18 | 2019-03-20 | Deutsches Krebsforschungszentrum | Labeled inhibitors of prostate specific membrane antigen (psma), their use as imaging agents and pharmaceutical agents for the treatment of prostate cancer |
| CN105849568B (zh) | 2013-11-14 | 2018-05-04 | 恩多塞特公司 | 用于正电子发射断层术的化合物 |
| WO2015074792A1 (en) | 2013-11-25 | 2015-05-28 | Ontochem Gmbh | Method for diagnosing g-protein coupled receptor-related diseases |
| SG11201605260VA (en) | 2013-12-27 | 2016-07-28 | Zymeworks Inc | Var2csa-drug conjugates |
| ES2916722T3 (es) | 2013-12-27 | 2022-07-05 | Zymeworks Inc | Sistemas de enlace que contienen sulfonamida para conjugados de fármacos |
| ES2843537T3 (es) | 2014-01-28 | 2021-07-19 | Tube Pharmaceuticals Gmbh | Compuestos citotóxicos de tubulisina y conjugados de los mismos |
| FI3122757T3 (fi) | 2014-02-28 | 2023-10-10 | Hangzhou Dac Biotech Co Ltd | Varautuneita linkkereitä ja niiden konjugointikäyttötapoja |
| WO2015135659A1 (en) | 2014-03-14 | 2015-09-17 | Ontochem Gmbh | Receptor ligand linked cytotoxic molecules |
| SG11201607818WA (en) | 2014-03-20 | 2016-10-28 | Bristol Myers Squibb Co | Stabilized fibronectin based scaffold molecules |
| UY36075A (es) * | 2014-04-11 | 2015-10-30 | Medimmune Llc | Derivados de tubulisina |
| CN106456799B (zh) * | 2014-06-03 | 2020-05-22 | 江苏佳瑞生物技术有限公司 | 肽-药物偶联物 |
| EP3184540A4 (en) | 2014-08-22 | 2018-03-21 | Yafei Shanghai Biolog Medicine Science& Technology | Specifically activated micromolecular target coupling body in tumor microenvironment and use thereof |
| CN104262455B (zh) * | 2014-08-22 | 2017-05-03 | 亚飞（上海）生物医药科技有限公司 | 肿瘤微环境靶向激活的紫杉醇衍生物及其制备和用途 |
| HRP20241124T1 (hr) * | 2014-09-11 | 2024-11-22 | Seagen Inc. | Ciljana isporuka lijekovitih tvari koje sadrže tercijarni amin |
| TW201625688A (zh) | 2014-09-12 | 2016-07-16 | 建南德克公司 | 經半胱胺酸改造之抗體及接合物 |
| EP3194421B1 (en) | 2014-09-17 | 2021-11-03 | Zymeworks Inc. | Cytotoxic and anti-mitotic compounds, and methods of using the same |
| US10077287B2 (en) | 2014-11-10 | 2018-09-18 | Bristol-Myers Squibb Company | Tubulysin analogs and methods of making and use |
| PL3221346T3 (pl) | 2014-11-21 | 2021-03-08 | Bristol-Myers Squibb Company | Przeciwciała ze zmodyfikowanym regionem stałym łańcucha ciężkiego |
| TWI711630B (zh) | 2014-11-21 | 2020-12-01 | 美商必治妥美雅史谷比公司 | 抗ｃｄ７３抗體及其用途 |
| WO2016086021A1 (en) | 2014-11-25 | 2016-06-02 | Bristol-Myers Squibb Company | Novel pd-l1 binding polypeptides for imaging |
| US10188759B2 (en) | 2015-01-07 | 2019-01-29 | Endocyte, Inc. | Conjugates for imaging |
| EA201791896A1 (ru) | 2015-02-25 | 2018-02-28 | Уильям Марш Райс Юниверсити | Дезацетокситубулизин н и его аналоги |
| ES2736106T3 (es) | 2015-03-10 | 2019-12-26 | Bristol Myers Squibb Co | Anticuerpos que se pueden conjugar mediante la transglutaminasa y conjugados producidos a partir de ellos |
| EA035412B1 (ru) | 2015-05-29 | 2020-06-10 | Бристол-Майерс Сквибб Компани | Антитела к ox40 и их применение |
| EP3319936B1 (en) | 2015-07-12 | 2025-12-17 | Hangzhou Dac Biotech Co., Ltd. | Bridge linkers for conjugation of cell-binding molecules |
| US9839687B2 (en) | 2015-07-15 | 2017-12-12 | Suzhou M-Conj Biotech Co., Ltd. | Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule |
| EP3353198B1 (en) | 2015-09-23 | 2020-06-17 | Bristol-Myers Squibb Company | Glypican-3binding fibronectin based scafflold molecules |
| TWI678364B (zh) * | 2015-09-24 | 2019-12-01 | 南韓商Ｌｇ化學股份有限公司 | 化合物及含有該化合物的有機發光裝置 |
| CN107029242A (zh) | 2015-11-03 | 2017-08-11 | 财团法人工业技术研究院 | 抗体药物复合物及其制造方法 |
| US11793880B2 (en) | 2015-12-04 | 2023-10-24 | Seagen Inc. | Conjugates of quaternized tubulysin compounds |
| TWI852735B (zh) | 2015-12-04 | 2024-08-11 | 美商思進公司 | 四級胺化妥布賴森(tubulysin)化合物之結合物 |
| US20180362619A1 (en) | 2015-12-21 | 2018-12-20 | Bristol-Myers Squibb Company | Variant antibodies for site-specific conjugation |
| WO2017134547A1 (en) | 2016-02-01 | 2017-08-10 | Pfizer Inc. | Tubulysin analogs and methods for their preparation |
| CA3016187A1 (en) | 2016-03-04 | 2017-09-08 | Bristol-Myers Squibb Company | Combination therapy with anti-cd73 antibodies |
| CN109620949A (zh) * | 2016-03-13 | 2019-04-16 | 曹帅 | 一种用于治疗骨癌的药物组合物 |
| US20170326249A1 (en) * | 2016-05-10 | 2017-11-16 | Bristol-Myers Squibb Company | Antibody-drug conjugate of an anti-glypican-3 antibody and a tubulysin analog, preparation and uses |
| JP2019518013A (ja) | 2016-05-10 | 2019-06-27 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | 安定性が向上したツブリシン類似体の抗体薬物結合体 |
| US10106560B2 (en) | 2016-06-16 | 2018-10-23 | Bristol-Myers Squibb Company | Process and intermediates for making tubulysin analogs |
| ES2902179T3 (es) | 2016-08-19 | 2022-03-25 | Bristol Myers Squibb Co | Compuestos de seco-ciclopropapirroloindol, conjugados de anticuerpo-fármaco de los mismos y métodos de elaboración y uso |
| US20190218294A1 (en) | 2016-09-09 | 2019-07-18 | Bristol-Myers Squibb Company | Use of an anti-pd-1 antibody in combination with an anti-mesothelin antibody in cancer treatment |
| US10517958B2 (en) | 2016-10-04 | 2019-12-31 | Zymeworks Inc. | Compositions and methods for the treatment of platinum-drug resistant cancer |
| WO2018075842A1 (en) | 2016-10-20 | 2018-04-26 | Bristol-Myers Squibb Company | Condensed benzodiazepine derivatives and conjugates made therefrom |
| AU2016429272A1 (en) | 2016-11-14 | 2019-05-02 | Hangzhou Dac Biotech Co., Ltd. | Conjugation linkers, cell binding molecule-drug conjugates containing the likers, methods of making and uses such conjugates with the linkers |
| JP6585650B2 (ja) * | 2017-03-23 | 2019-10-02 | ハンヂョウ ディーエイシー バイオテック カンパニー リミテッド | 細胞毒性剤と細胞結合受容体との共役体 |
| US20200299400A1 (en) | 2017-05-25 | 2020-09-24 | Bristol-Myers Squibb Company | Antibodies comprising modified heavy constant regions |
| WO2019108685A1 (en) * | 2017-11-29 | 2019-06-06 | William March Rice University | Tubulysin analogues as anticancer agents and payloads for antibody-drug conjugates and methods of treatment therewith |
| KR20210003135A (ko) | 2018-04-17 | 2021-01-11 | 엔도사이트, 인코포레이티드 | 암의 치료 방법 |
| WO2019209811A1 (en) | 2018-04-24 | 2019-10-31 | Bristol-Myers Squibb Company | Macrocyclic toll-like receptor 7 (tlr7) agonists |
| SG11202011739SA (en) | 2018-05-29 | 2020-12-30 | Bristol Myers Squibb Co | Modified self-immolating moieties for use in prodrugs and conjugates and methods of using and making |
| US11020490B2 (en) | 2018-06-22 | 2021-06-01 | Bristol-Myers Squibb Company | Antibody-drug conjugate with a tubulysin analog warhead having a stabilized acetate group in the TUV subunit |
| JP2022513653A (ja) | 2018-11-28 | 2022-02-09 | ブリストル－マイヤーズ スクイブ カンパニー | 修飾された重鎖定常領域を含む抗体 |
| KR102861586B1 (ko) | 2018-11-30 | 2025-09-17 | 브리스톨-마이어스 스큅 컴퍼니 | 글루타민-함유 경쇄 c-말단 연장부를 포함하는 항체, 그의 접합체, 및 방법 및 용도 |
| JP7514836B2 (ja) | 2018-12-12 | 2024-07-11 | ブリストル－マイヤーズ スクイブ カンパニー | トランスグルタミナーゼによるコンジュゲーションのための改変抗体、ならびにそのコンジュゲート、方法および用途 |
| CN118027137A (zh) | 2018-12-21 | 2024-05-14 | 里珍纳龙药品有限公司 | 微管溶素及蛋白质-微管溶素偶联物 |
| JP7604397B2 (ja) | 2019-05-20 | 2024-12-23 | エンドサイト・インコーポレイテッド | Ｐｓｍａコンジュゲートの調製方法 |
| JP6842127B2 (ja) * | 2019-05-22 | 2021-03-17 | ハンヂョウ ディーエイシー バイオテック カンパニー リミテッド | 細胞毒性剤と細胞結合受容体との共役体 |
| JP2022540395A (ja) | 2019-06-29 | 2022-09-15 | ハンジョウ ディーエーシー バイオテック シーオー．，エルティディ． | 細胞結合性分子－チューブリシン誘導体共役体及びその調製方法 |
| US20240377413A1 (en) | 2019-09-16 | 2024-11-14 | Bristol-Myers Squibb Company | Dual capture method for analysis of antibody-drug conjugates |
| CN113387829B (zh) * | 2020-03-13 | 2023-04-07 | 凯特立斯（深圳）科技有限公司 | 一种沙库必曲的制备方法 |
| EP4171653A2 (en) * | 2020-06-24 | 2023-05-03 | Regeneron Pharmaceuticals, Inc. | Tubulysins and protein-tubulysin conjugates |
| JP7044419B2 (ja) * | 2021-02-04 | 2022-03-30 | ハンヂョウ ディーエイシー バイオテック カンパニー リミテッド | 細胞毒性剤と細胞結合受容体との共役体 |
| CN117980327A (zh) | 2021-11-03 | 2024-05-03 | 杭州多禧生物科技有限公司 | 抗体的特异性偶联 |
Family Cites Families (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1981001145A1 (en) | 1979-10-18 | 1981-04-30 | Univ Illinois | Hydrolytic enzyme-activatible pro-drugs |
| US4475196A (en) | 1981-03-06 | 1984-10-02 | Zor Clair G | Instrument for locating faults in aircraft passenger reading light and attendant call control system |
| US4447233A (en) | 1981-04-10 | 1984-05-08 | Parker-Hannifin Corporation | Medication infusion pump |
| US5144011A (en) | 1981-06-26 | 1992-09-01 | Boston University | Acidity-sensitive spacer molecule to control the release of pharmaceuticals from molecular carriers |
| US4631190A (en) | 1981-06-26 | 1986-12-23 | Shen Wei C | Acidity-sensitive spacer molecule to control the release of pharmaceuticals from molecular carriers |
| US4439196A (en) | 1982-03-18 | 1984-03-27 | Merck & Co., Inc. | Osmotic drug delivery system |
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US4447224A (en) | 1982-09-20 | 1984-05-08 | Infusaid Corporation | Variable flow implantable infusion apparatus |
| US4487603A (en) | 1982-11-26 | 1984-12-11 | Cordis Corporation | Implantable microinfusion pump system |
| US4486194A (en) | 1983-06-08 | 1984-12-04 | James Ferrara | Therapeutic device for administering medicaments through the skin |
| US4698420A (en) | 1985-02-25 | 1987-10-06 | Xoma Corporation | Antibody hybrid molecules and process for their preparation |
| US4596556A (en) | 1985-03-25 | 1986-06-24 | Bioject, Inc. | Hypodermic injection apparatus |
| US5374548A (en) | 1986-05-02 | 1994-12-20 | Genentech, Inc. | Methods and compositions for the attachment of proteins to liposomes using a glycophospholipid anchor |
| MX9203291A (es) | 1985-06-26 | 1992-08-01 | Liposome Co Inc | Metodo para acoplamiento de liposomas. |
| US4941880A (en) | 1987-06-19 | 1990-07-17 | Bioject, Inc. | Pre-filled ampule and non-invasive hypodermic injection device assembly |
| US4790824A (en) | 1987-06-19 | 1988-12-13 | Bioject, Inc. | Non-invasive hypodermic injection device |
| US5108921A (en) | 1989-04-03 | 1992-04-28 | Purdue Research Foundation | Method for enhanced transmembrane transport of exogenous molecules |
| US5064413A (en) | 1989-11-09 | 1991-11-12 | Bioject, Inc. | Needleless hypodermic injection device |
| US5312335A (en) | 1989-11-09 | 1994-05-17 | Bioject Inc. | Needleless hypodermic injection device |
| US5383851A (en) | 1992-07-24 | 1995-01-24 | Bioject Inc. | Needleless hypodermic injection device |
| US6214345B1 (en) | 1993-05-14 | 2001-04-10 | Bristol-Myers Squibb Co. | Lysosomal enzyme-cleavable antitumor drug conjugates |
| TW420681B (en) | 1995-12-08 | 2001-02-01 | Lederle Japan Ltd | Carbapenem-3-carboxylic acid ester derivatives |
| DE19638870B4 (de) | 1996-09-23 | 2009-05-14 | Helmholtz-Zentrum für Infektionsforschung GmbH | Tubulysine, Verfahren zu ihrer Gewinnung und sie enthaltende Mittel |
| US7214487B2 (en) | 1998-06-26 | 2007-05-08 | Sunesis Pharmaceuticals, Inc. | Methods for identifying compounds that modulate enzymatic activities by employing covalently bonded target-extender complexes with ligand candidates |
| CN102766210B (zh) * | 1999-08-24 | 2015-07-08 | E.R.施贵宝&圣斯有限责任公司 | 人ctla-4抗体及其应用 |
| DE10008089A1 (de) | 2000-02-22 | 2001-10-31 | Biotechnolog Forschung Gmbh | Syntheseverfahren zur Herstellung von Tubulysinen |
| PE20020908A1 (es) * | 2001-03-21 | 2002-10-26 | Cell Therapeutics Inc | Produccion recombinante de polimeros polianionicos y uso de de los mismos |
| US7087600B2 (en) * | 2001-05-31 | 2006-08-08 | Medarex, Inc. | Peptidyl prodrugs and linkers and stabilizers useful therefor |
| US7091186B2 (en) | 2001-09-24 | 2006-08-15 | Seattle Genetics, Inc. | p-Amidobenzylethers in drug delivery agents |
| JP4562395B2 (ja) * | 2002-01-09 | 2010-10-13 | メダレックス， インク． | Ｃｄ３０に対するヒトモノクローナル抗体 |
| WO2004005326A2 (de) * | 2002-07-09 | 2004-01-15 | Morphochem Aktiengellschaft Fu | Tubulysinkonjugate |
| DK1523493T3 (da) * | 2002-07-09 | 2013-12-02 | Alexander Doemling | Nye tubulysinanaloge |
| DE10241152A1 (de) * | 2002-09-05 | 2004-03-18 | GESELLSCHAFT FüR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) | Tubulysin-Biosynthese-Gene |
| FR2845630B1 (fr) * | 2002-10-09 | 2005-09-30 | Helitest Ags | Dispositif de demasticage, notamment pour la refection de joints dans des structures de reservoirs d'aeronefs et container d'intervention |
| DE10254439A1 (de) * | 2002-11-21 | 2004-06-03 | GESELLSCHAFT FüR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) | Tubulysine, Herstellungsverfahren und Tubulysin-Mittel |
| TW200510454A (en) | 2003-04-15 | 2005-03-16 | Smithkline Beecham Corp | Conjugates comprising human IL-18 and substitution mutants thereof |
| JP4680902B2 (ja) * | 2003-07-22 | 2011-05-11 | バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト | Ｒｇ１抗体及びその使用 |
| EP1718667B1 (en) | 2004-02-23 | 2013-01-09 | Genentech, Inc. | Heterocyclic self-immolative linkers and conjugates |
| US7517903B2 (en) * | 2004-05-19 | 2009-04-14 | Medarex, Inc. | Cytotoxic compounds and conjugates |
| US7691962B2 (en) * | 2004-05-19 | 2010-04-06 | Medarex, Inc. | Chemical linkers and conjugates thereof |
| US7541330B2 (en) | 2004-06-15 | 2009-06-02 | Kosan Biosciences Incorporated | Conjugates with reduced adverse systemic effects |
| DE102004030227A1 (de) | 2004-06-23 | 2006-01-26 | Dömling, Alexander, Dr. | Wirkstoffe mit antiangiogenetischen Eigenschaften |
| ES2579805T3 (es) | 2004-09-23 | 2016-08-16 | Genentech, Inc. | Anticuerpos y conjugados modificados por ingeniería genética con cisteína |
| MX2007009878A (es) * | 2005-02-18 | 2007-10-03 | Medarex Inc | Anticuerpos monoclonales para antigeno de membrana especifica para prostata (amep). |
| US7714016B2 (en) * | 2005-04-08 | 2010-05-11 | Medarex, Inc. | Cytotoxic compounds and conjugates with cleavable substrates |
| PL2161336T5 (pl) | 2005-05-09 | 2017-10-31 | Ono Pharmaceutical Co | Ludzkie przeciwciała monoklonalne przeciwko białku Programmed Death 1 (PD-1) oraz sposoby leczenia raka z zastosowaniem samych przeciwciał anty-PD-1 lub w połączeniu z innymi środkami immunoterapeutycznymi |
| EP1899379B1 (en) * | 2005-06-20 | 2018-04-11 | E. R. Squibb & Sons, L.L.C. | Cd19 antibodies and their uses |
| EP2374480A3 (en) * | 2005-08-19 | 2013-05-01 | Endocyte, Inc. | Mutli-drug ligand conjugates |
| AU2006294554B2 (en) * | 2005-09-26 | 2013-03-21 | E. R. Squibb & Sons, L.L.C. | Antibody-drug conjugates and methods of use |
| NZ566395A (en) * | 2005-09-26 | 2012-03-30 | Medarex Inc | Human monoclonal antibodies to CD70 |
| CN101365679B (zh) * | 2005-10-26 | 2012-11-14 | 梅达莱克斯公司 | 制备cc-1065类似物的方法和化合物 |
| CA2627190A1 (en) * | 2005-11-10 | 2007-05-24 | Medarex, Inc. | Duocarmycin derivatives as novel cytotoxic compounds and conjugates |
| NZ568015A (en) * | 2005-12-08 | 2012-03-30 | Medarex Inc | Human monoclonal antibodies to O8E |
| AU2006321841C1 (en) * | 2005-12-08 | 2013-01-24 | E. R. Squibb & Sons, L.L.C. | Human monoclonal antibodies to protein tyrosine kinase 7 ( PTK7 ) and their use |
| EP2097097B1 (en) | 2006-12-01 | 2018-05-30 | E. R. Squibb & Sons, L.L.C. | Antibodies, in particular human antibodies, that bind cd22 and uses thereof |
| AU2007333098A1 (en) | 2006-12-14 | 2008-06-19 | Medarex, Inc. | Human antibodies that bind CD70 and uses thereof |
| UY30776A1 (es) * | 2006-12-21 | 2008-07-03 | Medarex Inc | Anticuerpos cd44 |
| TWI412367B (zh) | 2006-12-28 | 2013-10-21 | 梅達雷克斯有限責任公司 | 化學鏈接劑與可裂解基質以及其之綴合物 |
| US20080176958A1 (en) * | 2007-01-24 | 2008-07-24 | Insert Therapeutics, Inc. | Cyclodextrin-based polymers for therapeutics delivery |
| KR20090122439A (ko) * | 2007-02-21 | 2009-11-30 | 메다렉스, 인코포레이티드 | 단일 아미노산을 갖는 화학적 링커 및 이의 접합체 |
| WO2008106080A2 (en) * | 2007-02-27 | 2008-09-04 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Synthesis of desacetoxytubulysin h and analogs thereof |
| NZ580132A (en) * | 2007-03-14 | 2012-11-30 | Endocyte Inc | Binding ligand linked drug delivery conjugates of tubulysins to vitamins |
| EP2532673A3 (en) | 2007-05-10 | 2014-01-08 | R & D Biopharmaceuticals Gmbh | Tubulysine derivatives |
| CN104383553A (zh) | 2007-06-25 | 2015-03-04 | 恩多塞特公司 | 含有亲水性间隔区接头的共轭物 |
| US7387981B1 (en) | 2007-06-28 | 2008-06-17 | Lyondell Chemical Technology, L.P. | Direct epoxidation catalyst and process |
| WO2009012958A2 (en) | 2007-07-20 | 2009-01-29 | Helmholtz-Zentrum für Infektionsforschung GmbH | Tubulysin d analogues |
| US9193763B2 (en) | 2007-08-17 | 2015-11-24 | Purdue Research Foundation | PSMA binding ligand-linker conjugates and methods for using |
| EP2185188B1 (en) | 2007-08-22 | 2014-08-06 | Medarex, L.L.C. | Site-specific attachment of drugs or other agents to engineered antibodies with c-terminal extensions |
| SI2195017T1 (sl) | 2007-10-01 | 2015-01-30 | Bristol-Myers Squibb Company | Človeška protitelesa, ki vežejo mezotelin in njihova uporaba |
| WO2009055562A1 (en) | 2007-10-25 | 2009-04-30 | Endocyte, Inc. | Tubulysins and processes for preparing |
| EP2174947A1 (en) | 2008-09-25 | 2010-04-14 | Universität des Saarlandes | Bioactive pre-tubulysins and use thereof |
| US8394922B2 (en) | 2009-08-03 | 2013-03-12 | Medarex, Inc. | Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof |
| WO2011057805A1 (en) * | 2009-11-12 | 2011-05-19 | R&D Biopharmaceuticals Gmbh | Tubulin inhibitors |
-
2010
- 2010-07-29 US US12/846,493 patent/US8394922B2/en active Active
- 2010-08-02 PE PE2012000147A patent/PE20121087A1/es active IP Right Grant
- 2010-08-02 MX MX2012001665A patent/MX2012001665A/es active IP Right Grant
- 2010-08-02 WO PCT/US2010/044078 patent/WO2011017249A1/en not_active Ceased
- 2010-08-02 NZ NZ597985A patent/NZ597985A/xx not_active IP Right Cessation
- 2010-08-02 HR HRP20140976AT patent/HRP20140976T1/hr unknown
- 2010-08-02 CN CN201080045031.9A patent/CN102725001B/zh not_active Expired - Fee Related
- 2010-08-02 ES ES10739817.4T patent/ES2525351T3/es active Active
- 2010-08-02 SG SG10201503332XA patent/SG10201503332XA/en unknown
- 2010-08-02 HU HUE10739817A patent/HUE026997T2/en unknown
- 2010-08-02 CA CA2770042A patent/CA2770042C/en not_active Expired - Fee Related
- 2010-08-02 EP EP10739817.4A patent/EP2461830B1/en active Active
- 2010-08-02 BR BR112012002615-1A patent/BR112012002615A2/pt not_active Application Discontinuation
- 2010-08-02 EA EA201270242A patent/EA022288B1/ru not_active IP Right Cessation
- 2010-08-02 KR KR1020127005701A patent/KR101759359B1/ko not_active Expired - Fee Related
- 2010-08-02 SI SI201030809T patent/SI2461830T1/sl unknown
- 2010-08-02 CN CN201410720841.XA patent/CN104592351A/zh active Pending
- 2010-08-02 SG SG2012005054A patent/SG178095A1/en unknown
- 2010-08-02 PL PL10739817T patent/PL2461830T3/pl unknown
- 2010-08-02 AU AU2010279674A patent/AU2010279674B2/en not_active Ceased
- 2010-08-02 DK DK10739817.4T patent/DK2461830T3/en active
- 2010-08-02 PT PT107398174T patent/PT2461830E/pt unknown
- 2010-08-02 JP JP2012523678A patent/JP5859964B2/ja not_active Expired - Fee Related
- 2010-08-02 IN IN860DEN2012 patent/IN2012DN00860A/en unknown
- 2010-08-03 TW TW99125854A patent/TWI469794B/zh not_active IP Right Cessation
- 2010-08-03 AR ARP100102856A patent/AR077701A1/es active IP Right Grant
-
2012
- 2012-01-24 IL IL217717A patent/IL217717A/en active IP Right Grant
- 2012-02-03 CL CL2012000302A patent/CL2012000302A1/es unknown
- 2012-02-28 CO CO12034850A patent/CO6501196A2/es active IP Right Grant
-
2013
- 2013-01-29 US US13/752,664 patent/US8772542B2/en active Active
- 2013-01-29 US US13/752,619 patent/US8802632B2/en active Active
- 2013-01-29 US US13/752,721 patent/US8772543B2/en active Active
-
2014
- 2014-07-07 US US14/324,480 patent/US9226974B2/en active Active
- 2014-12-11 SM SM201400183T patent/SMT201400183B/xx unknown
-
2015
- 2015-11-12 US US14/939,547 patent/US9580467B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN100420672C (zh) | 选择性抑制cox-2并衍生于吲哚链烷醇的新酯以及衍生于吲哚链烷胺的新酰胺 | |
| US10280183B2 (en) | Therapeutic agent for treating tumors | |
| JP2008522981A5 (enExample) | ||
| HRP20140976T1 (hr) | Antiproliferativne tvari, njihovi konjugati, metode za njih i njihove uporabe | |
| KR930703305A (ko) | 5-헤테로일 인돌 유도체 | |
| HUP0301427A2 (hu) | Fotokemoterápiában alkalmazható fotoszenzitizáló, 5-aminolevulinsavészterek azokat tartalmazó gyógyszerkészítmények és alkalmazásuk | |
| WO2012037358A1 (en) | Asymmetric bifunctional silyl monomers and particles thereof as prodrugs and delivery vehicles for pharmaceutical, chemical and biological agents | |
| US11420949B2 (en) | Cystine diamide analogs for the prevention of cystine stone formation in cystinuria | |
| TWI326687B (en) | Amide prodrug of gemcitabine, compositions and use thereof | |
| CA2683383A1 (en) | Bridged polycyclic compound based compositions for the inhibition and amelioration of disease | |
| US5021571A (en) | Cyclohexyl EDTA monoanhydride | |
| CN110680823A (zh) | 联苯磷酸酯类化合物作为gpr84拮抗剂的应用 | |
| JP2025521241A (ja) | ビフェニル系化合物、医薬組成物およびその調製方法と使用 | |
| ES2449569T3 (es) | Sal de un antagonista de CD80 | |
| US8709486B2 (en) | Administrable compositions | |
| JP2004538278A5 (enExample) | ||
| ES2390052T3 (es) | Agonistas del receptor opioide kappa que comprende un derivado de 2-fenilbenzotiazolina | |
| CA2671816A1 (en) | Salts of imidazole-5-carboxylic acid derivatives, a method for preparing same and pharmaceutical compositions comprising same | |
| CN105199095B (zh) | 一种基于巯基物质检测的两亲性分子探针及其合成方法 | |
| Cai et al. | Lectin-mediated cytotoxicity and specificity of 5-fluorouracil conjugated with peanut agglutinin (5-Fu-PNA) in vitro | |
| CN110302390B (zh) | 类磷脂奥沙利铂前体，其制备方法及用途 | |
| CN112209922B (zh) | 阿魏酰胺衍生物及其医药用途与晶体结构 | |
| CN102531933B (zh) | 天然产物Bostrycin衍生物Ⅱ、其制备方法和用途 | |
| CN104327098B (zh) | 一种头孢他美酸二异丙胺盐 | |
| RU2474426C1 (ru) | Простамиды и их аналоги, обладающие нейрозащитным действием |